Postcard: Hand Written Message Regarding Finances

This black and white printed postcard contains correspondence from one man to another regarding finances. Handwriting is on the front and the back of the card.https://scholars.fhsu.edu/tj_postcards/2041/thumbnail.jp

Interventions to prevent burnout in high risk individuals: evidence review

Although there is existing evidence on what works to treat burnout and work-related stress, there is less on what works to prevent it from occurring in the first place. This report provides an overview of literature covering how to prevent burnout and work-related stress in individuals and within organisations

Exploring adolescents’ experiences of talking about race, ethnicity, and culture during Dialectical Behaviour Therapy (DBT): A qualitative study using thematic analysis

Background: Although anti-racist adaptations to Dialectical Behaviour Therapy (DBT) are emerging, little qualitative research exists exploring adolescents’ perspectives on therapists’ approach, cultural competency and humility regarding ethnicity, race, and culture (ERC) within DBT. This study explored diverse adolescents’ experiences of talking about ERC during all aspects of DBT treatment. Methods: Ten adolescents from diverse ERC backgrounds who attended DBT at a National and Specialist Child and Adolescent Mental Health Service (UK) completed semi-structured individual interviews that were transcribed verbatim and analysed using reflexive thematic analysis, adopting a critical realist approach. Results: Five overarching themes were developed from the data. Theme one captures the power for explicit ERC-related conversations to facilitate change, as they are frequently overlooked in therapy. Theme two discusses factors that facilitate or inhibit ERC-related discussions. Theme three captures the difficult “double bind” that adolescents find themselves in: not wanting to be a spokesperson for ERC issues whilst hoping for their therapist to facilitate/model ERC-related discussions. Theme four explores how adolescents navigated their identity in relation to ERC, their wider systemic context, and experiences of ERC-related trauma. Theme five explored therapeutic alliance, and how therapists might encourage DBT skills use with greater ERC sensitivity, emphasising validation. Conclusions: Using a bottom-up approach, we show a clear mandate from diverse adolescents for (White) clinicians to proactively create the space and safety required for ERC-related discussions. We emphasise the importance of anti-racist praxis including cultural humility, multi-cultural competencies, and validation of ERC-related difficult experiences within a wider systemic context

Detecting Forged Alcohol Non-invasively Through Vibrational Spectroscopy and Machine Learning

Alcoholic spirits are a common target for counterfeiting and adulteration, with potential costs to public health, the taxpayer and brand integrity. Current methods to authenticate spirits include examinations of superficial appearance and consistency, or require the tester to open the bottle and remove a sample. The former is inexact, while the latter is not suitable for widespread screening or for high-value spirits, which lose value once opened. We study whether non-invasive near infrared spectroscopy, in combination with traditional and time series classification methods, can correctly classify the alcohol content (a key factor in determining authenticity) of synthesised spirits sealed in real bottles. Such an experimental setup could allow for a portable, cheap to operate, and fast authentication device. We find that ethanol content can be classified with high accuracy, however methanol content proved difficult with the algorithms evaluated

A comparison of microfluidic methods for high-throughput cell deformability measurements

The mechanical phenotype of a cell is an inherent biophysical marker of its state and function, with many applications in basic and applied biological research. Microfluidics-based methods have enabled single-cell mechanophenotyping at throughputs comparable to those of flow cytometry. Here, we present a standardized cross-laboratory study comparing three microfluidics-based approaches for measuring cell mechanical phenotype: constriction-based deformability cytometry (cDC), shear flow deformability cytometry (sDC) and extensional flow deformability cytometry (xDC). All three methods detect cell deformability changes induced by exposure to altered osmolarity. However, a dose-dependent deformability increase upon latrunculin B-induced actin disassembly was detected only with cDC and sDC, which suggests that when exposing cells to the higher strain rate imposed by xDC, cellular components other than the actin cytoskeleton dominate the response. The direct comparison presented here furthers our understanding of the applicability of the different deformability cytometry methods and provides context for the interpretation of deformability measurements performed using different platforms. This Analysis compares microfluidics-based methods for assessing mechanical properties of cells in high throughput