Constructing topological models by symmetrization: A PEPS study

Symmetrization of topologically ordered wavefunctions is a powerful method for constructing new topological models. Here, we study wavefunctions obtained by symmetrizing quantum double models of a group $G$ in the Projected Entangled Pair States (PEPS) formalism. We show that symmetrization naturally gives rise to a larger symmetry group $\tilde G$ which is always non-abelian. We prove that by symmetrizing on sufficiently large blocks, one can always construct wavefunctions in the same phase as the double model of $\tilde G$. In order to understand the effect of symmetrization on smaller patches, we carry out numerical studies for the toric code model, where we find strong evidence that symmetrizing on individual spins gives rise to a critical model which is at the phase transitions of two inequivalent toric codes, obtained by anyon condensation from the double model of $\tilde G$.Comment: 10 pages. v2: accepted versio

Vitiligo-like Depigmentation in a Patient Undergoing Treatment with Nivolumab for Advanced Renal-cell Carcinoma

Nivolumab is a fully human monoclonal antibody that targets the programmed cell death 1 (PD-1) immune checkpoint. It has been approved for its use in several types of advanced solid tumors, including melanoma, lung cancer, and renal cell carcinoma (RCC). The inhibition of PD-1 leads to an enhanced adaptive immune response against tumor cells through the activation of T-cells

Vitiligo-like Depigmentation in a Patient Undergoing Treatment with Nivolumab for Advanced Renal-cell Carcinoma

Nivolumab is a fully human monoclonal antibody that targets the programmed cell death 1 (PD-1) immune checkpoint. It has been approved for its use in several types of advanced solid tumors, including melanoma, lung cancer, and renal cell carcinoma (RCC). The inhibition of PD-1 leads to an enhanced adaptive immune response against tumor cells through the activation of T-cells

3D numerical simulation of slope-flexible system interaction using a mixed FEM-SPH model

Flexible membranes are light structures anchored to the ground that protect infrastructures or dwellings from rock or soil sliding. One alternative to design these structures is by using numerical simulations. However, very few models were found until date and most of them are in 2D and do not include all their components. This paper presents the development of a numerical model combining Finite Element Modelling (FEM) with Smooth Particle Hydrodynamics (SPH) formulation. Both cylindrical and spherical failure of the slope were simulated. One reference geometry of the slope was designed and a total of 21 slip circles were calculated considering different soil parameters, phreatic level position and drainage solutions. Four case studies were extracted from these scenarios and simulated using different dimensions of the components of the system. As a validation model, an experimental test that imitates the soil detachment and its retention by the steel membrane was successfully reproduced.The FORESEE project has received funding from the EuropeanUnion’s Horizon 2020 research and innovation program undergrant agreement No 769373

Microstructure Evolution During Powder Compaction

The process of powder compaction consists of the synthesis of loose powders into a solid material. The applications of compaction of granular systems extend to pharmaceuticals, detergents, food, ceramic and metallurgical processes. It is indispensable to have a thorough understanding of the behavior of confined granular systems during compaction because the performance of the final desired product is related to the microstructural features that develop during the compaction process. To have a more realistic description of the compaction, it is also important to include the packing process of granular systems. However, there are different particle packing algorithms that account for the particle filling process. The Discrete Element Method (DEM) had been used to obtain a dynamic solution to this problem but requires high computational power. As an alternative to the computationally expensive DEM approach, a static based algorithm has recently been developed for the modelling and simulation of the particle packing process. The algorithm allows for the modelling of the packing process by placing spheres inside different shapes and sizes of containers. In this study, we present a new version of the nanoHUB Powder Compaction tool. It currently simulates the microstructure evolution of monodisperse, compressible granular systems up to high relative densities. The tool also models the plastic and elastic deformation of single particles described by different contact mechanics models. The new features use a general particle packing algorithm and thus allow the user to choose a particle size distribution in a specified range for the mean, standard deviation and number of particles to fill the die. The information is passed to the solver that in turn simulates the compaction in Purdue’s high-performance computer cluster

Identifikacija vinskih kvasaca postupkom PCR-RFLP bez prethodne izolacije na ploči

The population of wine yeasts during spontaneous must fermentation was characterized by direct 5.8S-ITS rDNA region amplification without previous plate isolation or enrichment. RFLP analysis was applied to each of the amplification products detected, and the corresponding yeast identifications were made. The method provides a fast and direct way of determining yeast population present during wine fermentation.Populacija vinskih kvasaca tijekom spontane fermentacije mošta karakterizirana je izravnom amplifikacijom regije 5,8S-ITS rDNA bez prethodne izolacije na ploči ili povećavanja količine. Primijenjena je RFLP analiza na svakom utvr|enom amplifikacijskom produktu te je provedena odgovarajuća identifikacija kvasca. Postupak omogućava brz i izravan put utvrđivanja populacije kvasca prisutnog u fermentaciji vina

Resistina: una nueva hormona expresada en el tejido adiposo

La resistina es una proteína de 12,5 kDa rica en residuos de cisteína que se secreta principalmente en los adipocitos. El descubrimiento de la resistina pareció ser un principio prometedor para el tratamiento de la resistencia a la insulina inducida por la obesidad. Sin embargo, aunque en roedores su función parece estar relacionada con el empeoramiento de la sensibilidad a la insulina, en humanos todavía no se puede afirmar con claridad su papel. En los roedores, la resistina actúa de forma perjudicial en la ruta de señalización de la insulina en los principales tejidos diana, como son el tejido adiposo, el hígado y el músculo. Esta hormona también estimula la producción hepática de glucosa y sus niveles circulantes son elevados en animales obesos, mientras que estos niveles disminuyen de manera muy significativa después de la restricción alimenticia. Todos estos datos sugieren que además de la resistencia a la insulina, la resistina también ejerce una acción importante en la regulación de la homeostasis metabólica. Además, en humanos, dada su expresión en células mononucleares, es de suponer que esta proteína juega un papel importante en los procesos inflamatorios y/o inmunitarios. Aunque los trabajos que han estudiado sus acciones en relación a la resistencia a insulina inducida por la obesidad son bastante contradictorios, es de esperar que pueda ejercer múltiples funciones biológicas, teniendo en cuenta la variedad de tejidos en que es expresada

Social Responsibility Practices in Companies: A Theoretical Review

The aim of this study is to understand, by a theoretical point of view, the potential impact of social responsibility practices in the business companies, taking in consideration several aspects and sundry approaches, by analysing the main defined strategies and policies. The concept is related with a philosophical and moral idea of corporate behaviour to the development of legally binding regulations, cultural and climate organizational characteristics. It is determined that development must be based on a sustainable economy while aligning these actions with the sustainable development goals established and at the same time the economic performance of the companies. For a social responsibility strategy, it is also crucial that the human resources departments, the commercial and marketing areas share and expose the actions that have an impact on the society where they are installed. Works on the establishment of this commitment and identification with the company through social responsibility policies have highlighted the role of management and leadership style in facilitating or not these processes.info:eu-repo/semantics/publishedVersio

A near-infrared study of the multi-phase outflow in the type-2 quasar J1509+0434

Based on new near-infrared spectroscopic data from the instrument EMIR on the 10.4 m Gran Telescopio Canarias (GTC) we report the presence of an ionized and warm molecular outflow in the luminous type-2 quasar J150904.22+043441.8 (z = 0.1118). The ionized outflow is faster than its molecular counterpart, although the outflow sizes that we derive for them are consistent within the errors (1.34±0.18 kpc and 1.46±0.20 kpc respectively). We use these radii, the broad emission-line luminosities and in the case of the ionized outflow, the density calculated from the trans-auroral [OII] and [SII] lines, to derive mass outflow rates and kinetic coupling efficiencies. Whilst the ionized and warm molecular outflows represent a small fraction of the AGN power (≤0.033% and 0.0001% of Lbol respectively), the total molecular outflow, whose mass is estimated from an assumed warm-to-cold gas mass ratio of 6× 10−5, has a kinetic coupling efficiency of ∼1.7%Lbol. Despite the large uncertainty, this molecular outflow represents a significant fraction of Lbol and it could potentially have a significant impact on the host galaxy. In addition, the quasar spectrum reveals bright and patchy narrow Paα emission extending out to 4″ (8 kpc) South-East and North-West from the active nucleus.Includes Horizon 202

Manejo clínico de la infección viral del herpes simple y Candidiasis oral: Reporte de un caso clínico

La infección por herpes simple tipo I es una de las enfermedades más frecuentes que afecta a la cavidad bucal, se manifiesta en forma de vesículas que tienden a remitir después de 10 a 12 días y es altamente recidivante. El siguiente trabajo tiene como finalidad presentar el caso clínico de un paciente con herpes simple recidivante intrabucal, acompañado de dolor intenso, con síntomas y signos clínicos persistentes por un largo periodo de tiempo, que no remitía con el tratamiento. Se detectó infección de Cándida Albicans acompañando al cuadro. Se realizaron análisis de laboratorio, incluyendo el test de Elisa para confirmar presencia de HIV resultando negativo, PCR para detección de VHS tipo 1 y cultivo de Cándida Albicans. Se trató la virosis con Aciclovir en altas dosis, la infección sobreagregada con nistatina y se indicó polivitamínicos para reforzar el huésped. El paciente fue tratado multidisciplinariamente y derivado al psicólogo por presentar un cuadro de estrés, lo que permitió disminuir la ansiedad del mismo ejerciendo un rol importante en el tratamiento.Fil: Gonzalez, Maria Mercedes. Universidad Nacional del Nordeste. Facultad de Odontologia; ArgentinaFil: Rosende, Roque O.. Universidad Nacional del Nordeste. Facultad de Odontologia; ArgentinaFil: Krupp, Sebastian. Universidad Nacional del Nordeste. Facultad de Odontologia; ArgentinaFil: Rosales, Carlos A.. Universidad Nacional del Nordeste. Facultad de Odontologia; ArgentinaFil: Fernandez, Estefania Raquel. Universidad Nacional del Nordeste. Facultad de Odontologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentin