MINIMUM EFFECTIVE LEVEL OF METHIOCARB FOR PROTECTING SPROUTING RICE IN LOUISIANA FROM BLACKBIRD DAMAGE

Blackbirds cause locally serious losses to rice. The Denver Wildlife Research Center, U. S. Fish and Wildlife Service, and the Rice Research Station, Louisiana State University Agricultural Center have been cooperating in tests to determine the efficacy of methiocarb seed treatments for protecting sprouting rice in Louisiana from blackbird damage. Results from four field tests (1980, 1982, 1983, and 1984) have shown that methiocarb provides good protection when applied to rice seed at the rate of 2.4 g and 1.25 g active ingredient (a.i.)/kg of rice seed (0.25 and 0.125%). Seed treated at 0.6 g a.i./kg appeared to be susceptible to damage; but, results were inconclusive due to low bird pressure on untreated fields. Fields planted with seed treated at 0.4 g a.i./kg were heavily damaged. Laboratory testing substantiated that \u3e1 g of methiocarb/kg was required to achieve acceptable repellency. We recommend that future field testing be restricted to treatments of \u3e1.0 g a.i./kg rice seed, and that \u3e1.0 g a.i./kg be accepted as the minimum seed treatment level for formulations under consideration for registration or use in conjunction with emergency (Section 18) exemptions to FIFRA by the Environmental Protection Agency

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

MINIMUM EFFECTIVE LEVEL OF METHIOCARB FOR PROTECTING SPROUTING RICE IN LOUISIANA FROM BLACKBIRD DAMAGE

Blackbirds cause locally serious losses to rice. The Denver Wildlife Research Center, U. S. Fish and Wildlife Service, and the Rice Research Station, Louisiana State University Agricultural Center have been cooperating in tests to determine the efficacy of methiocarb seed treatments for protecting sprouting rice in Louisiana from blackbird damage. Results from four field tests (1980, 1982, 1983, and 1984) have shown that methiocarb provides good protection when applied to rice seed at the rate of 2.4 g and 1.25 g active ingredient (a.i.)/kg of rice seed (0.25 and 0.125%). Seed treated at 0.6 g a.i./kg appeared to be susceptible to damage; but, results were inconclusive due to low bird pressure on untreated fields. Fields planted with seed treated at 0.4 g a.i./kg were heavily damaged. Laboratory testing substantiated that \u3e1 g of methiocarb/kg was required to achieve acceptable repellency. We recommend that future field testing be restricted to treatments of \u3e1.0 g a.i./kg rice seed, and that \u3e1.0 g a.i./kg be accepted as the minimum seed treatment level for formulations under consideration for registration or use in conjunction with emergency (Section 18) exemptions to FIFRA by the Environmental Protection Agency