Photometric scaling relations of antitruncated stellar discs in S0-Scd galaxies

It has been recently found that the characteristic photometric parameters of antitruncated discs in S0 galaxies follow tight scaling relations. We investigate if similar scaling relations are satisfied by galaxies of other morphological types. We have analysed the trends in several photometric planes relating the characteristic surface brightness and scalelengths of the breaks and the inner and outer discs of local antitruncated S0-Scd galaxies, using published data and fits performed to the surface brightness profiles of two samples of Type-III galaxies in the R and Spitzer 3.6 microns bands. We have performed linear fits to the correlations followed by different galaxy types in each plane, as well as several statistical tests to determine their significance. We have found that: 1) the antitruncated discs of all galaxy types from Sa to Scd obey tight scaling relations both in R and 3.6 microns, as observed in S0s; 2) the majority of these correlations are significant accounting for the numbers of the available data samples; 3) the trends are clearly linear when the characteristic scalelengths are plotted on a logarithmic scale; and 4) the correlations relating the characteristic surface brightnesses of the inner and outer discs and the breaks with the various characteristic scalelengths significantly improve when the latter are normalized to the optical radius of the galaxy. The results suggest that the scaling relations of Type-III discs are independent of the morphological type and the presence (or absence) of bars within the observational uncertainties of the available datasets, although larger and deeper samples are required to confirm this. The tight structural coupling implied by these scaling relations impose strong constraints on the mechanisms proposed for explaining the formation of antitruncated stellar discs in the galaxies across the whole Hubble Sequence (Abridged).Comment: Accepted for publication in Astronomy & Astrophysics, 18 pages, 12 figures, 7 table

The Neighbor-Locating-Chromatic Number of Pseudotrees

A $k$-coloring of a graph $G$ is a partition of the set of vertices of $G$ into $k$ independent sets, which are called colors. A $k$-coloring is neighbor-locating if any two vertices belonging to the same color can be distinguished from each other by the colors of their respective neighbors. The neighbor-locating chromatic number $\chi _{_{NL}}(G)$ is the minimum cardinality of a neighbor-locating coloring of $G$. In this paper, we determine the neighbor-locating chromatic number of paths, cycles, fans, and wheels. Moreover, a procedure to construct a neighbor-locating coloring of minimum cardinality for these families of graphs is given. We also obtain tight upper bounds on the order of trees and unicyclic graphs in terms of the neighbor-locating chromatic number. Further partial results for trees are also established.Comment: 18 pages, 8 figure

César Falcón y el grupo teatral Nosotros

In the theatre scene of the 1930s in Spain, in addition to the traditional commercial theatre and the republican avant-garde of Las Misiones Pedagógicas or La Barraca, an alternative proposal emerged whose objectives went beyond the pedagogical and the artistic. Proletarian, or political theatre, linked to European theatrical avant-garde with Soviet roots, was inspired by the principles of Bertolt Brecht and Erwin Piscator. They proposed, from a Marxist perspective, class struggle as means to achieve an alternative socialist model. The theatre company Nosotros, directed by Peruvian exile César Falcón, is the best example of this theatrical avant-garde.En la escena teatral de los años treinta en España, además del tradicional teatro comercial y la vanguardia republicana de Las Misiones Pedagógicas o La Barraca, surgió una propuesta alternativa cuyos objetivos fueron más allá de lo pedagógico y lo artístico. El teatro proletario, o político, heredero de la vanguardia teatral europea de raíz soviética, se inspiró en los principios de Bertold Brecht y Edwin Piscator que proponían, desde una óptica marxista, la lucha de clases que permitiese alcanzar un modelo alternativo socialista. La compañía teatral Nosotros, dirigida por el exiliado peruano César Falcón, es el mejor ejemplo de esta vanguardia teatral

Association Between APOL1 Genotypes and Risk of Cardiovascular Disease in MESA (Multi-Ethnic Study of Atherosclerosis).

BACKGROUND:APOL1 genetic variants confer an increased risk for kidney disease. Their associations with cardiovascular disease (CVD) are less certain. We aimed to compare the prevalence of subclinical CVD and incidence of atherosclerotic CVD and heart failure by APOL1 genotypes among self-identified black participants of MESA (Multi-Ethnic Study of Atherosclerosis). METHODS AND RESULTS:Cross-sectional associations of APOL1 genotypes (high-risk=2 alleles; low-risk=0 or 1 allele) with coronary artery calcification, carotid-intimal media thickness, and left ventricular mass were evaluated using logistic and linear regression. Longitudinal associations of APOL1 genotypes with incident myocardial infarction, stroke, coronary heart disease, and congestive heart failure were examined using Cox regression. We adjusted for African ancestry, age, and sex. We also evaluated whether hypertension or kidney function markers explained the observed associations. Among 1746 participants with APOL1 genotyping (mean age 62 years, 55% women, mean cystatin C-based estimated glomerular filtration rate 89 mL/min per 1.73 m2, 12% with albuminuria), 12% had the high-risk genotypes. We found no difference in prevalence or severity of coronary artery calcification, carotid-intimal media thickness, or left ventricular mass by APOL1 genotypes. The APOL1 high-risk group was 82% more likely to develop incident heart failure compared with the low-risk group (95% confidence interval, 1.01-3.28). Adjusting for hypertension (hazard ratio, 1.80; 95% confidence interval, 1.00-3.24) but not markers of kidney function (hazard ratio, 1.86; 95% confidence interval, 1.03-3.35) slightly attenuated this association. The APOL1 high-risk genotypes were not significantly associated with other clinical CVD outcomes. CONCLUSIONS:Among blacks without baseline CVD, the APOL1 high-risk variants may be associated with increased risk for incident heart failure but not subclinical CVD or incident clinical atherosclerotic CVD

Detection of transposons modifying genome background in probiotics

The study of probiotic microorganisms is very interesting in the aquaculture field. Administration of live microorganisms in adequate amounts confers some benefits to the host (Kechagia et al. 2013). Even if Shewanella putrafaciens include pathogens and saprophytic strains related to fish spoilage and fish infection (Esteve, Merchán, and Alcaide 2016). The Pdp11 strain of Shewanella putrefaciens has been proved to provide beneficial effects in Sparus aurata (Chabrillón et al. 2005) and Solea senegalensis (Rodrigáñez et al. 2008). Studies focused on Pdp11 could hed light on the origin of this probiotic character. We have designed a bioinformatic workflow to detect transposons in the newly sequenced Pdp11 genome (Tapia-Paniagua et al, in press). Their presence interrupting genes account for a contribution to its probiotic character due to the lost of virulence or the gain of probiotic effect. The workflow was developed in Ruby programming language and provides: the genomic localisation of known transposons, host coding regions disrupted by complete transposons or their repeated insertion sequences, and transposons and coding regions disrupted identifiers, to stablish the putative functions of Pdp11 that could be affect by the transposons disruption. These results would support new possible hypothesis about the Pdp11 probiotic character since 14 coding regions related to S. putrefaciens were disrupted by transposons, 4 of which are directly involved in pathogenic mechanisms. This work was supported by co-funding by the European Union through the European Regional Development Fund (ERDF) 2014-2020 "Programa Operativo de Crecimiento Inteligente" together with Spanish AEI "Agencia Estatal de Investigación" to grants RTA2013-00068-C03, AGL2017-83370-C3-3-R and RTA2017-00054-C03-03.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Teaching practice for subject of graphic expression through project based learning

Comunicación presentada en el XXIII International Conference on Graphic Engineering- Madrid 2013.Project-based learning PBL (Aprendizaje Basado en Proyectos, ABP) is a participatory methodology which foments skills demanded by the company, in addition to being a teaching strategy which helps to achieve competence in the subjects of graphic expression at/in the different degrees of industrial engineering. This article presents the design, development, analysis and evaluation of results obtained in a project of computer-aided design, based on PBL, aimed to students in electrical engineering degree from Polytechnic School of Malaga during the biennium 2008/2010, developed in the educational innovation project, PIE08-056.PIE08-05

Adverse Childhood Experiences and Adult Disease: Examining Mediating Pathways in the Hispanic Community Health Study/Study of Latinos Sociocultural Ancillary Study

OBJECTIVES: Adverse childhood experiences (ACEs) have been linked to adulthood chronic diseases, but there is little research examining the mechanisms underlying this association. We tested pathways from ACEs to adult disease mediated via risk factors of depression, smoking, and body mass index. METHOD: Prospective data from adults 18 to 74 years old from the Hispanic Community Health Study/Study of Latinos and Sociocultural Ancillary Study were used. Retrospectively reported ACEs and hypothesized mediators were measured at Visit 1 (2008-2011). Outcomes of disease prevalence were assessed at Visit 2, approximately 6 years later. The analytic sample includes 5,230 Hispanic/Latino participants with ACE data. Statistical mediation was examined using structural equation modeling on cardiometabolic and pulmonary disease prevalence and reported probit regression coefficients with 95% confidence intervals (CIs). RESULTS: We found a significant association between ACEs and the prevalence of asthma/chronic obstructive pulmonary disorder (standardized β = .07, 95% CI [0.02, 0.12]). In the mediational model, the direct association was nonsignificant (β = .02, 95% CI [-0.04, 0.07]) but was mediated by depressive symptoms (β = .03, 95% CI [0.02, 0.04]). There were no associations between ACEs and the prevalence of diabetes and self-reported coronary heart disease or cerebrovascular disease. However, a small indirect effect was identified via depressive symptoms and coronary heart disease (β = .02, 95% CI [0.01, 0.03]). CONCLUSION: In this diverse Hispanic/Latino sample, depressive symptoms were found to be a pathway linking ACEs to self-reported cardiopulmonary diseases, although the effects were of small magnitude. Future work should replicate pathways, confirm the magnitude of effects, and examine cultural moderators that may dampen expected associations. (PsycInfo Database Record (c) 2024 APA, all rights reserved)

Clickable albumin nanoparticles for pretargeted drug delivery toward PD-L1 overexpressing tumors in combination immunotherapy

We present a simple methodology to design a pretargeted drug delivery system, based on clickable anti-programmed death ligand 1 (anti-PD-L1) antibodies (Abs) and clickable bovine serum albumin (BSA) nanoparticles (NPs). Pretargeted drug delivery is based on the decoupling of a targeting moiety and a drug-delivering vector which can then react in vivo after separate injections. This may be key to achieve active targeting of drug-delivering NPs toward cancerous tissue. In pretargeted approaches, drug-delivering NPs were observed to accumulate in a higher amount in the targeted tissue due to shielding-related enhanced blood circulation and size-related enhanced tissue penetration. In this work, BSA NPs were produced using the solvent precipitation methodology that renders colloidally stable NPs, which were subsequently functionalized with a clickable moiety based on chlorosydnone (Cl-Syd). Those reactive groups are able to specifically react with dibenzocyclooctyne (DBCO) groups in a click-type fashion, reaching second-order reaction rate constants as high as 1.9 M-1·s-1, which makes this reaction highly suitable for in vivo applications. The presence of reactive Cl-Syd was demonstrated by reacting the functionalized NPs with a DBCO-modified sulfo-cyanine-5 dye. With this reaction, it was possible to infer the number of reactive moieties per NPs. Finally, and with the aim of demonstrating the suitability of this system to be used in pretargeted strategies, functionalized fluorescent NPs were used to label H358 cells with a clickable anti-PD-L1 Ab, applying the reaction between Cl-Syd and DBCO as corresponding clickable groups. The results of these experiments demonstrate the bio-orthogonality of the system to perform the reaction in vitro, in a period as short as 15 mi

Infective Endocarditis in Diabetic Patients: A Different Profile with Prognostic Consequences

Background. Infective Endocarditis (IE) is a severe condition. Diabetes mellitus (DM) has been associated with a poor prognosis in other settings. Our aim was to describe the profile and prognosis of IE with and without DM and to analyze the prognostic relevance of DM-related organ damage. Methods. Retrospective analysis of the Spanish IE Registry (2008–2020). Results. The cohort comprises 5590 IE patients with a mean age of 65.0 ± 15.5 years; 3764 (67.3%) were male. DM was found in 1625 patients (29.1%) and 515 presented DM-related organ damage. DM prevalence during the first half of the study period was 27.6% vs. 30.6% in the last half, p = 0.015. Patients with DM presented higher in-hospital mortality than those without DM (521 [32.1%] vs. 924 [23.3%], p < 0.001) and higher one-year mortality (640 [39.4%] vs. 1131 [28.5%], p < 0.001). Among DM patients, organ damage was associated with higher in-hospital (200 [38.8%] vs. 321 [28.9%], p < 0.001) and one-year mortality (247 [48.0%] vs. 393 [35.4%], p < 0.001). Multivariate analyses showed an independent association of DM with in-hospital (odds ratio [OR] = 1.34, 95% confidence interval [CI]: 1.16–1.55, p < 0.001) and one-year mortality (OR = 1.38, 95% CI: 1.21–1.59, p < 0.001). Among DM patients, organ damage was independently associated with higher in-hospital (OR = 1.37, 95% CI: 1.06–1.76, p = 0.015) and one-year mortality (OR = 1.59, 95% CI = 1.26–2.01, p < 0.001) Conclusions. The prevalence of DM among patients with IE is increasing and is already above 30%. DM is independently associated with a poor prognosis, particularly in the case of DM with organ damage