Stress and Exercise

Age-related immunological and endocrinological changes may have implications for resilience to stress in older adults. We hypothesise that the combination of adrenopause and immunesenescence may leave this population particularly vulnerable to the negative effects of stress on immunity. We propose that exercise may be an effective intervention to limit the impact of stress on immunity in chronically stressed older populations

Engaging community service or learning? Benchmarking community service in teacher education

The focus in this project has been on the extent of explicit commitment of teacher educators in universities to community service and community partnerships that find expression in the content and processes of programs. Such program expression reflects the reciprocity and mutual benefit of engagement with community in teacher education, albeit at a range of levels from superficial and isolated to complex and integrated. In teacher education, the focus is on community as a context for learning and in that sense the community provides significant benefit to the university and its students

Kinematic Properties and Stellar Populations of Faint Early-Type Galaxies. I. Velocity Dispersion Measurements of Central Coma Galaxies

We present velocity dispersion measurements for 69 faint early-type galaxies in the core of the Coma cluster, spanning -22.0<M_R<-17.5 mag. We examine the L-\sigma relation for our sample and compare it to that of bright ellipticals from the literature. The distribution of the the faint early-type galaxies in the L-sigma plane follows the relation L ~ \sigma^{2.01\pm0.36}, which is significantly shallower from L ~ \sigma^4 as defined for the bright ellipticals. While increased rotational support for fainter early-type galaxies could account for some of the difference in slope, we show that it cannot explain it. We also investigate the Colour-\sigma relation for our Coma galaxies. Using the scatter in this relation, we constrain the range of galaxy ages as a function of their formation epoch for different formation scenarios. Assuming a strong coordination in the formation epoch of faint early-type systems in Coma, we find that most had to be formed at least 6 Gyrs ago and over a short 1 Gyr period.Comment: 15 pages including 3 tables and 7 figures, accepted for publication in MNRA

Characterisation of RT1-E2, a multigenic family of highly conserved rat non-classical MHC class I molecules initially identified in cells from immunoprivileged sites

BACKGROUND: So-called "immunoprivileged sites" are tissues or organs where slow allograft rejection correlates with low levels of expression of MHC class I molecules. Whilst classical class I molecules are recognised by cytotoxic T lymphocytes (CTL), some MHC class I molecules are called "non-classical" because they exhibit low polymorphism and are not widely expressed. These last years, several studies have shown that these can play different, more specialised roles than their classical counterparts. In the course of efforts to characterise MHC class I expression in rat cells obtained from immunoprivileged sites such as the central nervous system or the placenta, a new family of non-classical MHC class I molecules, which we have named RT1-E2, has been uncovered. RESULTS: Members of the RT1-E2 family are all highly homologous to one another, and the number of RT1-E2 loci varies from one to four per MHC haplotype among the six rat strains studied so far, with some loci predicted to give rise to soluble molecules. The RT1(n )MHC haplotype (found in BN rats) carries a single RT1-E2 locus, which lies in the RT1-C/E region of the MHC and displays the typical exon-intron organisation and promoter features seen in other rat MHC class I genes. We present evidence that: i) RT1-E2 molecules can be detected at the surface of transfected mouse L cells and simian COS-7 cells, albeit at low levels; ii) their transport to the cell surface is dependent on a functional TAP transporter. In L cells, their transport is also hindered by protease inhibitors, brefeldin A and monensin. CONCLUSIONS: These findings suggest that RT1-E2 molecules probably associate with ligands of peptidic nature. The high homology between the RT1-E2 molecules isolated from divergent rat MHC haplotypes is particularly striking at the level of their extra-cellular portions. Compared to other class I molecules, this suggests that RT1-E2 molecules may associate with well defined sets of ligands. Several characteristics point to a certain similarity to the mouse H2-Qa2 and human HLA-G molecules

A novel method to allow noninvasive, longitudinal imaging of the murine immune system in vivo

In vivo imaging has revolutionized understanding of the spatiotemporal complexity that subserves the generation of successful effector and regulatory immune responses. Until now, invasive surgery has been required for microscopic access to lymph nodes (LNs), making repeated imaging of the same animal impractical and potentially affecting lymphocyte behavior. To allow longitudinal in vivo imaging, we conceived the novel approach of transplanting LNs into the mouse ear pinna. Transplanted LNs maintain the structural and cellular organization of conventional secondary lymphoid organs. They participate in lymphocyte recirculation and exhibit the capacity to receive and respond to local antigenic challenge. The same LN could be repeatedly imaged through time without the requirement for surgical exposure, and the dynamic behavior of the cells within the transplanted LN could be characterized. Crucially, the use of blood vessels as fiducial markers also allowed precise re-registration of the same regions for longitudinal imaging. Thus, we provide the first demonstration of a method for repeated, noninvasive, in vivo imaging of lymphocyte behavior

The gravitational dynamics of warped throats

We investigate the time evolution due to gravitational dynamics of a particular spacetime commonly used in brane-cosmology and string compactifications, namely the Klebanov-Strassler geometry, which is achieved by adding a perturbation to the momentum of the static solution. We observe the effects this has on the spacetime and look for evidence of black hole formation or collapsing cycles which could lead to singular geometry. The cycles are seen to commonly re-expand after reaching a minimum value, showing the stability of the solution against perturbations which would change its size. However black holes are observed to form for certain perturbations, which could impede common uses of the throat's stable tip

Evolution of the Red Sequence Giant to Dwarf Ratio in Galaxy Clusters out to z ~ 0.5

We analyze deep g' and r' band data of 97 galaxy clusters imaged with MegaCam on the Canada-France-Hawaii telescope. We compute the number of luminous (giant) and faint (dwarf) galaxies using criteria based on the definitions of de Lucia et al. (2007). Due to excellent image quality and uniformity of the data and analysis, we probe the giant-to-dwarf ratio (GDR) out to z ~ 0.55. With X-ray temperature (Tx) information for the majority of our clusters, we constrain, for the first time, the Tx-corrected giant and dwarf evolution separately. Our measurements support an evolving GDR over the redshift range 0.05 < z < 0.55. We show that modifying the (g'-r'), m_r' and K-correction used to define dwarf and giant selection do not alter the conclusion regarding the presence of evolution. We parameterize the GDR evolution using a linear function of redshift (GDR = alpha * z + beta) with a best fit slope of alpha = 0.88 +/- 0.15 and normalization beta = 0.44 +/- 0.03. Contrary to claims of a large intrinsic scatter, we find that the GDR data can be fully accounted for using observational errors alone. Consistently, we find no evidence for a correlation between GDR and cluster mass (via Tx or weak lensing). Lastly, the data suggest that the evolution of the GDR at z < 0.2 is driven primarily by dry merging of the massive giant galaxies, which when considered with previous results at higher redshift, suggests a change in the dominant mechanism that mediates the GDR.Comment: 20 pages, 15 figures. Accepted to MNRA

Structure of the Galaxies in the NGC 80 Group

BV-bands photometric data obtained at the 6-m telescope of the Special Astrophysical Observatory are used to analyze the structure of 13 large disk galaxies in the NGC 80 group. Nine of the 13 galaxies under consideration are classified by us as lenticular galaxies. The stellar populations in the galaxies are very different, from old ones with ages of T>10 Gyrs (IC 1541) to relatively young, with the ages of T<2-3 Gyr (IC 1548, NGC 85). In one case, current star formation is known (UCM 0018+2216). In most of the galaxies, more precisely in all of them more luminous than M(B) -18, two-tiered (`antitruncated') stellar disks are detected, whose radial surface brightness profiles can be fitted by two exponential segments with different scalelengths -- shorter near the center and longer at the periphery. All dwarf S0 galaxies with single-scalelength exponential disks are close companions to giant galaxies. Except for this fact, no dependence of the properties of S0 galaxies on distance from the center of the group is found. Morphological traces of minor merger are found in the lenticular galaxy NGC 85. Basing on the last two points, we conclude that the most probable mechanisms for the transformation of spirals into lenticular galaxies in groups are gravitational ones, namely, minor mergers and tidal interactions.Comment: 24 pages, 9 figures, slightly improved version of the paper published in the December, 2009, issue of the Astronomy Report