Combined analysis of the decays τ−→KSπ−ντ\tau^-\to K_S\pi^-\nu_\tau and τ−→K−ηντ\tau^-\to K^-\eta\nu_\tau

In a combined study of the decay spectra of $\tau^-\to K_S\pi^-\nu_\tau$ and $\tau^-\to K^-\eta\nu_\tau$ decays within a dispersive representation of the required form factors, we illustrate how the $K^*(1410)$ resonance parameters, defined through the pole position in the complex plane, can be extracted with improved precision as compared to previous studies. While we obtain a substantial improvement in the mass, the uncertainty in the width is only slightly reduced, with the findings $M_{K^{*\prime}}=1304 \pm 17\,$MeV and $\Gamma_{K^{*\prime}} = 171 \pm 62\,$MeV. Further constraints on the width could result from updated analyses of the $K\pi$ and/or $K\eta$ spectra using the full Belle-I data sample. Prospects for Belle-II are also discussed. As the $K^-\pi^0$ vector form factor enters the description of the decay $\tau^-\to K^-\eta\nu_\tau$, we are in a position to investigate isospin violations in its parameters like the form factor slopes. In this respect also making available the spectrum of the transition $\tau^-\to K^-\pi^0\nu_\tau$ would be extremely useful, as it would allow to study those isospin violations with much higher precision.Comment: 20 pages, 1figur

Developmental switch from prolonged insulin action to increased insulin sensitivity in protein tyrosine phosphatase 1B-deficient hepatocytes

15 pages, 10 figures.Protein tyrosine phosphatase 1B (PTP1B) is a negative regulator of insulin signaling and a therapeutic target for type 2 diabetes. The purpose of this study was to evaluate the differences in insulin sensitivity between neonate and adult hepatocytes lacking PTP1B. Immortalized neonatal hepatocytes and primary neonatal and adult hepatocytes have been generated from PTP1B(-/-) and wild-type mice. PTP1B deficiency in immortalized neonatal hepatocytes prolonged insulin-induced tyrosine phosphorylation of the insulin receptor (IR) and IR substrates (IRS) -1, -2 compared with wild-type control cells. Endogenous IR and IRS-2 were down-regulated, whereas IRS-1 was up-regulated in PTP1B(-/-) neonatal hepatocytes and livers of PTP1B(-/-) neonates. Insulin-induced activation of phosphatidylinositol 3-kinase/Akt pathway was prolonged in PTP1B(-/-) immortalized neonatal hepatocytes. However, insulin sensitivity was comparable to wild-type hepatocytes. Rescue of PTP1B in deficient cells suppressed the prolonged insulin signaling, whereas RNA interference in wild-type cells promoted prolonged signaling. In primary neonatal PTP1B(-/-) hepatocytes, insulin prolonged the inhibition of gluconeogenic mRNAs, but the sensitivity to this inhibition was similar to wild-type cells. By contrast, in adult PTP1B-deficient livers, p85alpha was down-regulated compared with the wild type. Moreover, primary hepatocytes from adult PTP1B(-/-) mice displayed enhanced Akt phosphorylation and a more pronounced inhibition of gluconeogenic mRNAs than wild-type cells. Hepatic insulin sensitivity due to PTP1B deficiency is acquired through postnatal development. Thus, changes in IR and IRS-2 expression and in the balance between regulatory and catalytic subunits of phosphatidylinositol 3-kinase are necessary to achieve insulin sensitization in adult PTP1B(-/-) hepatocytes.This work was supported by Grant BFU 2005-01615 (to A.M.V.) and Grant SAF 2004-5545 (to M.B.) from Ministerio de Educación y Ciencia (Spain), Grant CAM/GR/SAL/0384/2004 (to A.M.V.) from Comunidad de Madrid (Spain), and Red de Grupos de Diabetes Mellitus Grant G03/212, Instituto Carlos III (Spain). A.G.-R. was supported by Grant FPU (Ministerio de Educación, Spain). O.E. was supported by Juan de la Cierva programe (Ministerio de Educación, Spain).Peer reviewe

Nuevo Macrocystellidae (Echinodermata, Cystoidea Rhombifera) para el Ordovícico español.

Se describe un ejemplar de Macrocystella Callaway, 1877, procedente del Caradoc de El Viso del Marqués, provincia de Ciudad Real. El género Macrocystella es el único descrito para la familia Macrocystellidae y se trata de un taxón de especial interés al ser considerado uno de los Glyptocystitida más primitivos de los que derivarían los rombíferos con pectinirrombos. El género estaba hasta la fecha restringido al Ordovícico inferior y medio, resultando ser éste el primer hallazgo incuestionable de Macrocystella en materiales de edad Ordovícico superior; siendo, por otro lado, la primera especie que se describe para España, la cual proponemos denominar Macrocystella pauli. [ABSTRACT] A new species of Macrocystella Callaway, 1877, based on a specimen, from the Caradoc of El Viso del Marqués (Ciudad Real province, Spain) is described and named Macrocystella pauli. The family Macrocystellidae contains only the one genus Macrocystella which is considered to be the most primitive glyptocystitid from which later rhombiferans with pectinirhombs were derived. This paper presents the first record of Macrocystella from Spain and the first undoubted record from the Upper Ordovician

Fibroma desmoplásico del hueso: aportación de un nuevo caso

Se presenta un caso de Fibroma Desmoplásico localizado en cuello femoral en un paciente adulto joven de 34 años, al cual se le practicó una resección amplia de la lesión y una reconstrucción por medio de un compuesto de aloinjerto intercalar proximal y prótesis total de cadera (aloprótesis). Un año después de la intervención no hay recidiva local de la lesión y se objetiva una buena incorporación del aloinjerto al huésped; con buena función de la cadera. Se revisa la literatura y se discuten algunas consideraciones diagnósticas y terapéuticas de la lesión.A case of Desmoplastic Fibroma of the Bone, located in the femoral neck, in a 34 year old male patient is reported. The tumor was treated by wide resection, the reconstruction beem performed with an allograft-prostheses composite. One year after surgery, there was no local recurrence and a good is incorporation of the allograft to the host was observed. The patient showed a good hip function. The literature is reviewed and diagnostic and therapeutic considerations are discussed

Nuevo Macrocystellidae (Echinodermata, Cystoidea Rhombifera) para el Ordovícico español

A new species of Macrocystella Callaway, 1877, based on a specimen, from the Caradoc of El Viso del Marqués (Ciudad Real province, Spain) is described and named Macrocystella pauli. The family Macrocystellidae contains only the one genus Macrocystella which is considered to be the most primitive glyptocystitid from which later rhombiferans with pectinirhombs were derived. This paper presents the first record of Macrocystella from Spain and the first undoubted record from the Upper Ordovician.Se describe un ejemplar de Macrocystella Callaway, 1877, procedente del Caradoc de El Viso del Marqués, provincia de Ciudad Real. El género Macrocystella es el único descrito para la familia Macrocystellidae y se trata de un taxón de especial interés al ser considerado uno de los Glyptocystitida más primitivos de los que derivarían los rombíferos con pectinirrombos. El género estaba hasta la fecha restringido al Ordovícico inferior y medio, resultando ser éste el primer hallazgo incuestionable de Macrocystella en materiales de edad Ordovícico superior; siendo, por otro lado, la primera especie que se describe para España, la cual proponemos denominar Macrocystella pauli

The TT Genotype of the STAT4 rs7574865 Polymorphism Is Associated with High Disease Activity and Disability in Patients with Early Arthritis

[Background] The number of copies of the HLA-DRB1 shared epitope, and the minor alleles of the STAT4 rs7574865 and the PTPN22 rs2476601 polymorphisms have all been linked with an increased risk of developing rheumatoid arthritis. In the present study, we investigated the effects of these genetic variants on disease activity and disability in patients with early arthritis. [Methodology and Results] We studied 640 patients with early arthritis (76% women; median age, 52 years), recording disease-related variables every 6 months during a 2-year follow-up. HLA-DRB1 alleles were determined by PCR-SSO, while rs7574865 and rs2476601 were genotyped with the Taqman 5′ allelic discrimination assay. Multivariate analysis was performed using generalized estimating equations for repeated measures. After adjusting for confounding variables such as gender, age and ACPA, the TT genotype of rs7574865 in STAT4 was associated with increased disease activity (DAS28) as compared with the GG genotype (β coefficient [95% confidence interval] = 0.42 [0.01–0.83], p = 0.044). Conversely, the presence of the T allele of rs2476601 in PTPN22 was associated with diminished disease activity during follow-up in a dose-dependent manner (CT genotype = −0.27 [−0.56– −0.01], p = 0.042; TT genotype = −0.68 [−1.64– −0.27], p = 0.162). After adjustment for gender, age and disease activity, homozygosity for the T allele of rs7574865 in STAT4 was associated with greater disability as compared with the GG genotype. [Conclusions] Our data suggest that patients with early arthritis who are homozygous for the T allele of rs7574865 in STAT4 may develop a more severe form of the disease with increased disease activity and disability.This work was partially supported by the RETICS (Redes Tematicas de Investigación Cooperativa, Cooperative Research Thematic Networks) Program, RD08/0075 (RIER) and FIS (Fondo de Investigación en Salud) Health Research Fund grant FIS 08/0754 to IG-A from Instituto de Salud Carlos III (ISCIII; www.isciii.es) and by grants from the European Innovative Medicines Initiative and BTCure Program (http://www.life-sciences-europe.com/orga​nisation/btcure-project-imi-efpia-201103​-innovative-medicines-initiative-2001-28​657.html). The work of IG-A was in part supported by a Research Intensification Grant from the National Health Care System (Instituto Carlos III; www.isciii.es), Madrid, Spain

Optimisation of an oak chips-grape mix maceration process. Influence of chip dose and maceration time

[EN] Oak chips-related phenolics are able to modify the composition of red wine and modulate the colour stability. In this study, the effect of two maceration techniques, traditional and oak chips-grape mix process, on the phenolic composition and colour of Syrah red wines from warm climate was studied. Two doses of oak chips (3 and 6 g/L) at two maceration times (5 and 10 days) during fermentation was considered. Changes on phenolic composition (HPLC–DAD–MS), copigmentation/polymerisation (spectrophotometry), and colour (Tristimulus and Differential Colorimetry) were assessed by multivariate statistical techniques. The addition of oak chips at shorter maceration times enhanced phenolic extraction, colour and its stabilisation in comparison to the traditional maceration. On contrast, increasing chip dose in extended maceration time resulted in wines with lighter and less stable colour. Results open the possibility of optimise alternative technological applications to traditional grape maceration for avoiding the common loss of colour of wines from warm climate

Application of differential colorimetry to evaluate anthocyanin-flavonol-flavanol ternary copigmentation interactions in model solutions

The combined effect of anthocyanin−flavanol−flavonol ternary interactions on the colorimetric and chemical stability of malvidin-3-glucoside has been studied. Model solutions with fixed malvidin-3-glucoside/(+)-catechin ratio (MC) and variable quercetin-3-β-D-glucoside concentration (MC+Q) and solutions with fixed malvidin-3-glucoside/quercetin-3-β-Dglucoside ratio (MQ) and variable (+)-catechin concentration (MQ+C) were tested at levels closer to those existing in wines. Color variations during storage were evaluated by differential colorimetry. Changes in the anthocyanin concentration were monitored by HPLC-DAD. CIELAB color-difference formulas were demonstrated to be of practical interest to assess the stronger and more stable interaction of quercetin-3-β-D-glucoside with MC binary mixture than (+)-catechin with MQ mixture. The results imply that MC+Q ternary solutions kept their intensity and bluish tonalities for a longer time in comparison to MQ+C solutions. The stability of malvidin-3-glucoside improves when the concentration of quercetin-3-β-D-glucoside increases in MC+Q mixtures, whereas the addition of (+)-catechin in MQ+C mixtures resulted in an opposite effec

Historical Archaeology in the Iberian Peninsula

UID/HIS/04209/2019 DL 57/2016/CP1453/CT0084authorsversionpublishe

Dinámica de septinas y regulación de la separación celular durante el crecimiento hifal de Candida albicans ¿una diana de antifúngicos?

Resumen del trabajo presentado al "IV Congreso GEBMP: Simposio Hongos Patógenos" celebrado en Badajoz el 6 de julio del 2012.Peer Reviewe