3,563 research outputs found
Generic Subsequence Matching Framework: Modularity, Flexibility, Efficiency
Subsequence matching has appeared to be an ideal approach for solving many
problems related to the fields of data mining and similarity retrieval. It has
been shown that almost any data class (audio, image, biometrics, signals) is or
can be represented by some kind of time series or string of symbols, which can
be seen as an input for various subsequence matching approaches. The variety of
data types, specific tasks and their partial or full solutions is so wide that
the choice, implementation and parametrization of a suitable solution for a
given task might be complicated and time-consuming; a possibly fruitful
combination of fragments from different research areas may not be obvious nor
easy to realize. The leading authors of this field also mention the
implementation bias that makes difficult a proper comparison of competing
approaches. Therefore we present a new generic Subsequence Matching Framework
(SMF) that tries to overcome the aforementioned problems by a uniform frame
that simplifies and speeds up the design, development and evaluation of
subsequence matching related systems. We identify several relatively separate
subtasks solved differently over the literature and SMF enables to combine them
in straightforward manner achieving new quality and efficiency. This framework
can be used in many application domains and its components can be reused
effectively. Its strictly modular architecture and openness enables also
involvement of efficient solutions from different fields, for instance
efficient metric-based indexes. This is an extended version of a paper
published on DEXA 2012.Comment: This is an extended version of a paper published on DEXA 201
Psychosocial outcomes of an inclusive adapted sport and adventurous training course for military personnel.
PURPOSE: To explore the psychosocial outcomes of an inclusive adapted sport and adventurous training course that aims to support the rehabilitation and personal development of military personnel who have sustained physical and/or psychological disability. METHOD: Narrative life story interviews were conducted with 11 men aged 20-43 taking part in one of the 5-day courses. A thematic narrative analysis was conducted, focusing on accounts that provided insights into personally meaningful psychosocial outcomes of the course. FINDINGS: We identified six themes, falling into two distinct clusters. "Bringing me back to myself" was achieved through the themes of (1) returning to activity, (2) rediscovering a sense of purpose, and (3) reconnecting to others. "New rooms to explore" was realised through (4) experiencing new activities, (5) being valued/respected/cared for and (6) being inspired by other people. CONCLUSION: Involvement in the course stimulated a balance of present- and future-oriented psychosocial outcomes through which participants both recreated aspects of themselves that had been lost through injury/trauma and moved forward with their lives as a result of new horizons of possibility. IMPLICATIONS FOR REHABILITATION: This 5-day inclusive adapted sport and adventurous training course offered meaningful psychosocial outcomes among military personnel who had experienced physical and/or psychological disability. The course helped participants recover aspects of their previous life and self through becoming physically active again, rediscovering a sense of purpose and reconnecting to others. Participants describe a broadening of life horizons as a result of the course, through new activities, being valued/respected/cared for, and being inspired by other people
A comparative study for the pair-creation contact process using series expansions
A comparative study between two distinct perturbative series expansions for
the pair-creation contact process is presented. In contrast to the ordinary
contact process, whose supercritical series expansions provide accurate
estimates for its critical behavior, the supercritical approach does not work
properly when applied to the pair-creation process. To circumvent this problem
a procedure is introduced in which one-site creation is added to the
pair-creation. An alternative method is the generation of subcritical series
expansions which works even for the case of the pure pair-creation process.
Differently from the supercritical case, the subcritical series yields
estimates that are compatible with numerical simulations
Thermal Impact on Spiking Properties in Hodgkin-Huxley Neuron with Synaptic Stimulus
The effect of environmental temperature on neuronal spiking behaviors is
investigated by numerically simulating the temperature dependence of spiking
threshold of the Hodgkin-Huxley neuron subject to synaptic stimulus. We find
that the spiking threshold exhibits a global minimum in a "comfortable
temperature" range where spike initiation needs weakest synaptic strength,
indicating the occurrence of optimal use of synaptic transmission in neural
system. We further explore the biophysical origin of this phenomenon in ion
channel gating kinetics and also discuss its possible biological relevance in
information processing in neural systems.Comment: 10 pages, 4 figure
Aharonov-Bohm-Type Oscillations of Thermopower in a Quantum Dot Ring Geometry
We investigate Aharonov-Bohm-type oscillations of the thermopower of a
quantum dot embedded in a ring for the case when the interaction between
electrons can be neglected. The thermopower is shown to be strongly flux
dependent, and typically the amplitude of oscillations exceeds the background
value. It is also shown to be essentially dependent on the phase of the
scattering matrix which is determined by the experimental geometry and is not
known in the given experiment. Two procedures to compare theory and experiment
are proposed.Comment: Revtex, 5 figures include
Integrative Genomics Viewer
Author Manuscript 2012 May 07.To the Editor:
Rapid improvements in sequencing and array-based platforms are resulting in a flood of diverse genome-wide data, including data from exome and whole-genome sequencing, epigenetic surveys, expression profiling of coding and noncoding RNAs, single nucleotide polymorphism (SNP) and copy number profiling, and functional assays. Analysis of these large, diverse data sets holds the promise of a more comprehensive understanding of the genome and its relation to human disease. Experienced and knowledgeable human review is an essential component of this process, complementing computational approaches. This calls for efficient and intuitive visualization tools able to scale to very large data sets and to flexibly integrate multiple data types, including clinical data. However, the sheer volume and scope of data pose a significant challenge to the development of such tools.National Institute of General Medical Sciences (U.S.) (R01GM074024)National Cancer Institute (U.S.) (R21CA135827)National Human Genome Research Institute (U.S.) (U54HG003067
Staging and stratifying cognitive dysfunction in multiple sclerosis
BACKGROUND: The sequence in which cognitive domains become impaired in multiple sclerosis (MS) is yet to be formally demonstrated. It is unclear whether processing speed dysfunction temporally precedes other cognitive impairments, such as memory and executive function. OBJECTIVE: Determine the order in which different cognitive domains become impaired in MS and validate these findings using clinical and vocational outcomes. METHODS: In a longitudinal sample of 1073 MS patients and 306 healthy controls, we measured performance on multiple, consensus-standard, neurocognitive tests. We used an event-based staging approach to model the sequence in which cognitive domains become impaired. Linear and logistic mixed-effects models were used to explore associations between stages of impairment, neurological disability, and employment status. RESULTS: Our model suggested that the order of impairments was as follows: processing speed, visual learning, verbal learning, working memory/attention, and executive function. Stage of cognitive impairment predicted greater neurological disability, β = 0.16, SE = 0.02, p < 0.001, and probability of unemployment, β = 1.14, SE = 0.001, p < 0.001. CONCLUSION: This is the first study to introduce a cognitive staging and stratification system for MS. Findings underscore the importance of using the Symbol Digit Modalities Test in routine screening for cognitive impairment and memory testing to assess patients later in disease evolution
The deconfinement transition of finite density QCD with heavy quarks from strong coupling series
Starting from Wilson's action, we calculate strong coupling series for the
Polyakov loop susceptibility in lattice gauge theories for various small N_\tau
in the thermodynamic limit. Analysing the series with Pad\'e approximants, we
estimate critical couplings and exponents for the deconfinement phase
transition. For SU(2) pure gauge theory our results agree with those from
Monte-Carlo simulations within errors, which for the coarser N_\tau=1,2
lattices are at the percent level. For QCD we include dynamical fermions via a
hopping parameter expansion. On a N_\tau=1 lattice with N_f=1,2,3, we locate
the second order critical point where the deconfinement transition turns into a
crossover. We furthermore determine the behaviour of the critical parameters
with finite chemical potential and find the first order region to shrink with
growing \mu. Our series moreover correctly reflects the known Z(N) transition
at imaginary chemical potential.Comment: 18 pages, 7 figures, typos corrected, version published in JHE
Floquet scattering theory of quantum pumps
We develop the Floquet scattering theory for quantum mechanical pumping in
mesoscopic conductors. The nonequilibrium distribution function, the dc charge
and heat currents are investigated at arbitrary pumping amplitude and
frequency. For mesoscopic samples with discrete spectrum we predict a sign
reversal of the pumped current when the pump frequency is equal to the level
spacing in the sample. This effect allows to measure the phase of the
transmission coefficient through the mesoscopic sample. We discuss the
necessary symmetry conditions (both spatial and temporal) for pumping.Comment: 11 pages, 5 figure
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