953 research outputs found
Magnetic fields and accretion flows on the classical T Tauri star V2129 Oph
From observations collected with the ESPaDOnS spectropolarimeter, we report
the discovery of magnetic fields at the surface of the mildly accreting
classical T Tauri star V2129 Oph. Zeeman signatures are detected, both in
photospheric lines and in the emission lines formed at the base of the
accretion funnels linking the disc to the protostar, and monitored over the
whole rotation cycle of V2129 Oph. We observe that rotational modulation
dominates the temporal variations of both unpolarized and circularly polarized
line profiles. We reconstruct the large-scale magnetic topology at the surface
of V2129 Oph from both sets of Zeeman signatures simultaneously. We find it to
be rather complex, with a dominant octupolar component and a weak dipole of
strengths 1.2 and 0.35 kG, respectively, both slightly tilted with respect to
the rotation axis. The large-scale field is anchored in a pair of 2-kG unipolar
radial field spots located at high latitudes and coinciding with cool dark
polar spots at photospheric level. This large-scale field geometry is unusually
complex compared to those of non-accreting cool active subgiants with moderate
rotation rates. As an illustration, we provide a first attempt at modelling the
magnetospheric topology and accretion funnels of V2129 Oph using field
extrapolation. We find that the magnetosphere of V2129 Oph must extend to about
7R* to ensure that the footpoints of accretion funnels coincide with the
high-latitude accretion spots on the stellar surface. It suggests that the
stellar magnetic field succeeds in coupling to the accretion disc as far out as
the corotation radius, and could possibly explain the slow rotation of V2129
Oph. The magnetospheric geometry we derive produces X-ray coronal fluxes
typical of those observed in cTTSs.Comment: MNRAS, in press (18 pages, 17 figures
Non-invasive molecular imaging of inflammatory macrophages in allograft rejection.
BackgroundMacrophages represent a critical cell type in host defense, development and homeostasis. The ability to image non-invasively pro-inflammatory macrophage infiltrate into a transplanted organ may provide an additional tool for the monitoring of the immune response of the recipient against the donor graft. We therefore decided to image in vivo sialoadhesin (Sn, Siglec 1 or CD169) using anti-Sn mAb (SER-4) directly radiolabelled with (99m)Tc pertechnetate.MethodsWe used a heterotopic heart transplantation model where allogeneic or syngeneic heart grafts were transplanted into the abdomen of recipients. In vivo nanosingle-photon emission computed tomography (SPECT/CT) imaging was performed 7 days post transplantation followed by biodistribution and histology.ResultsIn wild-type mice, the majority of (99m)Tc-SER-4 monoclonal antibody cleared from the blood with a half-life of 167 min and was located predominantly on Sn(+) tissues in the spleen, liver and bone marrow. The biodistribution in the transplantation experiments confirmed data derived from the non-invasive SPECT/CT images, with significantly higher levels of (99m)Tc-SER-4 observed in allogeneic grafts (9.4 (±2.7) %ID/g) compared to syngeneic grafts (4.3 (±10.3) %ID/g) (p = 0.0022) or in mice which received allogeneic grafts injected with (99m)Tc-IgG isotype control (5.9 (±0.6) %ID/g) (p = 0.0185). The transplanted heart to blood ratio was also significantly higher in recipients with allogeneic grafts receiving (99m)Tc-SER-4 as compared to recipients with syngeneic grafts (p = 0.000004) or recipients with allogeneic grafts receiving (99m)Tc-IgG isotype (p = 0.000002).ConclusionsHere, we demonstrate that imaging of Sn(+) macrophages in inflammation may provide an important additional and non-invasive tool for the monitoring of the pathophysiology of cellular immunity in a transplant model
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Follow-up examination of linkage and association to chromosome 1q43 in multiple sclerosis.
Multiple sclerosis (MS) is a debilitating neuroimmunological and neurodegenerative disease affecting >4,00,000 individuals in the United States. Population and family-based studies have suggested that there is a strong genetic component. Numerous genomic linkage screens have identified regions of interest for MS loci. Our own second-generation genome-wide linkage study identified a handful of non-major histocompatibility complex regions with suggestive linkage. Several of these regions were further examined using single-nucleotide polymorphisms (SNPs) with average spacing between SNPs of approximately 1.0 Mb in a dataset of 173 multiplex families. The results of that study provided further evidence for the involvement of the chromosome 1q43 region. This region is of particular interest given linkage evidence in studies of other autoimmune and inflammatory diseases including rheumatoid arthritis and systemic lupus erythematosus. In this follow-up study, we saturated the region with approximately 700 SNPs (average spacing of 10 kb per SNP) in search of disease-associated variation within this region. We found preliminary evidence to suggest that common variation within the RGS7 locus may be involved in disease susceptibility
Non-stationary dynamo & magnetospheric accretion processes of the classical T Tauri star V2129 Oph
We report here the first results of a multi-wavelength campaign focussing on
magnetospheric accretion processes of the classical TTauri star (cTTS)
V2129Oph. In this paper, we present spectropolarimetric observations collected
in 2009 July with ESPaDOnS at the Canada-France-Hawaii Telescope (CFHT).
Circularly polarised Zeeman signatures are clearly detected, both in
photospheric absorption and accretion-powered emission lines, from time-series
of which we reconstruct new maps of the magnetic field, photospheric brightness
and accretion-powered emission at the surface of V2129Oph using our newest
tomographic imaging tool - to be compared with those derived from our old 2005
June data set, reanalyzed in the exact same way.
We find that in 2009 July, V2129Oph hosts octupolar & dipolar field
components of about 2.1 & 0.9kG respectively, both tilted by about 20deg with
respect to the rotation axis; we conclude that the large-scale magnetic
topology changed significantly since 2005 June (when the octupole and dipole
components were about 1.5 and 3 times weaker respectively), demonstrating that
the field of V2129Oph is generated by a non-stationary dynamo. We also show
that V2129Oph features a dark photospheric spot and a localised area of
accretion-powered emission, both close to the main surface magnetic region
(hosting fields of up to about 4kG in 2009 July). We finally obtain that the
surface shear of V2129Oph is about half as strong as solar.
From the fluxes of accretion-powered emission lines, we estimate that the
observed average logarithmic accretion rate (in Msun/yr) at the surface of
V2129Oph is -9.2+-0.3 at both epochs, peaking at -9.0 at magnetic maximum. It
implies in particular that the radius at which the magnetic field of V2129Oph
truncates the inner accretion disc is 0.93x and 0.50x the corotation radius in
2009 July and 2005 June respectively.Comment: MNRAS in press - 16 pages, 9 figure
New instability of non-extremal black holes: spitting out supertubes
We search for stable bound states of non-extremal rotating three-charge black
holes in five dimensions (Cvetic-Youm black holes) and supertubes. We do this
by studying the potential of supertube probes in the non-extremal black hole
background and find that generically the marginally bound state of the
supersymmetric limit becomes metastable and disappears with non-extremality
(higher temperature). However near extremality there is a range of parameters
allowing for stable bound states, which have lower energy than the
supertube-black hole merger. Angular momentum is crucial for this effect. We
use this setup in the D1-D5 decoupling limit to map a thermodynamic instability
of the CFT (a new phase which is entropically dominant over the black hole
phase) to a tunneling instability of the black hole towards the supertube-black
hole bound state. This generalizes the results of ArXiv:1108.0411 [hep-th],
which mapped an entropy enigma in the bulk to the dual CFT in a supersymmetric
setup.Comment: 28 pages + appendix, 15 figures, v2: References added, typos
corrected. Version published in JHE
On the kinematics of the Local cosmic void
We collected the existing data on the distances and radial velocities of
galaxies around the Local Void in the Aquila/Hercules to examine the peculiar
velocity field induced by its underdensity. A sample of 1056 galaxies with
distances measured from the Tip of the Red Giant Branch, the Cepheid
luminosity, the SNIa luminosity, the surface brightness fluctuation method, and
the Tully-Fisher relation has been used for this purpose. The amplitude of
outflow is found to be ~300 km/s. The galaxies located within the void produce
the mean intra-void number density about 1/5 of the mean external number
density of galaxies. The void's population has a lower luminosity and a later
morphological type with the medians: M_B = -15.7^m and T = 8 (Sdm),
respectively.Comment: Version 1. 14 pages, 8 figures, 2 tables. Accepted to Astrophysics,
Volume 54, Issue
Chiral Generations on Intersecting 5-branes in Heterotic String Theory
We show that there exist two 27 and one 27 bar of E6, net one D=4, N=1 chiral
matter supermultiplet as zero modes localized on the intersection of two
5-branes in the E8 x E8 heterotic string theory. The smeared intersecting
5-brane solution is used via the standard embedding to construct a heterotic
background, which provides, after a compactification of some of the transverse
dimensions, a five-dimensional Randall-Sundrum II like brane-world set-up in
heterotic string theory. As a by-product, we present a new proof of anomaly
cancellation between those from the chiral matter and the anomaly inflow onto
the brane without small instanton.Comment: 26 pages, 5 figures; references added, typo correcte
Structure and mechanism of human DNA polymerase η
The variant form of the human syndrome xeroderma pigmentosum (XPV) is caused by a deficiency in DNA polymerase eta (Pol eta), a DNA polymerase that enables replication through ultraviolet-induced pyrimidine dimers. Here we report high-resolution crystal structures of human Pol eta at four consecutive steps during DNA synthesis through cis-syn cyclobutane thymine dimers. Pol eta acts like a 'molecular splint' to stabilize damaged DNA in a normal B-form conformation. An enlarged active site accommodates the thymine dimer with excellent stereochemistry for two-metal ion catalysis. Two residues conserved among Pol eta orthologues form specific hydrogen bonds with the lesion and the incoming nucleotide to assist translesion synthesis. On the basis of the structures, eight Pol eta missense mutations causing XPV can be rationalized as undermining the molecular splint or perturbing the active-site alignment. The structures also provide an insight into the role of Pol eta in replicating through D loop and DNA fragile sites
Revised Lithostratigraphy of the Sonsela Member (Chinle Formation, Upper Triassic) in the Southern Part of Petrified Forest National Park, Arizona
BACKGROUND: Recent revisions to the Sonsela Member of the Chinle Formation in Petrified Forest National Park have presented a three-part lithostratigraphic model based on unconventional correlations of sandstone beds. As a vertebrate faunal transition is recorded within this stratigraphic interval, these correlations, and the purported existence of a depositional hiatus (the Tr-4 unconformity) at about the same level, must be carefully re-examined. METHODOLOGY/PRINCIPAL FINDINGS: Our investigations demonstrate the neglected necessity of walking out contacts and mapping when constructing lithostratigraphic models, and providing UTM coordinates and labeled photographs for all measured sections. We correct correlation errors within the Sonsela Member, demonstrate that there are multiple Flattops One sandstones, all of which are higher than the traditional Sonsela sandstone bed, that the Sonsela sandstone bed and Rainbow Forest Bed are equivalent, that the Rainbow Forest Bed is higher than the sandstones at the base of Blue Mesa and Agate Mesa, that strata formerly assigned to the Jim Camp Wash beds occur at two stratigraphic levels, and that there are multiple persistent silcrete horizons within the Sonsela Member. CONCLUSIONS/SIGNIFICANCE: We present a revised five-part model for the Sonsela Member. The units from lowest to highest are: the Camp Butte beds, Lot's Wife beds, Jasper Forest bed (the Sonsela sandstone)/Rainbow Forest Bed, Jim Camp Wash beds, and Martha's Butte beds (including the Flattops One sandstones). Although there are numerous degradational/aggradational cycles within the Chinle Formation, a single unconformable horizon within or at the base of the Sonsela Member that can be traced across the entire western United States (the "Tr-4 unconformity") probably does not exist. The shift from relatively humid and poorly-drained to arid and well-drained climatic conditions began during deposition of the Sonsela Member (low in the Jim Camp Wash beds), well after the Carnian-Norian transition
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