9 research outputs found
Association between convalescent plasma treatment and mortality in COVID-19: a collaborative systematic review and meta-analysis of randomized clinical trials.
- Author
- Aalborg University Hospital
- Abayomi Akin
- Abduljalil Manal
- Abdulrahman Abdulkarim
- Acosta-Ampudia Yeny
- Aguilar-Guisado Manuela
- Al-Beidh Farah
- Alejandria Marissa M.
- Alfonso Rachelle N.
- Ali Mohammad
- AlQahtani Manaf
- AlZamrooni Alaa
- Anaya Juan-Manuel
- Ang Mark Angelo C.
- Aomar Ismael F.
- Argumanis Luis E.
- Averyanov Alexander
- Axfors Cathrine
- Baklaushev Vladimir P.
- Balionis Olga
- Benfield Thomas
- Berry Scott
- Birocco Nadia
- Bonifacio Lynn B.
- Bowen Asha C.
- Bown Abbie
- Cabello-Gutierrez Carlos
- Camacho Bernardo
- Camacho-Ortiz Adrian
- Campbell-Lee Sally
- Cao Damon H.
- Cardesa Ana
- Carnate Jose M.
- Castillo German Jr. J.
- Cavallo Rossana
- Chowdhury Fazle R.
- Chowdhury Forhad U. H.
- Ciccone Giovannino
- Cingolani Antonella
- Climacosa Fresthel Monica M.
- Compernolle Veerle
- Cortez Carlo Francisco N.
- Costa Neto Abel
- D?Antico Sergio
- D?az Ponce-Medrano Juan A.
- D?az-Coronado Juan C.
- Daly James
- Danielle Franca
- Davis Joshua S.
- De Rosa Francesco Giuseppe
- Denholm Justin T.
- Denkinger Claudia M.
- Department of Clinical Medicine
- Department of Infectious Diseases
- Desmecht Daniel
- Donneau Anne-Fran?oise
- Dumagay Teresita E.
- Dunachie Susanna
- Dungog Cecile C.
- Erinoso Olufemi
- Escasa Ivy Mae S.
- Estcourt Lise J.
- Evans Amy
- Evasan Agnes L. M.
- Fareli Christian J.
- Fernandez-Sanchez Veronica
- G?mez-Almaguer David
- Galassi Claudia
- Gallo Juan E.
- Garcia Jesus A.
- Garcia Patricia J.
- Garcia Patricia L.
- Garigliany Mutien
- Garza-Gonzalez Elvira
- Gauiran Deonne Thaddeus V.
- Gaviria Garc?a Paula A.
- Giron-Gonzalez Jose-Antonio
- Goodman Steven N.
- Gordon Anthony C.
- Gothot Andr?
- Grass Guaqueta Jeser Santiago
- Green Cameron
- Grimaldi David
- Haber Noah A.
- Hammond Naomi E.
- Harvala Heli
- Hemkens Lars G.
- Heralde Francisco M.
- Herrick Jesica
- Higgins Alisa M.
- Hills Thomas E.
- Hines Jennifer
- Holm Karin
- Hoque Ashraful
- Hospital Universitario de Jerez de la Frontera
- Hoste Eric
- Ignacio Jose M.
- Ioannidis John P. A.
- Ivanov Alexander V.
- Janiaud Perrine
- Janssen Maike
- Jennings Jeffrey H.
- Jha Vivekanand
- Khanna Nina
- King Ruby Anne N.
- Kjeldsen-Kragh Jens
- Klenerman Paul
- Klinik Medicin og Akut
- Kotecha Aditya
- Krapp Fiorella
- L?pez-C?rdenas Salvador
- L?pez-Robles Concepci?n
- Labanca Luciana
- Laing Emma
- Landin-Olsson Mona
- Laterre Pierre-Fran?ois
- Lim Jodor
- Lim Lyn-Li
- Ljungquist Oskar
- Llaca-D?az Jorge M.
- Lopez-Plaza Ileana
- Lucero Josephine Anne C.
- Lundgren Maria
- M?ller-Tidow Carsten
- Mac?as Juan
- Maganito Sandy C.
- Malundo Anna Flor G.
- Manrique Rub?n D.
- Manzini Paola M.
- Marcos Miguel
- Marquez Ignacio
- Mart?nez-Marcos Francisco Javier
- Mata Ana M.
- McArthur Colin J.
- McQuilten Zoe K.
- McVerry Bryan J.
- Menon David K.
- Meyfroidt Geert
- Mirasol Ma. Angelina L.
- Misset Beno?t
- Moher David
- Molton James S.
- Mondragon Alric V.
- Monsalve Diana M.
- Moradi Choghakabodi Parastoo
- Morpeth Susan C.
- Mouncey Paul R.
- Moutschen Michel
- Murphy Erin
- Najdovski Tome
- Nichol Alistair D.
- Nielsen Henrik
- Novak Richard M.
- O?Sullivan Matthew V. N.
- Olalla Julian
- Osibogun Akin
- Osikomaiya Bodunrin
- Oyonarte Salvador
- P?rez-Alba Eduardo
- Pardo-Oviedo Juan M.
- Patel Mahesh C.
- Paterson David L.
- Pe?a-Perez Carlos A.
- Perez-Calatayud Angel A.
- Perkina Anastasia
- Perry Naomi
- Pouladzadeh Mandana
- Poyato Inmaculada
- Price David J.
- Quero Anne Kristine H.
- Rahman Md. M.
- Rahman Md. S.
- Ram?rez-Santana Carolina
- Ramesh Mayur
- Rasmussen Magnus
- Rees Megan A.
- Rego Eduardo
- Roberts David J.
- Roberts Jason A.
- Rodr?guez Yhojan
- Rodr?guez-Ba?o Jes?s
- Rogers Benjamin A.
- Rojas Manuel
- Romero Alberto
- Rowan Kathryn M.
- Saccona Fabio
- Safdarian Mehdi
- Santos Maria Clariza M.
- Sasadeusz Joe
- Schmitt Andreas M.
- Scozzari Gitana
- Shankar-Hari Manu
- Sharma Gorav
- Smith Emily R.
- Snelling Thomas
- Soto Alonso
- Tagayuna Pedrito Y.
- Tang Amy
- Tatem Geneva
- Teofili Luciana
- The Faculty of Medicine
- Tong Steven Y. C.
- Turgeon Alexis F.
- van?t Hooft Janneke
- Veloso Januario D.
- Venkatesh Balasubramanian
- Ventura-Enriquez Yanet
- Webb Steve A.
- Wiese Lothar
- Wik?n Christian
- Wood Erica M.
- Yusubalieva Gaukhar M.
- Zacharowski Kai
- Zarychanski Ryan
- Publication venue
- BMC Infect Dis
- Publication date
- 01/01/2021
- Field of study
Funder: laura and john arnold foundationBACKGROUND: Convalescent plasma has been widely used to treat COVID-19 and is under investigation in numerous randomized clinical trials, but results are publicly available only for a small number of trials. The objective of this study was to assess the benefits of convalescent plasma treatment compared to placebo or no treatment and all-cause mortality in patients with COVID-19, using data from all available randomized clinical trials, including unpublished and ongoing trials (Open Science Framework, https://doi.org/10.17605/OSF.IO/GEHFX ). METHODS: In this collaborative systematic review and meta-analysis, clinical trial registries (ClinicalTrials.gov, WHO International Clinical Trials Registry Platform), the Cochrane COVID-19 register, the LOVE database, and PubMed were searched until April 8, 2021. Investigators of trials registered by March 1, 2021, without published results were contacted via email. Eligible were ongoing, discontinued and completed randomized clinical trials that compared convalescent plasma with placebo or no treatment in COVID-19 patients, regardless of setting or treatment schedule. Aggregated mortality data were extracted from publications or provided by investigators of unpublished trials and combined using the Hartung-Knapp-Sidik-Jonkman random effects model. We investigated the contribution of unpublished trials to the overall evidence. RESULTS: A total of 16,477 patients were included in 33 trials (20 unpublished with 3190 patients, 13 published with 13,287 patients). 32 trials enrolled only hospitalized patients (including 3 with only intensive care unit patients). Risk of bias was low for 29/33 trials. Of 8495 patients who received convalescent plasma, 1997 died (23%), and of 7982 control patients, 1952 died (24%). The combined risk ratio for all-cause mortality was 0.97 (95% confidence interval: 0.92; 1.02) with between-study heterogeneity not beyond chance (I2â=â0%). The RECOVERY trial had 69.8% and the unpublished evidence 25.3% of the weight in the meta-analysis. CONCLUSIONS: Convalescent plasma treatment of patients with COVID-19 did not reduce all-cause mortality. These results provide strong evidence that convalescent plasma treatment for patients with COVID-19 should not be used outside of randomized trials. Evidence synthesis from collaborations among trial investigators can inform both evidence generation and evidence application in patient care
Additional file 2 of Association between convalescent plasma treatment and mortality in COVID-19: a collaborative systematic review and meta-analysis of randomized clinical trials
- Author
- Aalborg University Hospital
- Abayomi Akin
- Abduljalil Manal
- Abdulrahman Abdulkarim
- Acosta-Ampudia Yeny
- Aguilar-Guisado Manuela
- Al-Beidh Farah
- Alejandria Marissa M.
- Alfonso Rachelle N.
- Ali Mohammad
- AlQahtani Manaf
- AlZamrooni Alaa
- Anaya Juan-Manuel
- Ang Mark Angelo C.
- Aomar Ismael F.
- Argumanis Luis E.
- Averyanov Alexander
- Axfors Cathrine
- Baklaushev Vladimir P.
- Balionis Olga
- Benfield Thomas
- Berry Scott
- Birocco Nadia
- Bonifacio Lynn B.
- Bowen Asha C.
- Bown Abbie
- Cabello-Gutierrez Carlos
- Camacho Bernardo
- Camacho-Ortiz Adrian
- Campbell-Lee Sally
- Cao Damon H.
- Cardesa Ana
- Carnate Jose M.
- Castillo German Jr. J.
- Cavallo Rossana
- Chowdhury Fazle R.
- Chowdhury Forhad U. H.
- Ciccone Giovannino
- Cingolani Antonella
- Climacosa Fresthel Monica M.
- Compernolle Veerle
- Cortez Carlo Francisco N.
- Costa Neto Abel
- D?Antico Sergio
- D?az Ponce-Medrano Juan A.
- D?az-Coronado Juan C.
- Daly James
- Danielle Franca
- Davis Joshua S.
- De Rosa Francesco Giuseppe
- Denholm Justin T.
- Denkinger Claudia M.
- Department of Clinical Medicine
- Department of Infectious Diseases
- Desmecht Daniel
- Donneau Anne-Fran?oise
- Dumagay Teresita E.
- Dunachie Susanna
- Dungog Cecile C.
- Erinoso Olufemi
- Escasa Ivy Mae S.
- Estcourt Lise J.
- Evans Amy
- Evasan Agnes L. M.
- Fareli Christian J.
- Fernandez-Sanchez Veronica
- G?mez-Almaguer David
- Galassi Claudia
- Gallo Juan E.
- Garcia Jesus A.
- Garcia Patricia J.
- Garcia Patricia L.
- Garigliany Mutien
- Garza-Gonzalez Elvira
- Gauiran Deonne Thaddeus V.
- Gaviria Garc?a Paula A.
- Giron-Gonzalez Jose-Antonio
- Goodman Steven N.
- Gordon Anthony C.
- Gothot Andr?
- Grass Guaqueta Jeser Santiago
- Green Cameron
- Grimaldi David
- Haber Noah A.
- Hammond Naomi E.
- Harvala Heli
- Hemkens Lars G.
- Heralde Francisco M.
- Herrick Jesica
- Higgins Alisa M.
- Hills Thomas E.
- Hines Jennifer
- Holm Karin
- Hoque Ashraful
- Hospital Universitario de Jerez de la Frontera
- Hoste Eric
- Ignacio Jose M.
- Ioannidis John P. A.
- Ivanov Alexander V.
- Janiaud Perrine
- Janssen Maike
- Jennings Jeffrey H.
- Jha Vivekanand
- Khanna Nina
- King Ruby Anne N.
- Kjeldsen-Kragh Jens
- Klenerman Paul
- Klinik Medicin og Akut
- Kotecha Aditya
- Krapp Fiorella
- L?pez-C?rdenas Salvador
- L?pez-Robles Concepci?n
- Labanca Luciana
- Laing Emma
- Landin-Olsson Mona
- Laterre Pierre-Fran?ois
- Lim Jodor
- Lim Lyn-Li
- Ljungquist Oskar
- Llaca-D?az Jorge M.
- Lopez-Plaza Ileana
- Lucero Josephine Anne C.
- Lundgren Maria
- M?ller-Tidow Carsten
- Mac?as Juan
- Maganito Sandy C.
- Malundo Anna Flor G.
- Manrique Rub?n D.
- Manzini Paola M.
- Marcos Miguel
- Marquez Ignacio
- Mart?nez-Marcos Francisco Javier
- Mata Ana M.
- McArthur Colin J.
- McQuilten Zoe K.
- McVerry Bryan J.
- Menon David K.
- Meyfroidt Geert
- Mirasol Ma. Angelina L.
- Misset Beno?t
- Moher David
- Molton James S.
- Mondragon Alric V.
- Monsalve Diana M.
- Moradi Choghakabodi Parastoo
- Morpeth Susan C.
- Mouncey Paul R.
- Moutschen Michel
- Murphy Erin
- Najdovski Tome
- Nichol Alistair D.
- Nielsen Henrik
- Novak Richard M.
- O?Sullivan Matthew V. N.
- Olalla Julian
- Osibogun Akin
- Osikomaiya Bodunrin
- Oyonarte Salvador
- P?rez-Alba Eduardo
- Pardo-Oviedo Juan M.
- Patel Mahesh C.
- Paterson David L.
- Pe?a-Perez Carlos A.
- Perez-Calatayud Angel A.
- Perkina Anastasia
- Perry Naomi
- Pouladzadeh Mandana
- Poyato Inmaculada
- Price David J.
- Quero Anne Kristine H.
- Rahman Md. M.
- Rahman Md. S.
- Ram?rez-Santana Carolina
- Ramesh Mayur
- Rasmussen Magnus
- Rees Megan A.
- Rego Eduardo
- Roberts David J.
- Roberts Jason A.
- Rodr?guez Yhojan
- Rodr?guez-Ba?o Jes?s
- Rogers Benjamin A.
- Rojas Manuel
- Romero Alberto
- Rowan Kathryn M.
- Saccona Fabio
- Safdarian Mehdi
- Santos Maria Clariza M.
- Sasadeusz Joe
- Schmitt Andreas M.
- Scozzari Gitana
- Shankar-Hari Manu
- Sharma Gorav
- Smith Emily R.
- Snelling Thomas
- Soto Alonso
- Tagayuna Pedrito Y.
- Tang Amy
- Tatem Geneva
- Teofili Luciana
- The Faculty of Medicine
- Tong Steven Y. C.
- Turgeon Alexis F.
- van?t Hooft Janneke
- Veloso Januario D.
- Venkatesh Balasubramanian
- Ventura-Enriquez Yanet
- Webb Steve A.
- Wiese Lothar
- Wik?n Christian
- Wood Erica M.
- Yusubalieva Gaukhar M.
- Zacharowski Kai
- Zarychanski Ryan
- Publication venue
- Figshare
- Publication date
- 01/01/2021
- Field of study
Additional file 2. Email invitation
Additional file 7 of Association between convalescent plasma treatment and mortality in COVID-19: a collaborative systematic review and meta-analysis of randomized clinical trials
- Author
- Aalborg University Hospital
- Abayomi Akin
- Abduljalil Manal
- Abdulrahman Abdulkarim
- Acosta-Ampudia Yeny
- Aguilar-Guisado Manuela
- Al-Beidh Farah
- Alejandria Marissa M.
- Alfonso Rachelle N.
- Ali Mohammad
- AlQahtani Manaf
- AlZamrooni Alaa
- Anaya Juan-Manuel
- Ang Mark Angelo C.
- Aomar Ismael F.
- Argumanis Luis E.
- Averyanov Alexander
- Axfors Cathrine
- Baklaushev Vladimir P.
- Balionis Olga
- Benfield Thomas
- Berry Scott
- Birocco Nadia
- Bonifacio Lynn B.
- Bowen Asha C.
- Bown Abbie
- Cabello-Gutierrez Carlos
- Camacho Bernardo
- Camacho-Ortiz Adrian
- Campbell-Lee Sally
- Cao Damon H.
- Cardesa Ana
- Carnate Jose M.
- Castillo German Jr. J.
- Cavallo Rossana
- Chowdhury Fazle R.
- Chowdhury Forhad U. H.
- Ciccone Giovannino
- Cingolani Antonella
- Climacosa Fresthel Monica M.
- Compernolle Veerle
- Cortez Carlo Francisco N.
- Costa Neto Abel
- D?Antico Sergio
- D?az Ponce-Medrano Juan A.
- D?az-Coronado Juan C.
- Daly James
- Danielle Franca
- Davis Joshua S.
- De Rosa Francesco Giuseppe
- Denholm Justin T.
- Denkinger Claudia M.
- Department of Clinical Medicine
- Department of Infectious Diseases
- Desmecht Daniel
- Donneau Anne-Fran?oise
- Dumagay Teresita E.
- Dunachie Susanna
- Dungog Cecile C.
- Erinoso Olufemi
- Escasa Ivy Mae S.
- Estcourt Lise J.
- Evans Amy
- Evasan Agnes L. M.
- Fareli Christian J.
- Fernandez-Sanchez Veronica
- G?mez-Almaguer David
- Galassi Claudia
- Gallo Juan E.
- Garcia Jesus A.
- Garcia Patricia J.
- Garcia Patricia L.
- Garigliany Mutien
- Garza-Gonzalez Elvira
- Gauiran Deonne Thaddeus V.
- Gaviria Garc?a Paula A.
- Giron-Gonzalez Jose-Antonio
- Goodman Steven N.
- Gordon Anthony C.
- Gothot Andr?
- Grass Guaqueta Jeser Santiago
- Green Cameron
- Grimaldi David
- Haber Noah A.
- Hammond Naomi E.
- Harvala Heli
- Hemkens Lars G.
- Heralde Francisco M.
- Herrick Jesica
- Higgins Alisa M.
- Hills Thomas E.
- Hines Jennifer
- Holm Karin
- Hoque Ashraful
- Hospital Universitario de Jerez de la Frontera
- Hoste Eric
- Ignacio Jose M.
- Ioannidis John P. A.
- Ivanov Alexander V.
- Janiaud Perrine
- Janssen Maike
- Jennings Jeffrey H.
- Jha Vivekanand
- Khanna Nina
- King Ruby Anne N.
- Kjeldsen-Kragh Jens
- Klenerman Paul
- Klinik Medicin og Akut
- Kotecha Aditya
- Krapp Fiorella
- L?pez-C?rdenas Salvador
- L?pez-Robles Concepci?n
- Labanca Luciana
- Laing Emma
- Landin-Olsson Mona
- Laterre Pierre-Fran?ois
- Lim Jodor
- Lim Lyn-Li
- Ljungquist Oskar
- Llaca-D?az Jorge M.
- Lopez-Plaza Ileana
- Lucero Josephine Anne C.
- Lundgren Maria
- M?ller-Tidow Carsten
- Mac?as Juan
- Maganito Sandy C.
- Malundo Anna Flor G.
- Manrique Rub?n D.
- Manzini Paola M.
- Marcos Miguel
- Marquez Ignacio
- Mart?nez-Marcos Francisco Javier
- Mata Ana M.
- McArthur Colin J.
- McQuilten Zoe K.
- McVerry Bryan J.
- Menon David K.
- Meyfroidt Geert
- Mirasol Ma. Angelina L.
- Misset Beno?t
- Moher David
- Molton James S.
- Mondragon Alric V.
- Monsalve Diana M.
- Moradi Choghakabodi Parastoo
- Morpeth Susan C.
- Mouncey Paul R.
- Moutschen Michel
- Murphy Erin
- Najdovski Tome
- Nichol Alistair D.
- Nielsen Henrik
- Novak Richard M.
- O?Sullivan Matthew V. N.
- Olalla Julian
- Osibogun Akin
- Osikomaiya Bodunrin
- Oyonarte Salvador
- P?rez-Alba Eduardo
- Pardo-Oviedo Juan M.
- Patel Mahesh C.
- Paterson David L.
- Pe?a-Perez Carlos A.
- Perez-Calatayud Angel A.
- Perkina Anastasia
- Perry Naomi
- Pouladzadeh Mandana
- Poyato Inmaculada
- Price David J.
- Quero Anne Kristine H.
- Rahman Md. M.
- Rahman Md. S.
- Ram?rez-Santana Carolina
- Ramesh Mayur
- Rasmussen Magnus
- Rees Megan A.
- Rego Eduardo
- Roberts David J.
- Roberts Jason A.
- Rodr?guez Yhojan
- Rodr?guez-Ba?o Jes?s
- Rogers Benjamin A.
- Rojas Manuel
- Romero Alberto
- Rowan Kathryn M.
- Saccona Fabio
- Safdarian Mehdi
- Santos Maria Clariza M.
- Sasadeusz Joe
- Schmitt Andreas M.
- Scozzari Gitana
- Shankar-Hari Manu
- Sharma Gorav
- Smith Emily R.
- Snelling Thomas
- Soto Alonso
- Tagayuna Pedrito Y.
- Tang Amy
- Tatem Geneva
- Teofili Luciana
- The Faculty of Medicine
- Tong Steven Y. C.
- Turgeon Alexis F.
- van?t Hooft Janneke
- Veloso Januario D.
- Venkatesh Balasubramanian
- Ventura-Enriquez Yanet
- Webb Steve A.
- Wiese Lothar
- Wik?n Christian
- Wood Erica M.
- Yusubalieva Gaukhar M.
- Zacharowski Kai
- Zarychanski Ryan
- Publication venue
- Figshare
- Publication date
- 01/01/2021
- Field of study
Additional file 7. Sensitivity analyses: various meta-analytic approaches
Additional file 1 of Association between convalescent plasma treatment and mortality in COVID-19: a collaborative systematic review and meta-analysis of randomized clinical trials
- Author
- Aalborg University Hospital
- Abayomi Akin
- Abduljalil Manal
- Abdulrahman Abdulkarim
- Acosta-Ampudia Yeny
- Aguilar-Guisado Manuela
- Al-Beidh Farah
- Alejandria Marissa M.
- Alfonso Rachelle N.
- Ali Mohammad
- AlQahtani Manaf
- AlZamrooni Alaa
- Anaya Juan-Manuel
- Ang Mark Angelo C.
- Aomar Ismael F.
- Argumanis Luis E.
- Averyanov Alexander
- Axfors Cathrine
- Baklaushev Vladimir P.
- Balionis Olga
- Benfield Thomas
- Berry Scott
- Birocco Nadia
- Bonifacio Lynn B.
- Bowen Asha C.
- Bown Abbie
- Cabello-Gutierrez Carlos
- Camacho Bernardo
- Camacho-Ortiz Adrian
- Campbell-Lee Sally
- Cao Damon H.
- Cardesa Ana
- Carnate Jose M.
- Castillo German Jr. J.
- Cavallo Rossana
- Chowdhury Fazle R.
- Chowdhury Forhad U. H.
- Ciccone Giovannino
- Cingolani Antonella
- Climacosa Fresthel Monica M.
- Compernolle Veerle
- Cortez Carlo Francisco N.
- Costa Neto Abel
- D?Antico Sergio
- D?az Ponce-Medrano Juan A.
- D?az-Coronado Juan C.
- Daly James
- Danielle Franca
- Davis Joshua S.
- De Rosa Francesco Giuseppe
- Denholm Justin T.
- Denkinger Claudia M.
- Department of Clinical Medicine
- Department of Infectious Diseases
- Desmecht Daniel
- Donneau Anne-Fran?oise
- Dumagay Teresita E.
- Dunachie Susanna
- Dungog Cecile C.
- Erinoso Olufemi
- Escasa Ivy Mae S.
- Estcourt Lise J.
- Evans Amy
- Evasan Agnes L. M.
- Fareli Christian J.
- Fernandez-Sanchez Veronica
- G?mez-Almaguer David
- Galassi Claudia
- Gallo Juan E.
- Garcia Jesus A.
- Garcia Patricia J.
- Garcia Patricia L.
- Garigliany Mutien
- Garza-Gonzalez Elvira
- Gauiran Deonne Thaddeus V.
- Gaviria Garc?a Paula A.
- Giron-Gonzalez Jose-Antonio
- Goodman Steven N.
- Gordon Anthony C.
- Gothot Andr?
- Grass Guaqueta Jeser Santiago
- Green Cameron
- Grimaldi David
- Haber Noah A.
- Hammond Naomi E.
- Harvala Heli
- Hemkens Lars G.
- Heralde Francisco M.
- Herrick Jesica
- Higgins Alisa M.
- Hills Thomas E.
- Hines Jennifer
- Holm Karin
- Hoque Ashraful
- Hospital Universitario de Jerez de la Frontera
- Hoste Eric
- Ignacio Jose M.
- Ioannidis John P. A.
- Ivanov Alexander V.
- Janiaud Perrine
- Janssen Maike
- Jennings Jeffrey H.
- Jha Vivekanand
- Khanna Nina
- King Ruby Anne N.
- Kjeldsen-Kragh Jens
- Klenerman Paul
- Klinik Medicin og Akut
- Kotecha Aditya
- Krapp Fiorella
- L?pez-C?rdenas Salvador
- L?pez-Robles Concepci?n
- Labanca Luciana
- Laing Emma
- Landin-Olsson Mona
- Laterre Pierre-Fran?ois
- Lim Jodor
- Lim Lyn-Li
- Ljungquist Oskar
- Llaca-D?az Jorge M.
- Lopez-Plaza Ileana
- Lucero Josephine Anne C.
- Lundgren Maria
- M?ller-Tidow Carsten
- Mac?as Juan
- Maganito Sandy C.
- Malundo Anna Flor G.
- Manrique Rub?n D.
- Manzini Paola M.
- Marcos Miguel
- Marquez Ignacio
- Mart?nez-Marcos Francisco Javier
- Mata Ana M.
- McArthur Colin J.
- McQuilten Zoe K.
- McVerry Bryan J.
- Menon David K.
- Meyfroidt Geert
- Mirasol Ma. Angelina L.
- Misset Beno?t
- Moher David
- Molton James S.
- Mondragon Alric V.
- Monsalve Diana M.
- Moradi Choghakabodi Parastoo
- Morpeth Susan C.
- Mouncey Paul R.
- Moutschen Michel
- Murphy Erin
- Najdovski Tome
- Nichol Alistair D.
- Nielsen Henrik
- Novak Richard M.
- O?Sullivan Matthew V. N.
- Olalla Julian
- Osibogun Akin
- Osikomaiya Bodunrin
- Oyonarte Salvador
- P?rez-Alba Eduardo
- Pardo-Oviedo Juan M.
- Patel Mahesh C.
- Paterson David L.
- Pe?a-Perez Carlos A.
- Perez-Calatayud Angel A.
- Perkina Anastasia
- Perry Naomi
- Pouladzadeh Mandana
- Poyato Inmaculada
- Price David J.
- Quero Anne Kristine H.
- Rahman Md. M.
- Rahman Md. S.
- Ram?rez-Santana Carolina
- Ramesh Mayur
- Rasmussen Magnus
- Rees Megan A.
- Rego Eduardo
- Roberts David J.
- Roberts Jason A.
- Rodr?guez Yhojan
- Rodr?guez-Ba?o Jes?s
- Rogers Benjamin A.
- Rojas Manuel
- Romero Alberto
- Rowan Kathryn M.
- Saccona Fabio
- Safdarian Mehdi
- Santos Maria Clariza M.
- Sasadeusz Joe
- Schmitt Andreas M.
- Scozzari Gitana
- Shankar-Hari Manu
- Sharma Gorav
- Smith Emily R.
- Snelling Thomas
- Soto Alonso
- Tagayuna Pedrito Y.
- Tang Amy
- Tatem Geneva
- Teofili Luciana
- The Faculty of Medicine
- Tong Steven Y. C.
- Turgeon Alexis F.
- van?t Hooft Janneke
- Veloso Januario D.
- Venkatesh Balasubramanian
- Ventura-Enriquez Yanet
- Webb Steve A.
- Wiese Lothar
- Wik?n Christian
- Wood Erica M.
- Yusubalieva Gaukhar M.
- Zacharowski Kai
- Zarychanski Ryan
- Publication venue
- Figshare
- Publication date
- 01/01/2021
- Field of study
Additional file 1. Search strategy
Additional file 5 of Association between convalescent plasma treatment and mortality in COVID-19: a collaborative systematic review and meta-analysis of randomized clinical trials
- Author
- Aalborg University Hospital
- Abayomi Akin
- Abduljalil Manal
- Abdulrahman Abdulkarim
- Acosta-Ampudia Yeny
- Aguilar-Guisado Manuela
- Al-Beidh Farah
- Alejandria Marissa M.
- Alfonso Rachelle N.
- Ali Mohammad
- AlQahtani Manaf
- AlZamrooni Alaa
- Anaya Juan-Manuel
- Ang Mark Angelo C.
- Aomar Ismael F.
- Argumanis Luis E.
- Averyanov Alexander
- Axfors Cathrine
- Baklaushev Vladimir P.
- Balionis Olga
- Benfield Thomas
- Berry Scott
- Birocco Nadia
- Bonifacio Lynn B.
- Bowen Asha C.
- Bown Abbie
- Cabello-Gutierrez Carlos
- Camacho Bernardo
- Camacho-Ortiz Adrian
- Campbell-Lee Sally
- Cao Damon H.
- Cardesa Ana
- Carnate Jose M.
- Castillo German Jr. J.
- Cavallo Rossana
- Chowdhury Fazle R.
- Chowdhury Forhad U. H.
- Ciccone Giovannino
- Cingolani Antonella
- Climacosa Fresthel Monica M.
- Compernolle Veerle
- Cortez Carlo Francisco N.
- Costa Neto Abel
- D?Antico Sergio
- D?az Ponce-Medrano Juan A.
- D?az-Coronado Juan C.
- Daly James
- Danielle Franca
- Davis Joshua S.
- De Rosa Francesco Giuseppe
- Denholm Justin T.
- Denkinger Claudia M.
- Department of Clinical Medicine
- Department of Infectious Diseases
- Desmecht Daniel
- Donneau Anne-Fran?oise
- Dumagay Teresita E.
- Dunachie Susanna
- Dungog Cecile C.
- Erinoso Olufemi
- Escasa Ivy Mae S.
- Estcourt Lise J.
- Evans Amy
- Evasan Agnes L. M.
- Fareli Christian J.
- Fernandez-Sanchez Veronica
- G?mez-Almaguer David
- Galassi Claudia
- Gallo Juan E.
- Garcia Jesus A.
- Garcia Patricia J.
- Garcia Patricia L.
- Garigliany Mutien
- Garza-Gonzalez Elvira
- Gauiran Deonne Thaddeus V.
- Gaviria Garc?a Paula A.
- Giron-Gonzalez Jose-Antonio
- Goodman Steven N.
- Gordon Anthony C.
- Gothot Andr?
- Grass Guaqueta Jeser Santiago
- Green Cameron
- Grimaldi David
- Haber Noah A.
- Hammond Naomi E.
- Harvala Heli
- Hemkens Lars G.
- Heralde Francisco M.
- Herrick Jesica
- Higgins Alisa M.
- Hills Thomas E.
- Hines Jennifer
- Holm Karin
- Hoque Ashraful
- Hospital Universitario de Jerez de la Frontera
- Hoste Eric
- Ignacio Jose M.
- Ioannidis John P. A.
- Ivanov Alexander V.
- Janiaud Perrine
- Janssen Maike
- Jennings Jeffrey H.
- Jha Vivekanand
- Khanna Nina
- King Ruby Anne N.
- Kjeldsen-Kragh Jens
- Klenerman Paul
- Klinik Medicin og Akut
- Kotecha Aditya
- Krapp Fiorella
- L?pez-C?rdenas Salvador
- L?pez-Robles Concepci?n
- Labanca Luciana
- Laing Emma
- Landin-Olsson Mona
- Laterre Pierre-Fran?ois
- Lim Jodor
- Lim Lyn-Li
- Ljungquist Oskar
- Llaca-D?az Jorge M.
- Lopez-Plaza Ileana
- Lucero Josephine Anne C.
- Lundgren Maria
- M?ller-Tidow Carsten
- Mac?as Juan
- Maganito Sandy C.
- Malundo Anna Flor G.
- Manrique Rub?n D.
- Manzini Paola M.
- Marcos Miguel
- Marquez Ignacio
- Mart?nez-Marcos Francisco Javier
- Mata Ana M.
- McArthur Colin J.
- McQuilten Zoe K.
- McVerry Bryan J.
- Menon David K.
- Meyfroidt Geert
- Mirasol Ma. Angelina L.
- Misset Beno?t
- Moher David
- Molton James S.
- Mondragon Alric V.
- Monsalve Diana M.
- Moradi Choghakabodi Parastoo
- Morpeth Susan C.
- Mouncey Paul R.
- Moutschen Michel
- Murphy Erin
- Najdovski Tome
- Nichol Alistair D.
- Nielsen Henrik
- Novak Richard M.
- O?Sullivan Matthew V. N.
- Olalla Julian
- Osibogun Akin
- Osikomaiya Bodunrin
- Oyonarte Salvador
- P?rez-Alba Eduardo
- Pardo-Oviedo Juan M.
- Patel Mahesh C.
- Paterson David L.
- Pe?a-Perez Carlos A.
- Perez-Calatayud Angel A.
- Perkina Anastasia
- Perry Naomi
- Pouladzadeh Mandana
- Poyato Inmaculada
- Price David J.
- Quero Anne Kristine H.
- Rahman Md. M.
- Rahman Md. S.
- Ram?rez-Santana Carolina
- Ramesh Mayur
- Rasmussen Magnus
- Rees Megan A.
- Rego Eduardo
- Roberts David J.
- Roberts Jason A.
- Rodr?guez Yhojan
- Rodr?guez-Ba?o Jes?s
- Rogers Benjamin A.
- Rojas Manuel
- Romero Alberto
- Rowan Kathryn M.
- Saccona Fabio
- Safdarian Mehdi
- Santos Maria Clariza M.
- Sasadeusz Joe
- Schmitt Andreas M.
- Scozzari Gitana
- Shankar-Hari Manu
- Sharma Gorav
- Smith Emily R.
- Snelling Thomas
- Soto Alonso
- Tagayuna Pedrito Y.
- Tang Amy
- Tatem Geneva
- Teofili Luciana
- The Faculty of Medicine
- Tong Steven Y. C.
- Turgeon Alexis F.
- van?t Hooft Janneke
- Veloso Januario D.
- Venkatesh Balasubramanian
- Ventura-Enriquez Yanet
- Webb Steve A.
- Wiese Lothar
- Wik?n Christian
- Wood Erica M.
- Yusubalieva Gaukhar M.
- Zacharowski Kai
- Zarychanski Ryan
- Publication venue
- Figshare
- Publication date
- 01/01/2021
- Field of study
Additional file 5. Risk of bias
Association between convalescent plasma treatment and mortality in COVID-19: a collaborative systematic review and meta-analysis of randomized clinical trials
- Author
- Aalborg University
- Aalborg University Hospital
- Abayomi Akin
- Abduljalil Manal
- Abdulrahman Abdulkarim
- Acosta-Ampudia Yeny
- Aguilar-Guisado Manuela
- Ahvaz Jundishapur University of Medical Sciences
- Al-Beidh Farah
- Alejandria Marissa M.
- Alfonso Rachelle N.
- Ali Mohammad
- AlQahtani Manaf
- AlZamrooni Alaa
- Anaya Juan-Manuel
- Ang Mark Angelo C.
- Aomar Ismael F.
- Argumanis Luis E.
- Auckland City Hospital
- Auckland District Health Board
- Australian Red Cross Lifeblood
- Averyanov Alexander
- Axfors Cathrine
- Azienda Ospedaliera - Universitaria CittĂ della Salute e della Scienza di Torino
- Bahrain Defence Force Royal Medical Services
- Baklaushev Vladimir P.
- Balionis Olga
- Bangabandhu Sheikh Mujib Medical University
- Belgian Red Cross
- Benfield Thomas
- Berlin Institute of Health
- Berry Consultants
- Berry Scott
- Birocco Nadia
- Blood Bank Centro Medico Naval
- Blood Services Red Cross
- Bonifacio Lynn B.
- Bowen Asha C.
- Bown Abbie
- Box Hill Hospital
- Cabello-Gutierrez Carlos
- Camacho Bernardo
- Camacho-Ortiz Adrian
- Cambridge University Hospitals NHS Foundation Trust
- Campbell-Lee Sally
- Cao Damon H.
- Cardesa Ana
- Carnate Jose M.
- Castillo German Jr. J.
- Cavallo Rossana
- CENETEC (National Center for Health Technology Excellence)
- Centro Medico Naval
- Charles Darwin University
- Chowdhury Fazle R.
- Chowdhury Forhad U. H.
- CHU de NĂźmes
- Ciccone Giovannino
- Cingolani Antonella
- Climacosa Fresthel Monica M.
- Clinica del Occidente
- Clinica Quiron
- Clinical Department Red Andaluza de Dise?o y Traslacion de Terapias Avanzadas
- Compernolle Veerle
- Complejo Hospitalario TorrecĂĄrdenas
- Cortez Carlo Francisco N.
- Costa Neto Abel
- Daly James
- Danielle Franca
- Davis Joshua S.
- De Rosa Francesco Giuseppe
- Denholm Justin T.
- Denkinger Claudia M.
- Department of Clinical Medicine
- Department of Haematology Centro Transfusional Tejidos y Celulas de Granada
- Department of Haematology Monash Health
- Department of Infectious Diseases
- Department of Infectious Diseases Centro Transfusional Tejidos y Celulas de Sevilla
- Desmecht Daniel
- Dhaka Medical College and Hospital
- Donneau Anne-Françoise
- Dumagay Teresita E.
- Dunachie Susanna
- Dungog Cecile C.
- DĂaz Ponce-Medrano Juan A.
- DĂaz-Coronado Juan C.
- DâAntico Sergio
- Erinoso Olufemi
- Escasa Ivy Mae S.
- Estcourt Lise J.
- Evans Amy
- Evasan Agnes L. M.
- Fareli Christian J.
- Federal Medical-Biological Agency
- Fernandez-Sanchez Veronica
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
- Galassi Claudia
- Gallo Juan E.
- Garcia Jesus A.
- Garcia Patricia J.
- Garcia Patricia L.
- Garigliany Mutien
- Garza-Gonzalez Elvira
- Gauiran Deonne Thaddeus V.
- Gaviria GarcĂa Paula A.
- George Washington University
- Ghent University
- Giron-Gonzalez Jose-Antonio
- Goethe University Frankfurt
- Goodman Steven N.
- Gordon Anthony C.
- Gothot André
- Grass Guaqueta Jeser Santiago
- Green Cameron
- Grimaldi David
- GĂłmez-Almaguer David
- Haber Noah A.
- Hammond Naomi E.
- Harvala Heli
- Heidelberg UniversityÂ
- Hemkens Lars G.
- Henry Ford Health System
- Heralde Francisco M.
- Herrick Jesica
- Higgins Alisa M.
- Hills Thomas E.
- Hines Jennifer
- Holm Karin
- Hoque Ashraful
- Hospital Costa Del Sol
- Hospital General de Mexico
- Hospital Nacional Hipolito Unanue
- Hospital Regional Universitario Carlos Haya
- Hospital San Juan de Dios del Aljarafe
- Hospital Universitario de Jerez de La Frontera
- Hospital Universitario de Valme
- Hospital Universitario Juan Ramon Jimenez
- Hospital Universitario Mayor MĂ©deri
- Hospital Universitario San Cecilio
- Hospital Universitario Virgen de las Nieves
- Hospital Universitario Virgen del Rocio
- Hospital Universitario Virgen Macarena
- Hoste Eric
- Ignacio Jose M.
- Imperial College Healthcare NHS Trust
- Imperial College London
- Institute of Clinical Pathology and Medical Research
- Instituto D'or de Pesquisa e Ensino
- Instituto Distrital de Ciencia Biotecnolog?a e Investigaci?n en Salud (IDCBIS)
- Instituto Nacional de Enfermedades Respiratorias
- Intensive Care Medicine Alfred Health
- Intensive Care National Audit and Research Centre
- Ioannidis John P. A.
- Ivanov Alexander V.
- Janiaud Perrine
- Janssen Maike
- Jennings Jeffrey H.
- Jha Vivekanand
- Khanna Nina
- King's College London
- King Ruby Anne N.
- Kjeldsen-Kragh Jens
- Klenerman Paul
- Klinik Medicin og Akut
- Kotecha Aditya
- Krapp Fiorella
- KU Leuven
- Labanca Luciana
- Lagos State Ministry of Health
- Lagos State University
- Laing Emma
- Landin-Olsson Mona
- Laterre Pierre-François
- Lim Jodor
- Lim Lyn-Li
- Ljungquist Oskar
- Llaca-DĂaz Jorge M.
- Lopez-Plaza Ileana
- Lucero Josephine Anne C.
- Lund University
- Lundgren Maria
- LĂłpez-CĂĄrdenas Salvador
- LĂłpez-Robles ConcepciĂłn
- MacĂas Juan
- Maganito Sandy C.
- Malundo Anna Flor G.
- Manipal Academy of Higher Education
- Manrique Rubén D.
- Manzini Paola M.
- Marcos Miguel
- Marquez Ignacio
- MartĂnez-Marcos Francisco Javier
- Mata Ana M.
- McArthur Colin J.
- McQuilten Zoe K.
- McVerry Bryan J.
- Medical Research Institute of New Zealand
- Medical Team National Task Force for Combating the Coronavirus (COVID19)
- Menon David K.
- Meyfroidt Geert
- Middlemore Hospital
- Ministerio de Salud del PerĂș
- Ministry of Health Kingdom of Bahrain
- Mirasol Ma. Angelina L.
- Misset BenoĂźt
- Mohammed Bin Khalifa Cardiac Centre
- Moher David
- Molton James S.
- Monash University
- Mondragon Alric V.
- Monsalve Diana M.
- Moradi Choghakabodi Parastoo
- Morpeth Susan C.
- Mouncey Paul R.
- Moutschen Michel
- Murphy Erin
- MĂŒller-Tidow Carsten
- Najdovski Tome
- NHS Blood and Transplant
- Nichol Alistair D.
- Nielsen Henrik
- Novak Richard M.
- Olalla Julian
- Osibogun Akin
- Osikomaiya Bodunrin
- Oxford University Hospitals NHS Foundation Trust
- Oyonarte Salvador
- OâSullivan Matthew V. N.
- Pardo-Oviedo Juan M.
- Patel Mahesh C.
- Paterson David L.
- Perez-Calatayud Angel A.
- Perkina Anastasia
- Perry Naomi
- Perth Children?s Hospital
- Peña-Perez Carlos A.
- Philippine General Hospital
- Pouladzadeh Mandana
- Poyato Inmaculada
- Price David J.
- Public Health England
- PĂ©rez-Alba Eduardo
- Quero Anne Kristine H.
- Rahman Md. M.
- Rahman Md. S.
- Ramesh Mayur
- RamĂrez-Santana Carolina
- Rasmussen Magnus
- Rees Megan A.
- Rego Eduardo
- Roberts David J.
- Roberts Jason A.
- RodrĂguez Yhojan
- RodrĂguez-Baño JesĂșs
- Rogers Benjamin A.
- Rojas Manuel
- Romero Alberto
- Rowan Kathryn M.
- Royal Brisbane & Women's Hospital
- Royal College of Surgeons in Ireland-Medical University in Bahrain
- Royal Melbourne Hospital
- Russian Academy of Sciences
- Saccona Fabio
- Safdarian Mehdi
- Santos Maria Clariza M.
- Sasadeusz Joe
- Schmitt Andreas M.
- Scozzari Gitana
- Servicio de Hemoterapia y Banco de Sangre Instituto Nacional de Salud del Niño San Borja
- Shankar-Hari Manu
- Sharma Gorav
- Sheikh Hasina National Institute of Burn and Plastic Surgery
- SjĂŠllands Universitetshospital
- Smith Emily R.
- Snelling Thomas
- Soto Alonso
- St John of God Health Care
- Stanford University
- Sydney Children?s Hospital Network
- Tagayuna Pedrito Y.
- Tang Amy
- Tatem Geneva
- Telethon Kids Institute
- Teofili Luciana
- The Faculty of Medicine
- The George Institute for Global Health
- The Peter Doherty Institute for Infection and Immunity
- Tong Steven Y. C.
- Turgeon Alexis F.
- Universidad Autonoma de Nuevo Leon
- Universidad CES
- Universidad del Rosario
- Universidad Nacional AutĂłnoma de MĂ©xico
- Universidad Peruana Cayetano Heredia
- Universidad Ricardo Palma
- University and Regional Laboratories
- University College Dublin
- University Hospital Basel
- University of Amsterdam
- University of Basel
- University of Copenhagen
- University of CĂĄdiz
- University of Illinois at Chicago
- University of Lagos
- University of Liege
- University of Manitoba
- University of Melbourne
- University of New South Wales
- University of Ottawa
- University of Oxford
- University of Pittsburgh
- University of Queensland
- University of Seville
- University of Sydney
- University of the Philippines
- University of Western Australia
- Université catholique de Louvain
- Université Laval
- Université libre de Bruxelles
- Uppsala University
- vanât Hooft Janneke
- Veloso Januario D.
- Venkatesh Balasubramanian
- Ventura-Enriquez Yanet
- Victorian Infectious Diseases Reference Laboratory
- Webb Steve A.
- Western Health
- Westmead Hospital
- Wiese Lothar
- Wikén Christian
- Wood Erica M.
- Yusubalieva Gaukhar M.
- Zacharowski Kai
- Zarychanski Ryan
- Publication venue
- Figshare
- Publication date
- 01/01/2021
- Field of study
Abstract Background Convalescent plasma has been widely used to treat COVID-19 and is under investigation in numerous randomized clinical trials, but results are publicly available only for a small number of trials. The objective of this study was to assess the benefits of convalescent plasma treatment compared to placebo or no treatment and all-cause mortality in patients with COVID-19, using data from all available randomized clinical trials, including unpublished and ongoing trials (Open Science Framework, https://doi.org/10.17605/OSF.IO/GEHFX ). Methods In this collaborative systematic review and meta-analysis, clinical trial registries (ClinicalTrials.gov, WHO International Clinical Trials Registry Platform), the Cochrane COVID-19 register, the LOVE database, and PubMed were searched until April 8, 2021. Investigators of trials registered by March 1, 2021, without published results were contacted via email. Eligible were ongoing, discontinued and completed randomized clinical trials that compared convalescent plasma with placebo or no treatment in COVID-19 patients, regardless of setting or treatment schedule. Aggregated mortality data were extracted from publications or provided by investigators of unpublished trials and combined using the HartungâKnappâSidikâJonkman random effects model. We investigated the contribution of unpublished trials to the overall evidence. Results A total of 16,477 patients were included in 33 trials (20 unpublished with 3190 patients, 13 published with 13,287 patients). 32 trials enrolled only hospitalized patients (including 3 with only intensive care unit patients). Risk of bias was low for 29/33 trials. Of 8495 patients who received convalescent plasma, 1997 died (23%), and of 7982 control patients, 1952 died (24%). The combined risk ratio for all-cause mortality was 0.97 (95% confidence interval: 0.92; 1.02) with between-study heterogeneity not beyond chance (I2 = 0%). The RECOVERY trial had 69.8% and the unpublished evidence 25.3% of the weight in the meta-analysis. Conclusions Convalescent plasma treatment of patients with COVID-19 did not reduce all-cause mortality. These results provide strong evidence that convalescent plasma treatment for patients with COVID-19 should not be used outside of randomized trials. Evidence synthesis from collaborations among trial investigators can inform both evidence generation and evidence application in patient care
Association between convalescent plasma treatment and mortality in COVID-19: a collaborative systematic review and meta-analysis of randomized clinical trials
- Author
- Aalborg University
- Aalborg University Hospital
- Abayomi Akin
- Abduljalil Manal
- Abdulrahman Abdulkarim
- Acosta-Ampudia Yeny
- Aguilar-Guisado Manuela
- Ahvaz Jundishapur University of Medical Sciences
- Al-Beidh Farah
- Alejandria Marissa M.
- Alfonso Rachelle N.
- Ali Mohammad
- AlQahtani Manaf
- AlZamrooni Alaa
- Anaya Juan-Manuel
- Ang Mark Angelo C.
- Aomar Ismael F.
- Argumanis Luis E.
- Auckland City Hospital
- Australian Red Cross Lifeblood
- Averyanov Alexander
- Axfors Cathrine
- Azienda Ospedaliera - Universitaria CittĂ della Salute e della Scienza di Torino
- Bahrain Defence Force Royal Medical Services
- Baklaushev Vladimir P.
- Balionis Olga
- Bangabandhu Sheikh Mujib Medical University
- Belgian Red Cross
- Benfield Thomas
- Berlin Institute of Health
- Berry Consultants
- Berry Scott
- Birocco Nadia
- Blood Bank Centro Medico Naval
- Blood Services Red Cross
- Bonifacio Lynn B.
- Bowen Asha C.
- Bown Abbie
- Box Hill Hospital
- Cabello-Gutierrez Carlos
- Camacho Bernardo
- Camacho-Ortiz Adrian
- Campbell-Lee Sally
- Cao Damon H.
- Cardesa Ana
- Carnate Jose M.
- Castillo German Jr. J.
- Cavallo Rossana
- CENETEC (National Center for Health Technology Excellence)
- Centro Medico Naval
- Charles Darwin University
- Chowdhury Fazle R.
- Chowdhury Forhad U. H.
- CHU de NĂźmes
- Ciccone Giovannino
- Cingolani Antonella
- Climacosa Fresthel Monica M.
- Clinica del Occidente
- Clinica Quiron
- Clinical Department Red Andaluza de Dise?o y Traslacion de Terapias Avanzadas
- Compernolle Veerle
- Complejo Hospitalario TorrecĂĄrdenas
- Cortez Carlo Francisco N.
- Costa Neto Abel
- Daly James
- Danielle Franca
- Davis Joshua S.
- De Rosa Francesco Giuseppe
- Denholm Justin T.
- Denkinger Claudia M.
- Department of Clinical Medicine
- Department of Haematology Centro Transfusional Tejidos y Celulas de Granada
- Department of Haematology Monash Health
- Department of Infectious Diseases
- Department of Infectious Diseases Centro Transfusional Tejidos y Celulas de Sevilla
- Desmecht Daniel
- Dhaka Medical College and Hospital
- Donneau Anne-Françoise
- Dumagay Teresita E.
- Dunachie Susanna
- Dungog Cecile C.
- DĂaz Ponce-Medrano Juan A.
- DĂaz-Coronado Juan C.
- DâAntico Sergio
- Erinoso Olufemi
- Escasa Ivy Mae S.
- Estcourt Lise J.
- Evans Amy
- Evasan Agnes L. M.
- Fareli Christian J.
- Federal Medical-Biological Agency
- Fernandez-Sanchez Veronica
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
- Galassi Claudia
- Gallo Juan E.
- Garcia Jesus A.
- Garcia Patricia J.
- Garcia Patricia L.
- Garigliany Mutien
- Garza-Gonzalez Elvira
- Gauiran Deonne Thaddeus V.
- Gaviria GarcĂa Paula A.
- George Washington University
- Ghent University
- Giron-Gonzalez Jose-Antonio
- Goethe University Frankfurt
- Goodman Steven N.
- Gordon Anthony C.
- Gothot André
- Grass Guaqueta Jeser Santiago
- Green Cameron
- Grimaldi David
- GĂłmez-Almaguer David
- Haber Noah A.
- Hammond Naomi E.
- Harvala Heli
- Heidelberg UniversityÂ
- Hemkens Lars G.
- Henry Ford Health System
- Heralde Francisco M.
- Herrick Jesica
- Higgins Alisa M.
- Hills Thomas E.
- Hines Jennifer
- Holm Karin
- Hoque Ashraful
- Hospital Costa Del Sol
- Hospital General de Mexico
- Hospital Nacional Hipolito Unanue
- Hospital Regional Universitario Carlos Haya
- Hospital San Juan de Dios del Aljarafe
- Hospital Universitario de Jerez de La Frontera
- Hospital Universitario de Puerto Real
- Hospital Universitario de Valme
- Hospital Universitario Juan Ramon Jimenez
- Hospital Universitario Mayor MĂ©deri
- Hospital Universitario Puerta del Mar
- Hospital Universitario San Cecilio
- Hospital Universitario Virgen de las Nieves
- Hospital Universitario Virgen del Rocio
- Hospital Universitario Virgen Macarena
- Hoste Eric
- Ignacio Jose M.
- Imperial College Healthcare NHS Trust
- Imperial College London
- Institute of Clinical Pathology and Medical Research
- Instituto D'or de Pesquisa e Ensino
- Instituto Distrital de Ciencia Biotecnolog?a e Investigaci?n en Salud (IDCBIS)
- Instituto Nacional de Enfermedades Respiratorias
- Intensive Care Medicine Alfred Health
- Intensive Care National Audit and Research Centre
- Ioannidis John P. A.
- Ivanov Alexander V.
- Janiaud Perrine
- Janssen Maike
- Jennings Jeffrey H.
- Jha Vivekanand
- Khanna Nina
- King's College London
- King Ruby Anne N.
- Kjeldsen-Kragh Jens
- Klenerman Paul
- Klinik Medicin og Akut
- Kotecha Aditya
- Krapp Fiorella
- KU Leuven
- Labanca Luciana
- Lagos State Ministry of Health
- Lagos State University
- Laing Emma
- Landin-Olsson Mona
- Laterre Pierre-François
- Lim Jodor
- Lim Lyn-Li
- Ljungquist Oskar
- Llaca-DĂaz Jorge M.
- Lopez-Plaza Ileana
- Lucero Josephine Anne C.
- Lund University
- Lundgren Maria
- LĂłpez-CĂĄrdenas Salvador
- LĂłpez-Robles ConcepciĂłn
- MacĂas Juan
- Maganito Sandy C.
- Malundo Anna Flor G.
- Manipal Academy of Higher Education
- Manrique Rubén D.
- Manzini Paola M.
- Marcos Miguel
- Marquez Ignacio
- MartĂnez-Marcos Francisco Javier
- Mata Ana M.
- McArthur Colin J.
- McQuilten Zoe K.
- McVerry Bryan J.
- Medical Research Institute of New Zealand
- Medical Team National Task Force for Combating the Coronavirus (COVID19)
- Menon David K.
- Meyfroidt Geert
- Middlemore Hospital
- Ministerio de Salud del PerĂș
- Ministry of Health Kingdom of Bahrain
- Mirasol Ma. Angelina L.
- Misset BenoĂźt
- Mohammed Bin Khalifa Cardiac Centre
- Moher David
- Molton James S.
- Monash University
- Mondragon Alric V.
- Monsalve Diana M.
- Moradi Choghakabodi Parastoo
- Morpeth Susan C.
- Mouncey Paul R.
- Moutschen Michel
- Murphy Erin
- MĂŒller-Tidow Carsten
- Najdovski Tome
- NHS Blood and Transplant
- Nichol Alistair D.
- Nielsen Henrik
- Novak Richard M.
- Olalla Julian
- Osibogun Akin
- Osikomaiya Bodunrin
- Oxford University Hospitals NHS Foundation Trust
- Oyonarte Salvador
- OâSullivan Matthew V. N.
- Pardo-Oviedo Juan M.
- Patel Mahesh C.
- Paterson David L.
- Perez-Calatayud Angel A.
- Perkina Anastasia
- Perry Naomi
- Perth Children?s Hospital
- Peña-Perez Carlos A.
- Philippine General Hospital
- Pouladzadeh Mandana
- Poyato Inmaculada
- Price David J.
- Public Health England
- PĂ©rez-Alba Eduardo
- Quero Anne Kristine H.
- Rahman Md. M.
- Rahman Md. S.
- Ramesh Mayur
- RamĂrez-Santana Carolina
- RAS - Engelhardt Institute of Molecular Biology
- Rasmussen Magnus
- Rees Megan A.
- Rego Eduardo
- Roberts David J.
- Roberts Jason A.
- RodrĂguez Yhojan
- RodrĂguez-Baño JesĂșs
- Rogers Benjamin A.
- Rojas Manuel
- Romero Alberto
- Rowan Kathryn M.
- Royal Brisbane and Women's Hospital
- Royal College of Surgeons in Ireland-Medical University in Bahrain
- Royal Melbourne Hospital
- Saccona Fabio
- Safdarian Mehdi
- Santos Maria Clariza M.
- Sasadeusz Joe
- Schmitt Andreas M.
- Scozzari Gitana
- Servicio de Hemoterapia y Banco de Sangre Instituto Nacional de Salud del Niño San Borja
- Shankar-Hari Manu
- Sharma Gorav
- Sheikh Hasina National Institute of Burn and Plastic Surgery
- SjĂŠllands Universitetshospital
- Smith Emily R.
- Snelling Thomas
- Soto Alonso
- St John of God Health Care
- St. Thomas' Hospital
- Stanford University
- Tagayuna Pedrito Y.
- Tang Amy
- Tatem Geneva
- Telethon Kids Institute
- Teofili Luciana
- The Children's Hospital at Westmead
- The Faculty of Medicine
- The George Institute for Global Health
- The Peter Doherty Institute for Infection and Immunity
- Tong Steven Y. C.
- Turgeon Alexis F.
- Universidad Autonoma de Nuevo Leon
- Universidad CES
- Universidad del Rosario
- Universidad Nacional AutĂłnoma de MĂ©xico
- Universidad Peruana Cayetano Heredia
- Universidad Ricardo Palma
- University and Regional Laboratories
- University College Dublin
- University Hospital Basel
- University of Amsterdam
- University of Basel
- University of Cambridge
- University of Copenhagen
- University of Illinois at Chicago
- University of Lagos
- University of Liege
- University of Manitoba
- University of Melbourne
- University of New South Wales
- University of Ottawa
- University of Oxford
- University of Pittsburgh
- University of Queensland
- University of Seville
- University of Sydney
- University of the Philippines
- University of Western Australia
- Université catholique de Louvain
- Université Laval
- Université libre de Bruxelles
- Uppsala University
- vanât Hooft Janneke
- Veloso Januario D.
- Venkatesh Balasubramanian
- Ventura-Enriquez Yanet
- Victorian Infectious Diseases Reference Laboratory
- Webb Steve A.
- Western Health
- Westmead Hospital
- Wiese Lothar
- Wikén Christian
- Wood Erica M.
- Yusubalieva Gaukhar M.
- Zacharowski Kai
- Zarychanski Ryan
- Publication venue
- Figshare
- Publication date
- 01/01/2021
- Field of study
Abstract Background Convalescent plasma has been widely used to treat COVID-19 and is under investigation in numerous randomized clinical trials, but results are publicly available only for a small number of trials. The objective of this study was to assess the benefits of convalescent plasma treatment compared to placebo or no treatment and all-cause mortality in patients with COVID-19, using data from all available randomized clinical trials, including unpublished and ongoing trials (Open Science Framework, https://doi.org/10.17605/OSF.IO/GEHFX ). Methods In this collaborative systematic review and meta-analysis, clinical trial registries (ClinicalTrials.gov, WHO International Clinical Trials Registry Platform), the Cochrane COVID-19 register, the LOVE database, and PubMed were searched until April 8, 2021. Investigators of trials registered by March 1, 2021, without published results were contacted via email. Eligible were ongoing, discontinued and completed randomized clinical trials that compared convalescent plasma with placebo or no treatment in COVID-19 patients, regardless of setting or treatment schedule. Aggregated mortality data were extracted from publications or provided by investigators of unpublished trials and combined using the HartungâKnappâSidikâJonkman random effects model. We investigated the contribution of unpublished trials to the overall evidence. Results A total of 16,477 patients were included in 33 trials (20 unpublished with 3190 patients, 13 published with 13,287 patients). 32 trials enrolled only hospitalized patients (including 3 with only intensive care unit patients). Risk of bias was low for 29/33 trials. Of 8495 patients who received convalescent plasma, 1997 died (23%), and of 7982 control patients, 1952 died (24%). The combined risk ratio for all-cause mortality was 0.97 (95% confidence interval: 0.92; 1.02) with between-study heterogeneity not beyond chance (I2 = 0%). The RECOVERY trial had 69.8% and the unpublished evidence 25.3% of the weight in the meta-analysis. Conclusions Convalescent plasma treatment of patients with COVID-19 did not reduce all-cause mortality. These results provide strong evidence that convalescent plasma treatment for patients with COVID-19 should not be used outside of randomized trials. Evidence synthesis from collaborations among trial investigators can inform both evidence generation and evidence application in patient care
The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies
- Author
- Abad Jorge
- Abel Laurent
- Abel Laurent
- Abel Laurent
- Abel Laurent
- Accordino Giulia
- Achille Cristian
- Acosta-Ampudia Yeny
- Agra Juan José Cåceres
- Aguilera-Albesa Sergio
- AguilĂł-Cucurull Aina
- Aiuti Alessandro
- Aiuti Alessandro
- Aiuti Alessandro
- Akcan Ăzge Metin
- Al-Muhsen Saleh
- Al-Mulla Fahd
- Alavoine Loubna
- Albert Matthew
- Albisures Jonathan Antonio Roblero
- Alcover Andres
- Aldave Juan
- Algera Anne Geke
- Aliberti Anna
- Alkan Gulsum
- Alkhater Suzan
- Alkhater Suzan
- Allardet-Servent Jerome
- Allavena Clotilde
- Allende Luis
- Alonso-Arias Rebeca
- Alshahrani Mohammed
- Alsina Laia
- Alvarez Josep Trenado
- Alyanakian Marie-Alexandra
- Amador-Borrero Blanca
- Amat Karine
- Amoura Zahir
- Anaya Juan-Manuel
- Anderson Mark
- Anderson Mark
- Andreakos Evangelos
- Andreakos Evangelos
- Andrejak Claire
- Andrés Ana De
- Anglicheau Dany
- Angoulvant François
- Annereau Jean-Philippe
- AntolĂ Arnau
- Appelman Brent
- Arias Andrés
- Arias Andrés Augusto
- Arkin Lisa
- Arquero Miguel Fernandez
- Arranz MarĂa JesĂșs
- Arrestier Romain
- Arrestier Romain
- Asano Takaki
- Aschard Hugues
- Aubart MĂ©lodie
- Auguet Teresa
- Avramenko Iryna
- Aytekin Gökhan
- Aytekin Selma Erol
- Azot Axelle
- Azoulay Cecile
- Bachelet Delphine
- Bahram Seiamak
- Bajolle Fanny
- Baldanti Fausto
- Baldolli Aurélie
- Ballester Maite
- Baris-Feldman Hagit
- Barreiros Lucila
- Barrou Benoit
- Bartoli Marie
- Barzaghi Federica
- Basmaci Romain
- Basso Sabrina
- Bastard Paul
- Batten Isabella
- Bauters Fré
- Bax Diane
- Bayhan Gulsum Iclal
- Behillil Sylvie
- Behillill Sylvie
- Bellani Giacomo
- Belot Alexandre
- Belot Alexandre
- Belot Alexandre
- Beluze Marine
- Benech Nicolas
- Benkerrou Dehbia
- Beretta Ilaria
- Bergin Colm
- Bertholon Frédérique
- Bettini Laura Rachele
- Beudel Martijn
- Bezrodnik Liliana
- Bhavsar Krishna
- Biggs Catherine
- Biggs Catherine
- Bilbao Agurtzane
- Bilguvar Kaya
- Biondi Andrea
- Bitker Laurent
- Bizien Lucy
- Blanchard-Rohner Geraldine
- Blanco Ignacio
- BlandiniĂšres Adeline
- Bleibtreu Alexandre
- Bloomfield Marketa
- BlĂĄzquez-Gamero Daniel
- Bogaard Harm Jan
- Bogunovic Dusan
- Boisson Bertrand
- Bolivar-Prados Mireia
- Bolze Alexandre
- Bomers Marije
- Bondarenko Anastasiia
- Bondarenko Anastasiia
- Bondarenko Anastasiia
- Bonfanti Paolo
- Bonneaudeau Brigitte
- Bonta Peter
- Borghesi Alessandro
- Borie Raphael
- Borrero Blanca Amador
- Bos Lieuwe
- Bosteels CĂ©dric
- Botdhlo-Nevers Elisabeth
- Botelho-Nevers Elisabeth
- Botta Michela
- Bouadma Lila
- Bouadma Lila
- Boucherit Soraya
- Boudhabhay Idris
- Bouiller KĂ©vin
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- Bourgeois Fleur Le
- Bourgeon Marilou
- Bourke Nollaig
- Bourke Nollaig
- Bourke Nollaig
- Bouscambert-Duchamp Maude
- Bousfiha Ahmed
- Bousfiha Ahmed
- Bousfiha Ahmed
- Bousquet Aurore
- Bousso Philippe
- Boutolleau David
- Bouvattier Claire
- Boyarchuk Oksana
- Boyarchuk Oksana
- Bozdemir Ćefika Elmas
- Bravais Juliette
- Briones M. Luisa
- Briseño-Roa Luis
- Brodin Petter
- Brodin Petter
- Brouwer Matthijs
- Bruhns Pierre
- Bruneau LĂ©a
- Brunner Marie-Eve
- Bruno Raffaele
- Bryceson Yenan
- Bueno Maria Rita P.
- Bugiani Marianna
- Buis David
- Bukhari Huda
- Bulle Esther
- Burdet Charles
- Burdet Charles
- Burrel Sonia
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- Bustamante Jacinta
- Butte Manish
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- Castro Mateus
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- Ceschi Alessandro
- Chahine Abir
- Chair Anissa
- Chakravorty Samya
- Chalumeau Martin
- Charbit Bruno
- Charpentier Charlotte
- Chauvineau-Grenier Angélique
- Chen Jie
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- Chirouze Catherine
- Chirouze Catherine
- Chouchane Osoul
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- Christodoulou John
- Ciceri Fabio
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- Cloherty Alex
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- Cuadros Esmeralda Nuñez
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- de Brabander Justin
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- Ekwall Olov
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- Elbers Paul
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- Enouf Vincent
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- Gilardin Laurent
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- Girona-AlarcĂłn MĂČnica
- Gissot Valérie
- GodĂnez Karen Alejandra Cifuentes
- Goehringer François
- Goffard Jean-Christophe
- Goldberg Marcel
- Gomperts-Boneca Ivo
- Gonzales Nacho
- Gonzalez-Granado Luis
- GonzĂĄlez-Montelongo Rafaela
- Goorhuis Bram
- Gorochov Guy
- Got Stéphane Le
- Gregersen Peter
- Gregersen Peter
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- Guedj Jérémie
- Guerder Antoine
- Gumucio Victor Daniel
- Gunst Jan
- Gut Marta
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- GĂ©rardin Patrick
- GĂłmez Oscar
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- Pelet Anna
- Pelet Sophie
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- Pham Huong
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- Philippot Quentin
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- Piquard Valentine
- Piralla Antonio
- Pistone Thierry
- Planas Anna
- Planas Anna
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- Ploin Dominique
- Poissy Julien
- Poissy Julien
- Poissy Julien
- Poncelet GĂ©raldine
- Poulakou Garyphallia
- Pouletty Marie
- Pourshahnazari Persia
- Prado Maria Yolanda Ruiz Del
- Prando Carolina
- Prando Carolina
- Preckel Bennedikt
- Prins Jan
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- Pueyo David MartĂnez
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- Pujol Aurora
- Puéchal Oriane
- PĂ©rez Cristian Alejandro Ricaurte
- PĂ©rez-DĂaz Carlos
- Pérez-Fernåndez Xosé Luis
- Qiu-Chen Jia Li
- Quaresima Virginia
- Quentric Paul
- Quintana-Murci Lluis
- Quintana-Murci Lluis
- Quintana-Murci Lluis
- Quintin Caroline
- Quiros-Roldan Eugenia
- Raasveld Jorinde
- Ramaswamy Sathishkumar
- Rambaud Thomas
- Ramirez-Santana Carolina
- Ramos Miquel Alfonso
- Raoult Didier
- Raoult Didier
- Raoult Violette
- Rapti Vasiliki
- Rausell Antonio
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- Reddy Conor
- Redin Claire
- Reijnders Tom
- Renia Laurent
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- Resnick Igor
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- Ricart Pilar
- Ricaurte Oscar Andrés Briceño
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- Richard Lucie
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- Richard Pascale
- Rieux-Laucat Frédéric
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- Rigo-Bonnin RaĂșl
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- RiviĂšre Jacques
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- Rodero Mathieu
- Rodrigo Carlos
- Rodriguez Luis Antonio
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- Rodriguez-Palmero AgustĂ
- RodrĂguez Yhojan
- RodrĂguez-Gallego Carlos
- RodrĂguez-Gallego Carlos
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- SeppÀnen Mikko R.J.
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- Shahrooei Mohammed
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- Shcherbina Anna
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- Taccone Fabio
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- Tanaka Junko
- Tancevski Ivan
- Tancevski Ivan
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- Tandjaoui-Lambiotte Yacine
- Tangy Frédéric
- Tangye Stuart
- Tangye Stuart
- Tardivon Coralie
- Tardy Bernard
- Taupin Jean-Luc
- Tavernier Simon
- Tayoun Ahmad Abou
- Tellier Marie-Capucine
- Terrier Benjamin
- Terrier Olivier
- Teunissen Charlotte
- Tharaux Pierre-Louis
- Thibault Chloé
- Thiery Guillaume
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- Thorball Christian
- Thorn Karolina
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- Tiberghien Pierre
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- Tolstrup Martin
- Tomasoni Gabriele
- Toubert Antoine
- Toubiana Julie
- Touvier Mathilde
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- Trouillet-Assant Sophie
- Troya JesĂșs
- Troya JesĂșs
- Tsang Owen
- Tserel Liina
- Tso Eugene
- Tsonas Anissa
- Tsumura Miyuki
- Tual Christelle
- Tubiana Sarah
- Tubiana Sarah
- Tucci Alessandra
- Tuinman Pieter
- Turvey Stuart
- Tzourio Christophe
- Téoulé François
- Uddin K.
- Uddin Mohammed
- Ungeheuer Marie-Noëlle
- Ursini Matilde Valeria
- Utsumi Takanori
- Uzunhan Yurdagul
- Vabres Pierre
- Valencia-Ramos Juan
- Valsecchi Maria Grazia
- van Agtmael Michiel
- van Baarle Frank
- van Braeckel Eva
- van de Beek Diederik
- van de Beek Diederik
- van de Beek Diederik
- van den Rym Ana Maria
- van der Poll Tom
- van der Valk Marc
- van der Werf Sylvie
- van der Werf Sylvie
- van Mourik Niels
- van Praet Jens
- van Vugt MichĂšle
- Vanderlinden Dimitri
- Vandernoot Isabelle
- Vanel Noémie
- Vasse Marc
- Veelo Denise
- Veislinger Aurélie
- Velez-Santamaria Valentina
- Veliz Silvia Patricia Zuniga
- Venet Fabienne
- Vergara José Alejandro Daza
- Vidaur Loreto
- Vidaur Loreto
- Vidigal Mateus
- Vidigal Mateus
- Viel SĂ©bastien
- Vignali Valérie
- Vilaire-Meunier Marie
- Villain CĂ©dric
- Villar-GarcĂa Judit
- Vincent Audrey
- Vinh Donald
- Vinh Donald
- Visseaux Benoit
- Visseaux Benoit
- Vlaar Alexander
- Vogt Guillaume
- Voiriot Guillaume
- Volleman Carolien
- Volokha Alla
- von Bernuth Horst
- von Stemann Jakob Hjorth
- Vught Lonneke
- Vuotto Fanny
- VĂ©lez VerĂłnica Posada
- Waucquier Nawal
- Wauters Els
- Wauters Joost
- Wauters Joost
- Wauters Joost
- Wiedemann Aurélie
- Wiersinga W. Joost
- Wouters Dorien
- Wu Alan
- Wu Tak-Chiu
- YahĆi Aysun
- Yang Rui
- Yasar Kadriye Kart
- Yazdanpanah Yazdan
- Yazdanpanah Yazdan
- Yepes Jairo David Torres
- Yesilbas Osman
- Yildiz Mehmet
- Young Barnaby
- YĂŒkselmiĆ Ufuk
- Zatz Mayana
- Zatz Mayana
- Zatz Mayana
- Zawadzki Pawel
- Zhang Peng
- Zhang Qian
- Zhang Shen-Ying
- Zhang Yu
- Zimmer Christophe
- Zins Marie
- Zins Marie
- Zuccaro Valentina
- Zwinderman A.
- Ăñigo-Campos Antonio
- Ăz Ćadiye KĂŒbra TĂŒter
- Ăzkan Esra AkyĂŒz
- Ăzçelik Tayfun
- Publication venue
- 'Proceedings of the National Academy of Sciences'
- Publication date
- 24/05/2022
- Field of study
International audienceSignificance There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19 mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence of these autoantibodies and the risk of COVID-19 death increase with age and are higher in men. Using an unvaccinated sample of 1,261 deceased patients and 34,159 individuals from the general population, we found that autoantibodies against type I IFNs strongly increased the SARS-CoV-2 infection fatality rate at all ages, in both men and women. Autoantibodies against type I IFNs are strong and common predictors of life-threatening COVID-19. Testing for these autoantibodies should be considered in the general population
The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies
- Author
- Abad Jorge
- Abel Laurent
- Abel Laurent
- Abel Laurent
- Abel Laurent
- Accordino Giulia
- Achille Cristian
- Acosta-Ampudia Yeny
- Agra Juan José Cåceres
- Aguilera-Albesa Sergio
- AguilĂł-Cucurull Aina
- Aiuti Alessandro
- Aiuti Alessandro
- Aiuti Alessandro
- Akcan Ăzge Metin
- Al-Muhsen Saleh
- Al-Mulla Fahd
- Alavoine Loubna
- Albert Matthew
- Albisures Jonathan Antonio Roblero
- Alcover Andres
- Aldave Juan
- Algera Anne Geke
- Aliberti Anna
- Alkan Gulsum
- Alkhater Suzan
- Alkhater Suzan
- Allardet-Servent Jerome
- Allavena Clotilde
- Allende Luis
- Alonso-Arias Rebeca
- Alshahrani Mohammed
- Alsina Laia
- Alvarez Josep Trenado
- Alyanakian Marie-Alexandra
- Amador-Borrero Blanca
- Amat Karine
- Amoura Zahir
- Anaya Juan-Manuel
- Anderson Mark
- Anderson Mark
- Andreakos Evangelos
- Andreakos Evangelos
- Andrejak Claire
- Andrés Ana De
- Anglicheau Dany
- Angoulvant François
- Annereau Jean-Philippe
- AntolĂ Arnau
- Appelman Brent
- Arias Andrés
- Arias Andrés Augusto
- Arkin Lisa
- Arquero Miguel Fernandez
- Arranz MarĂa JesĂșs
- Arrestier Romain
- Arrestier Romain
- Asano Takaki
- Aschard Hugues
- Aubart MĂ©lodie
- Auguet Teresa
- Avramenko Iryna
- Aytekin Gökhan
- Aytekin Selma Erol
- Azot Axelle
- Azoulay Cecile
- Bachelet Delphine
- Bahram Seiamak
- Bajolle Fanny
- Baldanti Fausto
- Baldolli Aurélie
- Ballester Maite
- Baris-Feldman Hagit
- Barreiros Lucila
- Barrou Benoit
- Bartoli Marie
- Barzaghi Federica
- Basmaci Romain
- Basso Sabrina
- Bastard Paul
- Batten Isabella
- Bauters Fré
- Bax Diane
- Bayhan Gulsum Iclal
- Behillil Sylvie
- Behillill Sylvie
- Bellani Giacomo
- Belot Alexandre
- Belot Alexandre
- Belot Alexandre
- Beluze Marine
- Benech Nicolas
- Benkerrou Dehbia
- Beretta Ilaria
- Bergin Colm
- Bertholon Frédérique
- Bettini Laura Rachele
- Beudel Martijn
- Bezrodnik Liliana
- Bhavsar Krishna
- Biggs Catherine
- Biggs Catherine
- Bilbao Agurtzane
- Bilguvar Kaya
- Biondi Andrea
- Bitker Laurent
- Bizien Lucy
- Blanchard-Rohner Geraldine
- Blanco Ignacio
- BlandiniĂšres Adeline
- Bleibtreu Alexandre
- Bloomfield Marketa
- BlĂĄzquez-Gamero Daniel
- Bogaard Harm Jan
- Bogunovic Dusan
- Boisson Bertrand
- Bolivar-Prados Mireia
- Bolze Alexandre
- Bomers Marije
- Bondarenko Anastasiia
- Bondarenko Anastasiia
- Bondarenko Anastasiia
- Bonfanti Paolo
- Bonneaudeau Brigitte
- Bonta Peter
- Borghesi Alessandro
- Borie Raphael
- Borrero Blanca Amador
- Bos Lieuwe
- Bosteels CĂ©dric
- Botdhlo-Nevers Elisabeth
- Botelho-Nevers Elisabeth
- Botta Michela
- Bouadma Lila
- Bouadma Lila
- Boucherit Soraya
- Boudhabhay Idris
- Bouiller KĂ©vin
- Boulanger CĂ©cile
- Bourgeois Fleur Le
- Bourgeon Marilou
- Bourke Nollaig
- Bourke Nollaig
- Bourke Nollaig
- Bouscambert-Duchamp Maude
- Bousfiha Ahmed
- Bousfiha Ahmed
- Bousfiha Ahmed
- Bousquet Aurore
- Bousso Philippe
- Boutolleau David
- Bouvattier Claire
- Boyarchuk Oksana
- Boyarchuk Oksana
- Bozdemir Ćefika Elmas
- Bravais Juliette
- Briones M. Luisa
- Briseño-Roa Luis
- Brodin Petter
- Brodin Petter
- Brouwer Matthijs
- Bruhns Pierre
- Bruneau LĂ©a
- Brunner Marie-Eve
- Bruno Raffaele
- Bryceson Yenan
- Bueno Maria Rita P.
- Bugiani Marianna
- Buis David
- Bukhari Huda
- Bulle Esther
- Burdet Charles
- Burdet Charles
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- Bustamante Jacinta
- Butte Manish
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- Casanova Jean-Laurent
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- Cassaniti Irene
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- Castro Mateus
- Catherinot Emilie
- Cazzaniga Marina
- Celik Jale Bengi
- Cerf-Bensussan Nadine
- Cervantes-Gonzalez Minerva
- Ceschi Alessandro
- Chahine Abir
- Chair Anissa
- Chakravorty Samya
- Chalumeau Martin
- Charbit Bruno
- Charpentier Charlotte
- Chauvineau-Grenier Angélique
- Chen Jie
- Cheng Matthew
- Chirouze Catherine
- Chirouze Catherine
- Chouchane Osoul
- Chrabieh Maya
- Christodoulou John
- Ciceri Fabio
- Citerio Giuseppe
- Clavé Pere
- Clercq Jozefien De
- Cloherty Alex
- Clotet Bonaventura
- Cobat Aurélie
- Codina Anna
- Coelho Alexandra
- Coeuret-Pellicer Mireille
- Cognasse Fabrice
- Cognasse Fabrice
- Cohen Yves
- Colobran Roger
- Colobran Roger
- Comarmond Cloé
- Combes Alain
- Comoli Patrizia
- Condino-Neto Antonio
- Condino-Neto Antonio
- Conlon Niall
- Connolly Emma
- Constantinescu Stefan
- Conti Francesca
- Contro Ernesto
- Cooper Megan
- Cordel Hugues
- Correales Luisa Paola Duarte
- Corsico Angelo
- Couffignal Camille
- Couffin-Cadiergues Sandrine
- Couffin-Cadiergues Sandrine
- Coulongeat Matthieu
- CoĆkuner Taner
- Cruz InĂ©s MarĂn
- Cuadros Esmeralda Nuñez
- Cumano Ana
- Cvetkovski Aleksandar
- Cyrus Cyril
- Daganou Maria
- Dalgard Clifton
- Dalgard Clifton
- Dalmau David
- Dalmau David
- Danielson Jeffrey
- Danion François
- Darazam Ilad Alavi
- Darley David Ross
- Das Vincent
- Dauby Nicolas
- Dauger Stéphane
- de Brabander Justin
- de Bree Godelieve
- de Bruin Sanne
- de Chambrun Marc Pineton
- de Diego Rebeca Perez
- de Jong Menno
- de la Chapelle Aliénor
- de Lamballerie Xavier
- de Montmollin Etienne
- de Munter Paul
- de Pontual Loic
- de Prost Nicolas
- de Rotte Maurits
- de Vera MartĂn Castillo
- de Vries Heder
- Debard Alexa
- Debette Stéphanie
- Debette Stéphanie
- Debray Marie-Pierre
- Dechanet Aline
- Dehban Amin
- Delmonte Ottavia
- Delplancq Geoffroy
- Demar Magalie
- Demirkol Yasemin Kendir
- Demoule Alexandre
- Deplanque Dominique
- Deplanque Dominique
- Deriano Ludovic
- Desai Murkesh
- Descamps Diane
- Descamps Diane
- Desguerre Isabelle
- Desille-Dugast Mireille
- Desmarets Maxime
- Desvallée Mathilde
- Di Sabatino Antonio
- Di Santo James
- Diallo Alpha
- Diego Rebeca PĂ©rez De
- Diehl Jean-Luc
- Diehl Jean-Luc
- Dijkstra Mirjam
- Dillies Marie-AgnĂšs
- Ding Li
- Dinh Khoa Manh
- Diouf Alphonsine
- Djossou FĂ©lix
- Dobbelaere Stephanie
- Dobbs Kerry
- Dominguez-Garrido Elena
- DomĂnguez-Garrido Elena
- Dongelmans Dave
- Dorgham Karim
- Dorival CĂ©line
- Drolet Beth
- Dromer Françoise
- Dubos François
- Dubost Clément
- Duffy Darragh
- Duffy Darragh
- Dufouil Carole
- Dujardin Romein
- Dunne Jean
- Dupont Annabelle
- Duval Xavier
- Duval Xavier
- Duvlis Sotirija
- Dyer Adam
- Dâangio Mariella
- Dâenfert Christophe
- Dâortenzio Eric
- Eberl GĂ©rard
- Ecobichon Jean-Luc
- Ekwall Olov
- El Baghdadi Jamila
- El Bakkouri Jalila
- Elbers Paul
- Elnagdy Marwa
- Eloy Philippine
- Emiroglu Melike
- Endo Akifumi
- Enninga Jost
- Enouf Vincent
- Enouf Vincent
- Epaulard Olivier
- Erdeniz Emine Hafize
- Erikstrup Christian
- Erikstrup Christian
- Esperou HĂ©lĂšne
- Espinosa-Padilla Sara
- Esposito-Farase Marina
- Espérou HélÚne
- Etienne Manuel
- Eto Shohei
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- Fabio Giovanna
- Faivre Laurence
- Falck Antonin
- Fallon Aoife
- Fartoukh Muriel
- Faure Morgane
- Fekkar Arnaud
- Feldman Hagit Baris
- Feldman Hagit Baris
- Fellay Jacques
- Fellay Jacques
- Fellay Jacques
- Ferrer Ricard
- Ferreres Jose
- Fievet Nathalie
- Flaig Amandine
- Fleuren Lucas
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- Flores Carlos
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- Fontes Magnus
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- Fouchard Julie
- Franco José Luis
- Franco José Luis
- Francois Bruno
- Frezouls Wahiba
- Froidure Antoine
- FumadĂł Victoria
- Fung Kitty
- Fusco Francesca
- Gagneux-Brunon Amandine
- Gagro Alenka
- Gallian Pierre
- Garcia-Prat Marina
- GarcĂa Paula Andrea Gaviria
- Garot Denis
- Garçon Pierre
- Gatineau Audrey Giraud
- Gaudet Alexandre
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- Geerlings Suzanne
- Geijtenbeek Theo
- Gentile Stéphanie
- Gervais Adrian
- Ghirardello Stefano
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- Gil-Herrera Juana
- Gilardin Laurent
- Gilardin Laurent
- Gilg Morgane
- Girbes Armand
- Girona-AlarcĂłn MĂČnica
- Gissot Valérie
- GodĂnez Karen Alejandra Cifuentes
- Goehringer François
- Goffard Jean-Christophe
- Goldberg Marcel
- Gomperts-Boneca Ivo
- Gonzales Nacho
- Gonzalez-Granado Luis
- GonzĂĄlez-Montelongo Rafaela
- Goorhuis Bram
- Gorochov Guy
- Got Stéphane Le
- Gregersen Peter
- Gregersen Peter
- Gribouval Olivier
- Grimbacher Bodo
- Grobusch Martin
- Guaqueta Jeser Santiago Grass
- Guedj Jérémie
- Guerder Antoine
- Gumucio Victor Daniel
- Gunst Jan
- Gut Marta
- Gålvez-Romero José Luis
- GĂ©rardin Patrick
- GĂłmez Oscar
- GĂŒlhan Belgin
- Hadjadj JĂ©rĂŽme
- Haerynck Filomeen
- Haerynck Filomeen
- Haerynck Filomeen
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- Hagin David
- Hagin David
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- Halwani Rabih
- Halwani Rabih
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- Hammarström Lennart
- Hammarström Lennart
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- Heath James
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- Hoste Levi
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- Hulot Jean-SĂ©bastien
- Humbert Linda
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- Ingersoll Molly
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- Kisand Kai
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- Kwan Yat Wah M.
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- Landinez Sandra
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- Novelli Giuseppe
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- Nussenzweig Michel
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- Okada Satoshi
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- Okamoto Keisuke
- Okamoto Keisuke
- Oriol Roger Colobran
- Ostrowski Sisse Rye
- Oualha Mehdi
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- Ozcelik Tayfun
- Ozcelik Tayfun
- Ozguler Anna
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- Pagani Michele
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- Papadaki Maria
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- Pape Jean
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- Parola Philippe
- Parra-MartĂnez Alba
- Pascreau Tiffany
- Patin Etienne
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- Paul Stéphane
- Paul Stéphane
- Paulsen Isabella Worlewenut
- Paulus Frederique
- Payet Christine
- Paz Pauline Caraux
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- Pedraza-SĂĄnchez Sigifredo
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- Pelet Anna
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- Pellegrini Sandra
- Pellegrini Silvia
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- Pham Huong
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- Philippot Quentin
- Philippot Quentin
- Picod Adrien
- Picone Olivier
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- Piralla Antonio
- Pistone Thierry
- Planas Anna
- Planas Anna
- Planas-Serra Laura
- Ploin Dominique
- Poissy Julien
- Poissy Julien
- Poissy Julien
- Poncelet GĂ©raldine
- Poulakou Garyphallia
- Pouletty Marie
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- Prando Carolina
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- PĂ©rez Cristian Alejandro Ricaurte
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- Valsecchi Maria Grazia
- van Agtmael Michiel
- van Baarle Frank
- van Braeckel Eva
- van de Beek Diederik
- van de Beek Diederik
- van de Beek Diederik
- van den Rym Ana Maria
- van der Poll Tom
- van der Valk Marc
- van der Werf Sylvie
- van der Werf Sylvie
- van Mourik Niels
- van Praet Jens
- van Vugt MichĂšle
- Vanderlinden Dimitri
- Vandernoot Isabelle
- Vanel Noémie
- Vasse Marc
- Veelo Denise
- Veislinger Aurélie
- Velez-Santamaria Valentina
- Veliz Silvia Patricia Zuniga
- Venet Fabienne
- Vergara José Alejandro Daza
- Vidaur Loreto
- Vidaur Loreto
- Vidigal Mateus
- Vidigal Mateus
- Viel SĂ©bastien
- Vignali Valérie
- Vilaire-Meunier Marie
- Villain CĂ©dric
- Villar-GarcĂa Judit
- Vincent Audrey
- Vinh Donald
- Vinh Donald
- Visseaux Benoit
- Visseaux Benoit
- Vlaar Alexander
- Vogt Guillaume
- Voiriot Guillaume
- Volleman Carolien
- Volokha Alla
- von Bernuth Horst
- von Stemann Jakob Hjorth
- Vught Lonneke
- Vuotto Fanny
- VĂ©lez VerĂłnica Posada
- Waucquier Nawal
- Wauters Els
- Wauters Joost
- Wauters Joost
- Wauters Joost
- Wiedemann Aurélie
- Wiersinga W. Joost
- Wouters Dorien
- Wu Alan
- Wu Tak-Chiu
- YahĆi Aysun
- Yang Rui
- Yasar Kadriye Kart
- Yazdanpanah Yazdan
- Yazdanpanah Yazdan
- Yepes Jairo David Torres
- Yesilbas Osman
- Yildiz Mehmet
- Young Barnaby
- YĂŒkselmiĆ Ufuk
- Zatz Mayana
- Zatz Mayana
- Zatz Mayana
- Zawadzki Pawel
- Zhang Peng
- Zhang Qian
- Zhang Shen-Ying
- Zhang Yu
- Zimmer Christophe
- Zins Marie
- Zins Marie
- Zuccaro Valentina
- Zwinderman A.
- Ăñigo-Campos Antonio
- Ăz Ćadiye KĂŒbra TĂŒter
- Ăzkan Esra AkyĂŒz
- Ăzçelik Tayfun
- Publication venue
- 'Proceedings of the National Academy of Sciences'
- Publication date
- 24/05/2022
- Field of study
International audienceSignificance There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19 mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence of these autoantibodies and the risk of COVID-19 death increase with age and are higher in men. Using an unvaccinated sample of 1,261 deceased patients and 34,159 individuals from the general population, we found that autoantibodies against type I IFNs strongly increased the SARS-CoV-2 infection fatality rate at all ages, in both men and women. Autoantibodies against type I IFNs are strong and common predictors of life-threatening COVID-19. Testing for these autoantibodies should be considered in the general population