Occupational Therapy in Mental Health via Telehealth during the COVID-19 Pandemic

The COVID-19 pandemic has brought about changes in mental health occupational therapy. Research into these changes and the associated risks of relapse is insufficient. To explore the changes that have taken place in forms of occupational intervention (face-to-face and online) during the pandemic, and to analyze their association with subsequent relapses, a multicenter retrospective cohort study was carried out of 270 patients with mental disorder diagnoses under follow-up in day hospitals during 2020. Our results show that the frequency of face-to-face occupational therapy interventions decreased during lockdown and subsequently recovered. Interventions via telehealth increased during lockdown and have since been continued to a greater extent than before lockdown. Patients who received occupational intervention via telehealth relapsed less in the following six months (10.7% vs. 26.3%; χ2 = 10.372; p = 0.001), especially those who received intervention via videoconferencing (4.2% vs. 22%; χ2 = 5.718; p = 0.017). In conclusion, lockdown subsequent to the COVID-19 outbreak led to a reduction in face-to-face occupational therapy interventions, putting people with prior mental disorders at risk, while the implementation of telehealth tools helped reduce relapses

Physical principles of membrane remodelling during cell mechanoadaptation

Biological processes in any physiological environment involve changes in cell shape, which must be accommodated by their physical envelope-the bilayer membrane. However, the fundamental biophysical principles by which the cell membrane allows for and responds to shape changes remain unclear. Here we show that the 3D remodelling of the membrane in response to a broad diversity of physiological perturbations can be explained by a purely mechanical process. This process is passive, local, almost instantaneous, before any active remodelling and generates different types of membrane invaginations that can repeatedly store and release large fractions of the cell membrane. We further demonstrate that the shape of those invaginations is determined by the minimum elastic and adhesive energy required to store both membrane area and liquid volume at the cell-substrate interface. Once formed, cells reabsorb the invaginations through an active process with duration of the order of minutes

Physical principles of membrane remodelling during cell mechanoadaptation.

Biological processes in any physiological environment involve changes in cell shape, which must be accommodated by their physical envelope--the bilayer membrane. However, the fundamental biophysical principles by which the cell membrane allows for and responds to shape changes remain unclear. Here we show that the 3D remodelling of the membrane in response to a broad diversity of physiological perturbations can be explained by a purely mechanical process. This process is passive, local, almost instantaneous, before any active remodelling and generates different types of membrane invaginations that can repeatedly store and release large fractions of the cell membrane. We further demonstrate that the shape of those invaginations is determined by the minimum elastic and adhesive energy required to store both membrane area and liquid volume at the cell-substrate interface. Once formed, cells reabsorb the invaginations through an active process with duration of the order of minutes

Phase-dependent study of near-infrared disk emission lines in LB-1

The mass, origin and evolutionary stage of the binary system LB-1 has been the subject of intense debate, following the claim that it hosts an $\sim$70$M_{\odot}$ black hole, in stark contrast with the expectations for stellar remnants in the Milky Way. We conducted a high-resolution, phase-resolved spectroscopic study of the near-infrared Paschen lines in this system, using the 3.5-m telescope at Calar Alto Observatory. We find that Pa$\beta$ and Pa$\gamma$ (after proper subtraction of the stellar absorption component) are well fitted with a standard double-peaked model, typical of disk emission. We measured the velocity shifts of the red and blue peaks at 28 orbital phases: the line center has an orbital motion in perfect antiphase with the stellar motion, and the radial velocity amplitude ranges from 8 to 13 km/s for different choices of lines and profile modelling. We interpret this curve as proof that the disk is tracing the orbital motion of the primary, ruling out the circumbinary disk and the hierarchical triple scenarios. The phase-averaged peak-to-peak half-separation (proxy for the projected rotational velocity of the outer disk) is $\sim$70 km s$^{-1}$, larger than the stellar orbital velocity and also inconsistent with a circumbinary disk. From those results, we infer a primary mass 4--8 times higher than the secondary mass. Moreover, we show that the ratio of the blue and red peaks (V/R intensity ratio) has a sinusoidal behaviour in phase with the secondary star, which can be interpreted as the effect of external irradiation by the secondary star on the outer disk. Finally, we briefly discuss our findings in the context of alternative scenarios recently proposed for LB-1. Definitive tests between alternative solutions will require further astrometric data from $Gaia$.Comment: To be submitted to ApJ. Comments are welcom

Physical principles of membrane remodelling during cell mechanoadaptation

Biological processes in any physiological environment involve changes in cell shape, which must be accommodated by their physical envelope the bilayer membrane. However, the fundamental biophysical principles by which the cell membrane allows for and responds to shape changes remain unclear. Here we show that the 3D remodelling of the membrane in response to a broad diversity of physiological perturbations can be explained by a purely mechanical process. This process is passive, local, almost instantaneous, before any active remodelling and generates different types of membrane invaginations that can repeatedly store and release large fractions of the cell membrane. We further demonstrate that the shape of those invaginations is determined by the minimum elastic and adhesive energy required to store both membrane area and liquid volume at the cell-substrate interface. Once formed, cells reabsorb the invaginations through an active process with duration of the order of minutes

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

La renovación de la palabra en el bicentenario de la Argentina : los colores de la mirada lingüística

El libro reúne trabajos en los que se exponen resultados de investigaciones presentadas por investigadores de Argentina, Chile, Brasil, España, Italia y Alemania en el XII Congreso de la Sociedad Argentina de Lingüística (SAL), Bicentenario: la renovación de la palabra, realizado en Mendoza, Argentina, entre el 6 y el 9 de abril de 2010. Las temáticas abordadas en los 167 capítulos muestran las grandes líneas de investigación que se desarrollan fundamentalmente en nuestro país, pero también en los otros países mencionados arriba, y señalan además las áreas que recién se inician, con poca tradición en nuestro país y que deberían fomentarse. Los trabajos aquí publicados se enmarcan dentro de las siguientes disciplinas y/o campos de investigación: Fonología, Sintaxis, Semántica y Pragmática, Lingüística Cognitiva, Análisis del Discurso, Psicolingüística, Adquisición de la Lengua, Sociolingüística y Dialectología, Didáctica de la lengua, Lingüística Aplicada, Lingüística Computacional, Historia de la Lengua y la Lingüística, Lenguas Aborígenes, Filosofía del Lenguaje, Lexicología y Terminología

The Forgotten Myrtle of the Alhambra Gardens of Granada: Restoring and Authenticating World Heritage

In the Alhambra (Granada, Spain), and in other Moorish locations, several individuals of the original variety of myrtle, the emblematic plant of their gardens, have been identified and genetically authenticated. After microsatellite analysis, we differentiated between the wild form (Myrtus communis L.) and two cultivated varieties: the one original to the Alhambra, the Moorish myrtle (subsp. baetica), and the variety introduced in more modern times (subsp. tarentina). The genetic and morphological differences between these two varieties confirm the taxonomic distinctness of the subsp. baetica. With very few individuals known, this Moorish myrtle is on the verge of extinction. The genetic identification offers the opportunity to restore a key element of this 14th-century garden and enhance the authenticity of a World Heritage site.Departamento de Genética. Grupo BIO200. Facultad de Ciencias. Universidad de GranadaDepartamento de BotánicaJardín Botánico de la Universidad de GranadaThis work was been partially supported under the Agreement C-3161-00/ 01, “Botanical Studio, Historiographical and Genetic Variety of Myrtus communis in the Alhambra and Generalife” by the Council of the Alhambra and the Generalife and the University of Granada