Observation of the ϕ(1680)\phi(1680) and the Y(2175) in e+e−→ϕπ+π−e^+ e^- \to \phi\pi^+\pi^-

The cross sections for $e^+ e^- \to \phi\pi^+\pi^-$ and e^+ e^- \to \phi \fzero are measured from threshold to $\sqrt{s}=3.0$ $\hbox{GeV}$ using initial state radiation. The analysis is based on a data sample of 673 fb$^{-1}$ collected on and below the $\Upsilon(4S)$ resonance with the Belle detector at the KEKB asymmetric-energy $e^+e^-$ collider. First measurements are reported for the resonance parameters of the $\phi(1680)$ in the $\phi\pi^+\pi^-$ mode: $m=(1689\pm 7\pm 10)$ MeV/$c^2$ and $\Gamma=(211\pm 14\pm 19)$ MeV/$c^2$. A structure at $\sqrt{s}=2.1 \hbox{GeV}/c^2$, corresponding to the so called Y(2175), is observed; its mass and width are determined to be $2079\pm13^{+79}_{-28}$ MeV/$c^2$ and $192\pm23^{+25}_{-61} \hbox{MeV}/c^2$, respectively.Comment: 11 pages, 6 figures. Add one plot. Accepted by Phys.Rev.D(RC

Search for new charmonium states in the processes e+ e- --> J/psi D(*) D(*) at sqrt{s} ~ 10.6 GeV

We present a study of the X(3940) state in the process e+e- -> J/psi D* Dbar. The X(3940) mass and width are measured to be (3942 +7 -6 +- 6)MeV/c^2 and Gamma=(37 + 26 - 15 +- 8 MeV. In the process e+e- -> J/psi D* D*bar we have observed another charmonium-like state, which we denote as X(4160), in the spectrum of invariant masses of D*+ D*- combinations. The X(4160) parameters are M= 4156 + 25 - 20 +- 15 MeV/c^2 and Gamma = 139 + 111 -61 +- 21 MeV. The analysis is based on a data sample with an integrated luminosity of 693 /fb recorded near the Upsilon(4S) resonance with the Belle detector at the KEKB e+ e- asymmetric-energy collider.Comment: 7 pages, 2 figures Contribution paper for conferences EPS2007 and Lepton Photon 2007, Belle-Conference-070

Study of charmonia in four-meson final states produced in two-photon collisions

We report measurements of charmonia produced in two-photon collisions and decaying to four-meson final states, where the meson is either a charged pion or a charged kaon. The analysis is based on a 395fb^{-1} data sample accumulated with the Belle detector at the KEKB electron-positron collider. We observe signals for the three C-even charmonia eta_c(1S), chi_{c0}(1P) and chi_{c2}(1P) in the pi^+pi^-pi^+pi^-, K^+K^-pi^+pi^- and K^+K^-K^+K^- decay modes. No clear signals for eta_c(2S) production are found in these decay modes. We have also studied resonant structures in charmonium decays to two-body intermediate meson resonances. We report the products of the two-photon decay width and the branching fractions, Gamma_{gamma gamma}B, for each of the charmonium decay modes.Comment: 22 pages, 12 figure

Measurement of CP asymmetry in Cabibbo suppressed D0 decays

We measure the CP-violating asymmetries in decays to the D0 -> K+K- and D0 -> pi+pi- CP eigenstates using 540 fb^{-1} of data collected with the Belle detector at or near the Upsilon(4S) resonance. Cabibbo-favored D0 -> K-pi+ decays are used to correct for systematic detector effects. The results, A_{CP}^{KK} = (-0.43 +- 0.30 +- 0.11)% and A_{CP}^{pipi} = (+0.43 +- 0.52 +- 0.12)%, are consistent with no CP violation.Comment: Submitted to Phys. Lett.

Bio-analytical Assay Methods used in Therapeutic Drug Monitoring of Antiretroviral Drugs-A Review

Background: Several clinical trials, as well as observational statistics, have exhibited that the advantages of antiretroviral [ARV] treatment for humans with Human Immunodeficiency Virus / Acquired Immune Deficiency Syndrome HIV/AIDS exceed their risks. Therapeutic drug monitoring [TDM] plays a key role in optimization of ARV therapy. Determination of ARV's in plasma, blood cells, and other biological matrices frequently requires separation techniques capable of high effectiveness, specific selectivity and high sensitivity. High-performance liquid chromatography [HPLC] coupled with ultraviolet [UV], Photodiode array detectors [PDA], Mass spectrophotometer [MS] detectors etc. are the important quantitative techniques used for the estimation of pharmaceuticals in biological samples. Objective: This review article is aimed to give an extensive outline of different bio-analytical techniques which have been reported for direct quantitation of ARV's. This article aimed to establish an efficient role played by the TDM in the optimum therapeutic outcome of the ARV treatment. It also focused on establishing the prominent role played by the separation techniques like HPLC and UPLC along with the detectors like UV and Mass in TDM. Methods: TDM is based on the principle that for certain drugs, a close relationship exists between the plasma level of the drug and its clinical effect. TDM is of no value if the relationship does not exist. The analytical methodology employed in TDM should: 1) distinguish similar compounds; 2) be sensitive and precise and 3) is easy to use Results: This review highlights the advancement of the chromatographic techniques beginning from the HPLC-UV to the more advanced technique like UPLC-MS/MS. TDM is essential to ensure adherence, observe viral resistance and to personalize ARV dose regimens. It is observed that the analytical methods like immunoassays and liquid chromatography with detectors like UV, PDA, Florescent, MS, MS/MS and Ultra performance liquid chromatography (UPLC)-MS/MS have immensely contributed to the clinical outcome of the ARV therapy. Assay methods are not only helping physicians in limiting the side effects and drug interactions but also assisting in monitoring patient's compliance. Conclusion: The present review revealed that HPLC has been the most widely used system irrespective of the availability of more sensitive chromatographic technique like UPLC.VRAID (ex DIPUC