Evaluation of Urban Spaces from the Perspective of Universal Design Principles: The Case of Konya/Turkey

During the process of accessing services provided within urban interior and outer spaces the elderly and disabled individuals encounter with a myriad of problems due to the limitations posed by structured environments. This limitation hinders elderly and disabled individuals from mobility without assistance, which in turn negatively affects their full participation to urban and social life. Rearrangement of urban spaces to meet the needs of elderly and disabled individuals would correspondingly bolster life quality of the entire range of users. Within the scope of present research, as mandated by universal design principles to stick to plans and designs approaches inclusive for all users, it is aimed to conduct evaluations on the use of urban outer spaces situated within Konya City Center. In the hypothetical and theoretical part of this paper, the perception of disability throughout historical process has been examined from a sociological perspective. In addition, concept of universal design, its principles and gravity have also been elaborated. In the part dealing with the case study, outer spaces within Konya City Center have been analyzed with respect to universal design principles and a range of suggestions have been developed

Teleworking Implementation Process Model for Yebam (Elderly&Disabled Care, Research, Training and Implementation Center)/Konya-Turkey

People with disabilities are facing many constraints when using urban interior and exterior spaces. At the same time, aging brings with physical losses. Because of these physical restrictions, the participation of disabled and elderly people in working life gets much harder. New solutions should be developed for elderly and disabled people in order to improve the employment of them. In this context, the information and communication technologies (ICTs) provide opportunities for people with disabilities in all areas of life.  These opportunities also have importance for people having different mobility disabilities. At this point, teleworking, as a new way of working provides an opportunity for employee to work anywhere and anytime through ICTs so daily trips could be decreased with teleworking. This paper aims to evaluate opportunities for the employment of elderly and disabled people. Firstly, the concept and forms of teleworking are defined. Then the importance of this new way of working for elderly and disabled people is discussed. In Turkey, there are many institutions that provide services to the elderly and people with disabilities. However, these institutions are not enough for these people so new solutions should be developed. For this purpose, Yebam (Elderly&Disabled Care, Research, Training and Implementation Center) will be established in Selcuk University Campus-Konya/Turkey. Educational services, living spaces, production and rehabilitation centers will be combined in one place. Finally, teleworking implementation process model proposed for Yebam has been discussed in the last part of the paper

Denaturation of Circular DNA: Supercoil Mechanism

The denaturation transition which takes place in circular DNA is analyzed by extending the Poland-Scheraga model to include the winding degrees of freedom. We consider the case of a homopolymer whereby the winding number of the double stranded helix, released by a loop denaturation, is absorbed by \emph{supercoils}. We find that as in the case of linear DNA, the order of the transition is determined by the loop exponent $c$. However the first order transition displayed by the PS model for $c>2$ in linear DNA is replaced by a continuous transition with arbitrarily high order as $c$ approaches 2, while the second-order transition found in the linear case in the regime $1<c\le2$ disappears. In addition, our analysis reveals that melting under fixed linking number is a \emph{condensation transition}, where the condensate is a macroscopic loop which appears above the critical temperature.Comment: 9 pages, 4 figure

Solar Energy and the City’s Future Reflection

In this article, it is aimed to bring an intellectual declination to the aspects of “solar energy” deeply affecting the future of urbanization and planning activities and accordingly, the changes that may occur in urban macro form. The changes that may emerge in the forms of producing and consuming the energy naturally affects the urbanization process in addition to technological a socio-eonomical developments. The process should be evaluated through totalitarian developments. When the complexity of the matter is considered, deep theoretical declination is required. In this sudy, the references and basic resources which haven’t been explained in detail within the text for technological developments and biotope of the future were employed. The purpose of the study is to share our estimations about the demands of those developments and legal, administrative, and social behavior patterns that is required to occur accordingly not make interpretations about “technical” dimensions which require expertising on solar energy. In addition, we also aim to come up for discussion about important ontological problems we regarded vital in the relationships between energy and city. As a result of those discussions and researches, it is a beginning that is hopped to provide contributions to change the planning paradig

Synthesis, in vitro antioxidant and antimicrobial activities of some novel 3-substitued-4-(3-methoxy-4-isobutyryloxybenzylideneamino)-4,5-dihydro- 1H-1,2,4-triazol-5-one derivatives

271-282In this study, 3-alkyl(aryl)-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones have been reacted with 3-methoxy-4-isobutyryloxybenzaldehyde 2 to afford the corresponding nine new 3-alkyl(aryl)-4-(3-methoxy-4-isobutyryloxybenzylideneamino)-4,5-dihydro-1H-1,2,4-triazol-5-ones 3. Then, the acetylation reactions of compounds 3 have been investigated and 4 type compounds have been obtained. The compounds 3 have also been treated with morpholine/1-methylpiperazine in the presence of formaldehyde according to the Mannich reaction to synthesize 1-(morpholine-4-yl-methyl)-3-alkyl(aryl)-4-(3-methoxy-4-isobutyryloxy-benzylideneamino)-4,5-dihydro-1H-1,2,4-triazol-5-ones 5, and 1-(1-methylpiperazin-4-yl-methyl)-3-alkyl(aryl)-4-(3-methoxy-4-isobutyryloxybenzylideneamino)-4,5-dihydro-1H-1,2,4-triazol-5-ones 6, respectively. The structures of twenty four new compounds have been characterized by IR, 1H and 13C NMR and MS spectroscopic methods. In addition, the newly synthesized compounds have been screened for their antimicrobial activities. Furthermore, these twenty four new compounds have been analyzed for their in vitro potential antioxidant activities by three different methods

Deep Spin-Glass Hysteresis Area Collapse and Scaling in the d=3d=3 ±J\pm J Ising Model

We investigate the dissipative loss in the $\pm J$ Ising spin glass in three dimensions through the scaling of the hysteresis area, for a maximum magnetic field that is equal to the saturation field. We perform a systematic analysis for the whole range of the bond randomness as a function of the sweep rate, by means of frustration-preserving hard-spin mean field theory. Data collapse within the entirety of the spin-glass phase driven adiabatically (i.e., infinitely-slow field variation) is found, revealing a power-law scaling of the hysteresis area as a function of the antiferromagnetic bond fraction and the temperature. Two dynamic regimes separated by a threshold frequency $\omega_c$ characterize the dependence on the sweep rate of the oscillating field. For $\omega < \omega_c$, the hysteresis area is equal to its value in the adiabatic limit $\omega = 0$, while for $\omega > \omega_c$ it increases with the frequency through another randomness-dependent power law.Comment: 6 pages, 6 figure

Teleworking Implementation Process Model for Yebam (Elderly&Disabled Care, Research, Training and Implementation Center)/Konya-Turkey

People with disabilities are facing many constraints when using urban interior and exterior spaces. At the same time, aging brings with physical losses. Because of these physical restrictions, the participation of disabled and elderly people in working life gets much harder. New solutions should be developed for elderly and disabled people in order to improve the employment of them. In this context, the information and communication technologies (ICTs) provide opportunities for people with disabilities in all areas of life.  These opportunities also have importance for people having different mobility disabilities. At this point, teleworking, as a new way of working provides an opportunity for employee to work anywhere and anytime through ICTs so daily trips could be decreased with teleworking. This paper aims to evaluate opportunities for the employment of elderly and disabled people. Firstly, the concept and forms of teleworking are defined. Then the importance of this new way of working for elderly and disabled people is discussed. In Turkey, there are many institutions that provide services to the elderly and people with disabilities. However, these institutions are not enough for these people so new solutions should be developed. For this purpose, Yebam (Elderly&amp;Disabled Care, Research, Training and Implementation Center) will be established in Selcuk University Campus-Konya/Turkey. Educational services, living spaces, production and rehabilitation centers will be combined in one place. Finally, teleworking implementation process model proposed for Yebam has been discussed in the last part of the paper

Myoblasts and macrophages share molecular components that contribute to cell–cell fusion

Cell–cell fusion is critical to the normal development of certain tissues, yet the nature and degree of conservation of the underlying molecular components remains largely unknown. Here we show that the two guanine-nucleotide exchange factors Brag2 and Dock180 have evolutionarily conserved functions in the fusion of mammalian myoblasts. Their effects on muscle cell formation are distinct and are a result of the activation of the GTPases ARF6 and Rac, respectively. Inhibition of ARF6 activity results in a lack of physical association between paxillin and β1-integrin, and disruption of paxillin transport to sites of focal adhesion. We show that fusion machinery is conserved among distinct cell types because Dock180 deficiency prevented fusion of macrophages and the formation of multinucleated giant cells. Our results are the first to demonstrate a role for a single protein in the fusion of two different cell types, and provide novel mechanistic insight into the function of GEFs in the morphological maturation of multinucleated cells