Marx and Humanism : notes of a controversy in the philosophy of Sergio Vuskovic

El ejercicio filosófico de raíz marxista en Chile tiene un capítulo escrito por los intelectuales comunistas de la década del 60 del siglo XX. Uno de ellos, Sergio Vuskovic, se abocó a discutir con las tesis althusserianas que identificaron la teorización de Marx como un antihumanismo teórico. Para oponerse a tal perspectiva, Vuskovic realiza una operación teórica al interior de la obra de Marx con el objetivo de afirmar la categoría de sujeto, así como la interna relación entre ejercicio teórico y praxis socio-histórica.Chilean communist intellectuals of the 1960‟s wrote a chapter of the history of Marxist philosophy. One of them was Sergio Vuskovic who focused on discussing Marx‟s theories according to Althusser‟s thesis of anti-humanism. By affirming the subject category and the internal relationship between ‟theoretical operationˮ and socio-historical praxis within Marx‟s philosophy, Vuskovic opposes Althusser‟s perspectiveFil: González San Martín, Patricia. Universidad de Valparaís

Regulación y Análisis Económico del Servicio Postal en España

Las sociedades avanzadas han ido generando cada vez nuevos tipos de demandas; los clientes necesitan decidir cuándo, cómo y dónde utilizar, enviar y recibir información y mercancías de forma rápida. Estos hechos han llevado a liberalizar recientemente los servicios postales en muchos países para poder atender esas nuevas necesidades de servicios. Un buen ejemplo de ello es la elevada tasa de penetración del correo electrónico o de los courriers nacionales e internacionales que se dedicarán al reparto de paquetería. Ante este nuevo panorama, empresas antes dedicadas al sector transporte se van introduciendo en el sector postal. La innovación tecnológica, la nueva organización logística, el correo electrónico e Internet, favorecen la creación de nuevos productos y hacen necesaria una reestructuración del sector postal. Esta evolución del sector ha de ir acompañada de una legislación y una regulación adecuadas, además de un conjunto de estrategias que han de seguir los operadores postales para adaptarse al nuevo panorama sectorial. Por tanto, en la primera parte del artículo se resume la evolución de la estructura de mercado del sector postal español y su reciente legislación, para, posteriormente, hacer un análisis de las estrategias seguidas por los operadores europeos, y entre ellos el español. Por último, se presenta un análisis de Debilidades, Amenazas, Fortalezas y Oportunidades (DAFO) del sector postal español.Publicad

Regulación y Análisis Económico del Servicio Postal en España.

Las sociedades avanzadas han ido generando cada vez nuevos tipos de demandas; los clientes necesitan decidir cuándo, cómo y dónde utilizar, enviar y recibir información y mercancías de forma rápida. Estos hechos han llevado a liberalizar recientemente los servicios postales en muchos países para poder atender esas nuevas necesidades de servicios. Un buen ejemplo de ello es la elevada tasa de penetración del correo electrónico o de los courriers nacionales e internacionales que se dedicarán al reparto de paquetería. Ante este nuevo panorama, empresas antes dedicadas al sector transporte se van introduciendo en el sector postal. La innovación tecnológica, la nueva organización logística, el correo electrónico e Internet, favorecen la creación de nuevos productos y hacen necesaria una reestructuración del sector postal. Esta evolución del sector ha de ir acompañada de una legislación y una regulación adecuadas, además de un conjunto de estrategias que han de seguir los operadores postales para adaptarse al nuevo panorama sectorial. Por tanto, en la primera parte del artículo se resume la evolución de la estructura de mercado del sector postal español y su reciente legislación, para, posteriormente, hacer un análisis de las estrategias seguidas por los operadores europeos, y entre ellos el español. Por último, se presenta un análisis de Debilidades, Amenazas, Fortalezas y Oportunidades (DAFO) del sector postal español.Servicios postales; Tecnologías de la información; Nuevas tecnologías; Legislación; España; UE;

Raíces del cine ensayo en Latinoamérica

This paper proposes that certain cinematographic manifestations of the sixties and seventies are part of what is currently called, more appropriately, essay film. On the one hand, they are genuine and singular cinematographic pieces in relation to the European essay film, marking an important difference by constituting themselves as material reflections and not strictly formal. Likewise, the Latin American essay film of those years establishes roots, linked to politics, criticism and aesthetics, very different from the current definitions, of an analytical and linguistic nature. Without being modern, it builds alternative subjective processes, materializes cinematographic thought and discusses important concepts, such as Deleuze's image-time. Without elaborating a list, this paper generates a conceptual framework in which certain pieces from the period can be considered essays.El presente escrito propone que ciertas manifestaciones cinematográficas de los años sesenta y setenta se inscriben dentro de lo que actualmente se llama, con mayor propiedad, cine ensayo. Por un lado, se trata de piezas cinematográficas genuinas y singulares en relación al ensayo cinematográfico europeo, marcando una diferencia importante al constituirse como reflexiones materiales y no estrictamente formales, al decir de la mayoría de los estudios sobre cine ensayo en general. Asimismo, el ensayo cinematográfico latinoamericano de aquellos años establece unas raíces, ligadas a la política, a la crítica y a la estética, muy diferentes a las definiciones actuales, de carácter analítico y lingüístico. Sin llegar a ser moderno, por razones que aquí se discutirán, construye procesos subjetivos alternos, materializa el pensamiento cinematográfico y discute conceptos importantes, como el de la imagen-tiempo en Deleuze. Sin elaborar una lista, el presente escrito genera un marco conceptual con el cual ciertas piezas de la época pueden ser consideradas ensayísticas. Se nombran algunas

Integrative development of a short screening questionnaire of highly processed food consumption (sQ-HPF)

Background: Recent lifestyle changes include increased consumption of highly processed foods (HPF), which has been associated with an increased risk of non-communicable diseases (NCDs). However, nutritional information relies on the estimation of HPF consumption from food-frequency questionnaires (FFQ) that are not explicitly developed for this purpose. We aimed to develop a short screening questionnaire of HPF consumption (sQ-HPF) that integrates criteria from the existing food classification systems. Methods: Data from 4400 participants (48.1% female and 51.9% male, 64.9 +/- 4.9 years) of the Spanish PREDIMED-Plus (PREvention with MEDiterranean DIet) trial were used for this analysis. Items from the FFQ were classified according to four main food processing-based classification systems (NOVA, IARC, IFIC and UNC). Participants were classified into tertiles of HPF consumption according to each system. Using binomial logistic regression, food groups associated with agreement in the highest tertile for at least two classification systems were chosen as items for the questionnaire. ROC analysis was used to determine cut-off points for the frequency of consumption of each item, from which a score was calculated. Internal consistency of the questionnaire was assessed through exploratory factor analysis (EFA) and Cronbach's analysis, and agreement with the four classifications was assessed with weighted kappa coefficients. Results: Regression analysis identified 14 food groups (items) associated with high HPF consumption for at least two classification systems. EFA showed that items were representative contributors of a single underlying factor, the HPF dietary pattern (factor loadings around 0.2). We constructed a questionnaire asking about the frequency of consumption of those items. The threshold frequency of consumption was selected using ROC analysis. Comparison of the four classification systems and the sQ-HPF showed a fair to high agreement. Significant changes in lifestyle characteristics were detected across tertiles of the sQ-HPF score. Longitudinal changes in HPF consumption were also detected by the sQ-HPF, concordantly with existing classification systems. Conclusions: We developed a practical tool to measure HPF consumption, the sQ-HPF. This may be a valuable instrument to study its relationship with NCDs

Long-Term Real-World Effectiveness and Safety of Ustekinumab in Crohn’s Disease Patients: The SUSTAIN Study

Background Large real-world-evidence studies are required to confirm the durability of response, effectiveness, and safety of ustekinumab in Crohn’s disease (CD) patients in real-world clinical practice. Methods A retrospective, multicentre study was conducted in Spain in patients with active CD who had received ≥1 intravenous dose of ustekinumab for ≥6 months. Primary outcome was ustekinumab retention rate; secondary outcomes were to identify predictive factors for drug retention, short-term remission (week 16), loss of response and predictive factors for short-term efficacy and loss of response, and ustekinumab safety. Results A total of 463 patients were included. Mean baseline Harvey-Bradshaw Index was 8.4. A total of 447 (96.5%) patients had received prior biologic therapy, 141 (30.5%) of whom had received ≥3 agents. In addition, 35.2% received concomitant immunosuppressants, and 47.1% had ≥1 abdominal surgery. At week 16, 56% had remission, 70% had response, and 26.1% required dose escalation or intensification; of these, 24.8% did not subsequently reduce dose. After a median follow-up of 15 months, 356 (77%) patients continued treatment. The incidence rate of ustekinumab discontinuation was 18% per patient-year of follow-up. Previous intestinal surgery and concomitant steroid treatment were associated with higher risk of ustekinumab discontinuation, while a maintenance schedule every 12 weeks had a lower risk; neither concomitant immunosuppressants nor the number of previous biologics were associated with ustekinumab discontinuation risk. Fifty adverse events were reported in 39 (8.4%) patients; 4 of them were severe (2 infections, 1 malignancy, and 1 fever). Conclusions Ustekinumab is effective and safe as short- and long-term treatment in a refractory cohort of CD patients in real-world clinical practice

Using Interpretable Machine Learning to Identify Baseline Predictive Factors of Remission and Drug Durability in Crohn’s Disease Patients on Ustekinumab

Ustekinumab has shown efficacy in Crohn's Disease (CD) patients. To identify patient profiles of those who benefit the most from this treatment would help to position this drug in the therapeutic paradigm of CD and generate hypotheses for future trials. The objective of this analysis was to determine whether baseline patient characteristics are predictive of remission and the drug durability of ustekinumab, and whether its positioning with respect to prior use of biologics has a significant effect after correcting for disease severity and phenotype at baseline using interpretable machine learning. Patients' data from SUSTAIN, a retrospective multicenter single-arm cohort study, were used. Disease phenotype, baseline laboratory data, and prior treatment characteristics were documented. Clinical remission was defined as the Harvey Bradshaw Index <= 4 and was tracked longitudinally. Drug durability was defined as the time until a patient discontinued treatment. A total of 439 participants from 60 centers were included and a total of 20 baseline covariates considered. Less exposure to previous biologics had a positive effect on remission, even after controlling for baseline disease severity using a non-linear, additive, multivariable model. Additionally, age, body mass index, and fecal calprotectin at baseline were found to be statistically significant as independent negative risk factors for both remission and drug survival, with further risk factors identified for remission

Impact of the first wave of the SARS-CoV-2 pandemic on the outcome of neurosurgical patients: A nationwide study in Spain

Objective To assess the effect of the first wave of the SARS-CoV-2 pandemic on the outcome of neurosurgical patients in Spain. Settings The initial flood of COVID-19 patients overwhelmed an unprepared healthcare system. Different measures were taken to deal with this overburden. The effect of these measures on neurosurgical patients, as well as the effect of COVID-19 itself, has not been thoroughly studied. Participants This was a multicentre, nationwide, observational retrospective study of patients who underwent any neurosurgical operation from March to July 2020. Interventions An exploratory factorial analysis was performed to select the most relevant variables of the sample. Primary and secondary outcome measures Univariate and multivariate analyses were performed to identify independent predictors of mortality and postoperative SARS-CoV-2 infection. Results Sixteen hospitals registered 1677 operated patients. The overall mortality was 6.4%, and 2.9% (44 patients) suffered a perioperative SARS-CoV-2 infection. Of those infections, 24 were diagnosed postoperatively. Age (OR 1.05), perioperative SARS-CoV-2 infection (OR 4.7), community COVID-19 incidence (cases/10 5 people/week) (OR 1.006), postoperative neurological worsening (OR 5.9), postoperative need for airway support (OR 5.38), ASA grade =3 (OR 2.5) and preoperative GCS 3-8 (OR 2.82) were independently associated with mortality. For SARS-CoV-2 postoperative infection, screening swab test <72 hours preoperatively (OR 0.76), community COVID-19 incidence (cases/10 5 people/week) (OR 1.011), preoperative cognitive impairment (OR 2.784), postoperative sepsis (OR 3.807) and an absence of postoperative complications (OR 0.188) were independently associated. Conclusions Perioperative SARS-CoV-2 infection in neurosurgical patients was associated with an increase in mortality by almost fivefold. Community COVID-19 incidence (cases/10 5 people/week) was a statistically independent predictor of mortality. Trial registration number CEIM 20/217

El reto de la inclusión de los Objetivos de Desarrollo Sostenible en la formación inicial de profesores de secundaria: creación del MOOC curso cero sobre educación y ODS, inclusión en asignaturas y en trabajos fin de máster

Memoria ID-041. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2021-2022

Dietary Iron, Anemia Markers, Cognition, and Quality of Life in Older Community-Dwelling Subjects at High Cardiovascular Risk

Anemia causes hypo-oxygenation in the brain, which could lead to cognitive disorders. We examined dietary iron intake as well as anemia markers (i.e., hemoglobin, hematocrit, mean corpuscular volume) and diabetes coexistence in relation to neuropsychological function and quality of life. In this study, 6117 community-dwelling adults aged 55-75 years (men) and 60-75 years (women) with overweight/obesity and metabolic syndrome were involved. We performed the Mini-Mental State Examination (MMSE), the Trail Making Test parts A and B (TMT-A/B), Semantic Verbal Fluency of animals (VFT-a), Phonological Verbal Fluency of letter P (VFT-p), Digit Span Test (DST), the Clock Drawing Test (CDT), and the Short Form-36 Health Survey (SF36-HRQL test). Dietary iron intake did not influence neuropsychological function or quality of life. However, anemia and lower levels of anemia markers were associated with worse scores in all neurophysiological and SF36-HRQL tests overall, but were especially clear in the MMSE, TMT-B (cognitive flexibility), and the physical component of the SF36-HRQL test. The relationships between anemia and diminished performance in the TMT-A/B and VFT tasks were notably pronounced and statistically significant solely among participants with diabetes. In brief, anemia and reduced levels of anemia markers were linked to inferior cognitive function, worse scores in different domains of executive function, as well as a poorer physical, but not mental, component of quality of life. It was also suggested that the coexistence of diabetes in anemic patients may exacerbate this negative impact on cognition. Nevertheless, dietary iron intake showed no correlation with any of the outcomes. To make conclusive recommendations for clinical practice, our findings need to be thoroughly tested through methodologically rigorous studies that minimize the risk of reverse causality