Chronic disease in physical education

Se realizó un estudio epidemiológico de carácter descriptivo-observacional de las enfermedades crónicas en las clases de Educación Física de Educación Secundaria y Bachillerato. Se realizó en 36 Centros Educativos de la Comunidad de Madrid (España), en 4.527 alumnos, durante el periodo 2003-2009. Se utilizó un cuestionario como técnicas de recogida de datos. Se obtuvo que un elevado número de alumnos presentaron al menos una enfermedad crónica (53,19%), siendo alta la cantidad de alumnos que tienen varias (21,06%). Destacan por su prevalencia las alteraciones visuales y enfermedades del ojo (44,37%), las alergias (16,37%), las malposiciones dentales (8,61%), el asma (8,49%) y la escoliosis y cifoescoliosis (6,29%). Las patologías crónicas más importantes muestran un “patrón de prevalencia” que incluyen las enfermedades citadas. Las enfermedades más frecuentes en la cronología estudiada son compatibles con la realización de la clase de Educación Física, pero pueden ser importantes en el desarrollo de ésta si se ignoran.An observational and descriptive study of the epidemiology of chronic diseases in Physical Education classes in secondary education was carried out. It was conducted in 36 educational centers of the Autonomous Community of Madrid (Spain), in 4527 students, from 2003 to 2009. A questionnaire was used as data collection techniques. It revealed that a large number of students showed at least one chronic disease (53.19%) with a large amount of those suffering from multiple medical conditions (21.06%). The most prevalent illnesses include visual disturbances and eye diseases (44.37%), allergies (16.37%), misaligned teeth (8.61%), asthma (8.49%), scoliosis and kyphoscoliosis (6.29%). The most important chronic pathologies show a "prevalence pattern" which includes the previously mentioned diseases. The most common diseases in the analyzed chronology are compatible with the performance of the Physical Education lesson, but they may undermine its development if ignored

Design of Polymeric Nanocapsules for Intranasal Vaccination against Mycobacterium Tuberculosis: Influence of the Polymeric Shell and Antigen Positioning.

Tuberculosis (TB) is the leading cause of death from a single infectious microorganism and Bacillus Calmette Guerin (BCG), the only authorized vaccine, does not confer protection against pulmonary TB. Based on the hypothesis that mucosal protection could help to prevent the infection at the site of entrance, the objective of this work was to develop an intranasal vaccine against Mycobacterium tuberculosis (Mtb), the microorganism that causes TB. Our approach consisted of the use of polymeric nanocapsules (NCs) with an oily core and a polymer shell made of chitosan (CS) or inulin/polyarginine (INU/pArg). The immunostimulant Imiquimod, a Toll-like receptor-7 (TLR-7) agonist, was encapsulated in the oily core and a fusion protein, formed by two antigens of Mtb, was absorbed either onto the NC surface (CS:Ag and INU:pArg:Ag) or between two polymer layers (INU:Ag:pArg) in order to assess the influence of the antigen positioning on the immune response. Although CS NCs were more immunostimulant than the INU/pArg NCs in vitro, the in vivo experiments showed that INU:pArg:Ag NCs were the only prototype inducing an adequate immunoglobulin A (IgA) response. Moreover, a previous immunization with BCG increased the immune response for CS NCs but, conversely, decreased for INU/pArg NCs. Further optimization of the antigen and the vaccination regime could provide an efficacious vaccine, using the INU:pArg:Ag NC prototype as nanocarrier

Vertical distraction osteogenesis of a free vascularized fibula flap in a reconstructed hemimandible for mandibular reconstruction and optimization of the implant prosthetic rehabilitation. Report of a case

Free vascularized fibular flap is considered the treatment of choice in mandibular reconstruction for extensive bone defects (over 6 centimeters) resulting from trauma, infections or tumor resections. But, when the reconstruction involves a dentate mandible, the fibula has the limit as it does not offer sufficient bone height to restore the alveolar arch up to the occlusal plane. Therefore, the deficiency in bone height makes implant placement impractical. We report a case of vertical distraction osteogenesis of a free vascularized fibula flap used to reconstruct a hemimandible after resection of an odontogenic myxoma, for optimization of the implant prosthetic rehabilitation. The distraction device was applied intraorally. After 10 days of latency period, distraction protocol was performed at a distraction rate of 0.5 mm per day. A consolidation period of 3 months followed. Afterwards the distraction device was removed and 3 osseointegrated dental implants were placed in the distracted area. As a result, the vertical discrepancy between the fibula and the native hemimandible was corrected. The amount of vertical height achieved after distraction was 17 milimeters. The increase of vertical bone height was stable and enabled placement of dental implants without any complications. In conclusion, we consider that vertical distraction osteogenesis of free vascularized flaps is a reliable technique that optimizes implant positioning for ideal prosthetic rehabilitation, after mandibular reconstruction following tumor surger

Melanoma de la mucosa oral: casos clínicos y revisión de la literatura

La aparición de melanomas primarios de la mucosa oral es infrecuente. La agresividad de esta entidad y la ausencia de protocolos de tratamiento estandarizado, hacen que el pronóstico sea infausto. Se han relacionado la dificultad de la resección quirúrgica con márgenes libres, la tendencia elevada a la invasión en profundidad y las metástasis hematógenas tempranas, como consideraciones que justifican un peor pronóstico en relación al melanoma cutáneo. Sin embargo, no existen series clínicas grandes, y las series de casos clínicos constituyen la fuente principal de información en el momento actual. Ante la ausencia de modalidades de tratamiento que aumenten substancialmente la supervivencia a largo plazo, sugerimos el empleo de cirugía de resección con márgenes amplios y el diagnóstico precoz mediante la biopsia de lesiones pigmentadas melánicas sospechosas. En el presente trabajo presentamos 2 nuevos casos de melanoma primario de mucosa oral, con un seguimiento de 72 y 12 meses respectivamente, y realizamos una revisión de la literatura en relación con esta rara neoplasia.The appearance of primary melanomas of the oral mucosa is uncommon. The aggressiveness of this entity and the absence of any standardized treatment protocol make the prognostic unfortunate. The difficulty to obtain free surgical margins, the elevated tendency to invade in depth and the early haematogenous metastasis have been referred as features which may explain its bad prognosis, even in comparison with cutaneous melanoma. However, no large clinical series exist and actually, clinical cases are the main source of information. Due to the absence of any treatment modality which may substantially increase longterm survival, we suggest the use of resective surgery with wide margins and early diagnosis by means of biopsy for suspicious melanotic-pigmented lesions. In this work we present 2 new cases of primary melanoma of the oral mucosa, with a follow-up period of 72 and 12 months respectively, and we make a review of the literature in relation with this rare entity

Respuesta hidrológica y erosiva de un suelo forestal mediterráneo en recuperación de diferentes impactos

Land use changes, including land abandonment, and forest fires have been two key factors that have characterized the evolution of Mediterranean ecosystems. This work studies the evolution in the hydrologic characteristics and the erosive response of a Mediterranean forest soil, which has undergone during years changes in its forest use and the fire impact, are shown. This soil is in recovering stage since year 1996. The study has been carried out in the Experimental Station of Porta-Coeli in a system of four erosion plots (40 x 8 m) of closed type. The hydrologic behaviour and erosive parameters have been studied in each rain event during period 2006-2008. The temporal variability of soil moisture contents have been also studied through the characterization of its response curves regarding different episodes of rain, analyzing its relation with runoff generation.En las últimas décadas, dos de los factores más importantes que han caracterizado la evolución en los ecosistemas mediterráneos han sido los cambios de uso del suelo, incluyendo el abandono de cultivos, y los incendios forestales. En este trabajo se presenta la evolución de las características hidrológicas y de la respuesta erosiva de un suelo forestal mediterráneo que ha sufrido durante años cambios en su uso y el impacto de incendios forestales. Actualmente la zona de estudio se encuentra en recuperación desde el año 1996. El trabajo se ha desarrollado en la Estación Experimental de Porta-Coeli en un sistema de cuatro parcelas (40 x 8 m) de erosión de tipo cerrado. Se ha determinado su comportamiento hidrológico y sus parámetros erosivos en cada episodio de lluvia durante el período 2006-2008. También se ha estudiado la variabilidad temporal del contenido de humedad del suelo a través de la caracterización de sus curvas-respuesta en diferentes episodios de lluvia, y se analiza su relación con la generación de escorrentía

A functional variant in the stearoyl-CoA desaturase (SCD) gene promoter affects gene expression in ovine muscle

The nutritional quality of lambs may be improved with increased stearoyl-CoA desaturase (SCD) gene expression, which increases the desaturation of stearic acid to oleic acid. The aim of this study was to evaluate the effect of the rs412429481 (FJ513370: g.31C > A) SNP located at the SCD gene on the functionality of the gene in lambs reared under different production systems. The effect of the rs412429481 SNP on gene expression in Rasa Aragonesa male lambs slaughtered at 22–24 kg was studied in two experiments. In Experiment 1 (n = 44), the semitendinosus muscle of lambs grazing alfalfa (ALF) or fed concentrates indoors (IND) was analysed; in Experiment 2 (n = 48), the semitendinosus and longissimus thoracis muscles of lambs that received supplementation with dl-a-tocopheryl acetate for different finishing periods were used. In Experiment 1, the effect of the rs412429481 SNP on the expression of the SCD gene in the semitendinosus muscle depended on the feeding group (P < 0.001), as it had no effect in ALF lambs, but CA lambs had greater SCD expression than CC lambs under the IND conditions. Moreover, ALF lambs showed lower levels of SCD gene expression than IND lambs (P < 0.05). In Experiment 2, gene expression was affected by the rs412429481 SNP in both muscles. Animals carrying the C- allele showed a lower expression rate than animals carrying the A- allele. These different expression levels were not associated with changes in the DNA methylation pattern or by the binding of specific nuclear proteins. Finally, we confirmed these results by luciferase assays, demonstrating that the SCD promoter containing the A variant had a 23.9% higher activity than the promoter containing the C variant

Tamaño de área de drenaje y conectividad hidrológica en la formación de escorrentía en cuencas semiáridas mediterráneas. Cuenca aforada del Barranc del Carraixet

The rainfall-runoff conversion is analysed taking in consideration the contributing area and hydrological connectivity, factors needing better understanding. Within the same basin, the Barranc del Carraixet near Valencia, has been selected three scales of work: four experimental plots (8 x 40 m), micro-basin (17.01 ha) and small drainage basin (127.9 km2). For the analysis of runoff generation at different scales rainfall thresholds and runoff rates and thresholds were used. For hydrological connectivity, at plot level, coefficients of determination were analyzed. Inverse relationship is given between the volume of runoff and recurrence, with increasing scale. Connectivity, at plot level, is variable, increasing the R2 according the simplification of processes, when the interference of vegetation decreases, establishing better linearity between rain and surface flow.Se analizan las relaciones de la conversión de la lluvia en escorrentía superficial atendiendo al tamaño del área de aporte y la conectividad hidrológica, factores poco estudiados. En una misma cuenca, la del Barranc de Carraixet en las cercanías de Valencia, se han seleccionado tres escalas de trabajo: cuatro parcelas experimentales (8 x 40 m), microcuenca (17,01 ha) y cuenca de drenaje de pequeño tamaño (127,9 km2). Para el análisis de la formación de escorrentía en las distintas escalas se utilizaron los umbrales de precipitación, índices y umbrales de escorrentía. Para la conectividad hidrológica, a escala de parcela, se analizaron los coeficientes de determinación. Se ha obtenido una relación inversa en volumen de escorrentía y en recurrencia, según aumenta la escala. La conectividad, a escala de parcela, es variable, aumentando el R2 con la simplificación de los procesos, sobre todo al disminuir la interferencia de la vegetación, estableciéndose mayor linealidad entre la lluvia y el flujo superficial