Streptozocin Diabetes Elevates all Isoforms of TGF-β in the Rat Kidney

Transforming growth factor beta (TGF-β) is a major promoter of diabetic nephropathy. While TGF-β1 is the most abundaft renal isoform, types 2 and 3 are present as well and have identical in vitro effects. Whole kidney extracts were studied 2 weeks after induction of streptozocin diabetes and in control rats. Mean glomerular area was 25% greater in the diabetic animals. TGF-β1 showed a 2-fold increase in message with a 3-fold increase in protein. TGF-β2 mRNA increased approximately 6% while its protein doubled. TGF-β-message increased by 25%, producing a 35% increase in its protein. TGF-β- inducible gene H3 mRNA was increased 35% in the diabetic animals, consistent with increased activity of this growth factor. All isoforms of TGF-β are increased in the diabetic rat kidney. Future studies need to address the specific role that each isoform plays in diabetic nephropathy as well as the impact of therapies on each isoform

Enhancement of luminescence by pulse laser annealing of ion-implanted europium in sapphire and silica

Sapphire (Al2O3) and silica samples have been implanted with 400 keV europium ions at fluences between 5×1014 and 1×1016 ions cm-2. As-implanted, samples show luminescence at 622 nm, and although the intensity may be increased by furnace anneals up to 1000°C, higher temperatures, to 1200°C, result in less emission, as the impurity ions form precipitate clusters. This problem can be avoided by the use of pulsed laser anneals which dissociate the clusters and quench in atomically dispersed ions. The luminescence intensity has been increased by factors of 95 and 85 for sapphire and silica, respectively, relative to the initial implanted signal. On comparing with furnace anneals at 1200°C, the pulsed laser annealing is more effective, by factors of up to 45 times. Data for pulsed excimer and CO2 lasers are compared. Both types of laser appear to remove the ion-implanted radiation damage, but in the case of silica, higher luminescence performance was obtained with the excimer anneals. There was no evidence for diffusion of the implanted europium, as assessed by Rutherford backscattering spectrometry. © 1995 American Institute of Physics.We thank Barry Farmery for his help with the RBS work, and both the University of Ege in Turkey and the Science and Engineering Research Council for their financial assistance. We appreciate the use of a Lumonics (Hull Op- erations) Ltd. TEA CO, laser.Peer Reviewe

Spin splitting of X-related donor impurity states in an AlAs barrier

We use magnetotunneling spectroscopy to observe the spin splitting of the ground state of an X-valley-related Si-donor impurity in an AlAs barrier. We determine the absolute magnitude of the effective Zeeman spin splitting factors of the impurity ground state to be g$_{I}$= 2.2 $\pm$ 0.1. We also investigate the spatial form of the electron wave function of the donor ground state, which is anisotropic in the growth plane

The COMPTEL instrumental line background

The instrumental line background of the Compton telescope COMPTEL onboard the Compton Gamma-Ray Observatory is due to the activation and/or decay of many isotopes. The major components of this background can be attributed to eight individual isotopes, namely 2D, 22Na, 24Na, 28Al, 40K, 52Mn, 57Ni, and 208Tl. The identification of instrumental lines with specific isotopes is based on the line energies as well as on the variation of the event rate with time, cosmic-ray intensity, and deposited radiation dose during passages through the South-Atlantic Anomaly. The characteristic variation of the event rate due to a specific isotope depends on its life-time, orbital parameters such as the altitude of the satellite above Earth, and the solar cycle. A detailed understanding of the background contributions from instrumental lines is crucial at MeV energies for measuring the cosmic diffuse gamma-ray background and for observing gamma-ray line emission in the interstellar medium or from supernovae and their remnants. Procedures to determine the event rate from each background isotope are described, and their average activity in spacecraft materials over the first seven years of the mission is estimated.Comment: accepted for publication in A&A, 22 pages, 21 figure

Spin-orbit coupling effect on quantum Hall ferromagnets with vanishing Zeeman energy

We present the phase diagram of a ferromagnetic quantum Hall effect liquid in a narrow quantum well with vanishing single-particle Zeeman splitting, $\epsilon_{{\rm Z}}$ and pronounced spin-orbit coupling. Upon decreasing $\epsilon_{{\rm Z}}$, the spin-polarization field of a liquid takes, first, the easy-axis configuration, followed by the formation of a helical state, which affects the transport and NMR properties of a liquid and the form of topological defects in it. The analysis is extended over high odd integer filling factors.Comment: This revised version takes into account easy-axis terms in the energy and offers a corrected phase diagram of the ferromagnetic QHE liquid. Analysis is extended over higher filling factor

Understanding past climatic and hydrological variability in the Mediterranean from Lake Prespa sediment isotope and geochemical record over the Last Glacial cycle

Here we present stable isotope and geochemical data from Lake Prespa (Macedonia/Albania border) over the Last Glacial cycle (Marine Isotope Stages 5–1) and discuss past lake hydrology and climate (TIC, oxygen and carbon isotopes), as well as responses to climate of terrestrial and aquatic vegetation (TOC, Rock Eval pyrolysis, carbon isotopes, pollen). The Lake Prespa sediments broadly fall into 5 zones based on their sedimentology, geochemistry, palynology and the existing chronology. The Glacial sediments suggest low supply of carbon to the lake, but high summer productivity; intermittent siderite layers suggest that although the lake was likely to have mixed regularly leading to enhanced oxidation of organic matter, there must have been within sediment reducing conditions and methanogenesis. MIS 5 and 1 sediments suggest much more productivity, higher rates of organic material preservation possibly due to more limited mixing with longer periods of oxygen-depleted bottom waters. We also calculated lakewater δ18O from siderite (authigenic/Glacial) and calcite (endogenic/Holocene) and show much lower lakewater δ18O values in the Glacial when compared to the Holocene, suggesting the lake was less evaporative in the Glacial, probably as a consequence of cooler summers and longer winter ice cover. In the Holocene the oxygen isotope data suggests general humidity, with just 2 marked arid phases, features observed in other Eastern and Central Mediterranean lakes

Dark-bright magneto-exciton mixing induced by Coulomb interaction in strained quantum wells

Coupled magneto-exciton states between allowed (`bright') and forbidden (`dark') transitions are found in absorption spectra of strained In$_{0.2}$Ga$_{0.8}$As/GaAs quantum wells with increasing magnetic field up to 30 T. We found large (~ 10 meV) energy splittings in the mixed states. The observed anticrossing behavior is independent of polarization, and sensitive only to the parity of the quantum confined states. Detailed experimental and theoretical investigations indicate that the excitonic Coulomb interaction rather than valence band complexity is responsible for the splittings. In addition, we determine the spin composition of the mixed states.Comment: 4 pages, 4 figure

Genetic Variance and Covariance Components for Feed Intake, Average Daily Gain, and Postweaning Gain in Growing Beef Cattle

Feed is the greatest cost for a beef cattle production enterprise. Data collection to determine feed efficiency of animals is also costly, because both gain and intake records are needed to calculate feed efficiency. Electronic intake monitoring systems such as GrowSafe or Insentec to collect feed intake data are expensive and thus limit the number of animals that can be tested. Scientists have worked to pinpoint optimal test durations for collecting both weight gain and feed intake records to lessen costs. A 70-day performance test is currently recommended for accurate calculation of efficiency, with growth data as the limiting factor. Research has suggested that a 35-day test is adequate to measure feed intake, but a test period of at least 70 days is suggested to measure gain with sufficient accuracy. The objective of this study was to estimate genetic parameters for growth and intake traits with particular attention to the relationship between on-test average daily gain (ADG) and national cattle evaluation postweaning gain (PWG). If the correlation between these two traits is strong, it could allow for the use of PWG as a proxy for ADG in the genetic evaluation of feed efficiency. This substitution would allow producers to reduce the length of the test required to measure feed intake accurately

Nonequilibrium models of relativistic heavy-ion collisions

To be published in J. Phys. G - Proceedings of SQM 2004 : We review the results from the various hydrodynamical and transport models on the collective flow observables from AGS to RHIC energies. A critical discussion of the present status of the CERN experiments on hadron collective flow is given. We emphasize the importance of the flow excitation function from 1 to 50 A.GeV: here the hydrodynamic model has predicted the collapse of the v2-flow ~ 10 A.GeV; at 40 A.GeV it has been recently observed by the NA49 collaboration. Since hadronic rescattering models predict much larger flow than observed at this energy we interpret this observation as evidence for a first order phase transition at high baryon density r b. Moreover, the connection of the elliptic flow v2 to jet suppression is examined. It is proven experimentally that the collective flow is not faked by minijet fragmentation. Additionally, detailed transport studies show that the away-side jet suppression can only partially (< 50%) be due to hadronic rescattering. Furthermore, the change in sign of v1, v2 closer to beam rapidity is related to the occurence of a high density first order phase transition in the RHIC data at 62.5, 130 and 200 A.GeV

Exciton Spin Dynamics in Semiconductor Quantum Wells

In this paper we will review Exciton Spin Dynamics in Semiconductor Quantum Wells. The spin properties of excitons in nanostructures are determined by their fine structure. We will mainly focus in this review on GaAs and InGaAs quantum wells which are model systems.Comment: 55 pages, 27 figure