Al Hamsi, H

Al Kaabi, A

Al Mazrouee, T

Bagnall, K

D’souza, A

Scoliosis

English

PubMed

K Bagnall

A Al Kaabi

H Al Hamsi

T Al Mazrouee

A D’souza

Springer - Publisher Connector

The suitability and attraction of the population of the United Arab Emirates for the study of genetic inheritance in scoliosis

ORAL PRESENTATION Open Access
The suitability and attraction of the population of
the United Arab Emirates for the study of genetic
inheritance in scoliosis
K Bagnall*, A Al Kaabi, H Al Hamsi, T Al Mazrouee, A D’souza
From 8th International Conference on Conservative Management of Spinal Deformities and SOSORT 2011
Annual Meeting
Barcelona, Spain. 19-21 May 2011
Background
Recently, significant advances have been made in under-
standing the aetiology of adolescent idiopathic scoliosis
(AIS) in the area of genetic inheritance. Essential to the
success of these studies is the finding of large families with
several cases of AIS from which blood samples can be col-
lected and analysed. The emirati culture is unique and
encourages large families with many children, often several
wives with the same husband, and many cases of consan-
guinity especially among first cousins. This complex family
structure might very well be suited to provide more appro-
priate examples for the study of genetic heritage in AIS
than the more typical western family.
Material and methods
The genealogical history of 15 extended emirati families
was collected for 4 generations which would approxi-
mate that required for the study of AIS. The number of
children in each family and the incidence of consangui-
nity among first cousins were calculated. These data
were compared with similar, published data for western
families.
Results
The average number of children per family among the
emirati population was 6.29 (often >10), approximately 3x
that of the average western family. In each family there
were several examples of multiple wives and first cousin
marriages. Two families were found in which at least one
person had AIS.
Conclusions
These results suggest that the unique, well controlled
structure of the emirati families lend themselves to
being excellent for extensive study of the genetic inheri-
tance aspects of the aetiology of AIS because of the
greater familial component.
Published: 27 January 2012
doi:10.1186/1748-7161-7-S1-O72
Cite this article as: Bagnall et al.: The suitability and attraction of the
population of the United Arab Emirates for the study of genetic
inheritance in scoliosis. Scoliosis 2012 7(Suppl 1):O72.
Submit your next manuscript to BioMed Central
and take full advantage of: 
• Convenient online submission
• Thorough peer review
• No space constraints or color figure charges
• Immediate publication on acceptance
• Inclusion in PubMed, CAS, Scopus and Google Scholar
• Research which is freely available for redistribution
Submit your manuscript at 
www.biomedcentral.com/submit
UAE University, Al Ain, United Arab Emirates
Bagnall et al. Scoliosis 2012, 7(Suppl 1):O72
http://www.scoliosisjournal.com/content/7/S1/O72
© 2012 Bagnall et al; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons
Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in
any medium, provided the original work is properly cited.


Crossref

ORAL PRESENTATION Open AccessThe suitability and attraction of the population ofthe United Arab Emirates for the study of geneticinheritance in scoliosisK Bagnall*, A Al Kaabi, H Al Hamsi, T Al Mazrouee, A D’souzaFrom 8th International Conference on Conservative Management of Spinal Deformities and SOSORT 2011Annual MeetingBarcelona, Spain. 19-21 May 2011BackgroundRecently, significant advances have been made in under-standing the aetiology of adolescent idiopathic scoliosis(AIS) in the area of genetic inheritance. Essential to thesuccess of these studies is the finding of large families withseveral cases of AIS from which blood samples can be col-lected and analysed. The emirati culture is unique andencourages large families with many children, often severalwives with the same husband, and many cases of consan-guinity especially among first cousins. This complex familystructure might very well be suited to provide more appro-priate examples for the study of genetic heritage in AISthan the more typical western family.Material and methodsThe genealogical history of 15 extended emirati familieswas collected for 4 generations which would approxi-mate that required for the study of AIS. The number ofchildren in each family and the incidence of consangui-nity among first cousins were calculated. These datawere compared with similar, published data for westernfamilies.ResultsThe average number of children per family among theemirati population was 6.29 (often >10), approximately 3xthat of the average western family. In each family therewere several examples of multiple wives and first cousinmarriages. Two families were found in which at least oneperson had AIS.ConclusionsThese results suggest that the unique, well controlledstructure of the emirati families lend themselves tobeing excellent for extensive study of the genetic inheri-tance aspects of the aetiology of AIS because of thegreater familial component.Published: 27 January 2012doi:10.1186/1748-7161-7-S1-O72Cite this article as: Bagnall et al.: The suitability and attraction of thepopulation of the United Arab Emirates for the study of geneticinheritance in scoliosis. Scoliosis 2012 7(Suppl 1):O72.Submit your next manuscript to BioMed Centraland take full advantage of: • Convenient online submission• Thorough peer review• No space constraints or color figure charges• Immediate publication on acceptance• Inclusion in PubMed, CAS, Scopus and Google Scholar• Research which is freely available for redistributionSubmit your manuscript at www.biomedcentral.com/submitUAE University, Al Ain, United Arab EmiratesBagnall et al. Scoliosis 2012, 7(Suppl 1):O72http://www.scoliosisjournal.com/content/7/S1/O72© 2012 Bagnall et al; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative CommonsAttribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction inany medium, provided the original work is properly cited.

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The suitability and attraction of the population of the United Arab Emirates for the study of genetic inheritance in scoliosis

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