Fluid models and simulations of biological cell phenomena

The dynamics of coated droplets are examined within the context of biofluids. Of specific interest is the manner in which the shape of a droplet, the motion within it as well as that of aggregates of droplets can be controlled by the modulation of surface properties and the extent to which such fluid phenomena are an intrinsic part of cellular processes. From the standpoint of biology, an objective is to elucidate some of the general dynamical features that affect the disposition of an entire cell, cell colonies and tissues. Conventionally averaged field variables of continuum mechanics are used to describe the overall global effects which result from the myriad of small scale molecular interactions. An attempt is made to establish cause and effect relationships from correct dynamical laws of motion rather than by what may have been unnecessary invocation of metabolic or life processes. Several topics are discussed where there are strong analogies droplets and cells including: encapsulated droplets/cell membranes; droplet shape/cell shape; adhesion and spread of a droplet/cell motility and adhesion; and oams and multiphase flows/cell aggregates and tissues. Evidence is presented to show that certain concepts of continuum theory such as suface tension, surface free energy, contact angle, bending moments, etc. are relevant and applicable to the study of cell biology

A note concerning topography and inertial currents

A simple steady dynamical model of inertial currents incorporating the effects of bottom topography is studied. The results of this analysis and those of preceding investigations indicate that topography may exert considerable influence on the structure of the Gulf Stream, on its separation point from the coastline, and on its subsequent meander pattern

On the excitation of inertial modes in an experimental spherical Couette flow

Spherical Couette flow (flow between concentric rotating spheres) is one of flows under consideration for the laboratory magnetic dynamos. Recent experiments have shown that such flows may excite Coriolis restored inertial modes. The present work aims to better understand the properties of the observed modes and the nature of their excitation. Using numerical solutions describing forced inertial modes of a uniformly rotating fluid inside a spherical shell, we first identify the observed oscillations of the Couette flow with non-axisymmetric, retrograde, equatorially anti-symmetric inertial modes, confirming first attempts using a full sphere model. Although the model has no differential rotation, identification is possible because a large fraction of the fluid in a spherical Couette flow rotates rigidly. From the observed sequence of the excited modes appearing when the inner sphere is slowed down by step, we identify a critical Rossby number associated with a given mode and below which it is excited. The matching between this critical number and the one derived from the phase velocity of the numerically computed modes shows that these modes are excited by an instability likely driven by the critical layer that develops in the shear layer staying along the tangent cylinder of the inner sphere.Comment: 11 pages, 17 figure

Self-consistent simulations of a von K\'arm\'an type dynamo in a spherical domain with metallic walls

We have performed numerical simulations of boundary-driven dynamos using a three-dimensional non-linear magnetohydrodynamical model in a spherical shell geometry. A conducting fluid of magnetic Prandtl number Pm=0.01 is driven into motion by the counter-rotation of the two hemispheric walls. The resulting flow is of von K\'arm\'an type, consisting of a layer of zonal velocity close to the outer wall and a secondary meridional circulation. Above a certain forcing threshold, the mean flow is unstable to non-axisymmetric motions within an equatorial belt. For fixed forcing above this threshold, we have studied the dynamo properties of this flow. The presence of a conducting outer wall is essential to the existence of a dynamo at these parameters. We have therefore studied the effect of changing the material parameters of the wall (magnetic permeability, electrical conductivity, and thickness) on the dynamo. In common with previous studies, we find that dynamos are obtained only when either the conductivity or the permeability is sufficiently large. However, we find that the effect of these two parameters on the dynamo process are different and can even compete to the detriment of the dynamo. Our self-consistent approach allow us to analyze in detail the dynamo feedback loop. The dynamos we obtain are typically dominated by an axisymmetric toroidal magnetic field and an axial dipole component. We show that the ability of the outer shear layer to produce a strong toroidal field depends critically on the presence of a conducting outer wall, which shields the fluid from the vacuum outside. The generation of the axisymmetric poloidal field, on the other hand, occurs in the equatorial belt and does not depend on the wall properties.Comment: accepted for publication in Physical Review

Overcomplete steerable pyramid filters and rotation invariance

A given (overcomplete) discrete oriented pyramid may be converted into a steerable pyramid by interpolation. We present a technique for deriving the optimal interpolation functions (otherwise called 'steering coefficients'). The proposed scheme is demonstrated on a computationally efficient oriented pyramid, which is a variation on the Burt and Adelson (1983) pyramid. We apply the generated steerable pyramid to orientation-invariant texture analysis in order to demonstrate its excellent rotational isotropy. High classification rates and precise rotation identification are demonstrated

Turbulent Vortex Flow Responses at the AB Interface in Rotating Superfluid 3He-B

In a rotating two-phase sample of 3He-B and magnetic-field stabilized 3He-A the large difference in mutual friction dissipation at 0.20 Tc gives rise to unusual vortex flow responses. We use noninvasive NMR techniques to monitor spin down and spin up of the B-phase superfluid component to a sudden change in the rotation velocity. Compared to measurements at low field with no A-phase, where these responses are laminar in cylindrically symmetric flow, spin down with vortices extending across the AB interface is found to be faster, indicating enhanced dissipation from turbulence. Spin up in turn is slower, owing to rapid annihilation of remanent vortices before the rotation increase. As confirmed by both our NMR signal analysis and vortex filament calculations, these observations are explained by the additional force acting on the B-phase vortex ends at the AB interface.Comment: 6 pages, 6 figure

Breastfeeding and timing of pubertal onset in girls: a multiethnic population-based prospective cohort study.

BackgroundEarly puberty is associated with higher risk of adverse health and behavioral outcomes throughout adolescence and adulthood. US girls are experiencing earlier puberty with substantial racial/ethnic differences. We examined the association between breastfeeding and pubertal timing to identify modifiable risk factors of early puberty and potential sources of racial/ethnic differences in the timing of pubertal development.MethodsA prospective cohort study of 3331 racially/ethnically diverse girls born at Kaiser Permanente Northern California (KPNC) between 2004 and 06. All data were obtained from KPNC electronic clinical and administrative datasets. Mother-reported duration of breastfeeding was obtained from questionnaires administered at each 'well-baby' check-up exam throughout the baby's first year and categorized as 'Not breastfed', 'Breastfed < 6 months', and 'Breastfed ≥ 6 months'. Pubertal development data used Tanner stages assessed by pediatricians during routine pediatric checkups starting at age 6. Pubertal onset was defined as transition from Tanner Stage 1 to Tanner Stage 2+ for breast (thelarche) and pubic hair (pubarche). Weibull regression models accommodating for left, right, and interval censoring were used in all analyses. Models were adjusted for maternal age, education, race/ethnicity, parity and prepubertal body mass index (BMI). We also examined race/ethnicity as a potential effect modifier of these associations.ResultsNot breastfeeding was associated with earlier onset of breast and pubic hair development compared to breastfeeding ≥6 months (adjusted hazard ratio [HR]: 1.25; 95% confidence interval [CI]: 1.07-1.46; HR: 1.24; 95% CI: 1.05-1.46, respectively). Breastfeeding for < 6 months was also associated with the risk of earlier pubic hair development (HR: 1.14; 95% CI: 1.00-1.30, compared to breastfeeding ≥6 months). Inclusion of girls' prepubertal BMI slightly attenuated the association between breastfeeding and timing of breast onset but remained significant. The association between not breastfeeding and early breast development may be stronger among African American girls (HR: 1.92; 95% CI: 1.01-3.66, no breastfeeding vs. ≥6 months) than other racial/ethnic groups.ConclusionsBreastfeeding is an independent predictor of pubertal onset in girls, and the strength of the association may vary by race/ethnicity. Providing breastfeeding support and lactation education for high risk mothers may help prevent earlier pubertal onset and promote positive health outcomes later in life

A review of recent determinations of the composition and surface pressure of the atmos- phere of mars

Recent determinations of composition and surface pressure of Mars atmospher

Super Stability of Laminar Vortex Flow in Superfluid 3He-B

Vortex flow remains laminar up to large Reynolds numbers (Re~1000) in a cylinder filled with 3He-B. This is inferred from NMR measurements and numerical vortex filament calculations where we study the spin up and spin down responses of the superfluid component, after a sudden change in rotation velocity. In normal fluids and in superfluid 4He these responses are turbulent. In 3He-B the vortex core radius is much larger which reduces both surface pinning and vortex reconnections, the phenomena, which enhance vortex bending and the creation of turbulent tangles. Thus the origin for the greater stability of vortex flow in 3He-B is a quantum phenomenon. Only large flow perturbations are found to make the responses turbulent, such as the walls of a cubic container or the presence of invasive measuring probes inside the container.Comment: 4 pages, 6 figure

Anisotropy and non-universality in scaling laws of the large scale energy spectrum in rotating turbulence

Rapidly rotating turbulent flow is characterized by the emergence of columnar structures that are representative of quasi-two dimensional behavior of the flow. It is known that when energy is injected into the fluid at an intermediate scale $L_f$, it cascades towards smaller as well as larger scales. In this paper we analyze the flow in the \textit{inverse cascade} range at a small but fixed Rossby number, {$\mathcal{R}o_f \approx 0.05$}. Several {numerical simulations with} helical and non-helical forcing functions are considered in periodic boxes with unit aspect ratio. In order to resolve the inverse cascade range with {reasonably} large Reynolds number, the analysis is based on large eddy simulations which include the effect of helicity on eddy viscosity and eddy noise. Thus, we model the small scales and resolve explicitly the large scales. We show that the large-scale energy spectrum has at least two solutions: one that is consistent with Kolmogorov-Kraichnan-Batchelor-Leith phenomenology for the inverse cascade of energy in two-dimensional (2D) turbulence with a {$\sim k_{\perp}^{-5/3}$} scaling, and the other that corresponds to a steeper {$\sim k_{\perp}^{-3}$} spectrum in which the three-dimensional (3D) modes release a substantial fraction of their energy per unit time to 2D modes. {The spectrum that} emerges {depends on} the anisotropy of the forcing function{,} the former solution prevailing for forcings in which more energy is injected into 2D modes while the latter prevails for isotropic forcing. {In the case of anisotropic forcing, whence the energy} goes from the 2D to the 3D modes at low wavenumbers, large-scale shear is created resulting in another time scale $\tau_{sh}$, associated with shear, {thereby producing} a $\sim k^{-1}$ spectrum for the {total energy} with the 2D modes still following a {$\sim k_{\perp}^{-5/3}$} scaling