3C 273 with NuSTAR: Unveiling the Active Galactic Nucleus

We present results from a 244 ks NuSTAR observation of 3C 273 obtained during a cross-calibration campaign with the Chandra, INTEGRAL, Suzaku, Swift, and XMM-Newton observatories. We show that the spectrum, when fit with a power-law model using data from all observatories except INTEGRAL over the 1–78 keV band, leaves significant residuals in the NuSTAR data between 30 and 78 keV. The NuSTAR 3–78 keV spectrum is well described by an exponentially cutoff power law (Γ = 1.646 ± 0.006, E_(cutoff) = 202_(-34)^(+51) keV) with a weak reflection component from cold, dense material. There is also evidence for a weak (EW = 23 ± 11 eV) neutral iron line. We interpret these features as arising from coronal emission plus reflection off an accretion disk or distant material. Beyond 80 keV INTEGRAL data show clear excess flux relative to an extrapolation of the active galactic nucleus model fit to NuSTAR. This high-energy power law is consistent with the presence of a beamed jet, which begins to dominate over emission from the inner accretion flow at 30–40 keV. Modeling the jet locally (in the NuSTAR + INTEGRAL band) as a power law, we find that the coronal component is fit by Γ_(AGN) = 1.638 ± 0.045, E_(cutoff) = 47 ± 15 keV, and jet photon index by Γ_(jet) = 1.05 ± 0.4. We also consider Fermi/LAT observations of 3C 273, and here the broadband spectrum of the jet can be described by a log-parabolic model, peaking at ~2 MeV. Finally, we investigate the spectral variability in the NuSTAR band and find an inverse correlation between flux and Γ

Dynamical Zodiacal Cloud Models Constrained by High Resolution Spectroscopy of the Zodiacal Light (Icarus, in press)

The simulated Doppler shifts of the solar Mg I Fraunhofer line produced by scattering on the solar light by asteroidal, cometary, and trans-Neptunian dust particles are compared with the shifts obtained by Wisconsin H-Alpha Mapper (WHAM) spectrometer. The simulated spectra are based on the results of integrations of the orbital evolution of particles. The deviation of the derived spectral parameters for various sources of dust used in the model reached maximum at the elongation (measured eastward from the Sun) between 90 deg and 120 deg. For the future zodiacal light Doppler shifts measurements, it is important to pay a particular attention to observing at this elongation range. At the elongations of the fields observed by WHAM, the model-predicted Doppler shifts were close to each other for several scattering functions considered. Therefore the main conclusions of our paper don't depend on a scattering function and mass distribution of particles if they are reasonable. A comparison of the dependencies of the Doppler shifts on solar elongation and the mean width of the Mg I line modeled for different sources of dust with those obtained from the WHAM observations shows that the fraction of cometary particles in zodiacal dust is significant and can be dominant. Cometary particles originating inside Jupiter's orbit and particles originating beyond Jupiter's orbit (including trans-Neptunian dust particles) can contribute to zodiacal dust about 1/3 each, with a possible deviation from 1/3 up to 0.1-0.2. The fraction of asteroidal dust is estimated to be about 0.3-0.5. The mean eccentricities of zodiacal particles located at 1-2 AU from the Sun that better fit the WHAM observations are between 0.2 and 0.5, with a more probable value of about 0.3.Comment: Icarus, in pres

A Novel Adaptive Method for the Analysis of Next-Generation Sequencing Data to Detect Complex Trait Associations with Rare Variants Due to Gene Main Effects and Interactions

There is solid evidence that rare variants contribute to complex disease etiology. Next-generation sequencing technologies make it possible to uncover rare variants within candidate genes, exomes, and genomes. Working in a novel framework, the kernel-based adaptive cluster (KBAC) was developed to perform powerful gene/locus based rare variant association testing. The KBAC combines variant classification and association testing in a coherent framework. Covariates can also be incorporated in the analysis to control for potential confounders including age, sex, and population substructure. To evaluate the power of KBAC: 1) variant data was simulated using rigorous population genetic models for both Europeans and Africans, with parameters estimated from sequence data, and 2) phenotypes were generated using models motivated by complex diseases including breast cancer and Hirschsprung's disease. It is demonstrated that the KBAC has superior power compared to other rare variant analysis methods, such as the combined multivariate and collapsing and weight sum statistic. In the presence of variant misclassification and gene interaction, association testing using KBAC is particularly advantageous. The KBAC method was also applied to test for associations, using sequence data from the Dallas Heart Study, between energy metabolism traits and rare variants in ANGPTL 3,4,5 and 6 genes. A number of novel associations were identified, including the associations of high density lipoprotein and very low density lipoprotein with ANGPTL4. The KBAC method is implemented in a user-friendly R package

Multi-decadal changes in tundra environments and ecosystems: Synthesis of the International Polar Year-Back to the Future Project (IPY-BTF).

Understanding the responses of tundra systems to global change has global implications. Most tundra regions lack sustained environmental monitoring and one of the only ways to document multi-decadal change is to resample historic research sites. The International Polar Year (IPY) provided a unique opportunity for such research through the Back to the Future (BTF) project (IPY project #512). This article synthesizes the results from 13 papers within this Ambio Special Issue. Abiotic changes include glacial recession in the Altai Mountains, Russia; increased snow depth and hardness, permafrost warming, and increased growing season length in sub-arctic Sweden; drying of ponds in Greenland; increased nutrient availability in Alaskan tundra ponds, and warming at most locations studied. Biotic changes ranged from relatively minor plant community change at two sites in Greenland to moderate change in the Yukon, and to dramatic increases in shrub and tree density on Herschel Island, and in sub-arctic Sweden. The population of geese tripled at one site in northeast Greenland where biomass in non-grazed plots doubled. A model parameterized using results from a BTF study forecasts substantial declines in all snowbeds and increases in shrub tundra on Niwot Ridge, Colorado over the next century. In general, results support and provide improved capacities for validating experimental manipulation, remote sensing, and modeling studies

A Search for Extended Ultraviolet Disk (XUV-disk) Galaxies in the Local Universe

We have initiated a search for extended ultraviolet disk (XUV-disk) galaxies in the local universe. Herein, we compare GALEX UV and visible--NIR images of 189 nearby (D$<$40 Mpc) S0--Sm galaxies included in the GALEX Atlas of Nearby Galaxies and present the first catalogue of XUV-disk galaxies. We find that XUV-disk galaxies are surprisingly common but have varied relative (UV/optical) extent and morphology. Type~1 objects (\ga20% incidence) have structured, UV-bright/optically-faint emission features in the outer disk, beyond the traditional star formation threshold. Type~2 XUV-disk galaxies ($\sim$10% incidence) exhibit an exceptionally large, UV-bright/optically-low-surface-brightness (LSB) zone having blue $UV-K_s$ outside the effective extent of the inner, older stellar population, but not reaching extreme galactocentric distance. If the activity occuring in XUV-disks is episodic, a higher fraction of present-day spirals could be influenced by such outer disk star formation. Type~1 disks are associated with spirals of all types, whereas Type~2 XUV-disks are predominantly found in late-type spirals. Type~2 XUV-disks are forming stars quickly enough to double their [presently low] stellar mass in the next Gyr (assuming a constant SF rate). XUV-disk galaxies of both types are systematically more gas-rich than the general galaxy population. Minor external perturbation may stimulate XUV-disk incidence, at least for Type~1 objects. XUV-disks are the most actively evolving galaxies growing via inside-out disk formation in the current epoch, and may constitute a segment of the galaxy population experiencing significant, continued gas accretion from the intergalactic medium or neighboring objects.Comment: 83 pages, 16 figures, 2 tables. Appearing in the GALEX special issue of ApJS. (A version with high quality figures and proof corrections can be found at http://www.journals.uchicago.edu/toc/apjs/173/2

Seasonal and Ontogenetic Changes in Movement Patterns of Sixgill Sharks

Understanding movement patterns is fundamental to population and conservation biology. The way an animal moves through its environment influences the dynamics of local populations and will determine how susceptible it is to natural or anthropogenic perturbations. It is of particular interest to understand the patterns of movement for species which are susceptible to human activities (e.g. fishing), or that exert a large influence on community structure, such as sharks.We monitored the patterns of movement of 34 sixgill sharks Hexanchus griseus using two large-scale acoustic arrays inside and outside Puget Sound, Washington, USA. Sixgill sharks were residents in Puget Sound for up to at least four years before making large movements out of the estuary. Within Puget Sound, sixgills inhabited sites for several weeks at a time and returned to the same sites annually. Across four years, sixgills had consistent seasonal movements in which they moved to the north from winter to spring and moved to the south from summer to fall. Just prior to leaving Puget Sound, sixgills altered their behavior and moved twice as fast among sites. Nineteen of the thirty-four sixgills were detected leaving Puget Sound for the outer coast. Three of these sharks returned to Puget Sound.For most large marine predators, we have a limited understanding of how they move through their environment, and this clouds our ability to successfully manage their populations and their communities. With detailed movement information, such as that being uncovered with acoustic monitoring, we can begin to quantify the spatial and temporal impacts of large predators within the framework of their ecosystems

Mining the LIPG Allelic Spectrum Reveals the Contribution of Rare and Common Regulatory Variants to HDL Cholesterol

Genome-wide association studies (GWAS) have successfully identified loci associated with quantitative traits, such as blood lipids. Deep resequencing studies are being utilized to catalogue the allelic spectrum at GWAS loci. The goal of these studies is to identify causative variants and missing heritability, including heritability due to low frequency and rare alleles with large phenotypic impact. Whereas rare variant efforts have primarily focused on nonsynonymous coding variants, we hypothesized that noncoding variants in these loci are also functionally important. Using the HDL-C gene LIPG as an example, we explored the effect of regulatory variants identified through resequencing of subjects at HDL-C extremes on gene expression, protein levels, and phenotype. Resequencing a portion of the LIPG promoter and 5′ UTR in human subjects with extreme HDL-C, we identified several rare variants in individuals from both extremes. Luciferase reporter assays were used to measure the effect of these rare variants on LIPG expression. Variants conferring opposing effects on gene expression were enriched in opposite extremes of the phenotypic distribution. Minor alleles of a common regulatory haplotype and noncoding GWAS SNPs were associated with reduced plasma levels of the LIPG gene product endothelial lipase (EL), consistent with its role in HDL-C catabolism. Additionally, we found that a common nonfunctional coding variant associated with HDL-C (rs2000813) is in linkage disequilibrium with a 5′ UTR variant (rs34474737) that decreases LIPG promoter activity. We attribute the gene regulatory role of rs34474737 to the observed association of the coding variant with plasma EL levels and HDL-C. Taken together, the findings show that both rare and common noncoding regulatory variants are important contributors to the allelic spectrum in complex trait loci