Role of serum cathelicidin in diagnosis of patient with prostatitis and prostate carcinoma

Background: This study investigated the diagnostic role of 75 levels measured in serum prostatitis and prostate carcinoma and in the differentiation of these two conditions. Methods: The study was conducted with 75 patients histopathologically diagnosed with prostate carcinoma or prostatitis and followed up at the Departments of Urology and Medical Oncology and 21 healthy male subjects. Serum cathelicidin levels were investigated using the ELISA method. Statistical analyses were performed using the SPSS for Windows 22.0 package software. Compliance of the variables to normal distribution was examined using visual and analytic methods. In the Kolmogorov–Smirnov test, cases with a p value of greater than 0.05 were accepted as normal distribution. Results: A total of 75 patients including 45 diagnosed with prostate carcinoma and 30 diagnosed with prostatitis, as well as 21 healthy control subjects were included in the study. Prostate-specific antigen (PSA) was detected as 23 (4–1200) ng/mL in the patients with prostate carcinoma and as 9.85 (3.9–405 ng/mL) in the patients with prostatitis. The cathelicidin levels were diagnostically significant when assessed by ROC analysis in the prostate cancer, prostatitis and control groups (p = 0.005). The cutoff values derived from the ROC curve analysis were 3.5151 ng/mL for distinguishing prostate cancer from prostatitis, 2.2620 ng/mL for prostate cancer versus control group and 1.2340 ng/mL for prostatitis versus control group. Conclusions: In this study we showed that the serum cathelicidin levels were significantly higher in the patients diagnosed with prostate carcinoma. Measurement of serum cathelicidin levels could be used as a diagnostic marker in prostate carcinoma as well as facilitating differential diagnosis to strengthen the diagnostic suspicion before prostate biopsy and distinguish the diagnosis from prostatitis cases. © 2022, The Author(s)

Prostat adenokarsinomlarında IMP-3 ekspresyonunun araştırılması

Objective: Prostate cancer is the second most common cause of male cancer deaths after lung cancer in developed countries. The prognostic factors currently identified for prostate carcinoma include preoperative serum PSA, TNM staging system, histological grade and surgical margin status and are composed of the clinically most important and useful parameters. However, all the markers studied have not been applied in clinical practice. The oncofetal protein Insulin-Like Growth Factor II has been demonstrated to be associated with aggressive tumor behavior in many organs including urothelial tumors and renal cell carcinoma. Our aim was to investigate the expression status of Insulin-Like Growth Factor II in benign prostate glands, high grade PIN and prostate adenocarcinoma, and to determine the role of Insulin-Like Growth Factor II in pathogenesis of prostate adenocarcinoma. Material and Method: A total of 70 prostate adenocarcinoma cases accompanied by high grade PIN and benign prostate glands were evaluated by immunohistochemistry for the expression of Insulin-Like Growth Factor II. Results: Insulin-Like Growth Factor II expression was not seen in any of the 70 prostate adenocarcinoma and high grade PIN cases and benign prostate glands. Conclusion: Although the number of our cases was limited, our results suggested that Insulin-Like Growth Factor II protein expression was not included in the pathogenesis of the prostate adenocarcinomas and Insulin-Like Growth Factor II expression status cannot be used for diagnosis of prostate adenocarcinomas

6. - 8. Sınıf Öğrencilerinin Fiziksel Aktiviteye Katılımında Algıladıkları Sosyal Desteğin Rolü

The purpose of this study was to investigate the role of perceived social support on 6th, 7th and 8th grade students’ physical activity levels with regard to gender and school type (private versus public). In this study, both qualitative and quantitative research methodologies were applied. The participants were 266 students from one public and one private school. It is found that perceived social support seems to be an important factor on students’ physical activity patterns. Participants reported that they received more social support from their peers when compared to their parents, wherein their mothers were the only significant social support provider. Results also revealed that students from the private school significantly received more social support from their family compared to students from the public school. Moreover, physically active students, especially girls, reported that they received more social support from their mothers.Bu çalışmanın amacı, 6., 7. ve 8. sınıfta öğrenim gören öğrencilerin fiziksel aktivite düzeylerine göre algıladıkları sosyal destek sağlayıcıları ve türlerini, farklı okul türü (özeldevlet) ve cinsiyetleri açısından nicel ve nitel araştırma yöntemlerini kullanarak incelemektir. Araştırmanın örneklemini bir devlet okulu ve bir özel okulda öğrenim gören 266 altıncn, 7. ve 8. sınıf öğrencisi oluşturmaktadır. Araştırma sonuçları, sosyal desteğin bireylerin fiziksel aktiviteye katılımında önemli bir etken olabileceğini göstermektedir. Bu yaş grubundaki bireylerin, ailelerine oranla arkadaşlarından daha çok destek aldıkları; fakat aileden, özellikle de anneden algılanan sosyal desteğin fiziksel aktiviteye birlikte katılım, fiziksel aktiviteye teşvik etme ve aktivitenin türünü seçmede belirleyici bir rol oynadığı görülmektedir. Özel okuldaki katılımcıların devlet okulundaki katılımcılara oranla fiziksel aktiviteye katılımda ailelerinden algıladıkları sosyal desteğin anlamlı olarak daha yüksek olduğu görülmüştür. Bununla birlikte, fiziksel aktivite düzeyi yüksek olan özellikle de kız öğrencilerin, annelerinden algıladıkları sosyal desteğin fiziksel aktiviteye katılımda anlamlı olarak farklılaştığı görülmektedir

The effect of trust in the nurses on person-organization fit

Kesitsel nitelikte olan bu çalışma hemşirelerde yöneticiye duyulan güvenin kişi-örgüt uyumu üzerine etkisini araştırmak amacıyla yapılmıştır. Örneklem seçimine gidilmeden çalışmaya katılmayı kabul eden hemşirelerden veriler toplanmış ve toplamda örneklem sayısı (n=402) olmuştur. Veri Toplama Araçları olarak “Kişisel Bilgi Formu”, “Yöneticiye Güven Ölçeği” ve “Kişi - Örgüt Uyumu Ölçeği” kullanılmıştır. Verilerin analizinde Mann-Whitney U, Kruskal-Wallis H, ANOVA testi ve Spearman korelasyon kullanılmıştır. Çalışmaya katılan hemşirelerin çalışma yılı ortalaması, 7.47±6.54 (min:1.0, maks:26.0) yıl olup, %49.0’unun (n=197),1-5 yıl arasında çalıştığı tespit edilmiştir. Hemşirelerin %53.2’si (n=214) çalıştığı klinikten memnun, %37.6’sı (n=151) kısmen memnundur. Hemşirelerin %34.3’ü (n=138) çalıştığı klinikten ayrılmayı düşünmektedir. Hemşirelerin, Yöneticiye Güven Ölçeği ortalama puanı (Ort. = 18.33, S = 4.47), Kişi Örgüt Uyumu Ölçeği ortalama puanı (Ort. = 14.02, S = 3.86)’dir. Çalışmamızda yöneticiye duyulan güven ile kişi örgüt uyumu arasında anlamlı ilişki bulunmuştur.This cross-sectional study was conducted to investigate the effect of trust in manager on personorganization compliance in nurses. Data were collected from the nurses who agreed to participate in the study and the total number of samples (n=402) was taken. "Personal Information Form", "Supervisor Trust Scale" and "Person-Organization Fit Scale" were used as data collection tools. Mann-Whitney U, KruskalWallis H, ANOVA test and Spearman correlation were used for data analysis. Average of study year of nurses was 7.47 ± 6.54 (mim: 1.0, max: 26.0), and 49.0% (n= 197) were found to work between 1-5 years. 53.2% (n= 214) of the nurses were satisfied with the clinic and 37.6% (n= 151) were partially satisfied. 34.3% (n= 138) of the nurses were considering leaving the clinic. The average score of the nurses and the Manager Trust Scale was (M= 18.33, SD= 4.47), and the Person- Organization Fit was (M= 14.02, SD= 3.86) In our study, a significant relationship was found between trust in the manager and person organization compliance

FOXA1 is associated with high tumor grade, myometrial invasion and lymph node invasion in endometrial endometrioid carcinoma

Objectives: FOXA1 expression has been demonstrated in several hormone-dependent cancers. However, data are limited concerning the role of FOXA1 in endometrial cancers. The present study aimed to investigate FOXA1 expression via the microarray technique in benign hyperplasia, endometrial intraepithelial neoplasia, and endometrial endometrioid carcinoma. We also aimed to determine whether there were any associations between FOXA1 expression, tumor grade, myometrial invasion and lymphatic invasion.Material and methods: Paraffin-embedded sections prepared from samples obtained from 114 patients who underwent surgical hysterectomy or curettage were analyzed. Data were retrieved from digitally-stored medical records. Tissue microarrays were prepared from formalin-fixed, paraffin-embedded tissue blocks. Full tumor sections were used for immunohistochemical analysis performed.Results: Carcinomas with nuclear grade 3 had higher FOXA1 values than others, while grade 2 carcinomas also had higher FOXA1 values relative to grade 1 (p < 0.001). FOXA1 values of FIGO stage III carcinomas were significantly higher than others and stage II values were also significantly higher than stage I FOXA1 values (p < 0.001). Patients with myometrial and lymph node invasion had significantly higher FOXA1 values than others (p < 0.001 and p = 0.047, respectively). FOXA1 had 91.30% sensitivity, 63.60% specificity and 77.78% accuracy for predicting the presence of myometrial invasion with a cut-off value of 9.Conclusions: FOXA1 expression is higher in endometrial endometrioid carcinoma compared to benign endometrial hyperplasia or intraepithelial neoplasia. In patients with endometrial endometrioid carcinoma, high FOXA1 expression is associated with high tumor grade, myometrial and lymph node invasion. However, FOXA1 expression is not associated with lymphovascular or cervical invasion

GLI1 inactivation is associated with developmental phenotypes overlapping with Ellis–van Creveld syndrome

Peer reviewe

COVID-19 in pediatric nephrology centers in Turkey

Background/aim: There is limited data on COVID-19 disease in children with kidney disease. We aimed to investigate the characteristics and prognosis of COVID-19 in pediatric nephrology patients in Turkey. Materials and methods: This was a national, multicenter, retrospective cohort study based on an online survey evaluating the data between 11th March 2020 and 11th March 2021 as an initial step of a detailed pediatric nephrology COVID-19 registry. Results: Two hundred and three patients (89 girls and 114 boys) were diagnosed with COVID-19. One-third of these patients (36.9%) were between 10–15 years old. Half of the patients were on kidney replacement therapy: kidney transplant (KTx) recipients (n = 56, 27.5%), patients receiving chronic hemodialysis (n = 33, 16.3%) and those on peritoneal dialysis (PD) (n = 18, 8.9%). Fifty-four (26.6%) children were asymptomatic. Eighty-two (40.3%) patients were hospitalized and 23 (28%) needed intensive care unit admission. Fifty-five percent of the patients were not treated, while the remaining was given favipiravir (20.7%), steroid (16.3%), and hydroxychloroquine (11.3%). Acute kidney injury developed in 19.5% of hospitalized patients. Five (2.4%) had MIS-C. Eighty-three percent of the patients were discharged without any apparent sequelae, while 7 (3.4%) died. One hundred and eight health care staff were infected during the study period. Conclusion: COVID-19 was most commonly seen in patients who underwent KTx and received HD. The combined immunosuppressive therapy and frequent exposure to the hospital setting may increase these patients’ susceptibility. Staff infections before vaccination era were alarming, various precautions should be taken for infection control, particularly optimal vaccination coverage

Determination of essential oil components of leaves and some pomological and plant properties of myrtle plants (Myrtus communis L.) that grown on the ecological conditions of Adana and Mersin.

TEZ8900Tez (Yüksek Lisans) -- Çukurova Üniversitesi, Adana, 2012.Kaynakça (s. 73-79) var.xii, 110 s. : res. ; 29 cm.Bu araştırmada Adana ve Mersin ekolojik koşullarında yetişen mersin bitkisinin bazı bitkisel ve pomolojik özellikleri ile yaprak uçucu yağ bileşenleri belirlenmiştir. Mersin bitkisinde meyve ağırlığı, meyve boyu, meyve eni, suda çözünebilir kuru madde, yaprak boyu, yaprak eni, çiçek çapı, stamen sayısı gibi özellikleri sırasıyla 0.2-2.01 g, 7.52-16.73 mm, 5.52-14.74 mm, % 11.57-29.13, 28.20-53.61 mm, 7.47-20.86 mm, 19.58-29.70 mm, 129-264 adet olarak saptanmıştır. Mersin bitkisinin taze yapraklarından hidrodistilasyon yöntemiyle clevenger cihazı kullanılarak 2 saat süreyle elde edilen uçucu yağlar HS/ SPME/GC/MS tekniği kullanılarak analiz edilmiştir. Bu analizler sonucunda 146 bileşik bulunmuştur. Alpha-pinene ve eucalyptol ana bileşenler olarak belirlenmiştir.In this research essential oil components of leaves and some pomological and plant properties of myrtle plants (Myrtus communis L.) that grown on the ecological conditions of Adana and Mersin were determined. The myrtle plants were examined in terms of fruit weight, fruit length, fruit width, dry matter content, leave length, leave width, flower diameter, stamen number per flower and this properties were determined 0.2-2.01 g, 7.52-16.73 mm, 5.52-14.74 mm, % 11.57-29.13, 28.20-53.61 mm, 7.47-20.86 mm, 19.58-29.70 mm, 129-264 respectively. Fresh leaves of myrtle plants were subjected to hydrodistillation for 2 hours using a clevenger type apparatus and the oils obtained. The essential oils were analysed using HS/SPME-GC/MS (Headspace/Solid Phase Micro Extraction-Gas Chromatography Mass Spectrometry) techniques.146 components were detected. Alpha pinene and eucalyptol were detected essential oils of myrtle plants in a higher percentages.Bu çalışma Ç.Ü. Bilimsel Araştırma Projeleri Birimi tarafından desteklenmiştir. Proje No: ZF2010YL88

Bir eğitimsiz (Unsupervised) sınıflandırma metodunun geliştirilmesi üzerine araştırmalar ve bunun Ceylanpınar Ovası topraklarına uygulanması

TEZ692Tez (Yüksek Lisans) -- Çukurova Üniversitesi, Adana, 1989.Kaynakça (s. 92-97) var.x, 99 s. : hrt. ; 30 cm.