Constraints on anomalous QGC's in e+e−e^{+}e^{-} interactions from 183 to 209 GeV

The acoplanar photon pairs produced in the reaction e(+) e(-) - → vvyy are analysed in the 700 pb(-1) of data collected by the ALEPH detector at centre-of-mass energies between 183 and 209 GeV. No deviation from the Standard Model predictions is seen in any of the distributions examined. The resulting 95% C.L. limits set on anomalous QGCs, a(0)(Z), a(c)(Z), a(0)(W) and a(c)(W), are -0.012 lt a(0)(Z)/Lambda(2) lt +0.019 GeV-2, -0.041 lt a(c)(Z)/Lambda(2) lt +0.044 GeV-2, -0.060 lt a(0)(W)/Lambda(2) lt +0.055 GeV-2, -0.099 lt a(c)(W)/Lambda(2) lt +0.093 GeV-2, where Lambda is the energy scale of the new physics responsible for the anomalous couplings

Burden and risk factors for Pseudomonas aeruginosa community-acquired pneumonia:a Multinational Point Prevalence Study of Hospitalised Patients

Pseudornonas aeruginosa is a challenging bacterium to treat due to its intrinsic resistance to the antibiotics used most frequently in patients with community-acquired pneumonia (CAP). Data about the global burden and risk factors associated with P. aeruginosa-CAP are limited. We assessed the multinational burden and specific risk factors associated with P. aeruginosa-CAP. We enrolled 3193 patients in 54 countries with confirmed diagnosis of CAP who underwent microbiological testing at admission. Prevalence was calculated according to the identification of P. aeruginosa. Logistic regression analysis was used to identify risk factors for antibiotic-susceptible and antibiotic-resistant P. aeruginosa-CAP. The prevalence of P. aeruginosa and antibiotic-resistant P. aeruginosa-CAP was 4.2% and 2.0%, respectively. The rate of P. aeruginosa CAP in patients with prior infection/colonisation due to P. aeruginosa and at least one of the three independently associated chronic lung diseases (i.e. tracheostomy, bronchiectasis and/or very severe chronic obstructive pulmonary disease) was 67%. In contrast, the rate of P. aeruginosa-CAP was 2% in patients without prior P. aeruginosa infection/colonisation and none of the selected chronic lung diseases. The multinational prevalence of P. aeruginosa-CAP is low. The risk factors identified in this study may guide healthcare professionals in deciding empirical antibiotic coverage for CAP patients

Study of immunoglobulins, proinflammatory cytokines, lymphoproliferation and phagocytosis in peripheral blood of healthy young people exposed to different levels of atmospheric pollution [Estudio de inmunoglobulinas, citocinas proinflamatorias, linfoproliferación y fagocitosis en sangre periférica de jóvenes sanos expuestos a diferentes niveles de contaminación atmosférica.]

BACKGROUND: Urban environmental pollutants, resulting from the inadequate control in the industries and from the use of vehicles, still represent a great danger for millions of people all around the world. PATIENTS AND METHOD: We made a study in healthy young people without family history of atopy that lived in Guadalajara's downtown, as well as in another group of young people who lived in a rural area. According to the census of the year 2000, Guadalajara city has a population of 4 million habitants, and a vehicle number of about a million. The immunological parameters that we studied were: IgG, IgA and IgM immunoglobulins by nephelometry, serum levels of proinflammatory cytokines IL-6, IL-1alpha, IL1-beta and TNF-alpha by ELISAs test, and the phagocytic index in polymorphonuclears. The atmospheric parameters were: NO2, O3, SO2, CO and the suspended particles that were less than 10 micrometers (PM10). These parameters were obtained from a mobile unit found at the Instituto de Astronomia y Meteorología de la Universidad de Guadalajara, and from an automatic station of environmental monitoring. RESULTS: It stands out the high concentrations of NO2 and PM10, which in several occasions were over the standards established by the WHO. IgG, IgA and IgM immunoglobulins were lower in the subjects living in the city that in those who lived in the rural area. Phagocytic index in polymorphonuclears, as well as IL-1alpha levels were higher in the city group, though we did not find a significant difference in the immunological parameters analyzed in the studied groups. CONCLUSION: Environmental pollution levels found at Guadalajara's downtown does not modify the immunological parameters studied in the peripheral blood of healthy young people. This shows that this group of population is less vulnerable than others to the exposition of moderate levels of urban air pollution

IL-33 acts as a costimulatory signal to generate alloreactive Th1 cells in graft-versus-host disease.

Antigen-presenting cells (APCs) integrate signals emanating from local pathology and program appropriate T cell responses. In allogeneic hematopoietic stem cell transplantation (alloHCT), recipient conditioning releases damage-associated molecular patterns (DAMPs) that generate proinflammatory APCs that secrete IL-12, which is a driver of donor Th1 responses, causing graft-versus-host disease (GVHD). Nevertheless, other mechanisms exist to initiate alloreactive T cell responses, as recipients with disrupted DAMP signaling or lacking IL-12 develop GVHD. We established that tissue damage signals are perceived directly by donor CD4+ T cells and promoted T cell expansion and differentiation. Specifically, the fibroblastic reticular cell-derived DAMP IL-33 is increased by recipient conditioning and is critical for the initial activation, proliferation, and differentiation of alloreactive Th1 cells. IL-33 stimulation of CD4+ T cells was not required for lymphopenia-induced expansion, however. IL-33 promoted IL-12-independent expression of Tbet and generation of Th1 cells that infiltrated GVHD target tissues. Mechanistically, IL-33 augmented CD4+ T cell TCR-associated signaling pathways in response to alloantigen. This enhanced T cell expansion and Th1 polarization, but inhibited the expression of regulatory molecules such as IL-10 and Foxp3. These data establish an unappreciated role for IL-33 as a costimulatory signal for donor Th1 generation after alloHCT

Measurement of W pair productions in e+ e- collisions at centre-of-mass energies from 183-GeV to 209-GeV.

The W + W- production cross section is measured from a data sample corresponding to a total integrated luminosity of 683 pb-1, collected by the ALEPH experiment at LEP at centre-of-mass energies from 183 to 209 GeV. Individual cross sections for the different topologies arising from W decays into leptons or hadrons, as well as the total W-pair cross section are given at eight centre-of-mass energies. The results are found to be in agreement with recently developed Standard Model calculations at the one percent level. The hadronic branching fraction of the W boson is measured to be = 67.13 0.37(stat.) 0.15(syst.)%, from which the CKM matrix element is determined to be 0.958 0.017(stat.) 0.008(syst.

Studies of QCD at e+ e- centre-of-mass energies between 91-GeV and 209-GeV

The hadronic final states observed with the ALEPH detector at LEP in e+e− annihilation are analysed using 730 pb-1 of data collected between 91 and 209 GeV in the framework of QCD. In particular event-shape variables and inclusive charged particle spectra are measured. The energy evolution of quantities derived from these measurements is compared to analytic QCD predictions. The mean charged particle multiplicity, the charged particle momentum spectrum and its peak position are compared to predictions of the modified-leading-logarithmic approximation. The strong coupling constant αs is determined from a fit of the QCD prediction to distributions of six event-shape variables at eight centre-of-mass energies. A study of non-perturbative power law corrections is presented

Two-dimensional analysis of Bose-Einstein correlations in hadronic Z decays at LEP

LAL 04-92Bose-Einstein correlations are studied in pairs of charged pions from hadronic Z decays, collected by the ALEPH detector.The correlation function, measured using either the unlike-sign or the mixed reference sample, is studied in terms of the Lorentz-invariant four-momentum difference and its transverse, $Q_{\textrm{T}}$, and longitudinal, $Q_{\textrm{L}}$, components with respect to the longitudinal centre-of-mass system. Values for the correlation radii, $R_{\textrm{T}}$ and $R_{\textrm{L}}$, are obtained from the fit of the Goldhaber parametrisation.The results indicate that the correlation radii values depend on the chosen kind of reference sample and on the two-jet purity

Studies of QCD at e+e−e^{+}e^{-} centre-of-mass energies between 91 and 209 GeV

The hadronic final states observed with the ALEPH detector at LEP in e+e- annihilation are analysed using 730 pb-1 of data collected between 91 and 209 GeV in the framework of QCD. In particular event-shape variables and inclusive charged particle spectra are measured. The energy evolution of quantities derived from these measurements is compared to analytic QCD predictions. The mean charged particle multiplicity, the charged particle momentum spectrum and its peak position are compared to predictions of the modified-leading-logarithmic approximation. The strong coupling constant alpha_s is determined from a fit of the QCD prediction to distributions of six event-shape variables at eight centre-of-mass energies. A study of non-perturbative power law corrections is presente

Study of hadronic final states from double tagged γγ\gamma\gamma events at LEP

The interaction of virtual photons is investigated using double tagged gammagamma events with hadronic final states recorded by the ALEPH experiment at e^+e^- centre-of-mass energies between 188 and 209 GeV. The measured cross section is compared to Monte Carlo models, and to next-to-leading-order QCD and BFKL calculations