Desenvolvimento de atividade criativa de alunos-designers método de cartões associativos metafóricos (Mac)

The article presents the results of a study of the development of creative activity of students- designers in the artistic and project activities using the method of metaphorical associative cards. Creative activity is considered as a personal feature (set of properties and qualities of a person), its orientation and readiness for the implementation of artistic and project activities. The development of creative activity is conditioned by the necessity of forming the individual's need for creative activity, which will become the student's personal quality. To diagnose the development of creative activity, we offered a method of metaphorical associative cards. The works of artists, natural phenomena, and textures are offered as the metaphorical cards. Based on the selected cards, the students make the training tasks. As a result of a comparative analysis of the diagnosis of the zero and control stages of the creative works of the experimental group, we obtained quantitative and qualitative data that comprehensively characterize the level of development of creative activity of students in accordance with the criteria we have singled out. The reliability of the evaluation of obtained results was determined with the help of mathematical and static processing of the obtained data. To determine the effectiveness of this method, we used the questionnaires made by such authors as M. I. Rozhkova and L.V. Mishchenko, comparative analysis and observation methods. The criteria were determined as the need for mastering and acquiring new knowledge; the conceptual design - the use of expressive means in the composition solution.El artículo presenta los resultados de un estudio sobre el desarrollo de la actividad activa de los diseñadores de la industria en las actividades de diseño y de diseño con el método de las asociaciones de gráficos. La actividad cultural se considera como una característica personal y una orientación para la implementación de las actividades y las actividades de diseño. El desarrollo de la actividad económica está condicionado por la necesidad de formar a los individuos necesarios para la actividad activa, que convertirá a la calidad de la calidad personal. Para diagnosticar el desarrollo de la actividad activa, hemos planteado un método de metáforas asociadas. Las obras de los artistas, natural phenomena, y las texturas se presentan las cartas metaphorical. Basado en las cartas seleccionadas, los estudiantes realizan las tareas de formación. Las que resultan de un análisis comparativo de los diagnósticos de las etapas del ensayo y de las e tapas del desarrollo de las generaciones de trabajo del grupo experimental, obtenidos cuantitativa y cualitativa, que coinciden con el nivel del desarrollo del crecimiento de la actividad activa de los estudiantes de acuerdo con el criterio sencillo. La confiabilidad de la evaluación de resultados obtenidos se determinó con la ayuda de método matemático y de procesamiento de datos obtenidos. Para determinar la eficacia de este método, utilizamos los cuestionarios hechos por los autores de las M. I. Rozhkova y L.V. Mishchenko, comparativa de análisis y métodos de observación. Los criterios fueron determinados a los requeridos para el mastering y acquiring new knowledge; el diseño conceptual - el uso de la expresión expresiva en la solución de solución.O artigo apresenta os resultados de um estudo sobre o desenvolvimento da atividade criativa de estudantes-designers nas atividades artísticas e de projeto, utilizando o método de cartões associativos metafóricos. A atividade criativa é considerada como uma característica pessoal (conjunto de propriedades e qualidades de uma pessoa), sua orientação e prontidão para a implementação de atividades artísticas e de projeto. O desenvolvimento da atividade criativa é condicionado pela necessidade de formar a necessidade individual de atividade criativa, que se tornará a qualidade pessoal do aluno. Para diagnosticar o desenvolvimento da atividade criativa, oferecemos um método de cartões associativos metafóricos. As obras de artistas, fenômenos naturais e texturas são oferecidas como cartões metafóricos. Com base nos cartões selecionados, os alunos realizam as tarefas de treinamento. Como resultado de uma análise comparativa do diagnóstico do zero e estágios de controle dos trabalhos criativos do grupo experimental, foram obtidos dados quantitativos e qualitativos que exaustivamente caracterizar o nível de desenvolvimento da actividade criativa dos alunos de acordo com os critérios Nós temos destacado. A confiabilidade da avaliação dos resultados obtidos foi determinada com o auxílio do processamento matemático e estático dos dados obtidos. Para determinar a eficácia deste método, usamos os questionários feitos por autores como M. I. Rozhkova e L.V. Mishchenko, análise comparativa e métodos de observação. Os critérios foram determinados como a necessidade de dominar e adquirir novos conhecimentos; O design conceitual - o uso de meios expressivos na solução de composição

Discovery of Gamma-ray Emission from M31 via FERMI-LAT

2 years worth of archival FERMI-LAT data was used to search for the gamma-ray emission from the Andromeda galaxy. The data show no noticeable elliptical image. Subsequent on-off source aperture photometry analysis using a CO image template show a 7 sigma excess in the number of on-source apertures in comparison to the off-source apertures, yielding a flux of (4.95+/-0.71)x10-8 photons cm-2 s-1 for E>100 MeV.Comment: 7 pages, 5 figure

Merkel cell polyomavirus large T antigen disrupts lysosome clustering by translocating human Vam6p from the cytoplasm to the nucleus

Merkel cell polyomavirus (MCV) has been recently described as the cause for most human Merkel cell carcinomas. MCV is similar to simian virus 40 (SV40) and encodes a nuclear large T (LT) oncoprotein that is usually mutated to eliminate viral replication among tumor-derived MCV. We identified the hVam6p cytoplasmic protein involved in lysosomal processing as a novel interactor with MCV LT but not SV40 LT. hVam6p binds through its clathrin heavy chain homology domain to a unique region of MCV LT adjacent to the retinoblastoma binding site. MCV LT translocates hVam6p to the nucleus, sequestering it from involvement in lysosomal trafficking. A naturally occurring, tumor-derived mutant LT (MCV350) lacking a nuclear localization signal binds hVam6p but fails to inhibit hVam6p-induced lysosomal clustering. MCV has evolved a novel mechanism to target hVam6p that may contribute to viral uncoating or egress through lysosomal processing during virus replication

Sialendoscopy increases saliva secretion and reduces xerostomia up to 60 weeks in Sjogren's syndrome patients:a randomized controlled study

OBJECTIVE: To assess the effect of sialendoscopy of the major salivary glands on salivary flow and xerostomia in patients with Sjögren's syndrome (SS). METHODS: Forty-five patients with SS were randomly assigned to a control group (no irrigation, control, n = 15), to irrigation of the major salivary glands with saline (saline, n = 15) or to irrigation with saline followed by corticosteroid application (triamcinolone acetonide in saline, saline/TA, n = 15). Unstimulated whole saliva flow (UWSF), chewing-stimulated whole saliva flow (SWSF), citric acid-stimulated parotid flow, Clinical Oral Dryness Score (CODS), Xerostomia Inventory (XI) and EULAR SS Patient Reported Index (ESSPRI) scores were obtained 1 week before (T0), and 1, 8, 16, 24, 36, 48 and 60 weeks after sialendoscopy. Data were analysed using linear mixed models. RESULTS: Irrespective of the irrigation protocol used, sialendoscopy resulted in an increased salivary flow during follow-up up to 60 weeks. Significant between-group differences in the longitudinal course of outcomes were found for UWSF, SWSF, XI and ESSPRI scores (P = 0.028, P = 0.001, P = 0.03, P = 0.021, respectively). UWSF at 60 weeks was higher compared with T0 in the saline group (median: 0.14 vs median: 0.10, P = 0.02) and in the saline/TA group (median: 0.20, vs 0.13, P = 0.035). In the saline/TA group SWSF at 48 weeks was higher compared with T0 (median: 0.74 vs 0.38, P = 0.004). Increase in unstimulated salivary flow was also reflected in improved CODS, XI and ESSPRI scores compared with baseline. CONCLUSION: Irrigation of the major salivary glands in patients with SS increases salivary flow and reduces xerostomia

Minimally Invasive Periodontal Treatment Using the Er,Cr: YSGG Laser. A 2-year Retrospective Preliminary Clinical Study

Minimally invasive surgery (MIS) using the erbium, chromium: yttrium-scandium-gallium-garnet (Er,Cr:YSGG) laser (Waterlase MD, Biolase, Irvine, CA) to treat moderate to advanced periodontal disease is presented as an alternative to conventional therapies. To date, there are few short- or long-term studies to demonstrate the effects of this laser in treating and maintaining periodontal health. Electronic clinical records from 16 patients – total of 126 teeth, with pocket depths ranging from 4 mm to 9 mm – were treated with the same protocol using the Er,Cr:YSGG laser. The mean baseline probing depths (PD) were 5 mm and clinical attachment levels (CAL) were 5 mm in the 4 - 6 mm pretreated laser group. The mean baseline probing depths were 7.5 and 7.6 mm for PD and CAL respectfully in the 7 – 9 mm pretreatment laser group. At the 2 year mark, the average PD was 3.2 ± 1.1 mm for the 4-6 mm pocket group and the 7-9 mm pocket group had a mean PD of 3.7 ± 1.2 mm. mean CAL was 3.1 ± 1.1 mm for the 4-6 mm group and 3.6 ± 1.2 for the 7-9 mm group with an overall reduction of 1.9 mm and 4.0 mm respectively. At one and two years, both groups remained stable with PD comparable to the three-month gains. The CAL measurements at one and two years were also comparable to the three-month gains

Focus Raqqa: inventory of Museum collections and reconstruction of missing tablets

The National Museum of Raqqa in Syria has suffered immensely from the ongoing violence since 2011. Much of its valuable collection of movable archaeological heritage (ca. 6000 items) is considered lost. Starting from 500 of the most precious objects of the museum stored in the Raqqa Central Bank and stolen from there in 2013, the pilot project Focus Raqqa created a concrete, workable database to enable identification by Syrian and international police and heritage institutions. The project made a pivotal first step towards potential reconstruction of the Raqqa Museum in the future. The Raqqa museum collection included cuneiform tablets. Some of the tablets were cast before the war to allow detailed study in Europe. Today the tablets have vanished. The pilot project Scanning for Syria safeguarded information from the lost artefacts by making high-resolution three-dimensional scans of the silicone rubber moulds and subsequently physical replicas of the original objects by 3D printing. The short life expectancy (30 years) of the moulds necessitated measures for long-term preservation. The Scanning for Syria team not only succeeded at the preservation and sharing of knowledge in the academic circle. It also told the story of Syrian culture and its people to everyone for raising more voices in the united effort to keep cultural heritage safe in a zone of conflict. Digital Archaeolog

Comparison of the bifurcation scenarios predicted by the single-mode and multimode semiconductor laser rate equations

We present a detailed comparison of the bifurcation scenarios predicted by single-mode and multimode semiconductor laser rate equation models under large amplitude injection current modulation. The influence of the gain model on the predicted dynamics is investigated. Calculations of the dependence of the time averaged longitudinal mode intensities on modulation frequency are compared with experiments performed on an AlxGa1-xAs Fabry-Pérot semiconductor laser.K. A. Corbett and M. W. Hamilto

Onset and window of SARS-CoV-2 infectiousness and temporal correlation with symptom onset: a prospective, longitudinal, community cohort study.

BACKGROUND: Knowledge of the window of SARS-CoV-2 infectiousness is crucial in developing policies to curb transmission. Mathematical modelling based on scarce empirical evidence and key assumptions has driven isolation and testing policy, but real-world data are needed. We aimed to characterise infectiousness across the full course of infection in a real-world community setting. METHODS: The Assessment of Transmission and Contagiousness of COVID-19 in Contacts (ATACCC) study was a UK prospective, longitudinal, community cohort of contacts of newly diagnosed, PCR-confirmed SARS-CoV-2 index cases. Household and non-household exposed contacts aged 5 years or older were eligible for recruitment if they could provide informed consent and agree to self-swabbing of the upper respiratory tract. The primary objective was to define the window of SARS-CoV-2 infectiousness and its temporal correlation with symptom onset. We quantified viral RNA load by RT-PCR and infectious viral shedding by enumerating cultivable virus daily across the course of infection. Participants completed a daily diary to track the emergence of symptoms. Outcomes were assessed with empirical data and a phenomenological Bayesian hierarchical model. FINDINGS: Between Sept 13, 2020, and March 31, 2021, we enrolled 393 contacts from 327 households (the SARS-CoV-2 pre-alpha and alpha variant waves); and between May 24, 2021, and Oct 28, 2021, we enrolled 345 contacts from 215 households (the delta variant wave). 173 of these 738 contacts were PCR positive for more than one timepoint, 57 of which were at the start of infection and comprised the final study population. The onset and end of infectious viral shedding were captured in 42 cases and the median duration of infectiousness was 5 (IQR 3-7) days. Although 24 (63%) of 38 cases had PCR-detectable virus before symptom onset, only seven (20%) of 35 shed infectious virus presymptomatically. Symptom onset was a median of 3 days before both peak viral RNA and peak infectious viral load (viral RNA IQR 3-5 days, n=38; plaque-forming units IQR 3-6 days, n=35). Notably, 22 (65%) of 34 cases and eight (24%) of 34 cases continued to shed infectious virus 5 days and 7 days post-symptom onset, respectively (survival probabilities 67% and 35%). Correlation of lateral flow device (LFD) results with infectious viral shedding was poor during the viral growth phase (sensitivity 67% [95% CI 59-75]), but high during the decline phase (92% [86-96]). Infectious virus kinetic modelling suggested that the initial rate of viral replication determines the course of infection and infectiousness. INTERPRETATION: Less than a quarter of COVID-19 cases shed infectious virus before symptom onset; under a crude 5-day self-isolation period from symptom onset, two-thirds of cases released into the community would still be infectious, but with reduced infectious viral shedding. Our findings support a role for LFDs to safely accelerate deisolation but not for early diagnosis, unless used daily. These high-resolution, community-based data provide evidence to inform infection control guidance. FUNDING: National Institute for Health and Care Research