From mountain summits to roots: Crustal structure of the Eastern Alps and Bohemian Massif along longitude 13.3°E

The crustal structure of the Eastern Alps and adjacent tectonic units investigated in this work sheds new light on the relationship of surface geology to geodynamic processes operating at depth. Of particular interest are the nature of a previously proposed Moho gap south and east of the Tauern Window, the plate tectonic affinity of the steeply dipping Eastern Alpine slab, and the relationship of the Alps to the Neogene sedimentary basins and the Bohemian Massif. To address these questions, we use various seismological approaches based on converted waves from the temporary passive experiment EASI (Eastern Alpine Seismic Investigation), a complementary experiment of the AlpArray project. The EASI is a densely spaced, 540 km long seismic network along 13.3°E we operated for more than a year. The uppermost-crustal structures in and near the Alps exhibit dipping layers and/or tilted anisotropy that correlate well with surface geology observations. The Moho, despite its variable appearance, is clearly identified along most of the swath. The Variscan lithospheric blocks beneath the Bohemian Massif are imaged with sub-vertical boundaries. Beneath the Eastern Alps, the shape of the Moho is consistent with bi-vergent orogenic thickening, with a steeper and deeper-reaching Adriatic plate plunging northwards beneath the European plate in the north. At the junction of these plates at depth, around the previously proposed Moho gap, the root of the Eastern Alps is a broad trough characterized by a zone of low velocity-gradient that is up to 20 km thick, transitioning between crust and mantle. Our receiver-function results corroborate earlier lithosphere-upper mantle seismic tomography images, and highlight the Adriatic affinity of the Eastern Alpine slab. The zigzag deployment pattern of stations in the EASI experiment also allows distinction of short-wavelength variations perpendicular to the profile, both within the shallow and the deep crust. This underlines the importance of applying 3D imaging in complex geodynamic systems.ISSN:0040-195

Supporting Innovation in Organic Agriculture: A European Perspective Using Experience from the SOLID Project

Organic farming is recognized as one source for innovation helping agriculture to develop sustainably. However, the understanding of innovation in agriculture is characterized by technical optimism, relying mainly on new inputs and technologies originating from research. The paper uses the alternative framework of innovation systems describing innovation as the outcome of stakeholder interaction and examples from the SOLID (Sustainable Organic Low-Input Dairying) project to discuss the role of farmers, researchers and knowledge exchange for innovation. We used a farmer-led participatory approach to identify problems of organic and low-input dairy farming in Europe and develop and evaluate innovative practices. Experience so far shows that improvements of sustainability can be made through better exploitation of knowledge. For example, it is recognized that optimal utilization of good quality forage is vitally important, but farmers showed a lack of confidence in the reliability of forage production both in quantity and quality. We conclude that the systems framework improves the understanding of innovation processes in organic agriculture. Farmer-led research is an effective way to bring together the scientific approach with the farmers’ practical and context knowledge in finding solutions to problems experienced by farmers and to develop sustainability

High-resolution image of Calaveras Fault seismicity

By measuring relative earthquake arrival times using waveform cross correlation and locating earthquakes using the double difference technique, we are able to reduce hypocentral errors by 1 to 2 orders of magnitude over routine locations for nearly 8000 events along a 35-km section of the Calaveras Fault. This represents ∼92% of all seismicity since 1984 and includes the rupture zone of the M 6.2 1984 Morgan Hill, California, earthquake. The relocated seismicity forms highly organized structures that were previously obscured by location errors. There are abundant repeating earthquake sequences as well as linear clusters of earthquakes. Large voids in seismicity appear with dimensions of kilometers that have been aseismic over the 30-year time interval, suggesting that these portions of the fault are either locked or creeping. The area of greatest slip in the Morgan Hill main shock coincides with the most prominent of these voids, suggesting that this part of the fault may be locked between large earthquakes. We find that the Calaveras Fault at depth is extremely thin, with an average upper bound on fault zone width of 75 m. Given the location error, however, this width is not resolvably different from zero. The relocations reveal active secondary faults, which we use to solve for the stress field in the immediate vicinity of the Calaveras Fault. We find that the maximum compressive stress is at a high angle, only 13° from the fault normal, supporting previous interpretations that this fault is weak

TIDieR-Placebo: A guide and checklist for reporting placebo and sham controls

Background Placebo or sham controls are the standard against which the benefits and harms of many active interventions are measured. Whilst the components and the method of their delivery have been shown to affect study outcomes, placebo and sham controls are rarely reported and often not matched to those of the active comparator. This can influence how beneficial or harmful the active intervention appears to be. Without adequate descriptions of placebo or sham controls, it is difficult to interpret results about the benefits and harms of active interventions within placebo-controlled trials. To overcome this problem, we developed a checklist and guide for reporting placebo or sham interventions. Methods and findings We developed an initial list of items for the checklist by surveying experts in placebo research (n = 14). Because of the diverse contexts in which placebo or sham treatments are used in clinical research, we consulted experts in trials of drugs, surgery, physiotherapy, acupuncture, and psychological interventions. We then used a multistage online Delphi process with 53 participants to determine which items were deemed to be essential. We next convened a group of experts and stakeholders (n = 16). Our main output was a modification of the existing Template for Intervention Description and Replication (TIDieR) checklist; this allows the key features of both active interventions and placebo or sham controls to be concisely summarised by researchers. The main differences between TIDieR-Placebo and the original TIDieR are the explicit requirement to describe the setting (i.e., features of the physical environment that go beyond geographic location), the need to report whether blinding was successful (when this was measured), and the need to present the description of placebo components alongside those of the active comparator. Conclusions We encourage TIDieR-Placebo to be used alongside TIDieR to assist the reporting of placebo or sham components and the trials in which they are used

Targeting the epigenome: effects of epigenetic treatment strategies on genomic stability in healthy human cells

Epigenetic treatment concepts have long been ascribed as being tumour-selective. Over the last decade, it has become evident that epigenetic mechanisms are essential for a wide range of intracellular functions in healthy cells as well. Evaluation of possible side-effects and their underlying mechanisms in healthy human cells is necessary in order to improve not only patient safety, but also to support future drug development. Since epigenetic regulation directly interacts with genomic and chromosomal packaging density, increasing genomic instability may be a result subsequent to drug-induced epigenetic modifications. This review highlights past and current research efforts on the influence of epigenetic modification on genomic stability in healthy human cells

Feasibility studies for the measurement of time-like proton electromagnetic form factors from p¯ p→ μ+μ- at P ¯ ANDA at FAIR

This paper reports on Monte Carlo simulation results for future measurements of the moduli of time-like proton electromagnetic form factors, | GE| and | GM| , using the p¯ p→ μ+μ- reaction at P ¯ ANDA (FAIR). The electromagnetic form factors are fundamental quantities parameterizing the electric and magnetic structure of hadrons. This work estimates the statistical and total accuracy with which the form factors can be measured at P ¯ ANDA , using an analysis of simulated data within the PandaRoot software framework. The most crucial background channel is p¯ p→ π+π-, due to the very similar behavior of muons and pions in the detector. The suppression factors are evaluated for this and all other relevant background channels at different values of antiproton beam momentum. The signal/background separation is based on a multivariate analysis, using the Boosted Decision Trees method. An expected background subtraction is included in this study, based on realistic angular distributions of the background contribution. Systematic uncertainties are considered and the relative total uncertainties of the form factor measurements are presented

Computed dip-parameters derived from digitized FHR-curves II. The value of descriptive parameters

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