166 research outputs found

    Elizabeth Barrett Browning’s Latin Library: a Historiographical Approach

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    Este texto tentará delimitar e definir o tipo de aproximação de Elizabeth Barrett Browning (EBB) ao latim e à literatura latina a partir da análise da sua biblioteca pessoal. Desta maneira, observar-se-á o processo de aprendizagem de EBB, tendo em atenção tanto os manuais e textos académicos que utilizou como as amizades e contactos pessoais que a acompanharam na sua aproximação aos estudos clássicos. Estes dados permitirão avaliar até que ponto o interesse de EBB por esta matéria corresponde a uma opção pessoal ou foi determinado por outras circunstânciasThis article seeks to delimit and define Elizabeth Barrett Browning’s (EBB) type of approach to Latin and Latin literature, drawing on the analysis of her personal library. We will therefore examine EBB’s learning process, bearing in mind both the manuals and academic textbooks she used, as well as the friends and personal connections who guided her in her approach to Classical studies. This information will allow us to judge whether EBB’s interest in this matter corresponds to a personal option or was rather determined by other circumstancesEn este artículo se tratará de delimitar y definir el tipo de aproximación de Elizabeth Barrett Browning (EBB) al latín y a la literatura latina a partir del análisis de su biblioteca personal. De esta manera, se observará el proceso de aprendizaje de EBB, atendiendo tanto a los manuales y los textos académicos que utilizó como a las amistades y los contactos personales que la acompañaron en su acercamiento a los estudios clásicos. Estos datos permitirán valorar hasta qué punto el interés de EBB por esta materia responde a una opción personal o está determinado por otras circunstancia

    El mito de Frankenstein en series de televisión contemporáneas: Monstruosidad, rebelión y maternidad en la construcción de la identidad del siglo XXI

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    [ES] Los estudios de caso que integran el presente monográfico analizan muestras de las diversas transformaciones que se han venido llevando a cabo en el género gótico desde los años 70 hasta la actualidad en los ámbitos de la ficción, las artes visuales y otras formas de cultura popular. Se hace especial énfasis en los patrones de influencia, apropiación y reformulación, así como en la continuidad del imaginario gótico en la posmodernidad. Se invita así a la reflexión sobre las ansiedades del mundo contemporáneo y su reflejo o expresión en las diferentes manifestaciones artísticas y literarias del género del terror.[EN] The case studies in this volume assess the transformations undergone by the Gothic genre since the 1970s until today within the fields of fiction, the visual arts and other forms of popular culture. Special emphasis falls into the patterns of influence, appropriation and reformulation in the works under assessment, as well as the durability of gothic imagery in postmodernity. We thereby invite readers to reflect on how these visual and literary works echo, reflect or give voice to the anxieties in our contemporary society

    I. Ediciones y técnica filológica

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    Revisiones posmodernas del gótico en la literatura y las artes visuales

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    [ES] Los estudios de caso que integran el presente monográfico analizan muestras de las diversas transformaciones que se han venido llevando a cabo en el género gótico desde los años 70 hasta la actualidad en los ámbitos de la ficción, las artes visuales y otras formas de cultura popular. Se hace especial énfasis en los patrones de influencia, apropiación y reformulación, así como en la continuidad del imaginario gótico en la posmodernidad. Se invita así a la reflexión sobre las ansiedades del mundo contemporáneo y su reflejo o expresión en las diferentes manifestaciones artísticas y literarias del género del terror.[EN] The case studies in this volume assess the transformations undergone by the Gothic genre since the 1970s until today within the fields of fiction, the visual arts and other forms of popular culture. Special emphasis falls into the patterns of influence, appropriation and reformulation in the works under assessment, as well as the durability of gothic imagery in postmodernity. We thereby invite readers to reflect on how these visual and literary works echo, reflect or give voice to the anxieties in our contemporary society

    Introducción

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    [ES] Los estudios de caso que integran el presente monográfico analizan muestras de las diversas transformaciones que se han venido llevando a cabo en el género gótico desde los años 70 hasta la actualidad en los ámbitos de la ficción, las artes visuales y otras formas de cultura popular. Se hace especial énfasis en los patrones de influencia, apropiación y reformulación, así como en la continuidad del imaginario gótico en la posmodernidad. Se invita así a la reflexión sobre las ansiedades del mundo contemporáneo y su reflejo o expresión en las diferentes manifestaciones artísticas y literarias del género del terror.[EN] The case studies in this volume assess the transformations undergone by the Gothic genre since the 1970s until today within the fields of fiction, the visual arts and other forms of popular culture. Special emphasis falls into the patterns of influence, appropriation and reformulation in the works under assessment, as well as the durability of gothic imagery in postmodernity. We thereby invite readers to reflect on how these visual and literary works echo, reflect or give voice to the anxieties in our contemporary society

    Late-onset thymidine kinase 2 deficiency: a review of 18 cases

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    BACKGROUND: TK2 gene encodes for mitochondrial thymidine kinase, which phosphorylates the pyrimidine nucleosides thymidine and deoxycytidine. Recessive mutations in the TK2 gene are responsible for the 'myopathic form' of the mitochondrial depletion/multiple deletions syndrome, with a wide spectrum of severity. METHODS: We describe 18 patients with mitochondrial myopathy due to mutations in the TK2 gene with absence of clinical symptoms until the age of 12. RESULTS: The mean age of onset was 31 years. The first symptom was muscle limb weakness in 10/18, eyelid ptosis in 6/18, and respiratory insufficiency in 2/18. All patients developed variable muscle weakness during the evolution of the disease. Half of patients presented difficulty in swallowing. All patients showed evidence of respiratory muscle weakness, with need for non-invasive Mechanical Ventilation in 12/18. Four patients had deceased, all of them due to respiratory insufficiency. We identified common radiological features in muscle magnetic resonance, where the most severely affected muscles were the gluteus maximus, semitendinosus and sartorius. On muscle biopsies typical signs of mitochondrial dysfunction were associated with dystrophic changes. All mutations identified were previously reported, being the most frequent the in-frame deletion p.Lys202del. All cases showed multiple mtDNA deletions but mtDNA depletion was present only in two patients. CONCLUSIONS: The late-onset is the less frequent form of presentation of the TK2 deficiency and its natural history is not well known. Patients with late onset TK2 deficiency have a consistent and recognizable clinical phenotype and a poor prognosis, due to the high risk of early and progressive respiratory insufficiency.Instituto de Salud Carlos III PI16-01843 PI16/00579 CP09/00011Subdirección General de Evaluación y Fomento de la Investigación Sanitaria PI16-01843 PI16/00579 CP09/00011 PI 15/00431 PMP15/0002

    Late-onset thymidine kinase 2 deficiency: a review of 18 cases

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    Mitochondrial myopathy; Multiple deletions; TK2 deficiencyMiopatia mitocondrial; Delecions múltiples; Deficiència de TK2Miopatía mitocondrial; Deleciones múltiples; Deficiencia de TK2BACKGROUND: TK2 gene encodes for mitochondrial thymidine kinase, which phosphorylates the pyrimidine nucleosides thymidine and deoxycytidine. Recessive mutations in the TK2 gene are responsible for the 'myopathic form' of the mitochondrial depletion/multiple deletions syndrome, with a wide spectrum of severity. METHODS: We describe 18 patients with mitochondrial myopathy due to mutations in the TK2 gene with absence of clinical symptoms until the age of 12. RESULTS: The mean age of onset was 31 years. The first symptom was muscle limb weakness in 10/18, eyelid ptosis in 6/18, and respiratory insufficiency in 2/18. All patients developed variable muscle weakness during the evolution of the disease. Half of patients presented difficulty in swallowing. All patients showed evidence of respiratory muscle weakness, with need for non-invasive Mechanical Ventilation in 12/18. Four patients had deceased, all of them due to respiratory insufficiency. We identified common radiological features in muscle magnetic resonance, where the most severely affected muscles were the gluteus maximus, semitendinosus and sartorius. On muscle biopsies typical signs of mitochondrial dysfunction were associated with dystrophic changes. All mutations identified were previously reported, being the most frequent the in-frame deletion p.Lys202del. All cases showed multiple mtDNA deletions but mtDNA depletion was present only in two patients. CONCLUSIONS: The late-onset is the less frequent form of presentation of the TK2 deficiency and its natural history is not well known. Patients with late onset TK2 deficiency have a consistent and recognizable clinical phenotype and a poor prognosis, due to the high risk of early and progressive respiratory insufficiency

    A qualitative research of adolescents with behavioral problems about their experience in a dialectical behavior therapy skills training group

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    BACKGROUND: Several quantitative studies support the effectiveness of the Dialectical Behavior Therapy (DBT) psychosocial skills training group component for adolescents with impulse-control disorder and/or emotional dysregulation. However, qualitative research to assess this psychotherapeutic tool in the adolescent population is sparse. This study aims to examine the subjective experience of adolescents with behavioral issues who have completed DBT skills training group, as well as using this experience to extract hypotheses regarding its usefulness which can then be verified at a later time by means of quantitative instruments. METHODS: We developed a qualitative study by using focus groups with adolescents (N=20) whose diagnosis includes symptoms such as behavior disorder, impulse-control disorder and/or emotional dysregulation, and good informants, who have completed DBT skills training. Three focus groups were created. RESULTS: The subjective experience of adolescents who have completed a DBT skills training group is collected in four main categories: experience of illness, motivation for therapy, experience of therapy and results of the therapy. CONCLUSIONS: Adolescents with behavioral problems assess their participation in the DBT skills training group positively, even recommending its usefulness to healthy population. Beyond learning skills, they emphasize the intrapsychic changes (as improvement in reflective activity) that they objectify after the group experience.This study was partially funded by the Spanish Association of Child and Adolescent Psychiatry (AEPNYA) by awarding the research team the 2015 AEPNYA research prize. The funding body had no role in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript
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