PIV measurements of the effect of pulsed blowing jet on a NACA0012 wing model

Wingtip vortices are present in taking off, and landing operations and their presence in airport runways must be reduced. To that end, several strategies have been considered in the last decades, being the active control one possible technical solution. To compute the effectiveness of active control that corresponds to pulsed low-blowing-ratio transverse jet for the reduction of the wingtip vortex strength, we carry out 2D-PIV measurements in a towing tank for chord-based Reynolds numbers 15000 and 20000. We consider two cases: (i) no active control Rjet=0 and (ii) pulsating radial jet of blowing-ratio Rjet smaller than 1.7 (or momentum coefficient lower than 0.12) and different Strouhal numbers ranging from 0.27 to 0.94. Our observations show that the best reduction of wingtip vortex strength takes place at the lowest Strouhal number tested. We use the maximum azimuthal velocity and vorticity together with the circulation to quantify this decrease in the vortex strength. Besides, we define the spatial evolution of a disturbance parameter which allow us to detect again the optimal frequency that leads to vortex destruction.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Situações estressantes de vida, uso e abuso de álcool e drogas em idosos de Monterrey, México

This is a descriptive, qualitative, and correlation study with 112 elderly aged 60 years or older. This study aimed to identify differences in alcohol consumption according to gender and marital status, and differences in the consumption of medical drugs by gender. It also aims to determine differences in stressful life events by gender, and differences in stressful life events associated to alcohol and medical drugs use and abuse, as well as to know their perceptions on the most stressful life events they have experienced. The results showed significant differences in alcohol consumption by gender (U=154.0, pEstudio descriptivo correlacional con aproximación cualitativa de los datos en 112 adultos mayores de 60 años, con objeto de identificar las diferencias en el consumo de alcohol por sexo y estado marital y las diferencias en el consumo de drogas médicas por sexo, determinar los eventos de la vida estresantes que se asocian con el uso y abuso de alcohol y drogas médicas, y conocer las percepciones sobre los eventos de la vida que han experimentado como más estresantes. Los resultados mostraron diferencias significativas del consumo de alcohol de acuerdo al sexo (U=154.0, p< .001), donde el consumo fue mayor para los hombres. Se reportó que el consumo de drogas médicas (Ç2=5.95, pEstudo descritivo correlacional e abordagem qualitativa dos dados, realizado com 112 adultos maiores de 60 anos com o objetivo de identificar as diferenças no consumo de álcool por sexo e estado civil, identificar as diferenças do consumo de drogas médicas por sexo, determinar os eventos estressantes da vida que se associam com o uso e abuso de álcool e drogas médicas, e conhecer as percepções dos idosos sobre o que consideram eventos estressantes na vida. Os resultados mostraram diferenças significativas do consumo de álcool de acordo com sexo (U=154.0, p< 0,001), consumo foi muito maior para os homens. Reportou-se que o consumo de drogas médicas (Ç2=5.95,

PTEN Deletion in Adult Mice Induces Hypoinsulinemia With Concomitant Low Glucose Levels

The PI3K/AKT pathway, negatively regulated by PTEN, plays a paramount role in glucose metabolism regulation due to its activation by the insulin receptor signaling pathway. We generated a PTEN-KO mouse to evaluate the systemic effect of the overactivation of the PI3K/AKT pathway in insulin signaling and glucose homeostasis. Our results demonstrate that PTEN-KO mice show very low glucose levels in the fasted state, which poorly respond to glucose and pyruvate administration. Insulinemia decreased without alterations in pancreatic islets. Among the possible reasons, we uncover the deregulation of the expression of proximal tubule glucose transporter and consequent glycosuria. Moreover, we evidence an altered activation of hepatic gluconeogenesis-related genes. In addition, the expression of several genes related to β-oxidation showed a delayed or even absent response to fasting, suggesting that the lack of PTEN not only impairs glucose metabolism but also slows down the use of lipids as a metabolic fuel. We conclude that the inducible full PTEN-KO mice could be a good model to study the metabolic interactions between glycidic and lipidic metabolism in hypoinsulinemic hypoglycemia and that PTEN could be an important mediator in the disease and/or a potential drug target

Primary cardiac fibroma in infants: A case report and review of cases of cardiac fibroma managed through orthotopic heart transplant

Cardiac fibromas (CF) are the second most common cardiac tumors in children. They can be aggressive tumors despite their benign histopathologic nature, accounting for the highest mortality rate among primary cardiac tumors. CF usually show a progressive growth and spontaneous regression is rare. Therefore, a complete surgical excision is the preferred therapeutic approach when patients become symptomatic or if mass-related life-threatening complications are anticipated, even in asymptomatic patients. However, some cases are not good candidates for surgical excision due to the impossibility of preserving a normal cardiac anatomy or function after the tumor resection. Orthotopic heart transplantation (OHT) can be an exceptional but adequate alternative for some giant unresectable CF in children. In this article, we report our experience with the case of a 7-month-old infant with a giant unresectable cardiac fibroma who was successfully managed through OHT.Ye

Elimination of Vitamin D Signaling Causes Increased Mortality in a Model of Overactivation of the Insulin Receptor: Role of Lipid Metabolism

Vitamin D (VD) deficiency has been associated with cancer and diabetes. Insulin signaling through the insulin receptor (IR) stimulates cellular responses by activating the PI3K/AKT pathway. PTEN is a tumor suppressor and a negative regulator of the pathway. Its absence enhances insulin signaling leading to hypoglycemia, a dangerous complication found after insulin overdose. We analyzed the effect of VD signaling in a model of overactivation of the IR.We generated inducible double KO (DKO) mice for the VD receptor (VDR) and PTEN. DKO mice showed severe hypoglycemia, lower total cholesterol and increased mortality. No macroscopic tumors were detected. Analysis of the glucose metabolism did not show clear differences that would explain the increased mortality. Glucose supplementation, either systemically or directly into the brain, did not enhance DKO survival. Lipidic liver metabolism was altered as there was a delay in the activation of genes related to -oxidation and a decrease in lipogenesis in DKO mice. High-fat diet administration in DKO significantly improved its life span. Lack of vitamin D signaling increases mortality in a model of overactivation of the IR by impairing lipid metabolism. Clinically, these results reveal the importance of adequate Vitamin D levels in T1D patients

Thio- and selenosemicarbazones as antiprotozoal agents against Trypanosoma cruzi and Trichomonas vaginalis

Herein, we report the preparation of a panel of Schiff bases analogues as antiprotozoal agents by modification of the stereoelectronic effects of the substituents on N-1 and N-4 and the nature of the chalcogen atom (S, Se). These compounds were evaluated towards Trypanosoma cruzi and Trichomonas vaginalis. Thiosemicarbazide 31 showed the best trypanocidal profile (epimastigotes), similar to benznidazole (BZ): IC50 (31)=28.72 μM (CL-B5 strain) and 33.65 μM (Y strain), IC50 (BZ)=25.31 μM (CL-B5) and 22.73 μM (Y); it lacked toxicity over mammalian cells (CC50 > 256 µM). Thiosemicarbazones 49, 51 and 63 showed remarkable trichomonacidal effects (IC50 =16.39, 14.84 and 14.89 µM) and no unspecific cytotoxicity towards Vero cells (CC50 ≥ 275 µM). Selenoisosters 74 and 75 presented a slightly enhanced activity (IC50=11.10 and 11.02 µM, respectively). Hydrogenosome membrane potential and structural changes were analysed to get more insight into the trichomonacidal mechanism.Junta de Andalucía Grant PID2020- 116460RB-I00, funded by MCIN/AEI/10.13039/50110001103

Economic corridors in Asia : paradigm of integration?

460 páginasGlobal geopolitics has shifted dramatically over the last thirty years. After the vanishing expectations of a unipolar international system led by the United States, China has gained an increasingly dominant role in areas as innovative as quantum computing, robotics and artificial intelligence. In the ‘non-digital’ dimension, the eastern superpower has made gigantic investments in its Belt and Road Initiative, which include the development of a massive network of highways, industrial centers, harbors, pipelines and bridges, among many other works of infrastructure. These investments allow for the connection of more than 60 countries worldwide, guaranteeing China’s energetic security, easier conditions for trading goods and services and, perhaps more importantly, a significant influence in the political and economic events of the world

La reparación económica a la víctima en el sistema de justicia

En este libro se recogen las investigaciones llevadas a cabo en el marco de los Trabajos Fin de Grado de la Universidad Carlos III de Madrid en los dobles grados de Derecho y Administración de Empresas, Derecho y Economía durante los cursos 2015/16 y 2016/17. El objetivo principal es evaluar la eficacia de la reparación económica a la víctima. Para ello, se realizó un estudio de campo de las ejecutorias en los Juzgados de lo Penal y la Audiencia Provincial de Madrid en dos etapas, octubre de 2015 y octubre de 2016, , excluyendo delitos menores y delitos relacionados con delitos de tránsito y violencia de género, así como aquellos donde no hubiera víctima.Este trabajo ha sido subvencionado en parte por los proyectos DER2015-66435-P y MTM2014-56535-R, Ministerio de Economía y Competitividad, y se enmarca en el Proyecto innovación docente de la Universidad Carlos III de Madrid titulado Eficacia y Eficiencia de la Justicia, curso 2016/2017.Prólogo / Daniel Peña (pp. 19-20). -- La ineficacia del sistema español en la compensación a través del proceso / Helena Soleto y Aurea Grané (pp. 23-97). -- Asistencia jurídica y turno de oficio para la víctima / Alicia Calvo Barceló (pp. 101-138). -- Competencia judicial en ejecución penal / Alberto Rodríguez Abad (pp. 141-175). -- El fiscal en la ejecución / María García Navarro (pp. 177-214). -- La participación de la víctima en la ejecución / Sara González Pérez (pp. 215-247). -- Investigación patrimonial del condenado / Radad Sennouni El Harti (pp. 249-277). -- La suspensión de la pena privativa y libertad condicional / Sara Jiménez Olbea (pp. 281-306). -- La insolvencia del condenado / Catalina Guzmán Guzmán (pp. 307-324). -- Eficacia del pago y percepción de impunidad: consecuencias de la reparación en el condenado / Rosa González Espejo (pp. 325-342). -- Delitos contra la libertad sexual / María Belén Combarros Gómez (pp. 345-386). -- La víctima del delito de trata de seres humanos e inmigración ilegal / Eduardo Sagra González (pp. 387-407). -- La reparación en violencia de género / Marina García-Navas Gómez (pp. 409-439). -- Reparación en delitos contra la Administración Pública / Irea Riobó Mayo (pp. 441-459). -- La reparación económica en el caso Madrid Arena / Lucía Gimeno Malumbres (pp. 461-487). -- La reparación en el proceso de menores / Miriam López-Terradas Paniagua (pp. 489-513). -- La atenuante por reparación del daño / Adriana Noel Afonso Carracedo (pp. 517-540). -- Reparación y modelos de justicia reparativa / Victoria Martínez Martínez (pp. 541-567). -- Elementos básicos de justicia restaurativa / Mireia Galindo Perpiñán (pp. 569-614). -- El acuerdo de reparación en la justicia reparativa / Ainhoa Berrocal Cañadas (pp. 615-634). -- La indemnización a las víctimas en el Derecho comparado / Alba Peña Díaz (pp. 637-650). -- Las indemnizaciones de la Ley 35/1995 / Inmaculada Ramírez Rodríguez (pp. 651-702). -- El pago de indemnizaciones por el Estado en terrorismo / Ana Pérez Campón (pp. 703-734)

COVID-19 outbreaks in a transmission control scenario: challenges posed by social and leisure activities, and for workers in vulnerable conditions, Spain, early summer 2020

Severe acute respiratory syndrome coronavirus 2 community-wide transmission declined in Spain by early May 2020, being replaced by outbreaks and sporadic cases. From mid-June to 2 August, excluding single household outbreaks, 673 outbreaks were notified nationally, 551 active (>6,200 cases) at the time. More than half of these outbreaks and cases coincided with: (i) social (family/friends’ gatherings or leisure venues) and (ii) occupational (mainly involving workers in vulnerable conditions) settings. Control measures were accordingly applied