84 research outputs found
Treatment of Herpes Simplex Virus with Lignin-Carbohydrate Complex Tablet, an Alternative Therapeutic Formula
Estudio Clínico Comparativo de la Retención de Tres Selladores en un Grupo de Niños de la Ciudad de Toluca
Se incluyeron en el estudio 10 niños y 9 niñas que cumplieron con los criterios de inclusión, con un
total de 19 niños. El rango de edad de los niños que se incluyeron en el presente estudio fue de 7 a
8 años de edad de los cuales se atendieron 7 de 7 años de edad y 12 de 8 años de edad. La marca
de sellador que menos reporta desalojos totales es UltraSeal XT, aunque en los registros por molar
de cada marca no existe diferencia significativa entre las tres marcas. El método estadístico utilizado
fue SPSS vs 16La caries dental es un problema de salud pública que afecta los tejidos calcificados de los dientes
disolviendo la estructura inorgánica.1 La población con mayor riesgo de adquirir esta patología está
constituida por niños, las superficies oclusales son las más afectadas en los dientes posteriores
permanentes.2 Para prevenir la impactación de alimentos y bacterias que crean condiciones ácidas
que resultan en lesiones de caries, se han utilizado selladores de fosetas y fisuras, para prevenir la
caries en la región de fosetas y fisuras con buenos resultado
Effectiveness of Toki's criteria and determination of variables for identification of HPV L1 protein in oral lesions
Objectives: To evaluate the effectiveness of Toki's criteria in identifying the HPV L1 protein in oral lesions with the
use of immunohistochemistry (IHC) and to determine which criteria optimize such identification.
Study Design: Retrospective study of 277 cases diagnosed as HPV lesions at 22 years. Tests of sensitivity, specificity,
positive predictive value (PPV), negative predictive value (NPV), kappa coefficients, and chi
2
values, as well as two
logistic regression analyses (
(p≤0.05), were conducted.
Results: Of the lesions studied, 96.4% (267 of 277) were positive for HPV using Toki's criteria and 28.5% (79 of
277) were positive for L1 by IHC. Toki's criteria showed sensitivity=93.67%, specificity=2.53%, PPV=6.99%, and
NPV=46.55%. Neither concordance nor statistically significant associations were observed between both tests. The
logistic regression of Toki's criteria was useful in the diagnosis of L1, correctly classified 71.8% of the lesions positive for L1, and showed a Hosmer-Lemeshow adjustment of
p
=0.614 and a Nagelkerke's coefficient of determination
of 6.8%. The explanatory variables statistically significant at
p≤0.05 were dyskeratosis (
p
=0.01) and papillomatosis
(
p
=0.04). Forty-nine independent variables (clinical and histopathologic) were involved in the second regression
analysis. The model correctly classified 85.2% of the lesions and showed a Hosmer-Lemeshow adjustment of
p
=0.696
and a Nagelkerke's coefficient of determination of 60.2%. The explanatory variables statistically significant at
p≤0.05
were: age younger than 35 years (
p
=0.001), multiple lesions (
p
=0.031), hyperorthokeratosis (
p
=0.019), focal intra
-
cellular edema (
p
=0.002), and the presence of 1 to more than 5 cells with degenerative changes in their nucleus
(
p
=0.048).
Conclusions: Toki's criteria are not adequate to make a diagnosis of lesions by HPV in the mouth, but the logistic
regression analysis showed clinical and histopathologic variables which optimize the identification of lesions through
the L1 protein. However, a PCR study is advisable when the presence of high-risk HPV is suspected
Prevalencia de caries severa temprana de la infancia en pacientes que acuden a la clínica de la especialidad en Odontopediatría UAEM de Febrero 2006-Mayo del 2012
1571 expedientes fueron analizados, 1335 correspondieron a niños con CSTI. La prevalencia de caries fue de 85%, 699 (52.4%) del sexo masculino y 636 (47.6%) del sexo femenino. El grupo de edad más afectado por CTIS fue el de 37 a 48 meses en ambos géneros.Los niños más pequeños son los más susceptibles a padecer caries, debido a que presentan un esmalte poco mineralizado, dependen de los alimentos que les proporcionan sus padres y además la falta de información sobre la práctica de higiene oral en casa a edades tan tempranas
Caries Incidence in School Children Included in a Caries Preventive Program: A Longitudinal Study
Evaluation of caries risk factors associated with pregnancy
Tooth decay in pregnant women is frequent; the Cariogram is a useful tool for the identification of risk factors for dental caries. The aim is to determine risk to dental caries in pregnant women. A convenience sample of 55 healthy women between 18 and 40 years old in their last trimester of pregnancy, recruited from public hospitals of the State of Mexico, were studied. According to Cariogram factors 58% of patients can develop new carious lesions, due to their diet and presence of cariogenic bacteria (20%), susceptibility (11%) and circumstances (7%). The Cariogram is an efficient tool to identify caries risk factors in pregnant women. A correlation was observed between the identified factors and the Decayed Missing, Filled, Teeth surfaces Index (DMFT).Debido a que la caries dental es un problema común en mujeres embarazadas, el propósito es determinar el riesgo de padecerla en una muestra por conveniencia de 55 mujeres sanas en su último trimestre de embarazo, de entre 18 y 40 años de edad provenientes de hospitales públicos del Estado de México. Según los factores del cariograma, 58% de las pacientes puede desarrollar nuevas lesiones cariosas debido a su dieta y a la presencia de bacterias cariogénicas (20%), susceptibilidad (11%) y circunstancias (7%). Los resultados muestran que el cariograma es una herramienta útil para identificar factores de riesgo a la caries en mujeres embarazadas. Se observó una correlación entre los factores identificados y el índice de dientes cariados, perdidos y obturados (CPOD)
Sarcopenia and mortality in older hemodialysis patients
(1) Sarcopenia is a progressive loss of skeletal muscle mass and strength. The aim of this study was to determine the association of sarcopenia, defined according to the Working Group on Sarcopenia in Older People (EWGSOP2) diagnostic criteria, with mortality at 24 months in very elderly hemodialysis patients. (2) A prospective study was conducted in 60 patients on chronic hemodialysis who were older than 75 years. Sarcopenia was diagnosed according to EWGSOP2 criteria. Additionally, clinical, anthropometric and analytical variables and body composition by bioimpedance were assessed. The date and cause of death were recorded during 2 years of follow-up. (3) Among study participants, 41 (68%) were men, the mean age 81.85 ± 5.58 years and the dialysis vintage was 49.88 ± 40.29 months. The prevalence of probable sarcopenia was 75% to 97%, depending on the criteria employed: confirmed sarcopenia ranged from 37 to 40%, and severe sarcopenia ranged from 18 to 37%. A total of 30 (50%) patients died over 24 months. Sarcopenia probability variables were not related to mortality. In contrast, sarcopenia confirmation (appendicular skeletal muscle mass, ASM) and severity (gait speed, GS) variables were associated with mortality. In multivariate analysis, the hazard ratio (95% confidence interval) for all-cause death was 3.03 (1.14-8.08, p = 0.028) for patients fulfilling ASM sarcopenia criteria and 3.29 (1.04-10.39, p = 0.042) for patients fulfilling GS sarcopenia criteria. (4) The diagnosis of sarcopenia by EWGSOP2 criteria is associated with an increased risk of all-cause death in elderly dialysis patients. Specifically, ASM and GS criteria could be used as mortality risk markers in elderly hemodialysis patients. Future studies should address whether the early diagnosis and treatment of sarcopenia improve outcomes.This research received no external funding. E.G.-P., S.M.-F. and A.O.-A. research groups are funded by Ministerio de Economia, Industria y competitividad: FIS/Fondos FEDER (PI16/01298, PI17/00257, PI18/01386, PI19/00588, PI19/00815, PI20/00487, PI21/01430, ERA-PerMed-JTC2018 (KIDNEY ATTACK AC18/00064 and PERSTIGAN AC18/00071, ISCIII-RETIC REDinREN RD016/0009) and Sociedad Española de Nefrología, Comunidad de Madrid en Biomedicina B2017/BMD-3686 CIFRA2-CM. All authors want to thank Fundación Renal Íñigo Álvarez de Toledo (FRIAT) for its support to renal research in Spain. The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.
Financiadores
Comunidad de Madrid en Biomedicina
B2017/BMD-3686 CIFRA2-CM
FRIAT
Fundación Renal Íñigo Álvarez de Toledo
Ministerio de Economia
Sociedad Española de Nefrología Spain
Federación Española de Enfermedades Raras Spain
PI21/0143
Cemento de ionómero de vidrio, propiedades, clasificación y usos en la odontología restauradora: Revisión de la literatura.
Los cementos dentales constituyen un grupo de materiales que han sido utilizados a lo largo de los años en operatoria dental y, además, en otras ramas de la odontología como la prostodoncia, endodoncia, periodoncia y cirugía bucal. Un cemento dental es una sustancia que sirve para unir, pegar, y adherir dos cosas, es definido por ser una sal que ha resultado de una reacción ácido base y que a través de un proceso de fraguado ha endurecido. El objetivo de la formulación y el desarrollo de los cementos de ionómero de vidrio fue combinar las buenas propiedades del cemento de silicato y de policarboxilato de zinc. El ionómero de vidrio es un material de obturación basado en sílice, polvos de aluminio-silicato de calcio y soluciones homopolímeros y copolímeros del ácido acrílico. Se suministran en forma de polvo y líquido El líquido suele ser una solución al 47% de coopolímero de ácido poliacrílico e itacónico. El polvo del cemento es formado por la fusión de sus componentes principales, de sílice (????????), alúmina (??????????) y floruro de calcio (??????2). Existen varias clasificaciones de acuerdo a su composición. Los ionómeros se pueden clasificar en 5 tipos como son: los convencionales o vítreos, reforzados con metal, con partículas de resina (híbridos) coopómeros, nanoionómeros. El ionómero de vidrio es un material versátil con propiedades ideales como protector pulpar usado en cavidades profundas, para restaurar erosiones sin preparación cavitaria, como cemento, como sellador de fosas y fisuras, para la obturación de conductos radiculares, cementado de brackets y bandas de ortodoncia
Sarcopenia assessed by 4-step EWGSOP2 in elderly hemodialysis patients: Feasibility and limitations
In 2019, EWGSOP2 proposed 4 steps to diagnose and assess sarcopenia. We aimed to quantify the prevalence of sarcopenia according to the EWGSOP2 diagnostic algorithm and to assess its applicability in elderly patients on hemodialysis. Methods, Prospective study of 60 outpatients on chronic hemodialysis aged 75- to 95-years, sarcopenia was assessed according to the 4-step EWGSOP2: Find: Strength, Assistance walking, Rise from a chair, Climb stairs, and Falls (SARC-F); Assess: grip strength by dynamometry (GSD) and sit to stand to sit 5 (STS5); Confirm: appendicular skeletal muscle mass (ASM) by bioimpedance; Severity: gait speed (GS), Timed-Up and Go (TUG), and Short Physical Performance Battery (SPPB). Results, The sequential four steps resulted in a prevalence of confirmed or severe sarcopenia of 20%. Most (97%) patients fulfilled at least one criterion for probable sarcopenia. The sensitivity of SARC-F for confirmed sarcopenia was low (46%). Skipping the SARC-F step increased the prevalence of confirmed and severe sarcopenia to 40% and 37%, respectively. However, 78% of all patients had evidence of dynapenia consistent with severe sarcopenia. Muscle mass (ASM) was normal in 60% of patients, while only 25% had normal muscle strength values (GSD). Conclusions
According to the 4-step EWGSOP2, the prevalence of confirmed or severe sarcopenia was low in elderly hemodialysis patients. The diagnosis of confirmed sarcopenia underestimated the prevalence of dynapenia consistent with severe sarcopenia. Future studies should address whether a 2-step EWGSOP2 assessment (Assess-Severity) is simpler to apply and may provide better prognostic information than 4-step EWGSOP2 in elderly persons on hemodialysisThis research received no external funding. EGP, SM and AO research groups are funded by Ministerio de Economia, Industria y competitividad: FIS/Fondos FEDER (PI16/01298, PI17/00257, PI18/01386, PI19/00588, PI19/00815, PI20/00487, PI21/01430, ERA-PerMed-JTC2018 (KIDNEY ATTACK AC18/00064 and PERSTIGAN AC18/00071, ISCIII-RETIC REDinREN RD016/0009), and Sociedad Española de Nefrología, Comunidad de Madrid en Biomedicina B2017/BMD-3686 CIFRA2-CM. All authors want to thank Fundación Renal Íñigo Álvarez de Toledo (FRIAT) for it support to renal research in Spain. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscrip
Tratamiento del penfigoide de membranas mucosas con ácido hialurónico en gel al 0,2%. Reporte de caso.
Mucous membrane pemphigoid is a subepithelial, inflammatory, autoimmune blistering disorder that affects the body’s mucous membranes. Most of the cases appear in the oral mucosa. Corticosteroids and antimicrobials are the election treatment. This article describes the efficacy of 0.2% hyaluronic acid gel in mucous membrane pemphigoid. We report a case of a 57-year-old female patient with rheumatoid arthritis and mucous membrane pemphigoid in the upper and lower lips with three months of evolution. Lesions were treated with 0.2% hyaluronic acid gel, obtaining excellent results. The treatment of hyaluronic acid to mucous membrane pemphigoid demonstrated effectiveness in reducing inflammation, pain, and healing of the mucosa, without the need to suspend or adjust the dose of the drugs.El Penfigoide de membranas mucosas es un trastorno ampollar subepitelial, inflamatorio, autoinmune que afecta las mucosas del cuerpo. El 80% de los casos se presentan en la mucosa bucal. El tratamiento consiste en la administración de corticoesteroides y antimicrobianos. El objetivo de este articulo es describir la eficacia del ácido hialurónico en gel al 0,2% en el tratamiento del penfigoide de membranas mucosas. Se reporta el caso de una mujer de 57 años de edad con artritis reumatoide y penfigoide de membranas mucosas en el labio superior e inferior con tres meses de evolución. Las lesiones son tratadas con ácido hialurónico en gel al 0,2% obteniendo excelentes resultados. El tratamiento con ácido hialurónico demostró efectividad en la reducción del dolor y inflamación, sanando las lesiones sin necesidad de suspender o ajustar la dosis de los fármacos
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