Yield trends and yield gap analysis of major crops in the world

This study aims to quantify the gap between current and potential yields of major crops in the world, and the production constraints that contribute to this yield gap. Using an expert-based evaluation of yield gaps and the literature, global and regional yields and yield trends of major crops are quantified, yield gaps evaluated by crop experts, current yield progress by breeding estimated, and different yield projections compared. Results show decreasing yield growth for wheat and rice, but still high growth rates for maize. The yield gap analysis provides quantitative estimates of the production constraints for a number of crops and regions and reveals the difficulty to measure and compare yield potentials and actual yields consistently under a range of environmental conditions, and it shows the difficulty to disentangle interacting production constraints. FAO yield growth projections are generally lower than what possibly could be gained by closing current yield gaps

Stormwater management strategies: source control versus end of pipe

Storm sewers are known to significantly contribute to annual pollutant loads to receiving water bodies. The storm sewers of the city of Almere discharge the stormwater of 1384 ha of impervious area via 700 storm sewer outfalls (SSOs) to the local receiving water system. This water system suffers from eutrophication and long term build-up of pollutant levels in the sediment bed. In order to be able to select the most effective stormwater management strategy, the municipality of Almere and Water Authority Zuiderzeeland have launched a 2 year extensive monitoring project to measure the storm water quality and the potential impact of source control and end of pipe measures to decrease the emission via SSOs. Source control measures, such as removal of illicit connections and increasing the cleaning frequency of gully pots showed to be most effective. The potential impact of end of pipe solutions based on settling showed to be very limited due to the low settleability of solids in the storm water of Almere at the SSOs

Dopant-induced crossover from 1D to 3D charge transport in conjugated polymers

The interplay between inter- and intra-chain charge transport in bulk polythiophene in the hopping regime has been clarified by studying the conductivity as a function of frequency (up to 3 THz), temperature and doping level. We present a model which quantitatively explains the observed crossover from quasi-one-dimensional transport to three-dimensional hopping conduction with increasing doping level. At high frequencies the conductivity is dominated by charge transport on one-dimensional conducting chains.Comment: 4 pages, 2 figure

Search for Millicharged Particles at SLAC

Particles with electric charge q < 10^(-3)e and masses in the range 1--100 MeV/c^2 are not excluded by present experiments. An experiment uniquely suited to the production and detection of such "millicharged" particles has been carried out at SLAC. This experiment is sensitive to the infrequent excitation and ionization of matter expected from the passage of such a particle. Analysis of the data rules out a region of mass and charge, establishing, for example, a 95%-confidence upper limit on electric charge of 4.1X10^(-5)e for millicharged particles of mass 1 MeV/c^2 and 5.8X10^(-4)e for mass 100 MeV/c^2.Comment: 4 pages, REVTeX, multicol, 3 figures. Minor typo corrected. Submitted to Physical Review Letter

Social Competence as a Mediating Factor in Reduction of Behavioral Problems

The main purpose of the present study was to explore how social competence reduces behavioral problems. Based on previous findings, we assume that increased social competence can be regarded as a mediating factor in reducing behavior problems. All participants (children and adolescents, n ¼ 112) received an intervention intended to increase social competence: Aggresion Replacement Training (ART). Social competence and problem behavior were assessed twice before the ART intervention and then twice afterwards. Both measures improved following the training period, but no changes occurred during the pre-training period. Further, behavioral problems continued to reduce notably in follow-up probes after the training period. More detailed analyses indicate that in youngsters, increased social competence (e.g., improved self-control and cooperation) mediates the effect of ART on behavioral problems, but important moderating factors (e.g., age, individual levels of social competence, and problem behavior) need to be taken into consideration

Impacts of Renewable Energy on European Farmers. Creating benefits for farmers and society

This report presents results of the project Impacts of Renewable Energy on European Farmers. It focuses on the (potential) role that on-farm generation of Renewable Energy in the EU-27 may play both in realisation of national and EU environmental targets as in (re)vitalising agriculture and rural economy in different regions of the Union. Renewable Energy (RE) in this respect includes the energy generated on farms by using wind, PV, solar thermal, hydro, geothermal or biomass resources

Solving large 0–1 multidimensional knapsack problems by a new simplified binary artificial fish swarm algorithm

The artificial fish swarm algorithm has recently been emerged in continuous global optimization. It uses points of a population in space to identify the position of fish in the school. Many real-world optimization problems are described by 0-1 multidimensional knapsack problems that are NP-hard. In the last decades several exact as well as heuristic methods have been proposed for solving these problems. In this paper, a new simpli ed binary version of the artificial fish swarm algorithm is presented, where a point/ fish is represented by a binary string of 0/1 bits. Trial points are created by using crossover and mutation in the different fi sh behavior that are randomly selected by using two user de ned probability values. In order to make the points feasible the presented algorithm uses a random heuristic drop item procedure followed by an add item procedure aiming to increase the profit throughout the adding of more items in the knapsack. A cyclic reinitialization of 50% of the population, and a simple local search that allows the progress of a small percentage of points towards optimality and after that refines the best point in the population greatly improve the quality of the solutions. The presented method is tested on a set of benchmark instances and a comparison with other methods available in literature is shown. The comparison shows that the proposed method can be an alternative method for solving these problems.The authors wish to thank three anonymous referees for their comments and valuable suggestions to improve the paper. The first author acknowledges Ciˆencia 2007 of FCT (Foundation for Science and Technology) Portugal for the fellowship grant C2007-UMINHO-ALGORITMI-04. Financial support from FEDER COMPETE (Operational Programme Thematic Factors of Competitiveness) and FCT under project FCOMP-01-0124-FEDER-022674 is also acknowledged

Flow rate influence on sediment depth estimation in sewers using temperature sensors

Enhancing sediment accumulation monitoring techniques in sewers will enable a better understanding of the build-up processes to develop improved cleaning strategies. Thermal sensors provide a solution to sediment depth estimation by passively monitoring temperature fluctuations in the wastewater and sediment beds, which allows evaluation of the heat-transfer processes in sewer pipes. This study analyses the influence of the flow conditions on heat-transfer processes at the water–sediment interface during dry weather flow conditions. For this purpose, an experimental campaign was performed by establishing different flow, temperature patterns, and sediment depth conditions in an annular flume, which ensured steady flow and room-temperature conditions. Numerical simulations were also performed to assess the impact of flow conditions on the relationships between sediment depth and harmonic parameters derived from wastewater and sediment-bed temperature patterns. Results show that heat transfer between water and sediment occurred instantaneously for velocities greater than 0.1 m/s, and that sediment depth estimations using temperature-based systems were barely sensitive to velocities between 0.1 and 0.4 m/s. A depth estimation accuracy of ±7 mm was achieved. This confirms the ability of using temperature sensors to monitor sediment build-up in sewers under dry weather conditions, without the need for flow monitoring

Position statement on the role of healthcare professionals, patient organizations and industry in European Reference Networks

A call from the EU for the set-up of European Reference Networks (ERNs) is expected to be launched in the first quarter of 2016. ERNs are intended to improve the care for patients with low prevalent or rare diseases throughout the EU by, among other things, facilitating the pooling and exchange of experience and knowledge and the development of protocols and guidelines. In the past, for example where costly orphan drugs have been concerned, industry has played an important role in facilitating consensus meetings and publication of guidelines. The ERNs should provide a unique opportunity for healthcare professionals and patients to lead these activities in an independent way. However, currently costs for networking activities are not to be covered by EU funds and alternative sources of funding are being explored. There is growing concern that any involvement of the industry in the funding of ERNs and their core activities may create a risk of undue influence. To date, the European Commission has not been explicit in how industry will be engaged in ERNs. We believe that public funding and a conflict of interest policy are needed at the level of the ERNs, Centers of Expertise (CEs), healthcare professionals and patient organizations with the aim of maintaining scientific integrity and independence. Specific attention is needed where it concerns the development of clinical practice guidelines. A proposal for a conflict of interest policy is presented, which may support the development of a framework to facilitate collaboration, safeguard professional integrity and to establish and maintain public acceptability and trust among patients, their organizations and the general public

Gene-modified T cells for adoptive immunotherapy of renal cell cancer maintain transgene-specific immune functions in vivo

Abstract BACKGROUND: We have treated three patients with carboxy-anhydrase-IX (CAIX) positive metastatic renal cell cancer (RCC) by adoptive transfer of autologous T-cells that had been gene-transduced to express a single-chain antibody-G250 chimeric receptor [scFv(G250)], and encountered liver toxicity necessitating adaptation of the treatment protocol. Here, we investigate whether or not the in vivo activity of the infused scFv(G250)(+) T cells is reflected by changes of selected immune parameters measured in peripheral blood. METHODS: ScFv(G250)-chimeric receptor-mediated functions of peripheral blood mononuclear cells (PBMC) obtained from three patients during and after treatment were compared to the same functions of scFv(G250)(+) T lymphocytes prior to infusion, and were correlated with plasma cytokine levels. RESULTS: Prior to infusion, scFv(G250)(+) T lymphocytes showed in vitro high levels of scFv(G250)-chimeric receptor-mediated functions such as killing of CAIX(+) RCC cell lines and cytokine production upon exposure to these cells. High levels of IFN-gamma were produced, whilst production of TNF-alpha, interleukin-4 (IL-4), IL-5 and IL-10 was variable and to lower levels, and that of IL-2 virtually absent. PBMC taken from patients during therapy showed lower levels of in vitro scFv(G250)-receptor-mediated functions as compared to pre-infusion, whilst IFN-gamma was the only detectable cytokine upon in vitro PBMC exposure to CAIX. During treatment, plasma levels of IFN-gamma increased only in the patient with the most prominent liver toxicity. IL-5 plasma levels increased transiently during treatment in all patients, which may have been triggered by the co-administration of IL-2. CONCLUSION: ScFv(G250)-receptor-mediated functions of the scFv(G250)(+) T lymphocytes are, by and large, preserved in vivo upon administration, and may be reflected by fluctuations in plasma IFN-gamma levels