8 research outputs found

    Léon Parvillée : dialogue entre architecture et arts décoratifs

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    Élève de Viollet-le-Duc, sculpteur, décorateur, chargé par le gouvernement ottoman de la restauration de la ville de Brousse puis des installations turques de l´exposition universelle de 1867, céramiste orientaliste reconnu et maintes fois médaillé, créateur du magnifique décor japonisant de l´établissement thermal de Bourbon-l´Archambault, défenseur de l´architecture polychrome, chercheur et historien de l´art, Léon Parvillée (1830-1885) est un artiste « éclectique » dans tous les sens du terme. Sa passion pour la céramique, née de ses travaux d’ornemaniste puis d´architecte, le pousse sans cesse à faire passer ses recherches techniques ou esthétiques de l´objet au bâtiment ou du bâtiment à l’objet. Puisant dans tous les domaines et dans toutes les références, les décors et les émaux qu´il compose nouent un dialogue permanent entre architecture et arts décoratifs.Student of Viollet-le-Duc, sculptor, decorator, Léon Parvillée is mandated by the Ottoman government both for the restoration of the city of Bursa and for the turkish installations at the World’s Fair of 1867 in Paris. Renowned and many times medal winner as an orientalist ceramist, creator of the splendid decoration of the thermal baths of Bourbon-l’Archambault in a Japanese-inspired style, defender of polychrome architecture, researcher and historian of art, Léon Parvillée (1830-1885) is indeed a real « eclectic » artist. His passion for ceramic, born from his work of ornemanist and architect, pushes him in an ongoing quest to link object and building through his technical and aesthetic researches. Drawing from all fields and from all references, the decorations and the enamels he composes tie a permanent dialogue between architecture and decorative arts.Der Schüler Viollet-le-Ducs, Bildhauer und Ornamentist Léon Parvillée (1830-1885) wurde von der ottomanischen Regierung beauftragt, zuerst die Stadt Bursa zu restaurieren, dann die türkischen Einrichtungen der Weltaustellung 1867 zu errichten. Er wurde als orientalister Keramiker gerühmt und so mehrmals mit Medaillen ausgezeichnet, aber er schuf auch das wertvolle Dekor im japonischen Stil des Thermenbades von Bourbon-l´Archambault. Léon Parvillées Forschungen im Gebiet der Kunstgeschichte sowie dessen Neigung zur Polychromie in der Architektur lassen ihn als Eklektistist in jedem Sinn des Begriffs bezeichnen. In seinen Werken als Ornamentist und als Architekt bevorzugt er Keramik, so dass er in diesem Gebiet immer wieder neue technische und esthetischen Forschungen unternahm. Die Modelle seiner Ornamente und Emaillen schöpfte er aus verschiedenen Bereichen, so dass ein stetiger Dialog zwischen Architektur und dekorativer Kunst zustandekommt

    Developmental role of acetylcholinesterase in impulse control in zebrafish

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    Cellular and molecular processes that mediate individual variability in impulsivity, a key behavioural component of many neuropsychiatric disorders, are poorly understood. Zebrafish heterozygous for a nonsense mutation in Ache (achesb55/+) showed lower levels of impulsivity in a 5-choice serial reaction time task (5-CSRTT) than wild type and ache+/+. Assessment of expression of cholinergic (nAChR), serotonergic (5-HT) and dopamine (DR) receptor mRNA in both adult and larval (9dpf) achesb55/+ revealed significant downregulation of Chrna2, Chrna5 and Drd2 mRNA in achesb55/+ larvae, but no differences in adults. Acute exposure to cholinergic agonist/antagonists had no effect on impulsivity, supporting the hypothesis that behavioural effects observed in adults were due to lasting impact of developmental alterations in cholinergic and dopaminergic signalling. This shows the cross-species role of cholinergic signalling during brain development in impulsivity, and suggests zebrafish may be a useful model for the role of cholinergic pathways as a target for therapeutic advances in addiction medicine

    Cohort profile: the ESC EURObservational Research Programme Atrial Fibrillation III (AF III) Registry

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    International audienceAbstract Aims The European Society of Cardiology (ESC) EURObservational Research Programme (EORP)-Atrial Fibrillation (AF) III Registry aims to identify contemporary patterns in AF management in clinical practice, assess their compliance with the 2016 ESC AF Guidelines, identify major gaps in guideline implementation, characterize the clinical practice settings associated with good vs. poor guideline implementation and assess and compare the 1-year outcome of guideline-adherent vs. guideline non-adherent management strategies. Methods and results Consecutive adult AF patients (n = 8306) were enrolled between 1 July 2018 and 15 July 2019, and individual patient data were prospectively collected across 192 centres and 31 participating countries during the 3-month enrolment period per centre. The Registry collected baseline and 1-year follow-up data in the eight main domains: patient demographic/enrolment setting, AF diagnosis/characterization, diagnostic assessment, stroke prevention treatments, arrhythmia-directed therapies, integrated AF management, major outcomes (death, non-fatal stroke or systemic embolic event, and non-fatal bleeding event), and the quality of life questionnaire. Conclusion The EORP-AF III Registry is an international, prospective registry of care and outcomes of patients treated for AF, which will provide insights into the contemporary patterns in AF management, ESC AF Guidelines implementation in routine practice and barriers to optimal management of this highly prevalent arrhythmia
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