El síndrome de iris flácido. Estudio de cambios oculares inducidos por tamsulosina

Texto en español y resumen en inglésEl síndrome de iris flácido descrito en el año 2005 se ha relacionado con el consumo de tamsulosina. Tras estudiar 830 cirugías de catarata llevadas a cabo en el Hospital del Henares, determinamos que el consumo de tamsulosina en nuestro medio se asocia a un aumento importante de "complicaciones menores" durante la cirugía de catarata. Por ello este fármaco no modifica de forma importante el pronóstico "funcional" de la cirugía. Podría existir asimismo un efecto aditivo entre el consumo de este fármaco y la diabetes mellitus, que contraindica su utilización en estos pacientes.Se llevo a cabo una encuesta a los especialistas de urología de la Comunidad de Madrid, que demostró que los urólogos tienen un buen conocimiento de este síndrome, pero desconocen el carácter en parte irreversible de los cambios inducidos por su consumo.Tras seguir dos cohortes de pacientes que iniciaban y cesaban el tratamiento con tamsulosina se demostró que el inicio del tratamiento produce una reducción del diámetro pupilar y esta reducción es máxima en respuesta a fenilefrina. Asimismo en un estudio trasversal en el que se compararon consumidores y no consumidores de tamsulosina, este midriático demostró tener una buena sensibilidad y especificidad para detectar el consumo de este fármaco, si bien el bajo valor predictivo positivo, hace que este test no resulte útil en la práctica clínica. Puesto que la hendidura palpebral fue similar en ambos grupos, es probable que el receptor alfa-1A adrenérgico no se exprese en el músculo de Müller. No se demostró que la tamsulosina influya sobre la cuantificación del defecto pupilar aferente relativo. Palabras clave: tamsulosina, síndrome de iris flácido, cirugía de catarata, complicaciones quirúrgicas

La crisis de reproducibilidad de la ciencia y la necesidad de publicar los resultados negativos.

pre-print245 K

Laser pointer maculopathy. A new public health problem?

pre-print186 K

The church of San Pablo (Valladolid, Spain). The selection of the recording techniques: appropriateness, suitability and effectiveness for the documentation of a cultural heritage project

After almost five years of studies and works carried out to restore the façade of San Pablo in Valladolid (Spain), this paper aims at promoting a critical evaluation of these works in order to analyze the selection of the recording techniques used before, during and immediately after the development of the preliminary studies and the conservation works. During the restoration process the survey was continuously implemented, collecting new data and using different techniques in order to provide the kind of information requested by a multidisciplinary team of professionals with completely different needs. At the same time this project has had the exceptional feature of exposing to the public the development of the conservation works in real time through a lift platform which entailed the obligation of informing everyday through effective and understandable means about how and where the works were being carried out at the façade. In these terms, this paper will try to bring the attention to the difficulties found in choosing the most suitable, effective and appropriate recording technique for different and specific conservation and communication purposes, searching for a good relation between accuracy, cost, time and efficiency within the whole cultural project

Maculopatía por puntero láser. ¿Un nuevo problema de salud pública?

Available online 13 October 2016, publicado en papel n enero de 2017Depto. de Optometría y VisiónSección Deptal. de Óptica (Óptica)Fac. de Óptica y OptometríaTRUEpu

Open-globe-injury: A single center Spanish retrospective 5-year cohort study.

Purpose: To review and analyze the epidemiological profile, clinical characteristics and visual outcomes in patients attended for traumatic open globe injury (OGI) at our hospital over a 5-year period. Design: Retrospective chart review study. Methods: Retrospective analysis of all patients attended at Fundación Jiménez Díaz University Hospital for OGI between 2011 and 2015. Data from 104 patients including demographics, ocular examination, medical and surgical treatment, visual outcomes, and complications were analyzed. Results: Most patients were male (79.8%) and the median age at the time of injury was 41 years (interquartile range 31.5–58 years). Work-related accidents represent more than half of the cases and their main mechanism was penetrating trauma or foreign body. This type of accident had good prognosis (median final visual acuity in decimal scale 0.8; interquartile range 0.4–1). Falls were the second most common cause of OGI, predominantly affecting senior women (50%), with a high incidence of ocular rupture (50%) and associating a poor visual prognosis (median final visual acuity 0.01; interquartile range 0–0.5). There was a strong correlation (0.75; p < 0.001) between ocular trauma score (OTS) and final best corrected visual acuity. Conclusions: Two different patterns of OGI were identified in our sample. Work-related trauma in young males was the most common form of OGI and was associated with good prognosis. However, falls in senior women were associated with poor prognosis.pre-print484 K

Subclinical thinning of macular ganglion cell layer in Leber optic neuropathy carriers.

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December 13, 1474. Epidemic of blindness on the day of the proclamation of Queen Isabella I of Castile: A tourist license.

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Clinical, radiological and therapeutic features of keratocystic odontogenic tumours: a study over a decade

Factors associated with the potential for recurrence of keratocystic odontogenic tumours (KCOT) still remain to be clearly determined and no consensus exists concerning the management of KCOT. The purpose of this study was to evaluate different clinical factors associated with KCOT and its treatment methods. A retrospective review was performed of 55 cases treated from 2001 to 2010. Of the 55 cases, 27% were associated with an impacted or semi- impacted tooth. The majority of the lesions (82%) were located in tooth-bearing areas, and the overall mandibular to maxilla ratio of tumour occurrence was 5:1. The treatment options included enucleation, marsupialisation, or peripheral ostectomy, with or without the use of Carnoy ?s solution. Recurrence was found in 14 cases (25%). No significant association was seen between recurrence and age, symptomatic cases, location of the lesion, or unilocu - lar or multilocular appearance. The recurrence rate was higher in the group with tooth involvement, more marked in cases with third molar involvement. Statistical analysis showed a significant relation between recurrence and the type of treatment, with higher rates in cases treated with enucleation associated with tooth extraction. In our series, those cases with a closer relation with dental tissues showed a higher risk of recurrence, suggesting the need for a distinct classification for peripheral variants of KCOT

Difusión de las actividades del Grupo de Investigación Dirofilariosis Animal y Humana integrado en el departamento de Biología Animal, Parasitología, Ecología, Edafología y Química Agrícola

Memoria ID-0182. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2014-2015