ANÁLISIS Y EVALUACIÓN DE UN SISTEMA DE COMUNICACIÓN DE DATOS VÍA RADIO PUNTO A PUNTO DE CORTO ALCANCE EN UHF

RESUMENEn el desarrollo, investigación e innovación relacionada con la implementación de sistemas de comunicación de datos vía radio, resulta conveniente utilizar dispositivos que operen en las bandas de uso libre. Esto implica el estudio y la utilización de tecnologías de bajo costo, baja potencia y corto alcance relacionadas con Circuitos Integrados de Radiofrecuencia (RFIC, Radiofrequency Integrated Circuits), el análisis de las características de estabilidad y exactitud en frecuencia de dispositivos inalámbricos, análisis de esquemas de modulación y codificación, ingeniería de protocolos, control de errores, análisis de potencia, ancho de banda y consideraciones de desempeño del sistema ante ruido e interferencia.Este articulo es la implementación de un sistema de comunicación sencillo, práctico y confiable que por medio del uso de transceptores de radiofrecuencia permite establecer una comunicación de datos entre dos equipos terminales, la aplicación de un protocolo de comunicaciones que garantiza calidad en la transmisión y recepción de la información, evaluando y analizando las características principales de la comunicación y su desempeño para diferentes condiciones de propagación o escenarios. El sistema implementado es una herramienta que permite soportar procesos de enseñanza y aprendizaje en lo relacionado a sistemas de comunicación de datos vía radio, que involucra software y hardware y en especial el uso de circuitos integrados de radiofrecuencia y equipo especializado de medida.Este artículo es una primera aproximación a la evaluación y análisis del desempeño de sistemas de comunicación de datos utilizando pequeños dispositivos de baja potencia en la banda de 433 MHz, que puede ser utilizado en diferentes tipos de aplicaciones tanto de hogar como de industria.PALABRAS CLAVES: RFIC, Modulación, Codificación, Protocolo, Desempeño, ANALYTICAL SUMMARYIn development, research and innovation related to the implementation of radio data communication systems, it is convenient to use devices operating on free bands. It implies studying and using low cost technologies related to Radiofrequency Integrated Circuits (RFIC), frequency stability and accuracy analysis in wireless devices, modulation and encoding schemes analysis, protocol engineering, error control, power analysis, bandwidth and system performance against noise and interference.This article is about the implementation of a simple, practical and realiable communication system, which through radiofrequency transceivers allows establishing a data communication between two data terminal equipments, the application of a communication protocol which guarantees quality in information transmission and reception, evaluating and analyzing the main features of the communication and its performance for different propagation conditions or scenarios. The implemented system is a tool which allows supporting teaching and learning processes in relation to radio or wireless data communication systems, which involves software and hardware and specially the use of radiofrequency integrated circuits and specialized mesurement equipment.This article is a first approach to the performance evaluation and analysis of data communication systems, using low power small devices in 433 MHz, which can be use in different applications in home and industry. KEYWORDS: RFIC, Modulation, Coding, Protocol, Performanc

ANÁLISIS Y EVALUACIÓN DE UN SISTEMA DE COMUNICACIÓN DE DATOS VÍA RADIO PUNTO A PUNTO DE CORTO ALCANCE EN UHF

RESUMENEn el desarrollo, investigación e innovación relacionada con la implementación de sistemas de comunicación de datos vía radio, resulta conveniente utilizar dispositivos que operen en las bandas de uso libre. Esto implica el estudio y la utilización de tecnologías de bajo costo, baja potencia y corto alcance relacionadas con Circuitos Integrados de Radiofrecuencia (RFIC, Radiofrequency Integrated Circuits), el análisis de las características de estabilidad y exactitud en frecuencia de dispositivos inalámbricos, análisis de esquemas de modulación y codificación, ingeniería de protocolos, control de errores, análisis de potencia, ancho de banda y consideraciones de desempeño del sistema ante ruido e interferencia.Este articulo es la implementación de un sistema de comunicación sencillo, práctico y confiable que por medio del uso de transceptores de radiofrecuencia permite establecer una comunicación de datos entre dos equipos terminales, la aplicación de un protocolo de comunicaciones que garantiza calidad en la transmisión y recepción de la información, evaluando y analizando las características principales de la comunicación y su desempeño para diferentes condiciones de propagación o escenarios. El sistema implementado es una herramienta que permite soportar procesos de enseñanza y aprendizaje en lo relacionado a sistemas de comunicación de datos vía radio, que involucra software y hardware y en especial el uso de circuitos integrados de radiofrecuencia y equipo especializado de medida.Este artículo es una primera aproximación a la evaluación y análisis del desempeño de sistemas de comunicación de datos utilizando pequeños dispositivos de baja potencia en la banda de 433 MHz, que puede ser utilizado en diferentes tipos de aplicaciones tanto de hogar como de industria.PALABRAS CLAVES: RFIC, Modulación, Codificación, Protocolo, Desempeño, ANALYTICAL SUMMARYIn development, research and innovation related to the implementation of radio data communication systems, it is convenient to use devices operating on free bands. It implies studying and using low cost technologies related to Radiofrequency Integrated Circuits (RFIC), frequency stability and accuracy analysis in wireless devices, modulation and encoding schemes analysis, protocol engineering, error control, power analysis, bandwidth and system performance against noise and interference.This article is about the implementation of a simple, practical and realiable communication system, which through radiofrequency transceivers allows establishing a data communication between two data terminal equipments, the application of a communication protocol which guarantees quality in information transmission and reception, evaluating and analyzing the main features of the communication and its performance for different propagation conditions or scenarios. The implemented system is a tool which allows supporting teaching and learning processes in relation to radio or wireless data communication systems, which involves software and hardware and specially the use of radiofrequency integrated circuits and specialized mesurement equipment.This article is a first approach to the performance evaluation and analysis of data communication systems, using low power small devices in 433 MHz, which can be use in different applications in home and industry. KEYWORDS: RFIC, Modulation, Coding, Protocol, Performanc

Quality of life and oral health in elderly

We want to assess quality of life in elderly patients in relation to the number of remaining teeth, the number of ingested drugs and xerostomía and to determine the correlation between an increased intake of drugs and a greater feeling of dry mouth and to know the most commonly used measures to control xerostomia. 30 subjects aged between 65 and 95 years (14 males, 16 females) completed the OHIP questionnaire to determine quality of life. For oral status, the number of remaining teeth according to WHO criteria and xerostomia using the xerostomia index (XI) were studied. In cases of dry mouth sensation, the measures to alleviate it were asked. The average quality of life according to the OHIP rate is 19.23 (Dt = 10.58), being 56 the worst quality of life. The Pearson correlation coefficient indicates that quality of life is not related to the number of remaining teeth (r = -0.046; p = 0.810) nor the number of ingested drugs (r = 0.226; p = 0.23) but a greater sensation of dry mouth is related to a poorer quality of life (r = 0.678; p = 0.230). There is no association between the number of ingested drugs and the xerostomia index (r = 0.144; p = 0.447). The most frequently measures used against dry mouth were drinking water (21 subjects) and sugarless candies (15 subjects). Quality of life is not related to the number of remaining teeth nor the number of ingested drugs. However, a higher level of xerostomia was significantly associated with a poorer quality of life. There is no association between the number of drugs ingested and xerostomia index. Sugarless candies and drinking water are the more frequently used measures to alleviate dry mouth

Iterative dual-metal and energy transfer catalysis enables stereodivergence in alkyne difunctionalization: Carboboration as case study

Stereochemically defined tetrasubstituted olefins are widespread structural elements of organic molecules and key intermediates in organic synthesis. However, flexible methods enabling stereodivergent access to E and Z isomers of fully substituted alkenes from a common precursor represent a significant challenge and are actively sought after in catalysis, especially those amenable to complex multifunctional molecules. Herein, we demonstrate that iterative dual-metal and energy transfer catalysis constitutes a unique platform for achieving stereodivergence in the difunctionalization of internal alkynes. The utility of this approach is showcased by the stereodivergent synthesis of both stereoisomers of tetrasubstituted β-boryl acrylates from internal alkynoates with excellent stereocontrol via sequential carboboration and photoisomerization. The reluctance of electron-deficient internal alkynes to undergo catalytic carboboration has been overcome through cooperative Cu/Pd-catalysis, whereas an Ir complex was identified as a versatile sensitizer that is able to photoisomerize the resulting sterically crowded alkenes. Mechanistic studies by means of quantum-chemical calculations, quenching experiments, and transient absorption spectroscopy have been applied to unveil the mechanism of both stepsPGC2018-098660−B-I00, Horizon2020 (ERC) No.648319, PID2019-106315RB-I00, PID2020-118593RB-C22

Rituximab in the treatment of interstitial lung disease associated with autoimmune diseases: experience from a single referral center and literature review

ABSTRACT: In the present study, we aimed to report our experience with rituximab (RTX) in the treatment of patients with ILD associated with AD (AD-ILD) at a single center. For this purpose, clinical characteristics, radiological findings, and pulmonary function tests (PFTs) of RTX-treated AD-ILD-patients seen from May 2016 until March 2020 at a referral center for individuals with ILD were retrospectively reviewed. Additionally, an updated literature review was conducted. A total of 26 patients (mean age 58.3 ± 11.1 years at ILD diagnosis) was included. The most common ADs related to ILD were systemic sclerosis, idiopathic inflammatory myositis (including anti-synthetase syndrome) and rheumatoid arthritis. Non-specific interstitial pneumonia (n = 12) and usual interstitial pneumonia (n = 11) were the predominant radiological patterns. The sustained improvement in PFTs was observed from the start of RTX, with a statistically significant increase in DLCO from basal to one year after RTX (mean + 4.2%, p = 0.024). Overall, there were no differences when comparing PFT outcome according to the radiological pattern or the specific type of AD. In conclusion, RTX constitutes a good therapeutic option to preserve lung function in patients with AD-ILD, regardless of the radiological pattern or the underlying AD.This research received no external funding. B.A.-M. is recipient of a and “López Albo” Post-Residency Programme funded by Servicio Cántabro de Salud. S.R.-M. is supported by funds of the RETICS Program (RD16/0012/0009) (Instituto de Salud Carlos III, co-funded by the European Regional Development Fund)

Sistematización del proceso de creación y desarrollo de la Universiad URACCAN en el triangulo Minero período 1995-2005

El establecimiento de URACCAN ha sido fundamental para ya no depender de profesionales y técnicos exógenos, fortaleciendo la Autonomía en la dignificación de los habitantes. La mayoría de instituciones gubernamentales y no gubernamentales, asociaciones de pueblos indígenas, movimientos sociales y empresas tienen entre su personal a profesionales egresados de nuestra universidad. A su vez, representantes ante el Consejo Regional y ante la Asamblea Nacional. Las transformaciones positivas realizadas por la universidad se observa en los sistemas productivos y el fortalecimien- to de la asociatividad campesina, a través del proceso de acompañamiento social y comunitario. De todo este proceso versa este informe de sistematización que recrea la memo- ria de los primeros años. La década comprendida de1995 al 2005, constituye el hito histórico en las etapas de creación, fortalecimiento y desarrollo de URACCAN en el Triángulo Minero. Una década de trabajo apasionado y de sueños compartidos con la cooperación internacional, siendo las principales organizaciones donantes: Horizont 3000 (conocida en los primeros años como ÖED) y SAIH-Noruega. Esta es la narración de está década. Es la memoria de cómo nuestros sueños se hicieron realidad

Impact of Arterial Stiffness on All-Cause Mortality in Patients Hospitalized With COVID-19 in Spain

Older age and cardiovascular comorbidities are well-known risk factors for all-cause mortality in patients with coronavirus disease 2019 (COVID-19). Hypertension and age are the 2 principal determinants of arterial stiffness (AS). This study aimed to estimate AS in patients with COVID-19 requiring hospitalization and analyze its association with all-cause in-hospital mortality. This observational, retrospective, multicenter cohort study analyzed 12 170 patients admitted to 150 Spanish centers included in the SEMI-COVID-19 Network. We compared AS, defined as pulse pressure ≥60 mm Hg, and clinical characteristics between survivors and nonsurvivors. Mean age was 67.5 (±16.1) years and 42.5% were women. Overall, 2606 (21.4%) subjects died. Admission systolic blood pressure (BP) <120 and ≥140 mm Hg was a predictor of higher all-cause mortality (23.5% and 22.8%, respectively, P<0.001), compared with systolic BP between 120 and 140 mm Hg (18.6%). The 4379 patients with AS (36.0%) were older and had higher systolic and lower diastolic BP. Multivariate analysis showed that AS and systolic BP <120 mm Hg significantly and independently predicted all-cause in-hospital mortality (adjusted odds ratio [ORadj]: 1.27, P=0.0001; ORadj: 1.48, P=0.0001, respectively) after adjusting for sex (males, ORadj: 1.6, P=0.0001), age tertiles (second and third tertiles, ORadj: 2.0 and 4.7, P=0.0001), Charlson Comorbidity Index (second and third tertiles, ORadj: 4.8 and 8.6, P=0.0001), heart failure, and previous and in-hospital antihypertensive treatment. Our data show that AS and admission systolic BP <120 mm Hg had independent prognostic value for all-cause mortality in patients with COVID-19 requiring hospitalization

HLA association with the susceptibility to anti-synthetase syndrome

Objective To investigate the human leukocyte antigen (HLA) association with anti-synthetase syndrome (ASSD). Methods We conducted the largest immunogenetic HLA-DRB1 and HLA-B study to date in a homogeneous cohort of 168 Caucasian patients with ASSD and 486 ethnically matched healthy controls by sequencing-based-typing. Results A statistically significant increase of HLA-DRB1*03:01 and HLA-B*08:01 alleles in patients with ASSD compared to healthy controls was disclosed (26.2% versus 12.2%, P = 1.56E?09, odds ratio?OR [95% confidence interval?CI] = 2.54 [1.84?3.50] and 21.4% versus 5.5%, P = 18.95E?18, OR [95% CI] = 4.73 [3.18?7.05]; respectively). Additionally, HLA-DRB1*07:01 allele was significantly decreased in patients with ASSD compared to controls (9.2% versus 17.5%, P = 0.0003, OR [95% CI] = 0.48 [0.31?0.72]). Moreover, a statistically significant increase of HLA-DRB1*03:01 allele in anti-Jo-1 positive compared to anti-Jo-1 negative patients with ASSD was observed (31.8% versus 15.5%, P = 0.001, OR [95% CI] = 2.54 [1.39?4.81]). Similar findings were observed when HLA carrier frequencies were assessed. The HLA-DRB1*03:01 association with anti-Jo-1 was unrelated to smoking history. No HLA differences in patients with ASSD stratified according to the presence/absence of the most representative non-anti-Jo-1 anti-synthetase autoantibodies (anti-PL-12 and anti-PL-7), arthritis, myositis or interstitial lung disease were observed. Conclusions Our results support the association of the HLA complex with the susceptibility to ASS

Mendelian Randomisation Confirms the Role of Y-Chromosome Loss in Alzheimer’s Disease Aetiopathogenesis in Men

Mosaic loss of chromosome Y (mLOY) is a common ageing-related somatic event and has been previously associated with Alzheimer’s disease (AD). However, mLOY estimation from genotype microarray data only reflects the mLOY degree of subjects at the moment of DNA sampling. Therefore, mLOY phenotype associations with AD can be severely age-confounded in the context of genome-wide association studies. Here, we applied Mendelian randomisation to construct an age-independent mLOY polygenic risk score (mloy-PRS) using 114 autosomal variants. The mloy-PRS instrument was associated with an 80% increase in mLOY risk per standard deviation unit (p = 4.22 × 10−20) and was orthogonal with age. We found that a higher genetic risk for mLOY was associated with faster progression to AD in men with mild cognitive impairment (hazard ratio (HR) = 1.23, p = 0.01). Importantly, mloy-PRS had no effect on AD conversion or risk in the female group, suggesting that these associations are caused by the inherent loss of the Y chromosome. Additionally, the blood mLOY phenotype in men was associated with increased cerebrospinal fluid levels of total tau and phosphorylated tau181 in subjects with mild cognitive impairment and dementia. Our results strongly suggest that mLOY is involved in AD pathogenesis.P.G.-G. (Pablo García-González) is supported by CIBERNED employment plan CNV-304-PRF-866. CIBERNED is integrated into ISCIII (Instituto de Salud Carlos III). I.d.R is supported by a national grant from the Instituto de Salud Carlos III FI20/00215. A.C. (Amanda Cano) acknowledges the support of the Spanish Ministry of Science, Innovation, and Universities under the grant Juan de la Cierva (FJC2018-036012-I). M.B. (Mercé Boada) and A.R. (Agustín Ruiz) are also supported by national grants PI13/02434, PI16/01861, PI17/01474, PI19/01240, and PI19/01301. The Genome Research @ Fundació ACE project (GR@ACE) is supported by Grifols SA, Fundación bancaria “La Caixa”, Fundació ACE, and CIBERNED. Acción Estratégica en Salud is integrated into the Spanish National R + D + I Plan and funded by ISCIII (Instituto de Salud Carlos III)—Subdirección General de Evaluación—and the Fondo Europeo de Desarrollo Regional (FEDER—“Una manera de hacer Europa”). Genotyping of the ACE MCI-EADB samples was performed in the context of EADB (European Alzheimer DNA biobank) funded by the JPco-fuND FP-829-029 (ZonMW project number 733051061). This work was supported by a grant (European Alzheimer DNA BioBank, EADB) from the EU Joint Program—Neurodegenerative Disease Research (JPND). Partial funding for open access charge: Universidad de Málag