Improved ventricular function during inhalation of PGI(2) aerosol partly relies on enhanced myocardial contractility

Inhaled prostacyclin (PGI(2)) aerosol induces selective pulmonary vasodilation. Further, it improves right ventricular ( RV) function, which may largely rely on pulmonary vasodilation, but also on enhanced myocardial contractility. We investigated the effects of the inhaled PGI(2) analogs epoprostenol (EPO) and iloprost (ILO) on RV function and myocardial contractility in 9 anesthetized pigs receiving aerosolized EPO (25 and 50 ng center dot kg(-1) center dot min(-1)) and, consecutively, ILO (60 ng center dot kg(-1) center dot min(-1)) for 20 min each. We measured pulmonary artery pressure ( PAP), RV ejection fraction (RVEF) and RV end-diastolic-volume (RV-EDV), and left ventricular end-systolic pressure-volume-relation (end-systolic elastance, E-es). EPO and ILO reduced PAP, increased RVEF and reduced RVEDV. E-es was enhanced during all doses tested, which reached statistical significance during EPO25ng and ILO, but not during EPO50ng. PGI(2) aerosol enhances myocardial contractility in healthy pigs, contributing to improve RV function. Copyright (C) 2005 S. Karger AG, Basel

Effects of substituents in polyvinylcarbazole structures on their optical properties

Absorption, photoluminescence, and photoluminescence excitation spectra of solutions and thin films of N-vinylcarbazole polymers and copolymers with various substituents directly on the carbazole moiety and on the polymer chain were studied comprehensively. Polymers that were used previously to develop polymer composites with polymethine dyes having photosensitivity over a broad spectral range including the visible and near-IR regions were selected for the studies

Orexin Receptor Antagonism, a New Sleep-Enabling Paradigm: A Proof-of-Concept Clinical Trial

Peer reviewe

Use of near-infrared light to reduce symptoms associated with restless legs syndrome in a woman: a case report

<p>Abstract</p> <p>Introduction</p> <p>We describe a potential new treatment option for patients suffering from restless legs syndrome. Contemporary treatment for restless legs syndrome consists mostly of dopaminergic drugs that leave some patients feeling nauseated and dizzy. A non-invasive, drug-free option would open new doors for patients suffering from restless legs syndrome.</p> <p>Case presentation</p> <p>A 69-year-old Caucasian woman met International Restless Legs Syndrome Study Group criteria for the diagnosis of restless legs syndrome. She had been afflicted with restless legs syndrome for over 30 years and tried many of the available pharmaceutical remedies without success. For this study she received 30-minute treatment sessions with near-infrared light, three times a week for four weeks. The restless legs syndrome rating scale was used to track symptom changes; at baseline she scored "27" on the 0 to 40 point scale, which is considered to be "severe". Our patient was almost symptom free at week two, indicated by a score of "2" on the rating scale. By week four she was completely symptom free. The symptoms slowly returned during week three post treatment.</p> <p>Conclusions</p> <p>The findings suggest that near-infrared light may be a feasible method for treating patients suffering from restless legs syndrome. Undesirable side-effects from medication are non-existent. This study might revive the neglected vascular mechanism theory behind restless legs syndrome and encourage further research into this area.</p

Biomarkers of conversion to alpha-synucleinopathy in isolated rapid-eye-movement sleep behaviour disorder

Patients with isolated rapid-eye-movement sleep behaviour disorder (RBD) are commonly regarded as being in the early stages of a progressive neurodegenerative disease involving \u3b1-synuclein pathology, such as Parkinson's disease, dementia with Lewy bodies, or multiple system atrophy. Abnormal \u3b1-synuclein deposition occurs early in the neurodegenerative process across the central and peripheral nervous systems and might precede the appearance of motor symptoms and cognitive decline by several decades. These findings provide the rationale to develop reliable biomarkers that can better predict conversion to clinically manifest \u3b1-synucleinopathies. In addition, biomarkers of disease progression will be essential to monitor treatment response once disease-modifying therapies become available, and biomarkers of disease subtype will be essential to enable prediction of which subtype of \u3b1-synucleinopathy patients with isolated RBD might develop

Influence of firm size on the competencies required to management engineers in the Jordanian telecommunications sector

This is an Accepted Manuscript of an article published by Taylor & Francis in European Journal of Engineering Education on [13 jun 2016], available online:http://www.tandfonline.com/ doi/abs/10.1080/03043797.2016.1197890.[EN] The objective of this study is to identify the competencies required to achieve success in the transition from higher education to the labour market based on the perceptions of employers. This paper analyses the assessments made by a group of engineering company employers. An item-battery of 20 competencies was grouped into 3 dimensions by using factor analysis. Subsequently, respondents scores were also clustered into three groups and characterised through contingency tables. The competencies demanded by employers were grouped into business and finance, problem-solving and strategic planning. Significant differences were found between responses from employers working in medium and small companies, who placed more importance on competencies related to problem-solving and strategic planning, and employers in big companies, who were more concerned about the difficulties of finding well-trained graduates. The findings from this paper have important implications for research in the areas of higher education and organisations that usually employ graduate engineers.The authors would like to thank the Education, Audiovisual and Culture Executive Agency (EACEA) [Tempus program. Project number 511074] of the European Commission for providing funding for conducting this study. This publication reflects the views only of the authors, and the Commission cannot be held responsible for any use which may be made of the information contained therein.Conchado Peiró, A.; Bas Cerdá, MDC.; Gharaibeh, KM.; Kaylani, H. (2016). Influence of firm size on the competencies required to management engineers in the Jordanian telecommunications sector. European Journal of Engineering Education. 1-14. doi:10.1080/03043797.2016.1197890S114ALLEN, J., & DE WEERT, E. (2007). What Do Educational Mismatches Tell Us About Skill Mismatches? A Cross-country Analysis. European Journal of Education, 42(1), 59-73. doi:10.1111/j.1465-3435.2007.00283.xBarrella, E. M., & Buffinton, K. W. (2009). Corporate Assessment of Strategic Issues in Technology Management. Engineering Management Journal, 21(1), 27-33. doi:10.1080/10429247.2009.11431795Bartram, D., Lindley, P. A., Marshall, L., & Foster, J. (1995). The recruitment and selection of young people by small businesses. Journal of Occupational and Organizational Psychology, 68(4), 339-358. doi:10.1111/j.2044-8325.1995.tb00592.xBehrends, T. (2007). Recruitment Practices in Small and Medium Size Enterprises. An Empirical Study among Knowledge-intensive Professional Service Firms. management revu, 18(1), 55-74. doi:10.5771/0935-9915-2007-1-55Boshuizen, H. P. A. (s. f.). Does Practice Make Perfect? Innovation and Change in Professional Education, 73-95. doi:10.1007/1-4020-2094-5_5Branine, M. (2008). Graduate recruitment and selection in the UK. Career Development International, 13(6), 497-513. doi:10.1108/13620430810901660Butler, C. J., & Chinowsky, P. S. (2006). Emotional Intelligence and Leadership Behavior in Construction Executives. Journal of Management in Engineering, 22(3), 119-125. doi:10.1061/(asce)0742-597x(2006)22:3(119)Carbone, T. A., & Gholston, S. (2004). Project Manager Skill Development: A Survey of Programs and Practitioners. Engineering Management Journal, 16(3), 10-16. doi:10.1080/10429247.2004.11415252Cassell, C., Nadin, S., Gray, M., & Clegg, C. (2002). Exploring human resource management practices in small and medium sized enterprises. Personnel Review, 31(6), 671-692. doi:10.1108/00483480210445962Cattell, R. B., & Vogelmann, S. (1977). A Comprehensive Trial Of The Scree And Kg Criteria For Determining The Number Of Factors. Multivariate Behavioral Research, 12(3), 289-325. doi:10.1207/s15327906mbr1203_2Chan, A. P. C., Ho, D. C. K., & Tam, C. M. (2001). Effect of Interorganizational Teamwork on Project Outcome. Journal of Management in Engineering, 17(1), 34-40. doi:10.1061/(asce)0742-597x(2001)17:1(34)Coll, R. K., & Zegwaard, K. E. (2006). Perceptions of desirable graduate competencies for science and technology new graduates. Research in Science & Technological Education, 24(1), 29-58. doi:10.1080/02635140500485340Cronbach, L. J. (1951). Coefficient alpha and the internal structure of tests. Psychometrika, 16(3), 297-334. doi:10.1007/bf02310555Dekker, R., de Grip, A., & Heijke, H. (2002). The effects of training and overeducation on career mobility in a segmented labour market. International Journal of Manpower, 23(2), 106-125. doi:10.1108/01437720210428379Elfenbein, D. W., Hamilton, B. H., & Zenger, T. R. (2010). The Small Firm Effect and the Entrepreneurial Spawning of Scientists and Engineers. Management Science, 56(4), 659-681. doi:10.1287/mnsc.1090.1130Farr, J. V., & Brazil, D. M. (2009). Leadership Skills Development for Engineers. Engineering Management Journal, 21(1), 3-8. doi:10.1080/10429247.2009.11431792Garen, J. E. (1985). Worker Heterogeneity, Job Screening, and Firm Size. Journal of Political Economy, 93(4), 715-739. doi:10.1086/261327Gharaibeh, K. M., Kaylani, H., Murphy, N., Brennan, C., Itradat, A., Al-Bataineh, M., … Bany Salameh, H. (2014). A Masters Programme in telecommunications management – demand-based curriculum design. European Journal of Engineering Education, 40(3), 267-284. doi:10.1080/03043797.2014.944104Hayes, J., Rose‐Quirie, A., & Allinson, C. W. (2000). Senior managers’ perceptions of the competencies they require for effective performance: implications for training and development. Personnel Review, 29(1), 92-105. doi:10.1108/00483480010295835Hersch, J. (1991). Education Match and Job Match. The Review of Economics and Statistics, 73(1), 140. doi:10.2307/2109696Hoegl, M., & Parboteeah, K. P. (2007). Creativity in innovative projects: How teamwork matters. Journal of Engineering and Technology Management, 24(1-2), 148-166. doi:10.1016/j.jengtecman.2007.01.008Hoegl, M., Praveen Parboteeah, K., & Gemuenden, H. G. (2003). When teamwork really matters: task innovativeness as a moderator of the teamwork–performance relationship in software development projects. Journal of Engineering and Technology Management, 20(4), 281-302. doi:10.1016/j.jengtecman.2003.08.001Van Hoorn, T. P. (1979). Strategic planning in small and medium-sized companies. Long Range Planning, 12(2), 84-91. doi:10.1016/0024-6301(79)90076-1HUSELID, M. A. (1995). THE IMPACT OF HUMAN RESOURCE MANAGEMENT PRACTICES ON TURNOVER, PRODUCTIVITY, AND CORPORATE FINANCIAL PERFORMANCE. Academy of Management Journal, 38(3), 635-672. doi:10.2307/256741Kaiser, H. F. (1958). The varimax criterion for analytic rotation in factor analysis. Psychometrika, 23(3), 187-200. doi:10.1007/bf02289233Kaufman, L., & Rousseeuw, P. J. (Eds.). (1990). Finding Groups in Data. Wiley Series in Probability and Statistics. doi:10.1002/9780470316801Krug, J. (1997). People Skills: Teamwork. Journal of Management in Engineering, 13(2), 15-16. doi:10.1061/(asce)0742-597x(1997)13:2(15)Male, S. A., Bush, M. B., & Chapman, E. S. (2010). Perceptions of Competency Deficiencies in Engineering Graduates. Australasian Journal of Engineering Education, 16(1), 55-68. doi:10.1080/22054952.2010.11464039Mao, X., Zhang, X., & AbouRizk, S. M. (2009). Enhancing Value Engineering Process by Incorporating Inventive Problem-Solving Techniques. Journal of Construction Engineering and Management, 135(5), 416-424. doi:10.1061/(asce)co.1943-7862.0000001Mendelsohn, R. (1998). Teamwork—The Key to Productivity. Journal of Management in Engineering, 14(1), 22-25. doi:10.1061/(asce)0742-597x(1998)14:1(22)Moore, B. V. (1921). Personnel selection of graduate engineers: The differentiation of apprentice engineers for training as salesmen, designers, and executives of production. Psychological Monographs, 30(5), i-85. doi:10.1037/h0093191Moy, J. W., & Lee, S. M. (2002). The career choice of business graduates: SMEs or MNCs? Career Development International, 7(6), 339-347. doi:10.1108/13620430210444367Nair, C. S., Patil, A., & Mertova, P. (2009). Re-engineering graduate skills – a case study. European Journal of Engineering Education, 34(2), 131-139. doi:10.1080/03043790902829281Passow, H. J. (2012). Which ABET Competencies Do Engineering Graduates Find Most Important in their Work? Journal of Engineering Education, 101(1), 95-118. doi:10.1002/j.2168-9830.2012.tb00043.xPinnington, A. H. (2011). Competence development and career advancement in professional service firms. Personnel Review, 40(4), 443-465. doi:10.1108/00483481111133336Reio, T. G., & Sutton, F. C. (2006). Employer assessment of work-related competencies and workplace adaptation. Human Resource Development Quarterly, 17(3), 305-324. doi:10.1002/hrdq.1176Robar, T. Y. (1998). Communication and Career Advancement. Journal of Management in Engineering, 14(2), 26-28. doi:10.1061/(asce)0742-597x(1998)14:2(26)Rowold, J., & Kauffeld, S. (2008). Effects of career‐related continuous learning on competencies. Personnel Review, 38(1), 90-101. doi:10.1108/00483480910920732Ruiz-Mercader, J., Meroño-Cerdan, A. L., & Sabater-Sánchez, R. (2006). Information technology and learning: Their relationship and impact on organisational performance in small businesses. International Journal of Information Management, 26(1), 16-29. doi:10.1016/j.ijinfomgt.2005.10.003Soliman, F., & Spooner, K. (2000). Strategies for implementing knowledge management: role of human resources management. Journal of Knowledge Management, 4(4), 337-345. doi:10.1108/13673270010379894Srour, I., Abdul-Malak, M.-A., Itani, M., Bakshan, A., & Sidani, Y. (2013). Career Planning and Progression for Engineering Management Graduates: An Exploratory Study. Engineering Management Journal, 25(3), 85-100. doi:10.1080/10429247.2013.11431985Sunindijo, R. Y., Hadikusumo, B. H., & Ogunlana, S. (2007). Emotional Intelligence and Leadership Styles in Construction Project Management. Journal of Management in Engineering, 23(4), 166-170. doi:10.1061/(asce)0742-597x(2007)23:4(166)Tanova, C. (2003). Firm size and recruitment: staffing practices in small and large organisations in north Cyprus. Career Development International, 8(2), 107-114. doi:10.1108/13620430310465534Teichler, U. (1999). Higher education policy and the world of work: changing conditions and challenges. Higher Education Policy, 12(4), 285-312. doi:10.1016/s0952-8733(99)00019-7Tsang, M. C., & Levin, H. M. (1985). The economics of overeducation. Economics of Education Review, 4(2), 93-104. doi:10.1016/0272-7757(85)90051-2Ward, J. H. (1963). Hierarchical Grouping to Optimize an Objective Function. Journal of the American Statistical Association, 58(301), 236-244. doi:10.1080/01621459.1963.10500845Zenger, T. R. (1994). Explaining Organizational Diseconomies of Scale in R&D: Agency Problems and the Allocation of Engineering Talent, Ideas, and Effort by Firm Size. Management Science, 40(6), 708-729. doi:10.1287/mnsc.40.6.708Zenger, T. R., & Lazzarini, S. G. (2004). Compensating for innovation: Do small firms offer high-powered incentives that lure talent and motivate effort? Managerial and Decision Economics, 25(67), 329-345. doi:10.1002/mde.119

Swift trust and commitment: the missing links for humanitarian supply chain coordination?

Coordination among actors in a humanitarian relief supply chain decides whether a relief operation can be or successful or not. In humanitarian supply chains, due to the urgency and importance of the situation combined with scarce resources, actors have to coordinate and trust each other in order to achieve joint goals. This paper investigated empirically the role of swift trust as mediating variable for achieving supply chain coordination. Based on commitment-trust theory we explore enablers of swift-trust and how swift trust translates into coordination through commitment. Based on a path analytic model we test data from the National Disaster Management Authority of India. Our study is the first testing commitment-trust theory (CTT) in the humanitarian context, highlighting the importance of swift trust and commitment for much thought after coordination. Furthermore, the study shows that information sharing and behavioral uncertainty reduction act as enablers for swift trust. The study findings offer practical guidance and suggest that swift trust is a missing link for the success of humanitarian supply chains