ACTIVATION OF THE HYPOTHALAMIC– PITUITARY–ADRENAL AXIS INDUCES THE DIFFERENTIAL RELEASE OF PRO– INFLAMMATORY CYTOKINES IN BALB/C MICE

Physiological processes are associated with interactions between the nervous, endocrine and immune systems, which communicate through neurotransmitters, hormones and cytokines. The key to this communication is the hypothalamic–pituitary–adrenal (HPA) axis which can be activated by stress and pro–inflammatory cytokines. We have investigated the effects of acute and chronic stress on the release of pro–inflammatory cytokines through activation of the HPA axis. Accordingly, BALB/c mice were exposed to acute stress through the single application of bi–frontal electrical stimulation (ESa, 20V/10 mA/0.05s) and the effect produced by a single i.p. dose of Lipopolysacharide (LPS) (250 μg/100g). Chronic stress was (ESc) induced by applying the electrical stimulus to the animals in the same way for 7 consecutive days, as well as the effects of ascending LPS administration over 7 days (35–250 μg/100g i.p./day). Following stimulation, the levels of pro–inflammatory cytokines and corticosterone were quantified by ELISA. Unlike LPS that provoked an increase in TNF–α, IL–1β, IL–6, and corticosterone levels, acute electrical stress did not induce any change in the levels of pro–inflammatory cytokines or corticosterone. In contrast, chronic ESc stress produced an increase in the levels of TNF–α, while in the animals treated with LPS the IL–6 levels increased. These data suggest that the response of the HPA axis to stress depends on the duration, intensity and etiology of the stress agent, also suggest a suitable model for the evaluation of drugs with potential effect on inflammatory stress

ACTIVATION OF THE HYPOTHALAMIC– PITUITARY–ADRENAL AXIS INDUCES THE DIFFERENTIAL RELEASE OF PRO– INFLAMMATORY CYTOKINES IN BALB/C MICE

Physiological processes are associated with interactions between the nervous, endocrine and immune systems, which communicate through neurotransmitters, hormones and cytokines. The key to this communication is the hypothalamic–pituitary–adrenal (HPA) axis which can be activated by stress and pro–inflammatory cytokines. We have investigated the effects of acute and chronic stress on the release of pro–inflammatory cytokines through activation of the HPA axis. Accordingly, BALB/c mice were exposed to acute stress through the single application of bi–frontal electrical stimulation (ESa, 20V/10 mA/0.05s) and the effect produced by a single i.p. dose of Lipopolysacharide (LPS) (250 μg/100g). Chronic stress was (ESc) induced by applying the electrical stimulus to the animals in the same way for 7 consecutive days, as well as the effects of ascending LPS administration over 7 days (35–250 μg/100g i.p./day). Following stimulation, the levels of pro–inflammatory cytokines and corticosterone were quantified by ELISA. Unlike LPS that provoked an increase in TNF–α, IL–1β, IL–6, and corticosterone levels, acute electrical stress did not induce any change in the levels of pro–inflammatory cytokines or corticosterone. In contrast, chronic ESc stress produced an increase in the levels of TNF–α, while in the animals treated with LPS the IL–6 levels increased. These data suggest that the response of the HPA axis to stress depends on the duration, intensity and etiology of the stress agent, also suggest a suitable model for the evaluation of drugs with potential effect on inflammatory stress

Prevalencia De Sobrepeso U Obesidad En Escolares De Una Población Urbana Del Estado De Jalisco, México

Introduction. Urban populations in Mexico have not escaped the influence of today's world with an increase in sedentary lifestyles and inadequate food consumption patterns. These conditions have exacerbated the emerging and alarming problem of overweight and obesity in the country. Objective. To diagnose the nutritional status and determine the overweight and obesity prevalence in children between ages of 5 to 14 years of an urban community in the state of Jalisco, Mexico. Material and methods. Through a cross-sectional study, 188 students were evaluated. Weight and height were measured and compared with reference standards of the World Health Organization, the values obtained from the measurement of waist circumference percentiles were compared with the percentile charts made by Fernandez et al, 2004. Results. The combined prevalence of overweight and obesity in the total population was 36.7% (n = 69); in males the prevalence was 20.7% (12.2% for overweight and 8.5% for obesity) and in females was 16% (9.6% and 6.4%, respectively). Children from the fifth and sixth grade had a higher prevalence of both overweight and obesity. Conclusions. Our study shows the current nutritional problems manifested in urban areas, which is accentuated on children with higher increase between the 5th and 6th grades

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

The original version of this article unfortunately contained a mistake

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Taller de Proyecto I - SI644 - 202102

Descripción: El curso de especialidad de Taller de Proyecto I, de las carreras de Ciencias de la Computación (CC), Ingeniería de Software (ISW) e Ingeniería de Sistemas de Información (ISI), es de carácter teórico-práctico y está dirigido a los estudiantes del noveno ciclo. Es un curso obligatorio e importante dentro de la formación de los estudiantes pues permite definir el tema, objetivos, alcance y plan de ejecución de su proyecto profesional. El taller se desarrolla bajo la aplicación de trabajos por roles. Propósito: . El curso tiene como propósito que los estudiantes desempeñan una serie de roles para el análisis, diseño, implementación y producción de un sistema de información que permite ejemplificar muy cercano a la realidad, el trabajo profesional que desarrollarán los futuros egresados. Contribuye con el desarrollo de las competencias generales de comunicación oral, pensamiento crítico, razonamiento cuantitativo, pensamiento innovador a nivel de logro 3 y ciudadanía a nivel de logro 2. Así como las competencias específicas (1) Formula y resuelve problemas complejos; (2) Diseño y desarrollo de una solución; (3) Comunicacicón Efectiva; (4) Responsabilidad ética y profesional; (5) Trabajo en equipos multidisciplinarios; (6) Aprendizaje contínuo y autónomo para la carrera de Ciencias de la Computación. Así como las competencias específicas (1) Formula y resuelve problemas complejos; (2) Diseño y desarrollo de una solución; (3) Comunicacicón Efectiva; (4) Responsabilidad ética y profesional; (5) Trabajo en equipos multidisciplinarios; (6) Análisis y emisión de conclusiones; (7) Aprendizaje contínuo y autónomo para las carreras de Ingeniería de Sistemas de Información e Ingeniería de Software

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study (Intensive Care Medicine, (2021), 47, 2, (160-169), 10.1007/s00134-020-06234-9)

The original version of this article unfortunately contained a mistake. The members of the ESICM Trials Group Collaborators were not shown in the article but only in the ESM. The full list of collaborators is shown below. The original article has been corrected