The optical rebrightening of GRB100814A: an interplay of forward and reverse shocks?

We present a wide dataset of -ray, X-ray, UVOIR, and radio observations of the Swift GRB100814A. At the end of the slow decline phase of the X-ray and optical afterglow, this burst shows a sudden and prominent rebrightening in the optical band only, followed by a fast decay in both bands. The optical rebrightening also shows chromatic evolution. Such a puzzling behaviour cannot be explained by a single component model. We discuss other possible interpretations, and we find that a model that incorporates a long-lived reverse shock and forward shock fits the temporal and spectral properties of GRB100814 the best

Does aluminum play well with others? Intrinsic Al-A alloying behavior in 211/312 MAX phases

<p>The search for further control over the properties of MAX phases as well as the promise of discovering compounds with new functionalities has resulted in an increased interest in MAX solid solutions resulting from mixing in either the M, A, or X sublattices. The possibility of alloying MAX compounds not only enables finer tuning of their properties but can also be used to stabilize compounds that may otherwise be metastable in their pure state. In this letter, we present an <i>ab initio</i>-based investigation of the intrinsic alloying behavior in the A sublattice of Ti(Al,A)C, Zr(Al,A)C and Ti(Al,A)C MAX compounds.</p> <p><b>IMPACT STATEMENT</b></p> <p>In this work, we present for the first time a comprehensive study of the intrinsic alloying tendencies in MAX solid solutions with (Al,A) mixing in the A sublattice.</p

Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk

Elevated blood pressure is the leading heritable risk factor for cardiovascular disease worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse pressure) among UK Biobank participants of European ancestry with independent replication in other cohorts, leading to discovery and validation of 107 novel loci. We also identify new independent variants at 11 previously reported blood pressure loci. Combined with results from a range of in-silico functional analyses and wet bench experiments, our findings highlight new biological pathways for blood pressure regulation enriched for genes expressed in vascular tissues and identify potential therapeutic targets for hypertension. Results from genetic risk score models raise the possibility of a precision medicine approach through early lifestyle intervention to offset the impact of blood pressure raising variants on future cardiovascular disease risk

The Deep and Transient Universe in the SVOM Era: New Challenges and Opportunities - Scientific prospects of the SVOM mission

To take advantage of the astrophysical potential of Gamma-Ray Bursts (GRBs), Chinese and French astrophysicists have engaged the SVOM mission (Space-based multi-band astronomical Variable Objects Monitor). Major advances in GRB studies resulting from the synergy between space and ground observations, the SVOM mission implements space and ground instrumentation. The scientific objectives of the mission put a special emphasis on two categories of GRBs: very distant GRBs at z$>$5 which constitute exceptional cosmological probes, and faint/soft nearby GRBs which allow probing the nature of the progenitors and the physics at work in the explosion. These goals have a major impact on the design of the mission: the on-board hard X-ray imager is sensitive down to 4 keV and computes on line image and rate triggers, and the follow-up telescopes on the ground are sensitive in the NIR. At the beginning of the next decade, SVOM will be the main provider of GRB positions and spectral parameters on very short time scale. The SVOM instruments will operate simultaneously with a wide range of powerful astronomical devices. This rare instrumental conjunction, combined with the relevance of the scientific topics connected with GRB studies, warrants a remarkable scientific return for SVOM. In addition, the SVOM instrumentation, primarily designed for GRB studies, composes a unique multi-wavelength observatory with rapid slew capability that will find multiple applications for the whole astronomy community beyond the specific objectives linked to GRBs. This report lists the scientific themes that will benefit from observations made with SVOM, whether they are specific GRB topics, or more generally all the issues that can take advantage of the multi-wavelength capabilities of SVOM

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals.

To dissect the genetic architecture of blood pressure and assess effects on target organ damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 individuals of European ancestry, and genotypes from an additional 140,886 individuals were used for validation. We identified 66 blood pressure-associated loci, of which 17 were new; 15 harbored multiple distinct association signals. The 66 index SNPs were enriched for cis-regulatory elements, particularly in vascular endothelial cells, consistent with a primary role in blood pressure control through modulation of vascular tone across multiple tissues. The 66 index SNPs combined in a risk score showed comparable effects in 64,421 individuals of non-European descent. The 66-SNP blood pressure risk score was significantly associated with target organ damage in multiple tissues but with minor effects in the kidney. Our findings expand current knowledge of blood pressure-related pathways and highlight tissues beyond the classical renal system in blood pressure regulation