Does the Pulvinar-Lp Complex Contribute to Motor Programming?

[Abstract] Extracellular unit recording studies in the pulvinar lateral posterior complex (Pui-LP) of behaving monkeys have shown a response property not previously reported. In monkeys performing aimed arm reaching movements towards frontally located targets some cells showed a change in activity beginning 495 ± 84 ms before the onset of the reaching movement. This change in frequency precedes that observed in primary motor and parietal posterior cortex for reaching movements. These findings seem to indicate the involvement of the Pul-LP in motor functions and suggest its possible contribution to motor programming.Comisión Asesora de Investigacion Cientifica y Tecnica (España); PR83-210

Análisis de la actividad científica de la Comunidad Autónoma de la Región de Murcia. Biomedicina 1999-2005.

An analysis of scientific activity in Biomedicine in Murcia between 1999-2005 is presented

Integral field spectroscopy of H II region complexes: the outer disc of NGC 6946

This is an electronic version of an article published in Monthly Notices of the Royal Astronomical Society. García-Benito, R., Díaz, A., Hägele, G.F., Pérez-Montero, E., López, J., Vílchez, J.M., Pérez, E., Terlevich, E., Terlevich, R., D. Rosa-González. Integral field spectroscopy of H II region complexes: the outer disc of NGC 6946. Monthly Notices of the Royal Astronomical Society 408 (2010): 2234-225

WSPH and ISPH Calculations of a Counter-Rotating Vortex Dipole

Viscosity and vorticity are magnitudes playing an important role in many engineering physical phenomena such as: boundary layer separation, transition flows, shear flows, etc., demonstrating the importance of the vortical viscous flows commonly used among the SPH community. The simulation presented here, describes the physics of a pair of counter-rotating vortices in which the strain field felt by each vortex is due to the other one. Different from the evolution of a single isolated vortex, in this case each vortex is subjected to an external stationary strain field generated by the other, making the streamlines deform elliptically. To avoid the boundary influence, a large computational domain has been used ensuring insignificant effect of the boundary conditions on the solution. The performance of the most commonly used viscous models in simulating laminar flows, Takeda’s (TVT), Morris’ (MVT) and Monaghan-Cleary’s (MCGVT) has been discussed comparing their results. These viscous models have been used under two different compressibility hypotheses. Two cases have been numerically analyzed in this presentation. In the first case, a 2D system of two counter-rotating Lamb O seen vortices is considered. At first, the system goes through a rapid relaxation process in which both vortices equilibrate each other. This quasi-steady state is obtained after the relaxation phase is advected at a constant speed and slowly evolves owing to viscous diffusion. The results of the different Lamb-O seen numerical solutions have been validated with good agreement by comparison with the numerical results of a finite element code (ADFC) solution. A second case, somewhat more complex than the previous one, is a 3D Batchelor vortex dipole obtained by adding an axial flow to the system of the first case. The Batchelor vortex model considered here is a classical option normally used to model the structure of trailing vortices in the far-wake of an aircraft

“Nuevo procedimiento de síntesis y datos para la caracterización del ácido β-Mercaptoetilaminotriacético (MET)”

Se propone la síntesis del ácido β-mercaptoetilaminotriacético, HO2CCH2SC2H4N(CH2CO2H)2 (MET, H3A), en base a la reacción a fondo de cistamina, S2(C2H4NH2)2, con cloroacetato en medio alcalino, con rendimiento (70%) superior al descrito para la condensación de cisteamina (HSC2H4NH2) con cloroacetato (42%). Se discute la estructura más probable de las especies de MET en disolución a partir de los valores de pKa (1.93, 2.27, 3.52 y 9.05, para. I=0.1 M (KN03) y 25cº) y datos de (1H)-RMN. Los espectros IR y datos de análisis térmico (TG,ATD) informan del ordenamiento estructural de MET.H20 y MET.HC1.H20 en estado sólido

Traumatismo abdominal en un hospital de tercer nivel. Análisis de resultados, consideraciones terapéuticas y evaluación con índices pronóstico

Objetivo. Conocer la epidemiología y distribución de los traumatismos abdominales en nuestro medio. Evaluar el comportamiento y fiabilidad de la aplicación de índices pronósticos de gravedad analizando su correlación con las decisiones terapéuticas y los resultados obtenidos Método. Estudio retrospectivo en el que se han incluido todos los pacientes con diagnóstico de traumatismo abdominal grave ingresados en un hospital español de referencia, entre 2009 y 2015. Se registraron variables epidemiológicas, clínicas y de resultados, así como la puntuación de distintos índices pronósticos. Resultados. Muestra 153 pacientes, con mediana de edad de 38 años y predominio masculino (73, 9%). Correspondieron a traumatismos de tipo cerrado (94, 1%) y su etiología principal los accidentes de tráfico (60, 1%). El bazo fue el órgano más frecuentemente afectado (44, 4%), seguido por el hígado (36, 6%). La mediana de la estancia hospitalaria fue de 11 días y la mortalidad global de 13%. Aunque el 62, 7% se manejó con éxito de forma conservadora, se observó una mayor puntuación de Injury Severity Score (ISS) y Trauma and Injury Severity Score (TRISS) en aquellos pacientes que precisaron tratamiento quirúrgico (p = 0, 0001), en los que fallecieron (p = 0, 0001) y en aquellos con mayor estancia hospitalaria (RTS –Reevised Trauma Score– p = 0, 001 y TRISS p = 0, 016). Conclusiones. La etiología de los traumatismos abdominales y los balances lesionales en nuestro medio fueron similares a los observados a nivel nacional. La puntuación en las escalas estudiadas tuvo una asociación directa con la necesidad de tratamiento quirúrgico, los días de estancia hospitalaria, la morbilidad y la mortalidad. Objectives. To describe the abdominal injuries treated in our hospital. We assessed the behavior and reliability of prognostic scales, analyzing the correlations between them and therapeutic decisions and outcomes. Methods. Retrospective study including all patients with major abdominal injuries admitted to our hospital between 2009 and 2015. We gathered epidemiologic and clinical data, outcomes, and scores on several prognostic scales. Results. The median age of the 153 patients we identified from case records was 38 years; 73.9% were males. Most cases involved blunt trauma (94.1%) sustained in traffic accidents (60.1%). The spleen and the liver were the organs most often affected (in 44.4% and 36.6%, respectively). The median length of stay in the hospital was 11 days, and overall mortality was 13%. Although conservative management was successful in 62.7% of the cases, we found that patients who had a higher ISS (Injury Severity Score) or TRISS (Trauma and Injury Severity Score) assessments more often required surgery or died (P=.0001, both comparisons). Those who had longer hospital stays had a higher Revised Trauma Score or TRISS (P=.001 and P=.016, respectively). Conclusions. The causes of abdominal injuries and the types treated in our hospital were similar to those described for the rest of Spain. Punctuation on prognostic severity scales correlated directly with the need for surgery, length of hospital stay, complications, and mortality

Efficacy and safety of switching to abacavir/lamivudine (ABC/3TC) plus rilpivirine (RPV) in virologically suppressed HIV-infected patients on HAART.

We analysed the efficacy and safety of switching from a regimen based on nonnucleoside reverse transcriptase inhibitors (NNRTI) or integrase inhibitors (INI) to ABC/3TC + RPV in virologically suppressed HIV-infected patients. This multicentre, retrospective study comprised asymptomatic HIV-infected patients who switched from 2 NRTI + NNRTI or 2 NRTI + INI to ABC/3TC + RPV between February 2013 and December 2013; all had undetectable HIV viral load prior to switching. Efficacy and safety, and changes in lipids and cardiovascular risk (CVR) were analysed at 48 weeks. Of 85 patients (74.1 % men, mean age 49.5 years), 83 (97.6 %) switched from a regimen based on NNRTI (EFV 74, RPV 5, ETV 2, NVP 2), and 45 (53 %) switched from TDF/FTC to ABC/3TC. The main reasons for switching were toxicity (58.8 %) and convenience (29.4 %). At 48 weeks, 78 (91.8 %) patients continued taking the same regimen; efficacy was 88 % by intention to treat, and 96 % by per protocol. Two patients were lost to follow-up and five ceased the new regimen (4 due to adverse effects and 1 virologic failure). Mean CD4 cell counts increased (744 vs. 885 cells/μL; p = 0.0001), and there were mean decreases in fasting total cholesterol (-15.9 mg/dL; p < 0.0001) and LDL-cholesterol (-11.0 mg/dL; p < 0.004), with no changes in HDL-cholesterol, triglycerides, total cholesterol:HDL-cholesterol ratio, and CVR. ABC/3TC + RPV is effective and safe in virologically-suppressed patients on antiretroviral therapy (ART). Forty-eight weeks after switching the lipid profile improved with decreases in total and LDL cholesterol.This study has been supported in part by the RD12/0017/0017 project (Plan Nacional R+D+ I) and cofinanced by Instituto de Salud Carlos III-Subdirección General de Evaluación y el Fondo Europeo de Desarrollo Regional and a grant from by Janssen Cilag

Hidroxidos dobles laminares como materiales adsorbentes de contaminantes en aguas

II Encuentro sobre nanociencia y nanotecnología de investigadores y tecnólogos de la Universidad de Córdoba. NANOUC

Cadophora luteo-olivacea: endophytic fungus or grapevine trunk pathogen?

International Congress on Grapevine and Wine Sciences (1. 2018. Logroño)[EN] The objectives of this study were the detection of C. luteo-olivacea from nursery plants, field plants and soil samples; to analyse the pathogenicity of different C. luteo-olivacea isolates, and finally to test natural compounds and biocontrol agents able to fight against C. luteo-olivaceaRebeca Cobos acknowledge to Spanish Ministerio de Economía Industria y Competitividad for funding this research (PTQ14-06849)