[Introduction to] Black Lives and Bathrooms: Racial and Gendered Reactions to Minority Rights Movements.

Black Lives and Bathrooms: Racial and Gendered Reactions to Minority Rights Movements examines how people respond to minority movements in ways that maintain existing patterns of racial and gender inequality. By studying the Black Lives Matter and Transgender Bathroom Access movement efforts, J.E. Sumerau and Eric Anthony Grollman analyze how cisgender white people define minority movements in relation to their existing notions of United States social norms; react to minority movements utilizing racial, classed, gendered, and sexual stereotypes that reinforce racism, sexism, and cissexism in society; and propose ways that racial and gender minorities could gain conditional acceptance by behaving in ways cisgender white people find more comfortable and normal. Throughout this work, Sumerau and Grollman note how assumptions about whiteness and cisnormativity are spread as cisgender white people respond to racial and gender movements seeking social change.https://scholarship.richmond.edu/bookshelf/1393/thumbnail.jp

Constructing Allyship and the Persistence of Inequality.

We examine how people construct what it means to be an ally to marginalized groups. Based on 70 in-depth interviews with college students who identify as allies to one or more marginalized groups, we analyze how they construct allyship in ways that ultimately reproduce patterns of social inequality by (1) assigning responsibility for inequalities to minorities, and (2) suggesting individualized, rather than structural, remedies for combatting unequal systems. We find that the combination of these strategies allows them to claim identities as allies without having to engage in concrete efforts that could challenge systems of oppression. We argue that systematically examining processes through which people construct and perform what it means to be an ally may provide insights into mechanisms whereby inequality is maintained and justified. Such systematic examination may also point to potential avenues for combating social inequalities

Mutational profile and prognostic significance of TP53 in diffuse large B-cell lymphoma patients treated with R-CHOP: report from an International DLBCL Rituximab-CHOP Consortium Program Study

Contains fulltext : 108767.pdf (publisher's version ) (Closed access)TP53 mutation is an independent marker of poor prognosis in patients with diffuse large B-cell lymphoma (DLBCL) treated with cyclophosphamide, hydroxydaunorubicin, vincristine, and prednisone (CHOP) therapy. However, its prognostic value in the rituximab immunochemotherapy era remains undefined. In the present study of a large cohort of DLBCL patients treated with rituximab plus CHOP (R-CHOP), we show that those with TP53 mutations had worse overall and progression-free survival compared with those without. Unlike earlier studies of patients treated with CHOP, TP53 mutation has predictive value for R-CHOP-treated patients with either the germinal center B-cell or activated B-cell DLBCL subtypes. Furthermore, we identified the loop-sheet-helix and L3 motifs in the DNA-binding domain to be the most critical structures for maintaining p53 function. In contrast, TP53 deletion and loss of heterozygosity did not confer worse survival. If gene mutation data are not available, immunohistochemical analysis showing > 50% cells expressing p53 protein is a useful surrogate and was able to stratify patients with significantly different prognoses. We conclude that assessment of TP53 mutation status is important for stratifying R-CHOP-treated patients into distinct prognostic subsets and has significant value in the design of future therapeutic strategies