299 research outputs found

    Dominance-based rough set approach and analytic network process for assessing urban transformation scenarios

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    For half a century, the significant development of intensive farming has led to a massive use of products such as pesticides. The excessive use of these substances has contaminated surface water and groundwater. Drinking water extraction points have also had to be abandoned. Some thirty years ago, in the southwest of France, a group of farmers decided to improve their farming methods, as well as developing new Best Environmental Practices, such as grass strips along streams and riparian forests. By combining the use of ELECTRE TRI-C multi-criteria model with a GIS, we were able to characterise the contribution of each farming area to the risk of surface water contamination with pesticides. We also assessed the effectiveness of different environmental practices. We found that the use of Best Environmental Practices led to a reduction in the risk of pesticides transfer. This methodology re-enforces decision support tools for water resource managers and agricultural and environmental stakeholders

    Effect of the Glucagon-Like Peptide-1 Receptor Agonists on Autonomic Function in Subjects with Diabetes: A Systematic Review and Meta-Analysis

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    Background: In addition to the metabolic effects in diabetes, glucagon-like peptide 1 receptor (GLP-1R) agonists lead to a small but substantial increase in heart rate (HR). However, the GLP-1R actions on the autonomic nervous system (ANS) in diabetes remain debated. Therefore, this meta-analysis evaluates the effect of GLP-1R agonist on measures of ANS function in diabetes. Methods: According to the Cochrane Collaboration and Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) statement, we conducted a meta-analysis considering clinical trials in which the autonomic function was evaluated in diabetic subjects chronically treated with GLP-1R agonists. The outcomes were the change of ANS function measured by heart rate variability (HRV) and cardiac autonomic reflex tests (CARTs). Results: In the studies enrolled, HR significantly increased after treatment (P<0.001), whereas low frequency/high frequency ratio did not differ (P=0.410); no changes in other measures of HRV were detected. Considering CARTs, only the 30:15 value derived from lying-to-standing test was significantly lower after treatment (P=0.002), but only two studies reported this measurement. No differences in other CARTs outcome were observed. Conclusion: The meta-analysis confirms the HR increase but seems to exclude an alteration of the sympatho-vagal balance due to chronic treatment with GLP-1R agonists in diabetes, considering the available measures of ANS function

    How can school help victims of violence? Evaluation of online training for European schools' staff from a multidisciplinary approach

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    The interventions used to prevent or treat violence against children, particularly sexual abuse, tend to only consider the target audience as their main source of data. We tested the effect of an online training for school staff members in Europe through three studies. In Study I, we interviewed 5 adult women (Mage = 49.2, SD = 5.81) who were victims of sexual abuse during childhood to assess what school could have done during that time to protect them. Through Study II, we collected data on 66 school staff members to assess feasibility (based on quantitative indicators) and to explore the changes they would make to their everyday practice due to the training course (using qualitative analysis). In Study III, we used network analysis to assess to what extent the actions described by school staff in Study II met the needs expressed by the victims in Study I. Findings of Study I revealed new proposals from the victims’ perspective, such as working with the perpetrators. Study II showed the feasibility of training and identified five types of action that school staff members will include in their everyday working dynamics due to the training: detection (e.g., Greater attention to relationships with peers), reporting (e.g., Now I know that suspecting a case of child abuse is enough to report), everyday practices (e.g., Introducing a calming space), changes at school level (e.g., Propose the training course to the school management team) or practices that could belong to more than one category (e.g., Greater awareness of the activities undertaken by the school). Study III provided evidence that some of these changes (e.g., reporting without looking for proof) were in line with some of the victims’ expectations (e.g., listen to the children). We also identified gaps that need to be further developed

    Can endometrial arylsulfatase A activity predict the onset of endometrial polyps over the years?

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    PURPOSE: To assess if arylsulfatase A activity (ASA) and sulfatide (SL) concentration in the human endometrium can be predictive of the development of endometrial polyps over the years, since ASA activity reflects the endometrial sensitivity to hormones. METHODS: ASA activity and SL concentration were determined by biochemical procedures on endometrial samples collected between 1990 and 1994 in non-menopausal women. These women underwent a new endometrial sampling following the clinical indication some years after the first endometrial sampling. The histological assessment of the second endometrial specimens found four patients with normal endometrial pattern and 10 patients with one or more endometrial polyps. ASA activity/years elapsed and SL concentration/years elapsed were compared using two tailed Mann-Whitney test for unpaired data between patients with normal pattern and patients with endometrial polyps. RESULTS: Median ASA activities were 2.62 (normal pattern) versus 1.85 (endometrial polyps) nmol hydrolized substrate/min. Median activity/years elapsed is higher in patients with second endometrial sample presenting normal pattern (p=0.006) and median SL concentration/years elapsed does not differ significantly among groups, even if median SL concentration seems to be higher in patients who subsequently developed polyps (1031 µg/g of fresh tissue versus 341,5 µg/g of fresh tissue). CONCLUSIONS: ASA activity can predict the onset of endometrial polyps over the years. OBJETIVO: Avaliar se a atividade da arilsulfatase A (ASA) e a concentração de sulfatida (SL) no endométrio humano pode ser preditivo em relação ao desenvolvimento de pólipos endometriais ao longo dos anos, posto que atividade da ASA reflete a sensibilidade do endométrio aos hormônios. MÉTODOS: A atividade da ASA, assim como a concentração de SL, foi determinada por meio de procedimentos bioquímicos em amostras de endométrio coletadas entre 1990 e 1994, em mulheres que não se encontravam na menopausa. Essas mulheres foram submetidas a uma nova amostragem endometrial após indicação clínica alguns anos depois da primeira amostragem endometrial. A avaliação histológica dos segundos espécimes endometriais permitiu identificar quatro pacientes com padrão endometrial normal e 10 com um ou mais pólipos endometriais. A atividade da ASA/anos depois e a concentração de SL/anos depois foram comparadas, utilizando o teste bilateral U de Mann-Whitney para dados não pareados entre as pacientes com padrão normal e as pacientes com pólipos endometriais. RESULTADOS: A ativitade da ASA foi 2,62 (padrão normal) em comparação com 1,85 (endometrial pólipos) de substrato hidrolisado/min. A atividade da ASA/anos depois é maior em pacientes com segunda amostra endometrial a apresentarem um padrão normal (p=0,006), e a concentração mediana de SL/anos depois não difere de forma significativa entre os grupos, apesar de a concentração mediana de SL parecer maior em pacientes que posteriormente desenvolveram pólipos (1031 µg/g de tecido fresco em comparação com 341,5 µg/g de tecido fresco). CONCLUSÕES: A atividade da ASA pode prever a aparição de pólipos endometriais ao longo dos anos

    Mulher-Maravilha no Brasil: fãs, feminismo e práticas nas redes sociais

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    O artigo analisa as atividades de fãs da Mulher-Maravilha nas redes sociais. A partir do conteúdo criado e compartilhado pelos fãs em duas comunidades no Facebook, observamos parâmetros na circulação de conteúdo voltado à personagem e à cultura pop, bem como as interações dentro do fandom. Em exploração argumentativa, utilizamos exemplos de postagens, sites e redes sociais que contribuem com a análise de comportamento dos fãs em relação à interação digital, como criação de conteúdo (fanfics e fanarts), emancipação feminina e outras relações de afeto. Utilizamos autores como Booth (2010) e Jenkins (2009 e 2015), dentre outros que nos auxiliarão a compreender a cultura participativa dos fãs da Mulher-Maravilha. Palavra-chave: fãs; Mulher-Maravilha; cultura popular, redes sociais

    Os efeitos do processo de produção handmade na percepção de autenticidade de marca e intenção de compra

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    Orientador : Paulo Henrique Muller PradoTrabalho de Conclusão de Curso (artigo) (especialização) – Universidade Federal do Paraná, Setor de Ciências Sociais Aplicadas. Curso de Especialização MBA em MarketingInclui referênciasResumo: Na contramão da produção em massa e da industrialização, o handmade (feito à mão) nunca foi tão valorizado. Seja pelo consumo consciente, ressignificação de hábitos de consumo, busca por diferenciação, relacionamento próximo com as marcas ou valorização do trabalho humano, o processo de produção artesanal está sendo procurado pelos consumidores e utilizado como uma ferramenta de atração pelas marcas. O objetivo desta pesquisa é analisar a influência do Processo de Produção (handmade vs. Homem + máquina vs. Machine-made) na Autenticidade de Marca Percebida e na Intenção de Compra. Através de um experimento testamos 4 hipóteses e diferentemente do esperado, os resultados trazem insights e apontam diversos caminhos para pesquisas futuras
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