Adelantándose a la vida: Los recién nacidos prematuros y sus padres

Actualmente los recién nacidos antes de tiempo sobreviven a pesar de tener muy poco peso. Hace unas décadas el problema de los neonatólogos era qué podían hacer por bebés que pesaban 1500g., hoy su problema es qué podrían hacer con bebés que pesan 600-700g. En los últimos tiempos el progreso de la tecnología aplicada a la medicina y específicamente en lo referente a Cuidados Especiales Neonatales ha reducido notoriamente la tasa de mortalidad en esta etapa. Recién nacidos cada vez más pequeños sobreviven gracias a estos avances y a los equipos altamente especializados dedicados a ellos. La situación de parto prematuro, la separación temprana del vínculo madre-hijo y la internación prolongada de los bebes causa un gran impacto a nivel emocional en los padres. Por este motivo es que desde la creación del Centro de Tratamiento Intensivo Neonatal del Sanatorio No.3 de CASMU, el psicólogo se encuentra formando parte del equipo interdisciplinario que brinda asistencia a los recién nacidos prematuros y su familia. Se hará hincapié en el vínculo madre-bebé prematuro como fundamentación de la necesidad de una ‘licencia especial maternal’ para estas madres

Relaciones matrilineales de lobos marinos comunes de diferentes colonias del norte de Patagonia

La población del lobo marino común, Otaria flavescens (Of), del norte de Patagonia se encuentra en recuperación y expansión poblacional, mediante un proceso de recolonización particular en el cual el surgimiento de las nuevas colonias de cría no ocurre al azar en el espacio, sino que se ubican cerca de colonias reproductivas densas ya establecidas. Así la formación de nuevas colonias y la expansión poblacional serían la consecuencia de una dinámica compleja que involucra procesos de dispersión y selección de hábitat apropiado para reproducir, algún grado de fidelidad al sitio natal (filopatría) y diferencias en el éxito reproductivo en diferentes contextos de estructura social. En este trabajo se analizó si existe filopatría entre las hembras de Of de distintas colonias reproductivas.Fil: Grandi, Maria Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Centro para el Estudio de Sistemas Marinos; ArgentinaFil: Loizaga de Castro, Rocio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Centro para el Estudio de Sistemas Marinos; ArgentinaFil: Terán, Érika Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; ArgentinaFil: Santos, María Rita. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; ArgentinaFil: Bailliet, Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; ArgentinaFil: Crespo, Enrique Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Centro para el Estudio de Sistemas Marinos; Argentina. Universidad Nacional de la Patagonia "San Juan Bosco"; ArgentinaXI Congreso de la Sociedad Latinoamericana de Especialistas Mamíferos AcuáticosValparaisoChileSociedad Latinoamericana de Especialistas Mamíferos AcuáticosUniversidad de Valparaís

Instrument to assess research projects that apply for a fellowship by the Sociedad Argentina de Pediatría: Validation using the Delphi method

The objective of this study was to validate the format and contents of an instrument to assess research projects that apply for a fellowship by the Sociedad Argentina de Pediatría using an expert consultation technique, such as the Delphi method. Material and methods. A coordinating group selected a panel of research experts who were members of the Sociedad Argentina de Pediatría, designed, and analyzed each of the rounds of consultations. Semistructured questionnaires were sent by personalized e-mail. Agreement among experts ≥ 80 % was established as the criterion for consensus. At each round of consultation, non-consensual aspects were reformulated and new aspects suggested by experts were included. A measure of stability to conclude the consultation was determined when more than 70 % of experts sustained their opinion in successive rounds. Results. Thirteen research experts participated in the process. After 3 rounds, the consultation process was concluded. The consensual instrument contains 47 items. In relation to the total score, 10 % corresponds to the general presentation; 40 %, to methodological quality; 20 %, to relevance and applicability; 20 %, to feasibility;and10%,tothefellow\u27sanddirector\u27s background. Conclusions. The format and contents of the instrument to assess research projects that apply for a fellowship by the SociedadArgentina de Pediatría were validated based on expert consensus and objective assessment criteria were established

Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels.

Elevated serum urate levels cause gout and correlate with cardiometabolic diseases via poorly understood mechanisms. We performed a trans-ancestry genome-wide association study of serum urate in 457,690 individuals, identifying 183 loci (147 previously unknown) that improve the prediction of gout in an independent cohort of 334,880 individuals. Serum urate showed significant genetic correlations with many cardiometabolic traits, with genetic causality analyses supporting a substantial role for pleiotropy. Enrichment analysis, fine-mapping of urate-associated loci and colocalization with gene expression in 47 tissues implicated the kidney and liver as the main target organs and prioritized potentially causal genes and variants, including the transcriptional master regulators in the liver and kidney, HNF1A and HNF4A. Experimental validation showed that HNF4A transactivated the promoter of ABCG2, encoding a major urate transporter, in kidney cells, and that HNF4A p.Thr139Ile is a functional variant. Transcriptional coregulation within and across organs may be a general mechanism underlying the observed pleiotropy between urate and cardiometabolic traits.The Genotype-Tissue Expression (GTEx) Project was supported by the Common Fund of the Office of the Director of the National Institutes of Health, and by NCI, NHGRI, NHLBI, NIDA, NIMH, and NINDS. Variant annotation was supported by software resources provided via the Caché Campus program of the InterSystems GmbH to Alexander Teumer

Use of information and communication technologies in an agroindustrial cooperative in Concórdia, Santa Catarina

A sustentabilidade das propriedades de agricultura familiar passa por diversos estágios, e é possível referenciar a diversificação dos cultivos e a agroindustrialização de produtos primários como dois deles. Na medida em que o agricultor deixa de apenas entregar sua produção primária a outro agente da cadeia produtiva, ele passa a se deparar com desafios e barreiras que outrora não conhecia. As cooperativas de agricultores familiares apresentam-se como uma alternativa eficiente para auxiliar os produtores na superação dessas dificuldades. Nesse contexto as Tecnologias de Informação e Comunicação (TIC’s) surgem como ferramentas e aplicações para, criativamente, encarar um dos principais gargalos da agroindustrialização familiar: a comercialização. Objetivou-se contextualizar os limites e potencialidades da utilização de TIC’s na gestão organizacional, marketing, comunicação e comercialização na Cooperativa de Produção Agroindustrial Familiar de Concórdia (COPAFAC), localizada em Concórdia, Santa Catarina. Para tanto, realizou-se um estudo de caso de caráter exploratório e qualitativo, por meio de observação ativa e de um questionário semiestruturado. A cooperativa em questão se utilizava de TIC’s, objetivando desempenhar tarefas do dia a dia de maneira ágil e eficaz. Entretanto, nas agroindústrias cooperadas, observou-se uma maior fragilidade dos agricultores, especialmente pela dependência dos filhos na utilização das TIC’s, assim como pela falta de empenho, dedicação e hábito dos mesmos. Os gestores da cooperativa, apesar das dificuldades enfrentadas, têm se esforçado para aprimorar o uso das TIC’s, bem como para ampliar a utilização destas ferramentas por parte de seus cooperados, visando não só uma melhor organização, mas também diminuição dos custos e o aumento na comercialização dos produtos.The sustainability of family farming properties goes through several stages, and can refer to the diversification of crops and agro-industrialization of primary products as two of them. To the extent that the farmer gets only deliver primary production to another agent in the production chain, it happens to come across challenges and barriers that previously did not know. Cooperatives of farmers present as an efficient alternative to assist producers in overcoming these difficulties. In this context it has been the Information and Communication Technologies (ICTs) as tools and applications to creatively face one of the main bottlenecks of family agroindustrialization: marketing. The objective of this study was to contextualize the limits and potential of the use of ICT in organizational management, marketing, communication and marketing in a cooperative. Therefore, there was a case study of exploratory and qualitative, through participant observation and semi-structured questionnaire. The cooperative in question was using ICTs aiming perform tasks of daily life in a fast and effective way. However, the cooperative agribusinesses, there was a greater fragility of farmers, especially the dependence of children for the use of ICT, lack of commitment, dedication and habit. The managers of the cooperative have endeavored to improve the use of  ICT as well as to expand the use of these tools by their members, despite the difficulties faced, aiming not only better organization, but also reduced costs and increased marketing of the products

Utilização de tecnologias de informação e comunicação em uma cooperativa agroindustrial em Concórdia, Santa Catarina

The sustainability of family farming properties goes through several stages, and can refer to the diversification of crops and agro-industrialization of primary products as two of them. To the extent that the farmer gets only deliver primary production to another agent in the production chain, it happens to come across challenges and barriers that previously did not know. Cooperatives of farmers present as an efficient alternative to assist producers in overcoming these difficulties. In this context it has been the Information and Communication Technologies (ICTs) as tools and applications to creatively face one of the main bottlenecks of family agroindustrialization: marketing. The objective of this study was to contextualize the limits and potential of the use of ICT in organizational management, marketing, communication and marketing in a cooperative. Therefore, there was a case study of exploratory and qualitative, through participant observation and semi-structured questionnaire. The cooperative in question was using ICTs aiming perform tasks of daily life in a fast and effective way. However, the cooperative agribusinesses, there was a greater fragility of farmers, especially the dependence of children for the use of ICT, lack of commitment, dedication and habit. The managers of the cooperative have endeavored to improve the use of ICT as well as to expand the use of these tools by their members, despite the difficulties faced, aiming not only better organization, but also reduced costs and increased marketing of the products.A sustentabilidade das propriedades de agricultura familiar passa por diversos estágios, e é possível referenciar a diversificação dos cultivos e a agroindustrialização de produtos primários como dois deles. Na medida em que o agricultor deixa de apenas entregar sua produção primária a outro agente da cadeia produtiva, ele passa a se deparar com desafios e barreiras que outrora não conhecia. As cooperativas de agricultores familiares apresentam-se como uma alternativa eficiente para auxiliar os produtores na superação dessas dificuldades. Nesse contexto as Tecnologias de Informação e Comunicação (TIC’s) surgem como ferramentas e aplicações para, criativamente, encarar um dos principais gargalos da agroindustrialização familiar: a comercialização. Objetivou-se contextualizar os limites e potencialidades da utilização de TIC’s na gestão organizacional, marketing, comunicação e comercialização na Cooperativa de Produção Agroindustrial Familiar de Concórdia (COPAFAC), localizada em Concórdia, Santa Catarina. Para tanto, realizou-se um estudo de caso de caráter exploratório e qualitativo, por meio de observação ativa e de um questionário semiestruturado. A cooperativa em questão se utilizava de TIC’s, objetivando desempenhar tarefas do dia a dia de maneira ágil e eficaz. Entretanto, nas agroindústrias cooperadas, observou-se uma maior fragilidade dos agricultores, especialmente pela dependência dos filhos na utilização das TIC’s, assim como pela falta de empenho, dedicação e hábito dos mesmos. Os gestores da cooperativa, apesar das dificuldades enfrentadas, têm se esforçado para aprimorar o uso das TIC’s, bem como para ampliar a utilização destas ferramentas por parte de seus cooperados, visando não só uma melhor organização, mas também diminuição dos custos e o aumento na comercialização dos produtos

Secuencias genéticas parciales de Otaria flavescens: tRNA-Pro gene and control region; mitochondrial

Se detallan las secuencias de 23 nuevos haplotipos para la especie Otaria flavescens, del análisis de la región control del ADN mitocondrial, de individuos del norte de Patagonia ArgentinaFil: Grandi, Maria Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Centro para el Estudio de Sistemas Marinos; ArgentinaFil: Loizaga de Castro, Rocio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Centro para el Estudio de Sistemas Marinos; ArgentinaFil: Teran, Ester Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; ArgentinaFil: Santos, María Rita. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; ArgentinaFil: Bailliet, Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; ArgentinaFil: Crespo, Enrique Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Centro para el Estudio de Sistemas Marinos; Argentin

Is recolonization pattern related to female philopatry? An insight into a colonially breeding mammal

Colony formation is related to dispersal, philopatry, conspecific attraction, available suitable habitat, proximity and availability of food resources, and reproductive success. In this study we analyzed if female South American sea lions, (SASL, Otaria flavescens), exhibit natal fidelity at a small geographic scale (between colonies of the same breeding area) in a context of a recovering population with population expansion and recolonization. We examined the mitochondrial genetic diversity and investigated spatial genetic structure, considering new and traditional colonies. We recovered 36 haplotypes (23 novel), with the contemporary presence of common and private haplotypes in each colony. AMOVA analysis indicated no population genetic structure, however Fst, SAMOVA and AIS analyses suggested some level of genetic structure between northern and southern colonies. Therefore female SASL display different strategies when they choose where to breed: some are residents of -or return to- one particular colony whereas others disperse within the study area. In conclusion the recolonization of SASL may be the effect of weak female philopatry attenuated and/or interacting with other processes like site fidelity to near-by feeding grounds, breeding success, terrestrial habitat selection for breed and dispersal.Fil: Grandi, Maria Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Nacional Patagónico; ArgentinaFil: Loizaga de Castro, Rocio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Nacional Patagónico; ArgentinaFil: Teran, Ester Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; ArgentinaFil: Santos, María Rita. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; ArgentinaFil: Bailliet, Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; ArgentinaFil: Crespo, Enrique Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Nacional Patagónico; Argentina. Universidad Nacional de la Patagonia "San Juan Bosco"; Argentin

Oxytocin system polymorphisms rs237887 and rs2740210 variants increase the risk of depression in pregnant women with early abuse

Prepartum depression is associated with early adversity, pregnancy complications, preterm delivery, postpartum depression, and long-term effects on child neurodevelopment. The oxytocin (OXT) system is affected by early adverse experiences and has been associated with depression. In the current study, we investigated risk factors for prenatal depressive symptoms, mainly the effects of early childhood and adolescence trauma, in combination with the presence of certain variants of polymorphisms of OXT and OXT receptor (OXTR) genes. We hypothesized that early childhood and adolescence trauma has higher negative effects in carriers of genetic variants of the OXT/OXTR system, increasing their risk for depression. Early in pregnancy (8–14 weeks), 141 pregnant women from a Uruguayan population were asked to provide DNA samples and complete questionnaires that assessed their experience of child abuse, depression symptoms, and other variables that included demographic information. Our results showed that 23.5% of pregnant women had depressive symptoms. Several OXT and OXTR genetic variants were associated with higher risk of prepartum depression only in those pregnant women who suffered emotional abuse during infancy or adolescence. Logistic regression (Nagelkerke's R2 = .33) revealed that women who suffered early abuse and were carriers of the variants CC of rs2740210 (OXT) or AA of rs237887 (OXTR) had significantly higher risk of experiencing depressive symptoms. Antecedents of psychiatric disorders also contributed to the risk of depression. We conclude that emotional abuse contributes to the risk of depression in different ways in women carrying different OXT and OXTR genetic variants. Early detection and closer follow-up of women with child abuse and certain OXT genetic variants, among other risk factors, could reduce the long-term impact of prepartum depression

Snowmass2021 Cosmic Frontier Dark Matter Direct Detection to the Neutrino Fog

We present a summary of future prospects for direct detection of dark matter within the GeV/c2 to TeV/c2 mass range. This is paired with a new definition of the neutrino fog in order to better quantify the rate of diminishing returns on sensitivity due to irreducible neutrino backgrounds. A survey of dark matter candidates predicted to fall within this mass range demonstrates that fully testing multiple well-motivated theo-ries will require expanding the currently-funded generation of experiments down to and past the neutrino fog. We end with the status and plans for next-generation exper-iments and novel R&D concepts which will get us there