Vera; or, The Nihilists: Oscar Wilde’s “Wretched Play” and the Challenges of Reassessing “Minor” Works

Richard Ellmann termed Vera a "wretched play." In Oscar Wilde Revalued (1983), Ian Small could name only two critics gave it serious attention: Katherine Worth and Frances Miriam Reed. In Oscar Wilde Recent Research (2000), Small again found only two treatments worth mentioning: by Sos Eltis and George Rowell. Vera has come more to the fore in critical discussion, but interest continues to be outweighed by that afforded to the rest of Wilde's oeuvre, with the exception only of his unfinished works and scenarios. This article explores the reasons behind this neglect, discussing the strategies of some of the most recent, post-2000 studies of Vera. Paying closer attention to archival materials and to the broader literary (as opposed to political) context in which Vera was produced opens new ways of appreciating the significance of this work

Socioeconomic status and site-specific cancer incidence, a Bayesian approach in a French Cancer Registries Network study

International audienceThe aim of this study was to identify and compare cancer sites whose incidence is influenced by social deprivation. The study population comprised 189 144 cases of cancer diagnosed between 2006 and 2009, recorded in member registries of the French Network of Cancer Registries. Social environment was assessed at an aggregate level using the European Deprivation Index. The association between incidence and socioeconomic status was assessed by a geographical Bayesian Poisson model enabling a reduction of the overall variability and smoothing of the relative risks by sharing information provided by multiple geographic units. For cancers of the stomach, liver, lips-mouth-pharynx, and lung, a higher incidence in deprived populations was found for both sexes as well as for cancers of the larynx, esophagus, pancreas, and bladder in men and cervical cancer in women. For melanoma, prostate, testis, ovarian, and breast cancer, a higher incidence was observed in affluent populations. The highest relative risks of the lowest social class compared with the highest social class were found for larynx [relative risk (RR) = 1.67 (1.43-1.95)], lips-mouth-pharynx [RR = 1.89 (1.72-2.07)], and lung cancer [RR = 1.59 (1.50-1.68)] in men and for cervix [RR = 1.62 (1.40-1.88)] and lips-mouth-pharynx [RR = 1.56 (1.30-1.86)] cancer in women. By estimating the burden of social deprivation on cancer incidence throughout France, this study enables us to measure the gains that could be achieved by implementing targeted prevention efforts

Literary stylistics, authorial intention and the scientific study of literature: a critical overview

A tendency by literary stylisticians to overlook the role of the author in the generation of literary meaning has been a significant source of tension between linguistic approaches to literariness and other practices in the discipline, such as text-editing and literary biography. Recently, however, efforts have been made to close this gap, with the branch of stylistics, cognitive poetics, claiming to have developed a new and empirical method of integrating an appreciation of authorial imagination and creativity into the study of readers' responses to the language of literary texts. We examine these claims critically, testing the grounds of assertions about scientific rigour in relation to demands about model testing and falsifiability associated with the scientific study of literature more generally. We then explore how some other methodologies, technologies and insights associated with this last branch of the discipline might be brought to bear on the topic of authorial intention, with the aim of determining whether, and in what ways, our understanding of an authorial intention, and its role in literary processing, might be furthered through empirical enquiry

Challenges in editing late nineteenth-and early twentieth-century prose fiction: what is editorial “completeness”?

Guy, Scott, Conklin, and Carrol join forces to analyze controversial questions about multi-volume variorum editions of late nineteenth- and early twentieth-century writers such as Wilde, Conrad, Woolf, James, and Wyndam Lewis. What prompted such ambitious, costly editions that take years to complete? How do editors plan to compete with the many popular and scholarly editions readily available? Controversy has also emerged about the readership for these projects and how editorial principles have changed. At center is the thorny question of the role of an editor's value judgments and the "completeness" of an edition. On what grounds can a variorum edition claim to be "definitive"? Is there a better means of determining the "meaningfulness" of textual variants than a reliance on editorial judgment alone? Guy and company offer a timely consideration of variorum editions, the kinds of textual data such editorial scholarship provides and its relevance to literary critical judgments

The role of empirical methods in investigating readers’ constructions of authorial creativity in literary reading

The popularity of literary biographies and the importance publishers place on author publicity materials suggest the concept of an author’s creative intentions is important to readers’ appreciation of literary works. However, the question of how this kind of contextual information informs literary interpretation is contentious. One area of dispute concerns the extent to which readers’ constructions of an author’s creative intentions are text-centred and therefore can adequately be understood by linguistic evidence alone. The current study shows how the relationship between linguistic and contextual factors in readers’ constructions of an author’s creative intentions may be investigated empirically. We use eye-tracking to determine whether readers’ responses to textual features (changes to lexis and punctuation) are affected by prior, extra-textual prompts concerning information about an author’s creative intentions. We showed participants pairs of sentences from Oscar Wilde and Henry James while monitoring their eye movements. The first sentence was followed by a prompt denoting a different attribution (Authorial, Editorial/Publisher and Typographic) for the change that, if present, would appear in the second sentence. After reading the second sentence, participants were asked whether they had detected a change and, if so, to describe it. If the concept of an author’s creative intentions is implicated in literary reading this should influence participants’ reading behaviour and ability to accurately report a change based on the prompt. The findings showed that readers’ noticing of textual variants was sensitive to the prior prompt about its authorship, in the sense of producing an effect on attention and re-reading times. But they also showed that these effects did not follow the pattern predicted of them, based on prior assumptions about readers’ cultures. This last finding points to the importance, as well as the challenges, of further investigating the role of contextual information in readers’ constructions of an author’s creative intentions

Commentary:Transcranial stimulation of the frontal lobes increases propensity of mind-wandering without changing meta-awareness

A Commentary on Transcranial stimulation of the frontal lobes increases propensity of mind-wandering without changing meta-awareness by Axelrod, V., Zhu, X., & Qui, J. (2018). Scientific Reports, 8:15975. doi: 10.1038/s41598-018-34098-

RNA-seq of newly diagnosed patients in the PADIMAC study leads to a bortezomib/lenalidomide decision signature.

Improving outcomes in multiple myeloma will involve not only development of new therapies but also better use of existing treatments. We performed RNA sequencing on samples from newly diagnosed patients enrolled in the phase 2 PADIMAC (Bortezomib, Adriamycin, and Dexamethasone Therapy for Previously Untreated Patients with Multiple Myeloma: Impact of Minimal Residual Disease in Patients with Deferred ASCT) study. Using synthetic annealing and the large margin nearest neighbor algorithm, we developed and trained a 7-gene signature to predict treatment outcome. We tested the signature in independent cohorts treated with bortezomib- and lenalidomide-based therapies. The signature was capable of distinguishing which patients would respond better to which regimen. In the CoMMpass data set, patients who were treated correctly according to the signature had a better progression-free survival (median, 20.1 months vs not reached; hazard ratio [HR], 0.40; confidence interval [CI], 0.23-0.72; P = .0012) and overall survival (median, 30.7 months vs not reached; HR, 0.41; CI, 0.21-0.80; P = .0049) than those who were not. Indeed, the outcome for these correctly treated patients was noninferior to that for those treated with combined bortezomib, lenalidomide, and dexamethasone, arguably the standard of care in the United States but not widely available elsewhere. The small size of the signature will facilitate clinical translation, thus enabling more targeted drug regimens to be delivered in myeloma.Wellcome Trust, Bloodwise, Cancer Research UK

A randomised, controlled trial of a dietary intervention for adults with major depression (the "SMILES" trial): study protocol

Despite increased investment in its recognition and treatment, depression remains a substantial health and economic burden worldwide. Current treatment strategies generally focus on biological and psychological pathways, largely neglecting the role of lifestyle. There is emerging evidence to suggest that diet and nutrition play an important role in the risk, and the genesis, of depression. However, there are limited data regarding the therapeutic impact of dietary changes on existing mental illness. Using a randomised controlled trial design, we aim to investigate the efficacy and cost-efficacy of a dietary program for the treatment of Major Depressive Episodes. <br /

Circadian-Related Sleep Disorders and Sleep Medication Use in the New Zealand Blind Population: An Observational Prevalence Survey

STUDY OBJECTIVES: To determine the prevalence of self-reported circadian-related sleep disorders, sleep medication and melatonin use in the New Zealand blind population. DESIGN: A telephone survey incorporating 62 questions on sleep habits and medication together with validated questionnaires on sleep quality, chronotype and seasonality. PARTICIPANTS: PARTICIPANTS WERE GROUPED INTO: (i) 157 with reduced conscious perception of light (RLP); (ii) 156 visually impaired with no reduction in light perception (LP) matched for age, sex and socioeconomic status, and (iii) 156 matched fully-sighted controls (FS). SLEEP HABITS AND DISTURBANCES: The incidence of sleep disorders, daytime somnolence, insomnia and sleep timing problems was significantly higher in RLP and LP compared to the FS controls (p<0.001). The RLP group had the highest incidence (55%) of sleep timing problems, and 26% showed drifting sleep patterns (vs. 4% FS). Odds ratios for unconventional sleep timing were 2.41 (RLP) and 1.63 (LP) compared to FS controls. For drifting sleep patterns, they were 7.3 (RLP) and 6.0 (LP). MEDICATION USE: Zopiclone was the most frequently prescribed sleep medication. Melatonin was used by only 4% in the RLP group and 2% in the LP group. CONCLUSIONS: Extrapolations from the current study suggest that 3,000 blind and visually impaired New Zealanders may suffer from circadian-related sleep problems, and that of these, fewer than 15% have been prescribed melatonin. This may represent a therapeutic gap in the treatment of circadian-related sleep disorders in New Zealand, findings that may generalize to other countries