Recent Developments in Criminal Law in Nova Scotia

Judicial examination of the criminal process in Canada generally, and Nova Scotia in particular continues to grow. The consequent explosion of technical law, which some would regard as an implosion, places the academic writer on the horns of a dilemma when faced with the task of reviewing recent developments in the Nova Scotia criminal process. On the one hand, the writer may compress and omit detail in order to cover adequately developments in such widely disparate areas as murder and power to arrest. On the other hand, coverage may be sacrificed to detailed discussion of the law and its implications in a smaller number of selected areas. We have chosen the latter course. We do not, however, intend to imply that the topics discussed hereunder were selected at random. We have chosen to focus on three areas of recent development which in our view, will significantly affect the future course of criminal law. They are the struggle to develop a rational sentencing policy, the right to counsel in breathalyzer cases, and ignorance of law as a mitigation, if not outright defence, to certain offences. We join, of course, many people in selecting sentencing law. It is a dynamic area of law currently undergoing reexamination all across the country

Screw Compressors

Discussion GroupAPI Standard 619 for screw compressors Wet and dry Silencers for dry screw compressors Noise reduction methods Lubricants and lubricant carryover for flooded screw compressor Over-compression and under-compression Pulsation and vibration issue

Turbo Expanders & PRTs

Discussion GroupSuggested Topics: Group Input - Topics from attendees Turbo Expanders - High temperature corrosion Design Tools Process Recovery Machines Isokinetic Testing - Result accuracy Dehydration Units Pipeline Recovery Turbines Nitric Acid Trains Turbo Expanders - new technologies Hot Seals - Whats working Abrasive Cleaning Inlet Temperature Measurement - Skin/ Nosecone Performance Monitoring Tip rubs Recovery Units - Package

Screw Compressors

Discussion GroupAPI Standard 619 for screw compressors Wet and dry Silencers for dry screw compressors Noise reduction methods Lubricants and lubricant carryover for flooded screw compressor Over-compression and under-compression Pulsation and vibration issue

Turbo Expanders & PRTs

Discussion GroupSuggested Topics: Group Input - Topics from attendees Turbo Expanders - High temperature corrosion Design Tools Process Recovery Machines Isokinetic Testing - Result accuracy Dehydration Units Pipeline Recovery Turbines Nitric Acid Trains Turbo Expanders - new technologies Hot Seals - Whats working Abrasive Cleaning Inlet Temperature Measurement - Skin/ Nosecone Performance Monitoring Tip rubs Recovery Units - Package

Seeing the way: visual sociology and the distance runner's perspective

Employing visual and autoethnographic data from a two‐year research project on distance runners, this article seeks to examine the activity of seeing in relation to the activity of distance running. One of its methodological aims is to develop the linkage between visual and autoethnographic data in combining an observation‐based narrative and sociological analysis with photographs. This combination aims to convey to the reader not only some of the specific subcultural knowledge and particular ways of seeing, but also something of the runner's embodied feelings and experience of momentum en route. Via the combination of narrative and photographs we seek a more effective way of communicating just how distance runners see and experience their training terrain. The importance of subjecting mundane everyday practices to detailed sociological analysis has been highlighted by many sociologists, including those of an ethnomethodological perspective. Indeed, without the competence of social actors in accomplishing these mundane, routine understandings and practices, it is argued, there would in fact be no social order

ABCB1 (MDR1) polymorphisms and ovarian cancer progression and survival: A comprehensive analysis from the Ovarian Cancer Association Consortium and The Cancer Genome Atlas

<b>Objective</b> <i>ABCB1</i> encodes the multi-drug efflux pump P-glycoprotein (P-gp) and has been implicated in multi-drug resistance. We comprehensively evaluated this gene and flanking regions for an association with clinical outcome in epithelial ovarian cancer (EOC).<p></p> <b>Methods</b> The best candidates from fine-mapping analysis of 21 <i>ABCB1</i> SNPs tagging C1236T (rs1128503), G2677T/A (rs2032582), and C3435T (rs1045642) were analysed in 4616 European invasive EOC patients from thirteen Ovarian Cancer Association Consortium (OCAC) studies and The Cancer Genome Atlas (TCGA). Additionally we analysed 1,562 imputed SNPs around ABCB1 in patients receiving cytoreductive surgery and either ‘standard’ first-line paclitaxel–carboplatin chemotherapy (n = 1158) or any first-line chemotherapy regimen (n = 2867). We also evaluated ABCB1 expression in primary tumours from 143 EOC patients.<p></p> <b>Result</b> Fine-mapping revealed that rs1128503, rs2032582, and rs1045642 were the best candidates in optimally debulked patients. However, we observed no significant association between any SNP and either progression-free survival or overall survival in analysis of data from 14 studies. There was a marginal association between rs1128503 and overall survival in patients with nil residual disease (HR 0.88, 95% CI 0.77–1.01; p = 0.07). In contrast, <i>ABCB1</i> expression in the primary tumour may confer worse prognosis in patients with sub-optimally debulked tumours.<p></p> <b>Conclusion</b> Our study represents the largest analysis of <i>ABCB1</i> SNPs and EOC progression and survival to date, but has not identified additional signals, or validated reported associations with progression-free survival for rs1128503, rs2032582, and rs1045642. However, we cannot rule out the possibility of a subtle effect of rs1128503, or other SNPs linked to it, on overall survival.<p></p&gt

University of Texas / M.D. Anderson Cancer Center Newsletter

Monthly report discussing cancer care and research to inform physicians

Nutrient Processes at the Stream-Lake Interface for a Channelized Versus Unmodified Stream Mouth

Inorganic forms of nitrogen and phosphorous impact freshwater lakes by stimulating primary production and affecting water quality and ecosystem health. Communities around the world are motivated to sustain and restore freshwater resources and are interested in processes controlling nutrient inputs. We studied the environment where streams flow into lakes, referred to as the stream-lake interface (SLI), for a channelized and unmodified stream outlet. Channelization is done to protect infrastructure or recreational beach areas. We collected hydraulic and nutrient data for surface water and shallow groundwater in two SLIs to develop conceptual models that describe characteristics that are representative of these hydrologic features. Water, heat, and solute transport models were used to evaluate hydrologic conceptualizations and estimate mean residence times of water in the sediment. A nutrient mass balance model is developed to estimate net rates of adsorption and desorption, mineralization, and nitrification along subsurface flow paths. Results indicate that SLIs are dynamic sources of nutrients to lakes and that the common practice of channelizing the stream at the SLI decreases nutrient concentrations in pore water discharging along the lakeshore. This is in contrast to the unmodified SLI that forms a barrier beach that disconnects the stream from the lake and results in higher nutrient concentrations in pore water discharging to the lake. These results are significant because nutrient delivery through pore water seepage at the lakebed from the natural SLI contributes to nearshore algal communities and produces elevated concentrations of inorganic nutrients in the benthic zone where attached algae grow

Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans

Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in 25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16 regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP, while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium (LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region. Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the refined data for existing association signals, we estimate that these loci now explain ∼38.9% of the familial relative risk of PrCa, an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent signals within the same regio