Storytelling: the emotion a new educational tool

Tras la globalización y la disrupción de las nuevas tecnologías de la información, la sociedad ha cambiado y por consiguiente, el sistema educativo también. Se puede afirmar haber pasado de la era industrial a la era tecnológica y de la información, donde el sistema educativo debe plantearse su metodología para no quedar obsoleto ni anacrónico. El proceso de enseñanza- aprendizaje ha centralizado su desarrollo en el discente, el cual recibe mucha información, incapaz de transformar en conocimiento veraz si no se dispone de las herramientas adecuadas y de la motivación necesaria.The motivation has relevance since it is verified that when emotions are based on their own attributions, they are more predisposed to them. That is why it is necessary to incorporate the storytelling as a new educational tool in teaching, in this case in the Tourist Marketing module of the Higher Cycle in Guide, Information and Tourist Assistance and in the Travel Agencies and Events Management. In short, teaching has changed towards a technological world sans emotions, so it is urgent to incorporate storytelling as a tool for optimizing learning

Safety, reliability and quality of the products, processes and facilities in the food industry

La producción de alimentos es de gran importancia tanto para la economía de un país, como para el bienestar de su población. Con el objetivo de garantizar la seguridad de los consumidores, la industria alimentaria cuenta actualmente con una amplia serie de reglamentos y directrices en los que se consideran los peligros que se pueden encontrar en los alimentos, ya sean de origen químico, biológico o físico. Por otro lado, los integrantes de la cadena de producción de alimentos deben tener en cuenta las preferencias y exigencias de sus posibles consumidores para la elaboración de sus productos, para que estos puedan ser considerados de calidad. Estos factores se encuentran en constante cambio y no se establecen únicamente por la inocuidad del alimento, sino que dependerán de aspectos subjetivos y objetivos que deben de ser estudiados de manera adecuada. Este documento expone los pasos que debe de tomar la industria alimentaria para garantizar la seguridad y calidad tanto de los productos terminados como de las instalaciones y el proceso de producción, tomando en consideración tanto la legislación española vigente como las normas internacionales no obligatorias aplicables a la industria alimentaria y los requerimientos de los consumidores finales.The production of food is of great importance for both, for the economy of a country and the welfare of its population. In order to guarantee the safety of the consumers, the food industry currently counts with a wide variety of regulations and guidelines that take in consideration the chemicals, biological and physical dangers that can be found in the food. On the other hand, the members of the food -chain production must also considered the preferences and demands of their potential consumers for the elaboration of their products, so that these products can be seen as quality products. These factors are constantly changing and are not exclusively stablished by the food safety aspect, but they will also depend on several subjective and objective characteristics that must be studied properly. This document sets out the steps that the food industry must take to guarantee the safety and quality of both the finished products and the facilities and the production process, taking into account the Spanish legislation as well as the non-mandatory international standards applicable to the food industry and the requirements of the final consumer

FtsZ of filamentous, heterocyst-forming cyanobacteria has a conserved N-Terminal peptide required for normal FtsZ polymerization and cell division

Filamentous cyanobacteria grow by intercalary cell division, which should involve distinct steps compared to those producing separate daughter cells. The N-terminal region of FtsZ is highly conserved in the clade of filamentous cyanobacteria capable of cell differentiation. A derivative of the model strain Anabaena sp. PCC 7120 expressing only an FtsZ lacking the amino acids 2-51 of the N-terminal peptide (1N-FtsZ) could not be segregated. Strain CSL110 expresses both 1N-FtsZ, from the endogenous ftsZ gene promoter, and the native FtsZ from a synthetic regulated promoter. Under conditions of 1N-FtsZ predominance, cells of strain CSL110 progressively enlarge, reflecting reduced cell division, and show instances of asymmetric cell division and aberrant Z-structures notably differing from the Z-ring formed by FtsZ in the wild type. In bacterial 2-hybrid assays FtsZ interacted with 1N-FtsZ. However, 1N-FtsZ-GFP appeared impaired for incorporation into Z-rings when expressed together with FtsZ. FtsZ, but not 1N-FtsZ, interacted with the essential protein SepF. Both FtsZ and 1N-FtsZ polymerize in vitro exhibiting comparable GTPase activities. However, filaments of FtsZ show a distinct curling forming toroids, whereas 1N-FtsZ form thick bundles of straight filaments. Thus, the N-terminal FtsZ sequence appears to contribute to a distinct FtsZ polymerization mode that is essential for cell division and division plane location in Anabaena.Agencia Estatal de Investigación BFU2013-44686-P BFU2016-77097-

The effect of experience and clinical supervision on therapeutic success at the University Clinic of the Autonomous University of Madrid

El objetivo de esta investigación es estudiar el efecto de la experiencia y la supervisión clínica sobre el éxito terapéutico. El estudio se desarrolla dentro del programa de formación impartido en la Clínica Universitaria CPA-UAM. El fin último es establecer unos criterios de entrenamiento en la capacitación profesional basados en la evidencia empírica. El programa de formación consta de cuatro años en el que los terapeutas realizan práctica clínica bajo la supervisión de terapeutas con mayor experiencia y pericia. Se estudia cómo influye el año de formación en el que se encuentre el/la terapeuta sobre el éxito terapéutico de su paciente con diferentes variables. Los resultados muestran que no existen diferencias entre los terapeutas en cuanto a su efectividad, todos mantienen una tasa de éxito similar. No obstante, se encuentran diferencias entre la eficiencia, es decir, el tiempo que se necesita para alcanzar el cumplimiento de los objetivosThe aim of this research is to study the effect of experience and clinical supervision on therapeutic success. The study is developed within the training program offered at the University Clinic of Psychology of the Autonomous University of Madrid (CPA-UAM). The final aim is to establish training criteria in professional training based on empirical evidence. At CPAUAM there is a four-year training program in which therapists perform clinical practice under the supervision of more experienced and skilled therapists. We study with multiple variables how the training year of the therapist influences the therapeutic success of his/her patient. Results show that there are no differences between therapists in terms of their effectiveness, they all maintain a similar success rate. However, there are differences between the efficiency, that is, in the time needed to achieve the objective

Effect of Preoperative Infusion of Levosimendan on Biomarkers of Myocardial Injury and Haemodynamics After Paediatric Cardiac Surgery: A Randomised Controlled Trial

Trial registry number: EudraCT 2012-005310-19.Key Points A randomised controlled trial was conducted to test the hypothesis that preoperative infusion of levosimendan would decrease myocardial injury biomarkers (troponin I and B-type natriuretic peptide) after paediatric cardiac surgery more efficiently than placebo. Troponin I and B-type natriuretic peptide levels were higher with placebo at 12 and 24 h after cardiopulmonary bypass, but the differences were not statistically significant. Lactic acid level was significantly lower and oxygen delivery (DO2) was significantly higher at 12 and 24 h after surgery in Levosimendan group. The results highlight the importance of this new drug and its possible benefit with regard to myocardial injury; however, evaluation in larger, adequately powered trials is needed to determine the efficacy of levosimendan.Objective The aim was to test the hypothesis that preoperative infusion of levosimendan would decrease patients’ cardiac biomarker profiles during the immediate postoperative stage (troponin I and B-type natriuretic peptide levels) more efficiently than placebo after cardiopulmonary bypass. Methods In a randomised, placebo-controlled, double-blinded study, 30 paediatric patients were scheduled for congenital heart disease surgery. 15 patients (50%) received prophylactic levosimendan and 15 patients (50%) received placebo from 12 h before cardiopulmonary bypass to 24 h after surgery. Results Troponin I levels were higher in the placebo group at 0, 12, and 24 h after cardiopulmonary bypass, although the mean differences between the study groups and the 95% confidence intervals (CIs) for troponin I levels did not present statistically significant differences at any of the three time points considered (mean differences [95% CIs] − 3.32 pg/ml [− 19.34 to 12.70], − 2.42 pg/ml [− 19.78 to 13.95], and − 79.94 pg/ml [− 266.99 to 16.39] at 0, 12, and 24 h, respectively). A similar lack of statistically significant difference was observed for B-type natriuretic peptide (mean differences [95% CIs] 36.86 pg/dl [− 134.16 to 225.64], − 350.79 pg/dl [− 1459.67 to 557.45], and − 310.35 pg/dl [− 1505.76 to 509.82]). Lactic acid levels were significantly lower with levosimendan; the mean differences between the study groups and the 95% CIs for lactate levels present statistically significant differences at 0 h (− 1.52 mmol/l [− 3.19 to − 0.25]) and 12 h (− 1.20 mmol/l [− 2.53 to − 0.10]) after cardiopulmonary bypass. Oxygen delivery (DO2) was significantly higher at 12 h and 24 h after surgery (mean difference [95% CI] 627.70 ml/min/m2 [122.34–1162.67] and 832.35 ml/min/m2 [58.15 to 1651.38], respectively). Conclusions Levosimendan does not significantly improve patients’ postoperative troponin I and B-type natriuretic peptide profiles during the immediate postoperative stage in comparison with placebo, although both were numerically higher with placebo. Levosimendan, however, significantly reduced lactic acid levels and improved patients’ DO2 profiles. These results highlight the importance of this new drug and its possible benefit with regard to myocardial injury; however, evaluation in larger, adequately powered trials is needed to determine the efficacy of levosimendan

Implementar un servicio de publicidad inteligente en puntos de venta en la sub categoría ferreterías apoyados con software de inteligencia artificial

El siguiente trabajo tiene la finalidad de desarrollar un plan de negocios para la constitución de un negocio que brinda servicios de publicidad inteligente. Esta empresa utilizará las capacidades que brinda la inteligencia artificial (IA) explotando mecanismos innovadores como son el reconocimiento facial y el machine learning. La publicidad tradicional, a lo largo de los años, ha venido explotando canales como son la televisión, radio, medios impresos y fueron cambiando a formatos de paneles publicitarios, con anuncios estáticos y en videos; dicho ecosistema no ha evolucionado y se ha generado una gran competencia para obtener un mayor market share dentro del mismo. Por ello se hace necesario analizar el uso de canales diferentes para el lanzamiento de campañas publicitarias. Para romper esas barreras se propone un mecanismo de publicidad inteligente no existente en el mercado local. De otro lado, la pandemia hizo que los hábitos de los consumidores aceleren el uso de plataformas digitales, cuyo uso hubiera tomado más años. Pasados casi dos años de este ciclo, en el cual se han levantado muchas restricciones de tránsito de las personas, es importante aprovechar este cambio de hábitos para ofrecer mecanismos de engagement con los clientes, que ofrece el mundo digital. Pero se presentan interrogantes: ¿Cómo me diferencio del resto? ¿Qué canal usar? ¿Cómo logro ser más asertivo en mis campañas publicitarias? Estas preguntas se responden analizando un canal que vaya de la mano con el cambio de hábitos de los consumidores, y estos son los puntos de venta, que es un canal que ha crecido en los últimos años. Los formatos son variados, desde home centers, tiendas por conveniencia, autoservicios, ferreterías, entre otros. Analizando el número de puntos de venta existentes, las cadenas de ferreterías tienen un alcance mucho mayor que todo el resto, por ello se ha elegido este canal para el despliegue de la plataforma. Lo expuesto muestra las condiciones óptimas para que aparezca TINKUY, un servicio de publicidad inteligente que llevará las marcas de los anunciantes a un público objetivo analizado mediante mecanismos de inteligencia artificial, empezando a operar en establecimientos dentro de la ciudad de Lima. Se ha conseguido elaborar un plan de negocios que logra obtener una rentabilidad de 33% de TIR Económico y de 41% como TIR Financiero, según lo expuesto en el plan financiero, llegando a ser un proyecto atractivo en la industria que se ha elegido empezar. La tendencia del uso de inteligencia artificial, la innovación y la reactivación económica contribuyen a la creación de esta nueva compañía que pertenece a este tipo de negocios denominado TINKUY.Escuela de Postgrad

Early dysfunction of functional connectivity in healthy elderly with subjective memory complaints

It is still an open question whether subjective memory complaints (SMC) can actually be considered to be clinically relevant predictors for the development of an objective memory impairment and even dementia. There is growing evidence that suggests that SMC are associated with an increased risk of dementia and with the presence of biological correlates of early Alzheimer's disease. In this paper, in order to shed some light on this issue, we try to discern whether subjects with SMC showed a different profile of functional connectivity compared with subjects with mild cognitive impairment (MCI) and healthy elderly subjects. In the present study, we compare the degree of synchronization of brain signals recorded with magnetoencephalography between three groups of subjects (56 in total): 19 with MCI, 12 with SMC and 25 healthy controls during a memory task. Synchronization likelihood, an index based on the theory of nonlinear dynamical systems, was used to measure functional connectivity. Briefly, results show that subjects with SMC have a very similar pattern of connectivity to control group, but on average, they present a lower synchronization value. These results could indicate that SMC are representing an initial stage with a hypo-synchronization (in comparison with the control group) where the brain system is still not compensating for the failing memory networks, but behaving as controls when compared with the MCI subjects

Super-resolution imaging of live sperm reveals dynamic changes of the actin cytoskeleton during acrosomal exocytosis

Filamentous actin (F-actin) is a key factor in exocytosis in many cell types. In mammalian sperm, acrosomal exocytosis (denoted the acrosome reaction or AR), a special type of controlled secretion, is regulated by multiple signaling pathways and the actin cytoskeleton. However, the dynamic changes of the actin cytoskeleton in live sperm are largely not understood. Here, we used the powerful properties of SiR-actin to examine actin dynamics in live mouse sperm at the onset of the AR. By using a combination of super-resolution microscopy techniques to image sperm loaded with SiR-actin or sperm from transgenic mice containing Lifeact-EGFP, six regions containing F-actin within the sperm head were revealed. The proportion of sperm possessing these structures changed upon capacitation. By performing live-cell imaging experiments, we report that dynamic changes of F-actin during the AR occur in specific regions of the sperm head. While certain F-actin regions undergo depolymerization prior to the initiation of the AR, others remain unaltered or are lost after exocytosis occurs. Our work emphasizes the utility of live-cell nanoscopy, which will undoubtedly impact the search for mechanisms that underlie basic sperm functions.Fil: Romarowski, Ana. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Velasco Félix, Ángel G.. Universidad Nacional Autónoma de México; MéxicoFil: Rodriguez, Paulina Torres. Universidad Nacional Autónoma de México; MéxicoFil: Gervasi, Mar?á G.. University Of Massachusetts Amherst;Fil: Xu, Xinran. School Of Biomedical Engineering;Fil: Luque, Guillermina Maria. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Contreras-Jiménez, Gastón. Universidad Nacional Autónoma de México; MéxicoFil: Sánchez-Cárdenas, Claudia. Universidad Nacional Autónoma de México; MéxicoFil: Ramírez-Gómez, Héctor V.. Universidad Nacional Autónoma de México; MéxicoFil: Krapf, Diego. School Of Biomedical Engineering;Fil: Visconti, Pablo E.. University Of Massachusetts Amherst;Fil: Krapf, Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; ArgentinaFil: Guerrero, Adán. Universidad Nacional Autónoma de México; MéxicoFil: Darszon, Alberto. Universidad Nacional Autónoma de México; MéxicoFil: Buffone, Mariano Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin

Metodologías colaborativas a través de las tecnologías: hacia una evaluación equitativa.

Presentación de buenas prácticas metodológicas en el área de tecnología educativa, transferidas por el Grupo de investigación consolidado GTEA, Universidad de Málaga (SEJ-462

Usos sostenibles de la tierra y desarrollo humano

Compilación de los trabajos presentados al simposio nº 2 del Congreso Internacional sobre tierra y Derechos Humanos (Universidad de Sevilla, 12-14 de junio de 2019