An association between lifespan and variation in insulin-like growth factor I receptor in sheep

Longevity in livestock is a valuable trait. When productive animals live longer, fewer replacement animals need to be raised. However, selection for longevity is not commonly the focus of breeding programs as direct selection for long-lived breeding stock is virtually impossible until late in the reproductive life of the animal. Additionally the underlying genetic factors or genes associated with longevity are either not known, or not well understood. In humans, there is evidence that IGF 1 receptor (IGF1R) is involved in longevity. Polymorphism in the IGF1R gene has been associated with longevity in a number of species. Recently, 3 alleles of ovine IGF1R were identified, but no analysis of the effect of IGF1R variation on sheep longevity has been reported. In this study, associations between ovine IGF1R variation, longevity and fertility were investigated. Polymerase chain reaction-single strand conformational polymorphism (PCR-SSCP) was used to type IGF1R variation in 1,716 New Zealand sheep belonging to 6 breeds and 36 flocks. Ovine IGF1R C was associated with age when adjusting for flock (present 5.5 ± 0.2 yr, absent 5.0 ± 0.1 yr, P = 0.02). A general linear mixed effects model suggested an association (P = 0.06) between age and genotype, when correcting for flock. Pairwise comparison (least significant difference) of specific genotypes revealed the difference to be between AA (5.0± 0.1 yr) and AC (5.6 ± 0.2 yr, P = 0.02). A weak negative Pearson correlation between fertility and longevity traits was observed (r = -0.25, P < 0.01). The finding of an association between variation in IGF1R and lifespan in sheep may be useful in prolonging the lifespan of sheep

Large-Amplitude Ultraviolet Variations in the RR Lyrae Star ROTSE-I J143753.84+345924.8

The NASA Galaxy Evolution Explorer (GALEX) satellite has obtained simultaneous near and far ultraviolet light curves of the ROTSE-I Catalog RR Lyrae ab-type variable star J143753.84+345924.8. A series of 38 GALEX Deep Imaging Survey observations well distributed in phase within the star's 0.56432d period shows an AB=4.9mag variation in the far UV (1350-1750A) band and an AB=1.8mag variation in the near UV (1750-2750A) band, compared with only a 0.8mag variation in the broad, unfiltered ROTSE-I (4500-10000A) band. These GALEX UV observations are the first to reveal a large RR Lyrae amplitude variation at wavelengths below 1800A. We compare the GALEX and ROTSE-I observations to predictions made by recent Kurucz stellar atmosphere models. We use published physical parameters for the comparable period (0.57433d), well-observed RR Lyrae star WY Antliae to compute predicted FUV, NUV, and ROTSE-I light curves for J143753.84+345924.8. The observed light curves agree with the Kurucz predictions for [Fe/H]=-1.25 to within AB=0.2mag in the GALEX NUV and ROTSE-I bands, and within 0.5mag in the FUV. At all metallicities between solar and one hundredth solar, the Kurucz models predict 6-8mag of variation at wavelengths between 1000-1700A. Other variable stars with similar temperature variations, such as Cepheids, should also have large-amplitude FUV light curves, observable during the ongoing GALEX imaging surveys.Comment: This paper will be published as part of the Galaxy Evolution Explorer (GALEX) Astrophysical Journal Letters Special Issue. Links to the full set of papers will be available at http:/www.galex.caltech.edu/PUBLICATIONS after November 22, 200

GALEX UV Spectroscopy and Deep Imaging of LIRGs in the ELAIS S1 field

The ELAIS S1 field was observed by GALEX in both its Wide Spectroscopic and Deep Imaging Survey modes. This field was previously observed by the Infrared Space Observatory and we made use of the catalogue of multi-wavelength data published by the ELAIS consortium to select galaxies common to the two samples. Among the 959 objects with GALEX spectroscopy, 88 are present in the ELAIS catalog and 19 are galaxies with an optical spectroscopic redshift. The distribution of redshifts covers the range $0<z<1.6$. The selected galaxies have bolometric IR luminosities $10<Log(L_{IR})<13$ (deduced from the $15 \mu m$ flux using ISOCAM) which means that we cover a wide range of galaxies from normal to Ultra Luminous IR Galaxies. The mean ($\sigma$) UV luminosity (not corrected for extinction) amounts to $Log(\lambda.L_{1530}) = 9.8 (0.6)$ L_\sun for the low-z ($z \le 0.35$) sample. The UV slope $\beta$ (assuming $f_\lambda \propto \lambda^\beta$) correlates with the GALEX FUV-NUV color if the sample is restricted to galaxies below $z < 0.1$. Taking advantage of the UV and IR data, we estimate the dust attenuation from the IR/UV ratio and compare it to the UV slope $\beta$. We find that it is not possible to uniquely estimate the dust attenuation from $\beta$ for our sample of galaxies. These galaxies are highly extinguished with a median value $A_{FUV} = 2.7 \pm 0.8$. Once the dust correction applied, the UV- and IR-based SFRs correlate. For the closest galaxy with the best quality spectrum, we see a feature consistent with being produced by a bump near 220nm in the attenuation curve.Comment: This paper has been published as part of the GALEX ApJL Special Issue (ApJ 619, L63

The GALEX-VVDS Measurement of the Evolution of the 1500A Luminosity Function

We present the first measurement of the galaxy luminosity function at 1500A between 0.2<z<1.2 based on GALEX-VVDS observations (1000 spectroscopic redshifts for galaxies with NUV<24.5) and at higher z using existing datasets. Our main results are summarized as follows : (i) luminosity evolution is observed with Delta(Mstar)=-2.0 mag between z=0 and z=1 and Delta(Mstar)=-1.0mag between z=1 and z=3. This confirms that the star formation activity was significantly higher in the past. (ii) the LF slopes vary between -1.2< alpha <-1.65, with a marginally significant hint of increase at higher z. (iii) we split the sample in three restframe (B-I) intervals providing an approximate spectral type classification: Sb-Sd, Sd-Irr and unobscured starbursts. We find that the bluest class evolves less strongly in luminosity than the two other classes. On the other hand their number density increases sharply with z (15% in the local universe to 55% at z=1) while that of the reddest classes decreases.Comment: 4 pages, 4 figures. This paper will be published as part of the Galaxy Evolution Explorer (GALEX) Astrophysical Journal Letters Special Issue.Links to the full set of papers will be available at : http://www.galex.caltech.edu/PUBLICATIONS/ after November 22, 200

Predicting DNA methylation level across human tissues

Differences in methylation across tissues are critical to cell differentiation and are key to understanding the role of epigenetics in complex diseases. In this investigation, we found that locus-specific methylation differences between tissues are highly consistent across individuals. We developed a novel statistical model to predict locus-specific methylation in target tissue based on methylation in surrogate tissue. The method was evaluated in publicly available data and in two studies using the latest IlluminaBeadChips: a childhood asthma study with methylation measured in both peripheral blood leukocytes (PBL) and lymphoblastoid cell lines; and a study of postoperative atrial fibrillation with methylation in PBL, atrium and artery. We found that our method can greatly improve accuracy of cross-tissue prediction at CpG sites that are variable in the target tissue [R2 increases from 0.38 (original R2 between tissues) to 0.89 for PBL-to-artery prediction; from 0.39 to 0.95 for PBL-to-atrium; and from 0.81 to 0.98 for lymphoblastoid cell line-to-PBL based on cross-validation, and confirmed using cross-study prediction]. An extended model with multiple CpGs further improved performance. Our results suggest that large-scale epidemiology studies using easy-to-access surrogate tissues (e.g. blood) could be recalibrated to improve understanding of epigenetics in hard-to-access tissues (e.g. atrium) and might enable non-invasive disease screening using epigenetic profiles

GALEX UV Color-Magnitude Relations and Evidence for Recent Star Formation in Early-type Galaxies

We have used the GALEX UV photometric data to construct a first near-ultraviolet (NUV) color-magnitude relation (CMR) for the galaxies pre-classified as early-type by SDSS studies. The NUV CMR is a powerful tool for tracking the recent star formation history in early-type galaxies, owing to its high sensitivity to the presence of young stellar populations. Our NUV CMR for UV-weak galaxies shows a well-defined slope and thus will be useful for interpreting the restframe NUV data of distant galaxies and studying their star formation history. Compared to optical CMRs, the NUV CMR shows a substantially larger scatter, which we interpret as evidence of recent star formation activities. Roughly 15% of the recent epoch (z < 0.13) bright (M[r] < -22) early-type galaxies show a sign of recent (< 1Gyr) star formation at the 1-2% level (lower limit) in mass compared to the total stellar mass. This implies that low level residual star formation was common during the last few billion years even in bright early-type galaxies.Comment: This paper will be published as part of the Galaxy Evolution Explorer (GALEX) Astrophysical Journal Letters Special Issue. Links to the full set of papers will be available at http://www.galex.caltech.edu/PUBLICATIONS/ after November 22, 200

Preparation, structural characterisation and antibacterial properties of Ga-doped sol-gel phosphate-based glass

A sol-gel preparation of Ga-doped phosphate-based glass with potential application in antimicrobial devices has been developed. Samples of composition (CaO)(0.30)(Na2O)(0.20-x) (Ga2O3) (x) (P2O5)(0.50) where x = 0 and 0.03 were prepared, and the structure and properties of the gallium-doped sample compared with those of the sample containing no gallium. Analysis of the P-31 MAS NMR data demonstrated that addition of gallium to the sol-gel reaction increases the connectivity of the phosphate network at the expense of hydroxyl groups. This premise is supported by the results of the elemental analysis, which showed that the gallium-free sample contains significantly more hydrogen and by FTIR spectroscopy, which revealed a higher concentration of -OH groups in that sample. Ga K-edge extended X-ray absorption fine structure and X-ray absorption near-edge structure data revealed that the gallium ions are coordinated by six oxygen atoms. In agreement with the X-ray absorption data, the high-energy XRD results also suggest that the Ga3+ ions are octahedrally coordinated with respect to oxygen. Antimicrobial studies demonstrated that the sample containing Ga3+ ions had significant activity against Staphylococcus aureus compared to the control

Star formation in the nearby universe: the ultraviolet and infrared points of view

This work presents the main ultraviolet (UV) and far-infrared (FIR) properties of two samples of nearby galaxies selected from the GALEX ($\lambda = 2315$\AA, hereafter NUV) and IRAS ($\lambda = 60\mu$m) surveys respectively. They are built in order to get detection at both wavelengths for most of the galaxies. Star formation rate (SFR) estimators based on the UV and FIR emissions are compared. Systematic differences are found between the SFR estimators for individual galaxies based on the NUV fluxes corrected for dust attenuation and on the total IR luminosity. A combined estimator based on NUV and IR luminosities seems to be the best proxy over the whole range of values of SFR. Although both samples present similar average values of the birthrate parameter b, their star-formation-related properties are substantially different: NUV-selected galaxies tend to show larger values of $b$ for lower masses, SFRs and dust attenuations, supporting previous scenarios for the star formation history (SFH). Conversely, about 20% of the FIR-selected galaxies show high values of $b$, SFR and NUV attenuation. These galaxies, most of them being LIRGs and ULIRGs, break down the downsizing picture for the SFH, however their relative contribution per unit volume is small in the local Universe. Finally, the cosmic SFR density of the local Universe is estimated in a consistent way from the NUV and IR luminosities.Comment: 43 pages, 13 figures, accepted for publication in Astrophysical Journal Supplement Serie

A Multi-Inventory Ensemble Analysis of the Effects of Atmospheric Rivers on Precipitation and Streamflow in the Namgang-Dam Basin in Korea

Atmospheric rivers (ARs) are an important concern in regional water management; however, little is known about the AR impacts on hydrology in East Asia (EA). This study analyzes the characteristics of storms, precipitation (P), streamflow (Q), and runoff coefficient (R) in the Namgang-dam basin in Korea related to ARs for 2000–2013, as well as the sensitivity of the analysis results to AR detection methods, using observed P, Q, and three different AR inventories. The basin experiences 37.3 storms annually, of which 54% are AR storms that provide over 60% of the annual P and Q. The AR (non-AR) storms are dominant in storm frequency and the storm-total P and Q for January–July (August–December) with peaks in July (August). The monthly AR frequency varies closely with the seasonal variations in the EA monsoon and the North Pacific storm track which modulate the number of extratropical cyclones. The AR storms produce most of the extreme events; they also generate larger storm-mean P and Q than the non-AR storms for all months. The seasonal variations in R are related to the total (AR- and non-AR storms combined) P through the seasonal soil water variations, making the AR effects on R unclear. Considering 95% confidence intervals, the AR storms are distinguished well from the non-AR storms in storm frequency and the storm-total and storm-mean P and Q. The sensitivity to AR inventories is not critical in quantifying the AR-storm characteristics and their impacts on hydrologic variables except for R

The Ultraviolet Galaxy Luminosity Function from GALEX data: Color Dependent Evolution at Low Redshift

We present measurements of the FUV (1530A) and NUV (2310A) galaxy luminosity functions (LF) at low redshift (z<0.2) from GALEX observations matched to the 2dF Galaxy Redshift Survey. We split our FUV and NUV samples into two UV-bj color bins and two redshift bins. As observed at optical wavelengths, the local LF of the bluest galaxies tend to have steeper faint end slopes and fainter characteristic magnitudes M* than the reddest subsamples. We find evidence for color dependent evolution at very low redshift in both bands, with bright blue galaxies becoming dominant in the highest redshift bin. The evolution of the total LF is consistent with an 0.3 magnitude brightening between z=0 and 0.13, in agreement with the first analysis of deeper GALEX fields probing adjacent and higher redshifts.Comment: This paper will be published as part of the Galaxy Evolution Explorer (GALEX) Astrophysical Journal Letters Special Issue. Links to the full set of papers will be available at : http://www.galex.caltech.edu/PUBLICATIONS/ after November 22, 200