300 research outputs found
Evaluating blood-brain barrier permeability in delayed cerebral infarction after aneurysmal subarachnoid hemorrhage
BACKGROUND AND PURPOSE: Patients with SAH are at increased risk of delayed infarction. Early detection and treatment of delayed infarction remain challenging. We assessed blood-brain barrier permeability, measured as permeability surface area product, by using CTP in patients with SAH with delayed infarction. MATERIALS AND METHODS: We performed a retrospective study of patients with SAH with delayed infarction on follow-up NCCT. CTP was performed before the development of delayed infarction. CTP data were postprocessed into permeability surface area product, CBF, and MTT maps. Coregistration was performed to align the infarcted region on the follow-up NCCT with the corresponding location on the CTP maps obtained before infarction. Permeability surface area product, CBF, and MTT values were then obtained in the location of the subsequent infarction. The contralateral noninfarcted region was compared with the affected side in each patient. Wilcoxon signed rank tests were performed to determine statistical significance. Clinical data were collected at the time of CTP and at the time of follow-up NCCT. RESULTS: Twenty-one patients with SAH were included in the study. There was a statistically significant increase in permeability surface area product in the regions of subsequent infarction compared with the contralateral control regions (P \u3c .0001). However, CBF and MTT values were not significantly different in these 2 regions. Subsequent follow-up NCCT demonstrated new delayed infarction in all 21 patients, at which time 38% of patients had new focal neurologic deficits. CONCLUSIONS: Our study reveals a statistically significant increase in permeability surface area product preceding delayed infarction in patients with SAH. Further investigation of early permeability changes in SAH may provide new insights into the prediction of delayed infarction
Radio polarimetric imaging of the interstellar medium: magnetic field and diffuse ionized gas structure near the W3/W4/W5/HB3 complex
We have used polarimetric imaging to study the magneto-ionic medium of the
Galaxy, obtaining 1420 MHz images with an angular resolution of 1' over more
than 40 square-degrees of sky around the W3/W4/W5/HB3 HII region/SNR complex in
the Perseus Arm. Features detected in polarization angle are imposed on the
linearly polarized Galactic synchrotron background emission by Faraday rotation
arising in foreground ionized gas having an emission measure as low as 1
cm^{-6} pc. Several new remarkable phenomena have been identified, including:
mottled polarization arising from random fluctuations in a magneto-ionic screen
that we identify with a medium in the Perseus Arm, probably in the vicinity of
the HII regions themselves; depolarization arising from very high rotation
measures (several times 10^3 rad m^{-2}) and rotation measure gradients due to
the dense, turbulent environs of the HII regions; highly ordered features
spanning up to several degrees; and an extended influence of the HII regions
beyond the boundaries defined by earlier observations. In particular, the
effects of an extended, low-density ionized halo around the HII region W4 are
evident, probably an example of the extended HII envelopes postulated as the
origin of weak recombination-line emission detected from the Galactic ridge.
Our polarization observations can be understood if the uniform magnetic field
component in this envelope scales with the square-root of electron density and
is 20 microG at the edge of the depolarized region around W4, although this is
probably an over-estimate since the random field component will have a
significant effect.Comment: 18 pages, 8 figures (7 jpeg and 1 postscript), accepted for
publication in the Astrophysical Journa
The HII Region KR 140: Spontaneous Formation of a High Mass Star
We have used a multiwavelength data set from the Canadian Galactic Plane
Survey (CGPS) to study the Galactic HII region KR 140, both on the scale of the
nebula itself and in the context of the star forming activity in the nearby
W3/W4/W5 complex of molecular clouds and HII regions. From both radio and
infrared data we have found a covering factor of about 0.5 for KR 140 and we
interpret the nebula as a bowl-shaped region viewed close to face on.
Extinction measurements place the region on the near side of its parent
molecular cloud. The nebula is kept ionized by one O8.5 V(e) star, VES 735,
which is less than a few million years old. CO data show that VES 735 has
disrupted much of the original molecular cloud for which the estimated mass and
density are about 5000 and 100 cm, respectively. KR 140 is
isolated from the nearest star forming activity, in W3. Our data suggest that
KR 140 is an example of spontaneous (i.e., non-triggered) formation of,
unusually, a high mass star.Comment: 46 pages; includes 15 figures; accepted by the Ap
A Sino-German 6 cm polarization survey of the Galactic plane II. The region from 129 degree to 230 degree longitude
Linearly polarized Galactic synchrotron emission provides valuable
information about the properties of the Galactic magnetic field and the
interstellar magneto-ionic medium, when Faraday rotation along the line of
sight is properly taken into account. We aim to survey the Galactic plane at 6
cm including linear polarization. At such a short wavelength Faraday rotation
effects are in general small and the Galactic magnetic field properties can be
probed to larger distances than at long wavelengths. The Urumqi 25-m telescope
is used for a sensitive 6 cm survey in total and polarized intensities. WMAP
K-band (22.8 GHz) polarization data are used to restore the absolute zero-level
of the Urumqi U and Q maps by extrapolation. Total intensity and polarization
maps are presented for a Galactic plane region of 129 degree < l < 230 degree
and |b| < 5 degree in the anti-centre with an angular resolution of 9'5 and an
average sensitivity of 0.6 mK and 0.4 mK Tb in total and polarized intensity,
respectively. We briefly discuss the properties of some extended Faraday
Screens detected in the 6 cm polarization maps. The Sino-German 6 cm
polarization survey provides new information about the properties of the
magnetic ISM. The survey also adds valuable information for discrete Galactic
objects and is in particular suited to detect extended Faraday Screens with
large rotation measures hosting strong regular magnetic fields.Comment: 17 pages, 20 figures, accepted by A&A. Resolutions of the figures
have been significantly reduced. For version with full resolution, see
http://159.226.88.6/zmtt/6cm/papers/gao.paper2.pd
Food processing and technology 1978: a summary of research
Evaluation of tomato cultivars for processing / W. A. Gould, W. Stone, J. Mount, L. Witt, Y. Yamada, and S. Z. Berry -- Geotrichum candidum in midwestern tomato processing plants and various methods of inhibiting its growth / James G. Fox and Wilbur A. Gould -- Effects of various qualities of raw tomatoes (subjective evaluation) on color of extractable juice (objective evaluation) / Yasunori Yamada and Wilbur A. Gould -- Protein content of seeds taken from tomatoes at various stages of ripeness / Daniel Brodowski and J. R. Geisman -- Effects of cultivar, break temperature, and extraction methods on the viscosity of tomato juice / Hashmy Bel-Haj and Wilbur A. Gould -- A study of some factors affecting the solid content of canned tomatoes / J. R. Mount and W. A. Gould -- Prediction of ascorbic acid stability in canned apple juice / Mohamed I. Mahmoud and Wilbur A. Gould -- Investigation of protein content of ohio grown soybeans / Girish N. Desai and Andrew C. Peng -- Recovery and functionality of soybean leaf proteins / Mohammed H. Ali and Andrew C. Peng -- Carotene content of green snap beans / H. Fenercioglu and D. E. Crean -- Effect of reconditioning on the ascorbic acid content of potato cultivars / I. S. Arkoudilos and D. E. Crean -- Kinetic studies of polyphenol oxidase from HiDri cabbage / Ling-May Chen and Andrew C. Peng -- Refinements in pickle brine recycling / T. Glares and J. R. Geisman -- Use of ultraviolet light to inhibit Staphylococcus aureus growth on the surface of baked pumpkin pie / Nicholas N. Kallas and Wilbur A. Gould -- Development of a nutritionally improved corn masa / Thomas H. Rieman and Wilbur A. Gould -- Mechanical deboning of Lake Erie freshwater drum / W. E. Stone and W. A. Gould -- Lake Erie freshwater drum fillet processing, storage, and evaluation / W. E. Stone and W. A. Goul
Detection of Extended VHE Gamma Ray Emission from G106.3+2.7 with VERITAS
We report the detection of very-high-energy (VHE) gamma-ray emission from
supernova remnant (SNR) G106.3+2.7. Observations performed in 2008 with the
VERITAS atmospheric Cherenkov gamma-ray telescope resolve extended emission
overlapping the elongated radio SNR. The 7.3 sigma (pre-trials) detection has a
full angular extent of roughly 0.6deg by 0.4deg. Most notably, the centroid of
the VHE emission is centered near the peak of the coincident 12CO (J = 1-0)
emission, 0.4deg away from the pulsar PSR J2229+6114, situated at the northern
end of the SNR. Evidently the current-epoch particles from the pulsar wind
nebula are not participating in the gamma-ray production. The VHE energy
spectrum measured with VERITAS is well characterized by a power law dN/dE =
N_0(E/3 TeV)^{-G} with a differential index of G = 2.29 +/- 0.33stat +/-
0.30sys and a flux of N_0 = (1.15 +/- 0.27stat +/- 0.35sys)x 10^{-13} cm^{-2}
s^{-1} TeV^{-1}. The integral flux above 1 TeV corresponds to ~5 percent of the
steady Crab Nebula emission above the same energy. We describe the observations
and analysis of the object and briefly discuss the implications of the
detection in a multiwavelength context.Comment: 5 pages, 2 figure
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Syphilis Predicts HIV Incidence Among Men and Transgender Women Who Have Sex With Men in a Preexposure Prophylaxis Trial
Background. Syphilis infection may potentiate transmission of human immunodeficiency virus (HIV). We sought to determine the extent to which HIV acquisition was associated with syphilis infection within an HIV preexposure prophylaxis (PrEP) trial and whether emtricitabine/tenofovir (FTC/TDF) modified that association. Methods. The Preexposure Prophylaxis Initiative (iPrEx) study randomly assigned 2499 HIV-seronegative men and transgender women who have sex with men (MSM) to receive oral daily FTC/TDF or placebo. Syphilis prevalence at screening and incidence during follow-up were measured. Hazard ratios for the effect of incident syphilis on HIV acquisition were calculated. The effect of FTC/TDF on incident syphilis and HIV acquisition was assessed. Results. Of 2499 individuals, 360 (14.4%) had a positive rapid plasma reagin test at screening; 333 (92.5%) had a positive confirmatory test, which did not differ between the arms (FTC/TDF vs placebo, P = .81). The overall syphilis incidence during the trial was 7.3 cases per 100 person-years. There was no difference in syphilis incidence between the study arms (7.8 cases per 100 person-years for FTC/TDF vs 6.8 cases per 100 person-years for placebo, P = .304). HIV incidence varied by incident syphilis (2.8 cases per 100 person-years for no syphilis vs 8.0 cases per 100 person-years for incident syphilis), reflecting a hazard ratio of 2.6 (95% confidence interval, 1.6–4.4; P < .001). There was no evidence for interaction between randomization to the FTC/TDF arm and incident syphilis on HIV incidence. Conclusions. In HIV-seronegative MSM, syphilis infection was associated with HIV acquisition in this PrEP trial; a syphilis diagnosis should prompt providers to offer PrEP unless otherwise contraindicated
Elevated Risk for HIV-1 Infection in Adolescents and Young Adults in São Paulo, Brazil
Background. Recent studies have sought to describe HIV infection and transmission characteristics around the world. Identification of early HIV-1 infection is essential to proper surveillance and description of regional transmission trends. In this study we compare people recently infected (RI) with HIV-1, as defined by Serologic Testing Algorithm for Recent HIV Seroconversion (STARHS), to those with chronic infection. Methodology/Principal Findings Subjects were identified from 2002-2004 at four testing sites in São Paulo. Of 485 HIV-1-positive subjects, 57 (12%) were defined as RI. Of the participants, 165 (34.0%) were aware of their serostatus at the time of HIV-1 testing. This proportion was statistically larger (p<0.001) among the individuals without recent infection (n = 158, 95.8%) compared to 7 individuals (4.2%) with recently acquired HIV-1 infection. In the univariate analysis, RI was more frequent in <25 and >59 years-old age strata (p<0.001). The majority of study participants were male (78.4%), 25 to 45 years-old (65.8%), white (63.2%), single (61.7%), with family income of four or more times the minimum wage (41.0%), but with an equally distributed educational level. Of those individuals infected with HIV-1, the predominant route of infection was sexual contact (89.4%), with both hetero (47.5%) and homosexual (34.5%) exposure. Regarding sexual activity in these individuals, 43.9% reported possible HIV-1 exposure through a seropositive partner, and 49.4% reported multiple partners, with 47% having 2 to 10 partners and 37.4% 11 or more; 53.4% of infected individuals reported condom use sometimes; 34.2% reported non-injecting, recreational drug use and 23.6% were reactive for syphilis by VDRL. Subjects younger than 25 years of age were most vulnerable according to the multivariate analysis. ) Conclusions/Significance In this study, we evaluated RI individuals and discovered that HIV-1 has been spreading among younger individuals in São Paulo and preventive approaches should, therefore, target this age stratu
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