Variation in Quantitative Myocardial Perfusion Due to Arterial Input Selection

ObjectivesThis study compared the clinical implications of quantifying myocardial perfusion among different potential arterial input sites: the high (HAo) and basal (BAo) ascending aorta, descending aorta (DA), left atrium (LA), and left ventricular (LV) cavity.BackgroundAbsolute myocardial perfusion and its hyperemic reserve imaged by positron emission tomography (PET) can serve as noninvasive functional measures of physiologic severity. Quantitative myocardial perfusion by PET depends on the time–concentration of vascular activity, called arterial input (AI). However, arterial activity imaged by PET can vary among sites due to partial volume effects from anatomic size, cardiac or respiratory motion out of fixed regions of interest, and spillover from neighboring vascular structures.MethodsPatients underwent cardiac rubidium-82 PET imaging with flow quantification using various anatomic AI. After excluding sites with overt spillover or misregistration, we selected the customized, highest AI among the BAo, HAo, DA, and LA. Average whole heart flows and percent of LV with substantial definite ischemia were compared among sites.ResultsOf 288 cases, LA was selected in roughly half, with HAo in another quarter to one-third. Compared with using the customized AI, rest and stress absolute flow were higher by 5% to 10% for HAo, 14% for BAo, 19% to 23% for DA, and 46% to 49% for LV due to artifactually low AI values. The ratio of coronary flow reserve to its customized value was less affected, although its 95% confidence interval increased among AI locations: 7% for LA, 16% for HAo, 20% for BAo, 28% for DA, and 31% for LV.ConclusionsThe best customized site for AI activity varies for each patient among potential anatomic locations. Selection of the customized arterial site for each individual improved quantification of myocardial perfusion and coronary flow reserve with less variability compared with utilizing a single, pre-selected, fixed anatomic site

Supersymmetric t-J Gaudin Models and KZ Equations

Supersymmetric t-J Gaudin models with both periodic and open boundary conditions are constructed and diagonalized by means of the algebraic Bethe ansatz method. Off-shell Bethe ansatz equations of the Gaudin systems are derived, and used to construct and solve the KZ equations associated with $sl(2|1)^{(1)}$ superalgebra.Comment: LaTex 21 page

Gauge Singlet Scalars as Cold Dark Matter

In light of recent interest in minimal extensions of the Standard Model and gauge singlet scalar cold dark matter, we provide an arXiv preprint of the paper, published as Phys.Rev. D50 (1994) 3637, which presented the first detailed analysis of gauge singlet scalar cold dark matter.Comment: 37 pages, 11 figures, LaTe

Exploiting Locally Imposed Anisotropies in (Ga,Mn)As: a Non-volatile Memory Device

Progress in (Ga,Mn)As lithography has recently allowed us to realize structures where unique magnetic anisotropy properties can be imposed locally in various regions of a given device. We make use of this technology to fabricate a device in which we study transport through a constriction separating two regions whose magnetization direction differs by 90 degrees. We find that the resistance of the constriction depends on the flow of the magnetic field lines in the constriction region and demonstrate that such a structure constitutes a non-volatile memory device

OGLE-2009-BLG-023/MOA-2009-BLG-028: Characterization of a Binary Microlensing Event Based on Survey Data

We report the result of the analysis of the light curve of a caustic-crossing binary-lens microlensing event OGLE-2009-BLG-023/MOA-2009-BLG-028. Even though the event was observed solely by survey experiments, we could uniquely determine the mass of the lens and distance to it by simultaneously measuring the Einstein radius and lens parallax. From this, we find that the lens system is composed of M-type dwarfs with masses $(0.50\pm 0.07) \ M_\odot$ and $(0.15\pm 0.02)\ M_\odot$ located in the Galactic disk with a distance of $\sim 1.8$ kpc toward the Galactic bulge direction. The event demonstrates that physical lens parameters of binary-lens events can be routinely determined from future high-cadence lensing surveys and thus microlensing can provide a new way to study Galactic binaries.Comment: 8 pages, 5 figure

Does the Milky Way have a Maximal Disk?

The Milky Way is often considered to be the best example of a spiral for which the dark matter not only dominates the outer kinematics, but also plays a major dynamical role in the inner galaxy: the Galactic disk is therefore said to be ``sub-maximal.'' This conclusion is important to the understanding of the evolution of galaxies and the viability of particular dark matter models. The Galactic evidence rests on a number of structural and kinematic measurements, many of which have recently been revised. The new constraints indicate not only that the Galaxy is a more typical member of its class (Sb-Sc spirals) than previously thought, but also require a re-examination of the question of whether or not the Milky Way disk is maximal. By applying to the Milky Way the same definition of ``maximal disk'' that is applied to external galaxies, it is shown that the new observational constraints are consistent with a Galactic maximal disk of reasonable $M/L$. In particular, the local disk column can be substantially less than the oft-quoted required \Sigma_{\odot} \approx 100 \msolar pc^{-2} - as low as 40 \msolar pc^{-2} in the extreme case - and still be maximal, in the sense that the dark halo provides negligible rotation support in the inner Galaxy. This result has possible implications for any conclusion that rests on assumptions about the potentials of the Galactic disk or dark halo, and in particular for the interpretation of microlensing results along both LMC and bulge lines of sight.Comment: Accepted for publication in The Astrophysical Journal. 23 Latex-generated pages, one (new) table, three figures (two new). A few additions to the bibliography, an expanded discussion, and slight quantitative changes, none of which affect the conclusion

Direct Distance Measurements to Superluminal Radio Sources

We present a new technique for directly measuring the distances to superluminal radio sources. By comparing the observed proper motions of components in a parsec scale radio jet to their measured Doppler factors, we can deduce the distance to the radio source independent of the standard rungs in the cosmological distance ladder. This technique requires that the jet angle to the line of sight and the ratio of pattern to flow velocities are sufficiently constrained. We evaluate a number of possibilities for constraining these parameters and demonstrate the technique on a well defined component in the parsec scale jet of the quasar 3C279 (z = 0.536). We find an angular size distance to 3C279 of greater than 1.8 (+0.5,-0.3) n^{1/8} Gpc, where n is the ratio of the energy density in the magnetic field to the energy density in the radiating particles in that jet component. For an Einstein-de Sitter Universe, this measurement would constrain the Hubble constant to be H < 65 n^{-1/8} km/s/Mpc at the two sigma level. Similar measurements on higher redshift sources may help discriminate between cosmological models.Comment: 18 pages, 8 figures, to be published in The Astrophysical Journa

The Extreme Microlensing Event OGLE-2007-BLG-224: Terrestrial Parallax Observation of a Thick-Disk Brown Dwarf

Parallax is the most fundamental technique to measure distances to astronomical objects. Although terrestrial parallax was pioneered over 2000 years ago by Hipparchus (ca. 140 BCE) to measure the distance to the Moon, the baseline of the Earth is so small that terrestrial parallax can generally only be applied to objects in the Solar System. However, there exists a class of extreme gravitational microlensing events in which the effects of terrestrial parallax can be readily detected and so permit the measurement of the distance, mass, and transverse velocity of the lens. Here we report observations of the first such extreme microlensing event OGLE-2007-BLG-224, from which we infer that the lens is a brown dwarf of mass M=0.056 +- 0.004 Msun, with a distance of 525 +- 40 pc and a transverse velocity of 113 +- 21 km/s. The velocity places the lens in the thick disk, making this the lowest-mass thick-disk brown dwarf detected so far. Follow-up observations may allow one to observe the light from the brown dwarf itself, thus serving as an important constraint for evolutionary models of these objects and potentially opening a new window on sub-stellar objects. The low a priori probability of detecting a thick-disk brown dwarf in this event, when combined with additional evidence from other observations, suggests that old substellar objects may be more common than previously assumed.Comment: ApJ Letters, in press, 15 pages including 2 figure

Influence of contrast media dose and osmolality on the diagnostic performance of contrast fractional flow reserve

Background—Contrast fractional flow reserve (cFFR) is a method for assessing functional significance of coronary stenoses, which is more accurate than resting indices and does not require adenosine. However, contrast media volume and osmolality may affect the degree of hyperemia and therefore diagnostic performance. Methods and Results—cFFR, instantaneous wave–free ratio, distal pressure/aortic pressure at rest, and FFR were measured in 763 patients from 12 centers. We compared the diagnostic performance of cFFR between patients receiving low or iso-osmolality contrast (n=574 versus 189) and low or high contrast volume (n=341 versus 422) using FFR≤0.80 as a reference standard. The sensitivity, specificity, and overall accuracy of cFFR for the low versus iso-osmolality groups were 73%, 93%, and 85% versus 87%, 90%, and 89%, and for the low versus high contrast volume groups were 69%, 99%, and 83% versus 82%, 93%, and 88%. By receiver operating characteristics (ROC) analysis, cFFR provided better diagnostic performance than resting indices regardless of contrast osmolality and volume (P&lt;0.001 for all groups). There was no significant difference between the area under the curve of cFFR in the low- and iso-osmolality groups (0.938 versus 0.957; P=0.40) and in the low- and high-volume groups (0.939 versus 0.949; P=0.61). Multivariable logistic regression analysis showed that neither contrast osmolality nor volume affected the overall accuracy of cFFR; however, both affected the sensitivity and specificity. Conclusions—The overall accuracy of cFFR is greater than instantaneous wave–free ratio and distal pressure/aortic pressure and not significantly affected by contrast volume and osmolality. However, contrast volume and osmolality do affect the sensitivity and specificity of cFFR

Determining the Physical Lens Parameters of the Binary Gravitational Microlensing Event MOA-2009-BLG-016

We report the result of the analysis of the light curve of the microlensing event MOA-2009-BLG-016. The light curve is characterized by a short-duration anomaly near the peak and an overall asymmetry. We find that the peak anomaly is due to a binary companion to the primary lens and the asymmetry of the light curve is explained by the parallax effect caused by the acceleration of the observer over the course of the event due to the orbital motion of the Earth around the Sun. In addition, we detect evidence for the effect of the finite size of the source near the peak of the event, which allows us to measure the angular Einstein radius of the lens system. The Einstein radius combined with the microlens parallax allows us to determine the total mass of the lens and the distance to the lens. We identify three distinct classes of degenerate solutions for the binary lens parameters, where two are manifestations of the previously identified degeneracies of close/wide binaries and positive/negative impact parameters, while the third class is caused by the symmetric cycloid shape of the caustic. We find that, for the best-fit solution, the estimated mass of the lower-mass component of the binary is (0.04 +- 0.01) M_sun, implying a brown-dwarf companion. However, there exists a solution that is worse only by \Delta\chi^2 ~ 3 for which the mass of the secondary is above the hydrogen-burning limit. Unfortunately, resolving these two degenerate solutions will be difficult as the relative lens-source proper motions for both are similar and small (~ 1 mas/yr) and thus the lens will remain blended with the source for the next several decades.Comment: 7 pages, 2 tables, and 5 figure