1,334 research outputs found
Periodic Neural Activity Induced by Network Complexity
We study a model for neural activity on the small-world topology of Watts and
Strogatz and on the scale-free topology of Barab\'asi and Albert. We find that
the topology of the network connections may spontaneously induce periodic
neural activity, contrasting with chaotic neural activities exhibited by
regular topologies. Periodic activity exists only for relatively small networks
and occurs with higher probability when the rewiring probability is larger. The
average length of the periods increases with the square root of the network
size.Comment: 4 pages, 5 figure
Scaling law for the transient behavior of type-II neuron models
We study the transient regime of type-II biophysical neuron models and
determine the scaling behavior of relaxation times near but below the
repetitive firing critical current, . For both
the Hodgkin-Huxley and Morris-Lecar models we find that the critical exponent
is independent of the numerical integration time step and that both systems
belong to the same universality class, with . For appropriately
chosen parameters, the FitzHugh-Nagumo model presents the same generic
transient behavior, but the critical region is significantly smaller. We
propose an experiment that may reveal nontrivial critical exponents in the
squid axon.Comment: 6 pages, 9 figures, accepted for publication in Phys. Rev.
Self-Organized Criticality model for Brain Plasticity
Networks of living neurons exhibit an avalanche mode of activity,
experimentally found in organotypic cultures. Here we present a model based on
self-organized criticality and taking into account brain plasticity, which is
able to reproduce the spectrum of electroencephalograms (EEG). The model
consists in an electrical network with threshold firing and activity-dependent
synapse strenghts. The system exhibits an avalanche activity power law
distributed. The analysis of the power spectra of the electrical signal
reproduces very robustly the power law behaviour with the exponent 0.8,
experimentally measured in EEG spectra. The same value of the exponent is found
on small-world lattices and for leaky neurons, indicating that universality
holds for a wide class of brain models.Comment: 4 pages, 3 figure
A power-law distribution of phase-locking intervals does not imply critical interaction
Neural synchronisation plays a critical role in information processing,
storage and transmission. Characterising the pattern of synchronisation is
therefore of great interest. It has recently been suggested that the brain
displays broadband criticality based on two measures of synchronisation - phase
locking intervals and global lability of synchronisation - showing power law
statistics at the critical threshold in a classical model of synchronisation.
In this paper, we provide evidence that, within the limits of the model
selection approach used to ascertain the presence of power law statistics, the
pooling of pairwise phase-locking intervals from a non-critically interacting
system can produce a distribution that is similarly assessed as being power
law. In contrast, the global lability of synchronisation measure is shown to
better discriminate critical from non critical interaction.Comment: (v3) Fixed error in Figure 1; (v2) Added references. Minor edits
throughout. Clarified relationship between theoretical critical coupling for
infinite size system and 'effective' critical coupling system for finite size
system. Improved presentation and discussion of results; results unchanged.
Revised Figure 1 to include error bars on r and N; results unchanged; (v1) 11
pages, 7 figure
Increasing the frequency of hand washing by healthcare workers does not lead to commensurate reductions in staphylococcal infection in a hospital ward
Hand hygiene is generally considered to be the most important measure that can be applied to prevent the spread of healthcare-associated infection (HAI). Continuous emphasis on this intervention has lead to the widespread opinion that HAI rates can be greatly reduced by increased hand hygiene compliance alone. However, this assumes that the effectiveness of hand hygiene is not constrained by other factors and that improved compliance in excess of a given level, in itself, will result in a commensurate reduction in the incidence of HAI. However, several researchers have found the law of diminishing returns to apply to hand hygiene, with the greatest benefits occurring in the first 20% or so of compliance, and others have demonstrated that poor cohorting of nursing staff profoundly influences the effectiveness of hand hygiene measures. Collectively, these findings raise intriguing questions about the extent to which increasing compliance alone can further reduce rates of HAI.
In order to investigate these issues further, we constructed a deterministic Ross-Macdonald model and applied it to a hypothetical general medical ward. In this model the transmission of staphylococcal infection was assumed to occur after contact with the transiently colonized hands of HCWs, who, in turn, acquire contamination only by touching colonized patients. The aim of the study was to evaluate the impact of imperfect hand cleansing on the transmission of staphylococcal infection and to identify, whether there is a limit, above which further hand hygiene compliance is unlikely to be of benefit.
The model demonstrated that if transmission is solely via the hands of HCWs, it should, under most circumstances, be possible to prevent outbreaks of staphylococcal infection from occurring at a hand cleansing frequencies <50%, even with imperfect hand hygiene. The analysis also indicated that the relationship between hand cleansing efficacy and frequency is not linear - as efficacy decreases, so the hand cleansing frequency required to ensure R0<1 increases disproportionately.
Although our study confirmed hand hygiene to be an effective control measure, it demonstrated that the law of diminishing returns applies, with the greatest benefit derived from the first 20% or so of compliance. Indeed, our analysis suggests that there is little benefit to be accrued from very high levels of hand cleansing and that in most situations compliance >40% should be enough to prevent outbreaks of staphylococcal infection occurring, if transmission is solely via the hands of HCWs. Furthermore we identified a non-linear relationship between hand cleansing efficacy and frequency, suggesting that it is important to maximise the efficacy of the hand cleansing process
TERC polymorphisms are associated both with susceptibility to colorectal cancer and with longer telomeres.
Shorter telomeres have been associated with increased risk of malignancy, including colorectal cancer (CRC). Telomere length is heritable and may be an intermediate phenotype linked to genetic susceptibility to CRC
The Serre spectral sequence of a noncommutative fibration for de Rham cohomology
For differential calculi on noncommutative algebras, we construct a twisted
de Rham cohomology using flat connections on modules. This has properties
similar, in some respects, to sheaf cohomology on topological spaces. We also
discuss generalised mapping properties of these theories, and relations of
these properties to corings. Using this, we give conditions for the Serre
spectral sequence to hold for a noncommutative fibration. This might be better
read as giving the definition of a fibration in noncommutative differential
geometry. We also study the multiplicative structure of such spectral
sequences. Finally we show that some noncommutative homogeneous spaces satisfy
the conditions to be such a fibration, and in the process clarify the
differential structure on these homogeneous spaces. We also give two explicit
examples of differential fibrations: these are built on the quantum Hopf
fibration with two different differential structures.Comment: LaTeX, 33 page
A simple spontaneously active Hebbian learning model: homeostasis of activity and connectivity, and consequences for learning and epileptogenesis
A spontaneously active neural system that is capable of continual learning
should also be capable of homeostasis of both firing rate and connectivity.
Experimental evidence suggests that both types of homeostasis exist, and that
connectivity is maintained at a state that is optimal for information
transmission and storage. This state is referred to as the critical state. We
present a simple stochastic computational Hebbian learning model that
incorporates both firing rate and critical homeostasis, and we explore its
stability and connectivity properties. We also examine the behavior of our
model with a simulated seizure and with simulated acute deafferentation. We
argue that a neural system that is more highly connected than the critical
state (i.e., one that is "supercritical") is epileptogenic. Based on our
simulations, we predict that the post-seizural and post-deafferentation states
should be supercritical and epileptogenic. Furthermore, interventions that
boost spontaneous activity should be protective against epileptogenesis.Comment: 37 pages, 1 table, 7 figure
Point-occurrence self-similarity in crackling-noise systems and in other complex systems
It has been recently found that a number of systems displaying crackling
noise also show a remarkable behavior regarding the temporal occurrence of
successive events versus their size: a scaling law for the probability
distributions of waiting times as a function of a minimum size is fulfilled,
signaling the existence on those systems of self-similarity in time-size. This
property is also present in some non-crackling systems. Here, the uncommon
character of the scaling law is illustrated with simple marked renewal
processes, built by definition with no correlations. Whereas processes with a
finite mean waiting time do not fulfill a scaling law in general and tend
towards a Poisson process in the limit of very high sizes, processes without a
finite mean tend to another class of distributions, characterized by double
power-law waiting-time densities. This is somehow reminiscent of the
generalized central limit theorem. A model with short-range correlations is not
able to escape from the attraction of those limit distributions. A discussion
on open problems in the modeling of these properties is provided.Comment: Submitted to J. Stat. Mech. for the proceedings of UPON 2008 (Lyon),
topic: crackling nois
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