Multiplexer uses insulated gate-field effect transistors

Small lightweight multiplexer incorporates IG-FETs /Insulated Gate-Field Effect Transistors/ for all digital logic functions, including the internally generated 3.6-kHz clock. It consists of 30 primary channels, each of which is sampled 120 times per second

Design procedure for improved active filters

Synthesis technique for active filters gives high degree of accuracy for frequencies as high as 500 kHz and covers frequencies most used for telemetry. Frequency response can be realized within few percent of specified cutoff frequencies without need for tuning

Computerized logic design of digital circuits

Procedure performs all work required for logic design of digital counters or sequential circuits and simplification of Boolean expressions. Program provides simple, accurate, and comprehensive logic design capability to users both experienced and totally inexperienced in logic desig

Pseudo-noise test set for communication system evaluation

A test set for communications systems is described which includes a pseudo noise sequence generator providing a test signal that is fed to a pair of signal channels. The first channel includes a spectrum shaping filter and a conditioning amplifier. The second channel includes a variable delay circuit, a spectrum shaping filter matched to the first filter, and an amplifier. The output of the first channel was applied to the system under test. The output of the system and the output of the second channel are compared to determine the degree of distortion suffered by the test signal due to the communications system

Method of and means for testing a tape record/playback system

A tape record/playback system was tested by first deriving an analog test signal and a band-limited digital reference signal from a pseudo-noise sequence generator driven by a clock signal. It recorded the signals on respective tracks of the system during operation in a record mode. During the playback mode of operation of the system, a delayed analog reference signal without time base variations was reconstructed from the played back reference signal. It was compared with the played back test signal in order to obtain an error signal that was a measure of the performance of the system

Evaluation of jitter in multichannel tape recorders used in shaft motion reproducers

http://www.archive.org/details/evaluationofjitt00gus

Orion: Detecting regions of the human non-coding genome that are intolerant to variation using population genetics

There is broad agreement that genetic mutations occurring outside of the protein-coding regions play a key role in human disease. Despite this consensus, we are not yet capable of discerning which portions of non-coding sequence are important in the context of human disease. Here, we present Orion, an approach that detects regions of the non-coding genome that are depleted of variation, suggesting that the regions are intolerant of mutations and subject to purifying selection in the human lineage. We show that Orion is highly correlated with known intolerant regions as well as regions that harbor putatively pathogenic variation. This approach provides a mechanism to identify pathogenic variation in the human non-coding genome and will have immediate utility in the diagnostic interpretation of patient genomes and in large case control studies using whole-genome sequences

The intolerance to functional genetic variation of protein domains predicts the localization of pathogenic mutations within genes

Ranking human genes based on their tolerance to functional genetic variation can greatly facilitate patient genome interpretation. It is well established, however, that different parts of proteins can have different functions, suggesting that it will ultimately be more informative to focus attention on functionally distinct portions of genes. Here we evaluate the intolerance of genic sub-regions using two biological sub-region classifications. We show that the intolerance scores of these sub-regions significantly correlate with reported pathogenic mutations. This observation extends the utility of intolerance scores to indicating where pathogenic mutations are mostly likely to fall within genes

Critical Dietetics and Sustainable Food Systems

In this chapter, we invite readers to consider a food system that is based on values where individual health, the health of the society (social system) and ecosystem health are of equal importance. With this as a lens, there is a clear need to move beyond the biosciences to consider transdisciplinary approaches as important for nutrition and Dietetic in today and tomorrow’s reality