Trapped ions in Rydberg-dressed atomic gases

We theoretically study trapped ions that are immersed in an ultracold gas of Rydberg-dressed atoms. By off-resonant coupling on a dipole-forbidden transition, the adiabatic atom-ion potential can be made repulsive. We study the energy exchange between the atoms and a single trapped ion and find that Langevin collisions are inhibited in the ultracold regime for these repulsive interactions. Therefore, the proposed system avoids recently observed ion heating in hybrid atom-ion systems caused by coupling to the ion's radio frequency trapping field and retains ultracold temperatures even in the presence of excess micromotion.Comment: 9 pages, 5 figures including appendice

Prospects of reaching the quantum regime in Li-Yb+^+ mixtures

We perform numerical simulations of trapped $^{171}$Yb$^+$ ions that are buffer gas cooled by a cold cloud of $^6$Li atoms. This species combination has been suggested to be the most promising for reaching the quantum regime of interacting atoms and ions in a Paul trap. Treating the atoms and ions classically, we compute that the collision energy indeed reaches below the quantum limit for a perfect linear Paul trap. We analyze the effect of imperfections in the ion trap that cause excess micromotion. We find that the suppression of excess micromotion required to reach the quantum limit should be within experimental reach. Indeed, although the requirements are strong, they are not excessive and lie within reported values in the literature. We analyze the detection and suppression of excess micromotion in our experimental setup. Using the obtained experimental parameters in our simulation, we calculate collision energies that are a factor 2-11 larger than the quantum limit, indicating that improvements in micromotion detection and compensation are needed there. We also analyze the buffer-gas cooling of linear and two-dimensional ion crystals. We find that the energy stored in the eigenmodes of ion motion may reach 10-100 $\mu$K after buffer-gas cooling under realistic experimental circumstances. Interestingly, not all eigenmodes are buffer-gas cooled to the same energy. Our results show that with modest improvements of our experiment, studying atom-ion mixtures in the quantum regime is in reach, allowing for buffer-gas cooling of the trapped ion quantum platform and to study the occurrence of atom-ion Feshbach resonances.Comment: 39 pages, 22 figure

On the hierarchical classification of G Protein-Coupled Receptors

Motivation: G protein-coupled receptors (GPCRs) play an important role in many physiological systems by transducing an extracellular signal into an intracellular response. Over 50% of all marketed drugs are targeted towards a GPCR. There is considerable interest in developing an algorithm that could effectively predict the function of a GPCR from its primary sequence. Such an algorithm is useful not only in identifying novel GPCR sequences but in characterizing the interrelationships between known GPCRs. Results: An alignment-free approach to GPCR classification has been developed using techniques drawn from data mining and proteochemometrics. A dataset of over 8000 sequences was constructed to train the algorithm. This represents one of the largest GPCR datasets currently available. A predictive algorithm was developed based upon the simplest reasonable numerical representation of the protein's physicochemical properties. A selective top-down approach was developed, which used a hierarchical classifier to assign sequences to subdivisions within the GPCR hierarchy. The predictive performance of the algorithm was assessed against several standard data mining classifiers and further validated against Support Vector Machine-based GPCR prediction servers. The selective top-down approach achieves significantly higher accuracy than standard data mining methods in almost all cases

Probability and consequences of a rapid boron dilution sequence in a PWR

The reactor restart scenario is one of several beyond-design-basis events in a pressurized water reactor (PWR) which can lead to rapid boron dilution in the core. This in turn can lead to a power excursion and the potential for fuel damage. A probabilistic analysis had been done for this event for a European PWR. The estimated core damage frequency was found to be high partially because of a high frequency for a LOOP and assumptions regarding operator actions. As a result, a program of analysis and experiment was initiated and corrective actions were taken. A system was installed so that the suction of the charging pumps would switch to the highly borated refueling water storage tank (RWST) when there was a trip of the RCPs. This was felt to reduce the estimated core damage frequency to an acceptable level. In the US, this original study prompted the Nuclear Regulatory Commission to issue an information notice to follow work being done in this area and to initiate studies such as the work at BNL reported herein. In order to see if the core damage frequency might be as high in US plants, a probabilistic assessment of this scenario was done for three plants. Two important conservative assumptions in this analysis were that (1) the mixing of the injectant was insignificant and (2) fuel damage occurs when the slug passes through the core. In order to study the first assumption, analysis was carried out for two of the plants using a mixing model. The second assumption was studied by calculating the neutronic response of the core to a slug of deborated water for one of the plants. All three types of analyses are summarized below. More information is available in the original report

The role of primary healthcare professionals in oral cancer prevention and detection

AIM: To investigate current knowledge, examination habits and preventive practices of primary healthcare professionals in Scotland, with respect to oral cancer, and to determine any relevant training needs. SETTING: Primary care. METHOD: Questionnaires were sent to a random sample of 357 general medical practitioners (GMPs) and 331 dental practitioners throughout Scotland. Additionally, focus group research and interviews were conducted amongst primary healthcare team members. RESULTS: Whilst 58% of dental respondents reported examining regularly for signs of oral cancer, GMPs examined patients' mouths usually in response to a complaint of soreness. The majority of GMPs (85%) and dentists (63%) indicated that they felt less than confident in detecting oral cancer, with over 70% of GMPs identifying lack of training as an important barrier. Many practitioners were unclear concerning the relative importance of the presence of potentially malignant lesions in the oral cavity. A high proportion of the GMPs indicated that they should have a major role to play in oral cancer detection (66%) but many felt strongly that this should be primarily the remit of the dental team. CONCLUSION: The study revealed a need for continuing education programmes for primary care practitioners in oral cancer-related activities. This should aim to improve diagnostic skills and seek to increase practitioners' participation in preventive activities

A Multicriteria Analysis on the Strategies to Open Taiwan's Mobile Virtual Network Operators Services

[[abstract]]This study investigates the trends followed by MVNOs (Mobile Virtual Network Operators) in the last three years and analyzes the strategies that can contribute to the success of Taiwan's telecommunications industry and marketing. We apply the method and concept of PATTERN (Planning Assistance Through Technical Evaluation of Relevance Number) to establish relevant systems for searching out the key successful factors of strategies to attract MVNOs. We also use the fuzzy Multi-Criteria Decision Making (MCDM) method for analyzing the different preference of a decision group in the criteria weights and for ranking the alternatives in a fuzzy environment in order to provide a strategy scheme. These results provide a reference to assist telecommunications operators, 3G license owners, potential MVNOs, and equipment manufacturers when working out business plans.[[incitationindex]]SCI[[booktype]]紙

Methods of a national colorectal cancer cohort study: the PIPER Project

A national study looking at bowel cancer in New Zealand has previously been completed (the PIPER Project). The study included 5,610 patients and collected medical information about how each person was found to have bowel cancer and the treatment they received. This paper reports how the study was carried out. The information collected in the study will be used to look at the quality of care being provided to New Zealand patients with bowel cancer, and to find out if differences in care occur based on where people live, their ethnicity and their socioeconomic status

Relative luminosity measurement of the LHC with the ATLAS forward calorimeter

In this paper it is shown that a measurement of the relative luminosity changes at the LHC may be obtained by analysing the currents drawn from the high voltage power supplies of the electromagnetic section of the forward calorimeter of the ATLAS detector. The method was verified with a reproduction of a small section of the ATLAS forward calorimeter using proton beams of known beam energies and variable intensities at the U-70 accelerator at IHEP in Protvino, Russia. The experimental setup and the data taking during a test beam run in April 2008 are described in detail. A comparison of the measured high voltage currents with reference measurements from beam intensity monitors shows a linear dependence on the beam intensity. The non-linearities are measured to be less than 0.5 % combining statistical and systematic uncertainties.Comment: 16 page

Panspermia, Past and Present: Astrophysical and Biophysical Conditions for the Dissemination of Life in Space

Astronomically, there are viable mechanisms for distributing organic material throughout the Milky Way. Biologically, the destructive effects of ultraviolet light and cosmic rays means that the majority of organisms arrive broken and dead on a new world. The likelihood of conventional forms of panspermia must therefore be considered low. However, the information content of dam-aged biological molecules might serve to seed new life (necropanspermia).Comment: Accepted for publication in Space Science Review

Relating basic properties of bright early-type dwarf galaxies to their location in Abell 901/902

We present a study of the population of bright early-type dwarf galaxies in the multiple-cluster system Abell 901/902. We use data from the STAGES survey and COMBO-17 to investigate the relation between the color and structural properties of the dwarfs and their location in the cluster. The definition of the dwarf sample is based on the central surface brightness and includes galaxies in the luminosity range -16 >= M_B >~-19 mag. Using a fit to the color magnitude relation of the dwarfs, our sample is divided into a red and blue subsample. We find a color-density relation in the projected radial distribution of the dwarf sample: at the same luminosity dwarfs with redder colors are located closer to the cluster centers than their bluer counterparts. Furthermore, the redder dwarfs are on average more compact and rounder than the bluer dwarfs. These findings are consistent with theoretical expectations assuming that bright early-type dwarfs are the remnants of transformed late-type disk galaxies involving processes such as ram pressure stripping and galaxy harassment. This indicates that a considerable fraction of dwarf elliptical galaxies in clusters are the results of transformation processes related to interactions with their host cluster.Comment: 12 pages, 8 figures, accepted for publication in A&A, typo corrected in abstrac