391 research outputs found
Cardiovascular-renal axis disorders in the domestic dog and cat: a veterinary consensus statement
OBJECTIVES
There is a growing understanding of the complexity of interplay between renal and cardiovascular systems in both health and disease. The medical profession has adopted the term "cardiorenal syndrome" (CRS) to describe the pathophysiological relationship between the kidney and heart in disease. CRS has yet to be formally defined and described by the veterinary profession and its existence and importance in dogs and cats warrant investigation. The CRS Consensus Group, comprising nine veterinary cardiologists and seven nephrologists from Europe and North America, sought to achieve consensus around the definition, pathophysiology, diagnosis and management of dogs and cats with "cardiovascular-renal disorders" (CvRD). To this end, the Delphi formal methodology for defining/building consensus and defining guidelines was utilised.
METHODS
Following a literature review, 13 candidate statements regarding CvRD in dogs and cats were tested for consensus, using a modified Delphi method. As a new area of interest, well-designed studies, specific to CRS/CvRD, are lacking, particularly in dogs and cats. Hence, while scientific justification of all the recommendations was sought and used when available, recommendations were largely reliant on theory, expert opinion, small clinical studies and extrapolation from data derived from other species.
RESULTS
Of the 13 statements, 11 achieved consensus and 2 did not. The modified Delphi approach worked well to achieve consensus in an objective manner and to develop initial guidelines for CvRD.
DISCUSSION
The resultant manuscript describes consensus statements for the definition, classification, diagnosis and management strategies for veterinary patients with CvRD, with an emphasis on the pathological interplay between the two organ systems. By formulating consensus statements regarding CvRD in veterinary medicine, the authors hope to stimulate interest in and advancement of the understanding and management of CvRD in dogs and cats. The use of a formalised method for consensus and guideline development should be considered for other topics in veterinary medicine
Transiting extrasolar planetary candidates in the Galactic bulge
More than 200 extrasolar planets have been discovered around relatively
nearby stars, primarily through the Doppler line shifts owing to the reflex
motions of their host stars, and more recently through transits of some planets
across the face of the host stars. The detection of planets with the shortest
known periods, 1.2 to 2.5 days, has mainly resulted from transit surveys which
have generally targeted stars more massive than 0.75 M_sun. Here we report the
results from a planetary transit search performed in a rich stellar field
towards the Galactic bulge. We discovered 16 candidates with orbital periods
between 0.4 and 4.2 days, five of which orbit stars of 0.44 to 0.75 M_sun. In
two cases, radial-velocity measurements support the planetary nature of the
companions. Five candidates have orbital periods below 1.0 day, constituting a
new class of ultra-short-period planets (USPPs), which occur only around stars
of less than 0.88 M_sun. This indicates that those orbiting very close to more
luminous stars might be evaporatively destroyed, or that jovian planets around
lower-mass stars might migrate to smaller radii.Comment: To appear in October 5, 2006 issue of Natur
Observations of the pulsating subdwarf B star Feige 48: Constraints on evolution and companions
Since pulsating subdwarf B (sdBV or EC14026) stars were first discovered
(Kilkenny et al, 1997), observational efforts have tried to realize their
potential for constraining the interior physics of extreme horizontal branch
(EHB) stars. Difficulties encountered along the way include uncertain mode
identifications and a lack of stable pulsation mode properties. Here we report
on Feige 48, an sdBV star for which follow-up observations have been obtained
spanning more than four years, which shows some stable pulsation modes.
We resolve the temporal spectrum into five stable pulsation periods in the
range 340 to 380 seconds with amplitudes less than 1%, and two additional
periods that appear in one dataset each. The three largest amplitude
periodicities are nearly equally spaced, and we explore the consequences of
identifying them as a rotationally split l=1 triplet by consulting with a
representative stellar model.
The general stability of the pulsation amplitudes and phases allows us to use
the pulsation phases to constrain the timescale of evolution for this sdBV
star. Additionally, we are able to place interesting limits on any stellar or
planetary companion to Feige 48.Comment: accepted for publication in MNRA
Universal intermittent properties of particle trajectories in highly turbulent flows
We present a collection of eight data sets, from state-of-the-art experiments
and numerical simulations on turbulent velocity statistics along particle
trajectories obtained in different flows with Reynolds numbers in the range
. Lagrangian structure functions from all data sets
are found to collapse onto each other on a wide range of time lags, revealing a
universal statistics, and calling for a unified theoretical description.
Parisi-Frisch Multifractal theory, suitable extended to the dissipative scales
and to the Lagrangian domain, is found to capture intermittency of velocity
statistics over the whole three decades of temporal scales here investigated.Comment: 5 pages, 1 figure; content changed, references update
Evolutionary and pulsational properties of white dwarf stars
Abridged. White dwarf stars are the final evolutionary stage of the vast
majority of stars, including our Sun. The study of white dwarfs has potential
applications to different fields of astrophysics. In particular, they can be
used as independent reliable cosmic clocks, and can also provide valuable
information about the fundamental parameters of a wide variety of stellar
populations, like our Galaxy and open and globular clusters. In addition, the
high densities and temperatures characterizing white dwarfs allow to use these
stars as cosmic laboratories for studying physical processes under extreme
conditions that cannot be achieved in terrestrial laboratories. They can be
used to constrain fundamental properties of elementary particles such as axions
and neutrinos, and to study problems related to the variation of fundamental
constants.
In this work, we review the essentials of the physics of white dwarf stars.
Special emphasis is placed on the physical processes that lead to the formation
of white dwarfs as well as on the different energy sources and processes
responsible for chemical abundance changes that occur along their evolution.
Moreover, in the course of their lives, white dwarfs cross different
pulsational instability strips. The existence of these instability strips
provides astronomers with an unique opportunity to peer into their internal
structure that would otherwise remain hidden from observers. We will show that
this allows to measure with unprecedented precision the stellar masses and to
infer their envelope thicknesses, to probe the core chemical stratification,
and to detect rotation rates and magnetic fields. Consequently, in this work,
we also review the pulsational properties of white dwarfs and the most recent
applications of white dwarf asteroseismology.Comment: 85 pages, 28 figures. To be published in The Astronomy and
Astrophysics Revie
Pregnancy and low back pain
Back pain is ubiquitous in today’s society and is particularly common during pregnancy. There are multiple factors contributing to these symptoms during pregnancy including pelvic changes as well as alterations to loading. Potential imaging modalities are limited during pregnancy due to the desire to limit ionizing radiation exposure to the fetus. Treatments are generally conservative, exercise-based interventions and alternative modalities may also be considered. Low back pain associated with pregnancy does generally resolve postpartum
TRPV6 Determines the Effect of Vitamin D3 on Prostate Cancer Cell Growth
Despite remarkable advances in the therapy and prevention of prostate cancer it is still the second cause of death from cancer in industrialized countries. Many therapies initially shown to be beneficial for the patients were abandoned due to the high drug resistance and the evolution rate of the tumors. One of the prospective therapeutical agents even used in the first stage clinical trials, 1,25-dihydroxyvitamin D3, was shown to be either unpredictable or inefficient in many cases. We have already shown that TRPV6 calcium channel, which is the direct target of 1,25-dihydroxyvitamin D3 receptor, positively controls prostate cancer proliferation and apoptosis resistance (Lehen'kyi et al., Oncogene, 2007). However, how the known 1,25-dihydroxyvitamin D3 antiproliferative effects may be compatible with the upregulation of pro-oncogenic TRPV6 channel remains a mystery. Here we demonstrate that in low steroid conditions 1,25-dihydroxyvitamin D3 upregulates the expression of TRPV6, enchances the proliferation by increasing the number of cells entering into S-phase. We show that these pro-proliferative effects of 1,25-dihydroxyvitamin D3 are directly mediated via the overexpression of TRPV6 channel which increases calcium uptake into LNCaP cells. The apoptosis resistance of androgen-dependent LNCaP cells conferred by TRPV6 channel is drastically inversed when 1,25-dihydroxyvitamin D3 effects were combined with the successful TRPV6 knockdown. In addition, the use of androgen-deficient DU-145 and androgen-insensitive LNCaP C4-2 cell lines allowed to suggest that the ability of 1,25-dihydroxyvitamin D3 to induce the expression of TRPV6 channel is a crucial determinant of the success or failure of 1,25-dihydroxyvitamin D3-based therapies
Mechanisms of the reaction pi^-p --> a^0_0(980)n --> p-^0 eta n at high energies
The main dynamical mechanisms of the reaction at high energies, currently investigated at
Serpukhov and Brookhaven, are considered in detail. It is shown that the
observed forward peak in its differential cross section can be explained within
the framework of the Regge pole model only by the conspiring Regge
pole exchange. The tentative estimates of the absolute reaction cross section at GeV/c are obtained: nb and, in the forward direction,
nb/GeV. The contribution of the one pion exchange,
which is forbidden by -parity and which can rise owing to the
mixing, is also estimate. A role of the Regge cuts in
the non-flip helicity amplitude is briefly examined and a conclusion is made
that the contributions of the cuts have to be inessential in comparison with
the conspiring Regge pole exchange.Comment: 14 pages, Latex, 2 ps figure
Selective cancer-germline gene expression in pediatric brain tumors
Cancer-germline genes (CGGs) code for immunogenic antigens that are present in various human tumors and can be targeted by immunotherapy. Their expression has been studied in a wide range of human tumors in adults. We measured the expression of 12 CGGs in pediatric brain tumors, to identify targets for therapeutic cancer vaccines. Real Time PCR was used to quantify the expression of genes MAGE-A1, MAGE-A2, MAGE-A3, MAGE-A4, MAGE-A6, MAGE-A10, MAGE-A12, MAGE-C2, NY-ESO-1 and GAGE-1,2,8 in 50 pediatric brain tumors of different histological subtypes. Protein expression was examined with immunohistochemistry. Fifty-five percent of the medulloblastomas (n = 11), 86% of the ependymomas (n = 7), 40% of the choroid plexus tumors (n = 5) and 67% of astrocytic tumors (n = 27) expressed one or more CGGs. Immunohistochemical analysis confirmed qPCR results. With exception of a minority of tumors, the overall level of CGG expression in pediatric brain tumors was low. We observed a high expression of at least one CGG in 32% of the samples. CGG-encoded antigens are therefore suitable targets in a very selected group of pediatric patients with a brain tumor. Interestingly, glioblastomas from adult patients expressed CGGs more often and at significantly higher levels compared to pediatric glioblastomas. This observation is in line with the notion that pediatric and adult glioblastomas develop along different genetic pathways
Understanding the Cool DA White Dwarf, G29-38
The white dwarfs are promising laboratories for the study of cosmochronology
and stellar evolution. Through observations of the pulsating white dwarfs, we
can measure their internal structures and compositions, critical to
understanding post main sequence evolution, along with their cooling rates,
allowing us to calibrate their ages directly. The most important set of white
dwarf variables to measure are the oldest of the pulsators, the cool DAVs,
which have not previously been explored through asteroseismology due to their
complexity and instability. Through a time-series photometry data set spanning
ten years, we explore the pulsation spectrum of the cool DAV, G29-38 and find
an underlying structure of 19 (not including multiplet components) normal-mode,
probably l=1 pulsations amidst an abundance of time variability and linear
combination modes. Modelling results are incomplete, but we suggest possible
starting directions and discuss probable values for the stellar mass and
hydrogen layer size. For the first time, we have made sense out of the
complicated power spectra of a large-amplitude DA pulsator. We have shown its
seemingly erratic set of observed frequencies can be understood in terms of a
recurring set of normal-mode pulsations and their linear combinations. With
this result, we have opened the interior secrets of the DAVs to future
asteroseismological modelling, thereby joining the rest of the known white
dwarf pulsators.Comment: 29 pages including 5 figures To appear in ApJ 1 Mar 9
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