Enhancing market-oriented R&D planning by integrated market and patent portfolios

Marketing and R&D strategies need to be aligned to increase the return from investment in new technologies. Various portfolio techniques have been widely used to support strategic planning. A new portfolio approach integrating market and technology portfolios to support market-oriented R&D planning is developed. The integrated portfolio is based on objective market and patent data and empirical evidence that the respective portfolio dimensions impact a company’s business performance. This contributes significantly to the relevance of the proposed integrated portfolio approach for strategic planning. It is tested in a practical application in the chemical industry. Based on these experiences, a set of recommendations for the effective use of the integrated portfolio for market-orientated strategic R&D planning is derived

Computer and internet interventions to optimize listening and learning for people with hearing loss: accessibility, use, and adherence

Purpose: The aim of this research forum article was to examine accessibility, use, and adherence to computerized and online interventions for people with hearing loss. Method: Four intervention studies of people with hearing loss were examined: 2 auditory training studies, 1 working memory training study, and 1 study of multimedia educational support. Results: A small proportion (approximately 15%) of participants had never used a computer, which may be a barrier to the accessibility of computer and Internet based interventions. Computer competence was not a factor in intervention use or adherence. Computer skills and Internet access influenced participant preference for the delivery method of the multimedia educational support program. Conclusions: It is important to be aware of current barriers to computer and Internet-delivered interventions for people with hearing loss. However, there is a clear need to develop and future-proof hearing-related applications for online delivery

Beiträge zur Paget'schen Erkrankung

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On the Linearization of the First and Second Painleve' Equations

We found Fuchs--Garnier pairs in 3X3 matrices for the first and second Painleve' equations which are linear in the spectral parameter. As an application of our pairs for the second Painleve' equation we use the generalized Laplace transform to derive an invertible integral transformation relating two its Fuchs--Garnier pairs in 2X2 matrices with different singularity structures, namely, the pair due to Jimbo and Miwa and the one found by Harnad, Tracy, and Widom. Together with the certain other transformations it allows us to relate all known 2X2 matrix Fuchs--Garnier pairs for the second Painleve' equation with the original Garnier pair.Comment: 17 pages, 2 figure

Mechanical Translation

Contains research objectives and reports on two research objectives.National Science Foundation (Grant GN-244

Biomembrane-mimicking lipid bilayer system as a mechanically tunable cell substrate

Cell behavior such as cell adhesion, spreading, and contraction critically depends on the elastic properties of the extracellular matrix. It is not known, however, how cells respond to viscoelastic or plastic material properties that more closely resemble the mechanical environment that cells encounter in the body. In this report, we employ viscoelastic and plastic biomembrane-mimicking cell substrates. The compliance of the substrates can be tuned by increasing the number of polymer-tethered bilayers. This leaves the density and conformation of adhesive ligands on the top bilayer unaltered. We then observe the response of fibroblasts to these property changes. For comparison, we also study the cells on soft polyacrylamide and hard glass surfaces. Cell morphology, motility, cell stiffness, contractile forces and adhesive contact size all decrease on more compliant matrices but are less sensitive to changes in matrix dissipative properties. These data suggest that cells are able to feel and respond predominantly to the effective matrix compliance, which arises as a combination of substrate and adhesive ligand mechanical properties

Extensive dissolution of live pteropods in the Southern Ocean

The carbonate chemistry of the surface ocean is rapidly changing with ocean acidification, a result of human activities. In the upper layers of the Southern Ocean, aragonite—a metastable form of calcium carbonate with rapid dissolution kinetics—may become undersaturated by 2050 (ref. 2). Aragonite undersaturation is likely to affect aragonite-shelled organisms, which can dominate surface water communities in polar regions. Here we present analyses of specimens of the pteropod Limacina helicina antarctica that were extracted live from the Southern Ocean early in 2008. We sampled from the top 200m of the water column, where aragonite saturation levels were around 1, as upwelled deep water is mixed with surface water containing anthropogenic CO2. Comparing the shell structure with samples from aragonite-supersaturated regions elsewhere under a scanning electron microscope, we found severe levels of shell dissolution in the undersaturated region alone. According to laboratory incubations of intact samples with a range of aragonite saturation levels, eight days of incubation in aragonite saturation levels of 0.94– 1.12 produces equivalent levels of dissolution. As deep-water upwelling and CO2 absorption by surface waters is likely to increase as a result of human activities2,4, we conclude that upper ocean regions where aragonite-shelled organisms are affected by dissolution are likely to expand

piRNA-guided co-transcriptional silencing coopts nuclear export factors.

The PIWI-interacting RNA (piRNA) pathway is a small RNA-based immune system that controls the expression of transposons and maintains genome integrity in animal gonads. In Drosophila, piRNA-guided silencing is achieved, in part, via co-transcriptional repression of transposons by Piwi. This depends on Panoramix (Panx); however, precisely how an RNA binding event silences transcription remains to be determined. Here we show that Nuclear Export Factor 2 (Nxf2) and its co-factor, Nxt1, form a complex with Panx and are required for co-transcriptional silencing of transposons in somatic and germline cells of the ovary. Tethering of Nxf2 or Nxt1 to RNA results in silencing of target loci and the concomitant accumulation of repressive chromatin marks. Nxf2 and Panx proteins are mutually required for proper localization and stability. We mapped the protein domains crucial for the Nxf2/Panx complex formation and show that the amino-terminal portion of Panx is sufficient to induce transcriptional silencing

Photoproduction of pi0 omega off protons for E(gamma) < 3 GeV

Differential and total cross-sections for photoproduction of gamma proton to proton pi0 omega and gamma proton to Delta+ omega were determined from measurements of the CB-ELSA experiment, performed at the electron accelerator ELSA in Bonn. The measurements covered the photon energy range from the production threshold up to 3GeV.Comment: 8 pages, 13 figure

Is HR 6819 a triple system containing a black hole? -- An alternative explanation

HR 6819 was recently proposed to be a triple system consisting of an inner B-type giant + black hole binary with an orbital period of 40d and an outer Be tertiary. This interpretation is mainly based on two inferences: that the emission attributed to the outer Be star is stationary, and that the inner star, which is used as mass calibrator for the black hole, is a B-type giant. We re-investigate the properties of HR 6819 by spectral disentangling and an atmosphere analysis of the disentangled spectra to search for a possibly simpler alternative explanation for HR 6819. Disentangling implies that the Be component is not a static tertiary, but rather a component of the binary in the 40-d orbit. The inferred radial velocity amplitudes imply an extreme mass ratio of M_2/M_1 = 15 +/- 3. We infer spectroscopic masses of 0.4$^{+0.3}_{-0.1}$ Msun and 6$^{+5}_{-3}$ Msun for the primary and secondary, which agree well with the dynamical masses for an inclination of i = 32 deg. This indicates that the primary might be a stripped star rather than a B-type giant. Evolutionary modelling suggests that a possible progenitor system would be a tight (P_i ~ 2d) B+B binary system that experienced conservative mass transfer. While the observed nitrogen enrichment of the primary conforms with the predictions of the evolutionary models, we find no indications for the predicted He enrichment. We suggest that HR 6819 is a binary system consisting of a stripped B-type primary and a rapidly-rotating Be star that formed from a previous mass-transfer event. In the framework of this interpretation, HR 6819 does not contain a black hole. Interferometry can distinguish between these two scenarios by providing an independent measurement of the separation between the visible components.Comment: Submitted to A&A, 13 pages (16 figures and 2 tables); 4 pages supplementary material (4 figures and 4 tables). Comments are welcom