Aceite de oliva virgen y regulación hormonal de la presión arterial: una revisión del papel de los enzimas proteolíticos

Numerosos estudios realizados en los últimos años, han puesto de manifiesto que los niveles elevados de grasa en la dieta están directamente relacionados con el desarrollo de diversas patologías, entre las que destacan enfermedades cardiovasculares, diabetes o incluso diversos tipos de cánceres. Estudios epidemiológicos también han demostrado que no sólo es importante la cantidad, sino también el tipo de grasa de la dieta. Son especialmente conocidos los efectos beneficiosos de la dieta mediterránea, caracterizada entre otros aspectos, por un consumo elevado de ácidos grasos monoinsaturados como el oleico. En cualquier caso, no se conoce con exactitud las relaciones existentes entre el tipo de grasa de la dieta y el desarrollo de las distintas patologías. Las aminopeptidasas son enzimas proteolíticos implicados en una amplia variedad de procesos biológicos, destacando su papel en el control de la presión arterial a través del sistema renina-angiotensina. En esta revisión se estudia la influencia de una dieta enriquecida en aceite de oliva sobre la actividad aminopeptidásica sérica y de tejidos periféricos, analizando su influencia en la regulación del sistema renina-angiotensina para el control de la presión arterial y el balance de líquidos y electrolitos.The intake of high fat dietary levels is related to the development of several pathologies such as cardiovascular diseases, diabetes and cancer. However, epidemiological studies have demonstrated that not only the amount but also the type of dietary fat participates in the origin of the diseases. In fact, several important beneficts have been attributed to the Mediterranean diet, characterized by the high intake of monoinsaturated fatty acids such as oleic acid preferently. In any case, the relationship between the type of dietary fat an the development of diseases are unknown. Aminopeptidases are proteolytic enzymes involved in several biological proccesses, regulating blood pressure through the renin-angiotensin system. In this review, the influence of an olive oil-enriched diet is presented, analyzing their role in the regulation of blood pressure, local blood flow and fluid and electrolytic balance among other functions

Clasificación de cultivos y de sus medidas agroambientales mediante segmentación de imágenes QuickBird

En la últimas décadas han ido creciendo considerablemente los conocimientos y la sensibilización sobre la protección al medioambiente en muy diversas áreas, entre las que se encuentra la Agricultura. El uso intensivo del laboreo ocasiona graves daños medioambientales como la erosión del suelo, la contaminación de las aguas superficiales (escorrentía y colmatación de embalses), el descenso del contenido de la materia orgánica y de la biodiversidad de los suelos labrados, y el aumento de la emisión de CO2 del suelo a la atmósfera. Actualmente, la Unión Europea sólo subvenciona a los agricultores que cumplen lo que se conoce como “Medidas Agroambientales o de Condicionalidad” cuyo diseño ha estado dentro de las competencias de las Políticas Agrarias Autonómicas, Nacionales y Europeas. Estas medidas consisten en alterar el perfil y la estructura del suelo lo menos posible, dejando éste sin labrar y permanentemente protegido por cubiertas vegetales (rastrojo) en el caso de cultivos herbáceos (ej. trigo, maíz, girasol), o por cubiertas vegetales vivas o inertes (restos de poda) en el caso de cultivos leñosos (principalmente cítricos y olivar). El seguimiento del cumplimiento de estas medidas se realiza a través de visitas presenciales a un 1% de los campos susceptibles de recibir ayudas. Este método es ineficiente y provoca muchos errores con la consiguiente presentación de un ingente número de reclamaciones. Para subsanar esta problemática, en este artículo presentamos los resultados obtenidos en la clasificación de los cultivos y las medidas agroambientales asociadas a éstos en una imagen multiespectral QuickBird tomada a principios de Julio de una zona típica de cultivos en régimen de secano de Andalucía. Se aplicaron 5 métodos de clasificación (Paralelepípedos, P; Mínima Distancia, MD; Distancia de Mahalanobis, MC; Mapeo del Ángulo Espectral, SAM; y Máxima Probabilidad, ML) para la discriminación de rastrojo de trigo quemado y sin quemar, arbolado, carreteras, olivar, cultivos herbáceos de siembra primaveral y suelo desnudo. Además, la imagen es segmentada en objetos para comparar la fiabilidad obtenida aplicando los métodos anteriores partiendo tanto de píxeles como de objetos como Unidades Mínimas de Información (MIU). El análisis de los resultados permite concluir que las clasificaciones de todos los usos de suelo basadas en objetos claramente mejoraron las basadas en píxeles, obteniéndose precisiones (overall accuracy) mayores al 85%. La elección de un método de clasificación u otro influye en gran medida en la precisión de los mapas obtenidos. Debido a que la precisión del mapa temático que necesitamos obtener ha de ser muy elevada para tomar decisiones sobre Conceder / No conceder las ayudas, sería interesante estudiar si el incremento de la resolución espacial que se obtenga gracias a la fusión de imágenes multiespectral y pancromática de QuickBird para obtener una imagen fusionada con resolución espacial de la pancromática (0.7 m) y espectral de la multiespectral (4 bandas) mejora la precisión de cualquiera de los métodos de clasificación estudiadosSoil management in crops is mainly based on intensive tillage operations, which have a great relevancy in terms of increase of atmospheric CO2, desertification, erosion and land degradation. Due to these negative environmental impacts, the European Union only subsidizes cropping systems which require the implementation of certain no-tillage systems and agro-environmental measures, such as keeping the winter cereal residues and non-burning of stubble to reduce erosion, and to increase the organic matter, the fertility of soils and the crop production. Nowadays, the follow-up of these agrarian policy actions is achieved by ground visits to sample targeted farms; however, this procedure is time-consuming and very expensive. To improve this control procedure, a study of the accuracy performance of several classification methods has been examined to verify if remote sensing can offer the ability to efficiently identify crops and their agro-environmental measures in a typical agricultural Mediterranean area of dry conditions. Five supervised classification methods based on different decision rule routines, Parallelepiped (P), Minimum Distance (MD), Mahalanobis Classifier Distance (MC), Spectral Angle Mapper (SAM), and Maximum Likelihood (ML), were examined to determine the most suitable classification algorithm for the identification of agro-environmental measures such as winter cereal stubble and burnt stubble areas and other land uses such as river side trees, vineyard, olive orchards, spring sown crops, roads and bare soil. An object segmentation of the satellite information was also added to compare the accuracy of the classification results of pixel and object as Minimum Information Unit (MIU). A multispectral QuickBird image taken in early summer was used to test these MIU and classification methods. The resulting classified images indicated that object-based analyses clearly outperformed pixel ones, yielding overall accuracies higher than 85% in most of the classifications. The choice of a classification method can markedly influence the accuracy of classification maps

La estructura sísmica de la corteza de la Zona de Ossa Morena y su interpretación geológica

El experimento de sísmica de reflexión profunda IBERSEIS ha proporcionado una imagen de la corteza del Orógeno Varisco en el sudoeste de Iberia. Este artículo se centra en la descripción de la corteza de la Zona de Ossa Morena (OMZ), que está claramente dividida en una corteza superior, con reflectividad de buzamiento al NE, y una corteza inferior de pobre reflectividad. Las estructuras geológicas cartografiadas en superficie se correlacionan bien con la reflectividad de la corteza superior, y en la imagen sísmica se ven enraizar en la corteza media. Ésta está constituida por un cuerpo muy reflectivo, interpretado como una gran intrusión de rocas básicas. La imagen de las suturas que limitan la OMZ muestra el carácter fuertemente transpresivo de la colisión orogénica varisca registrada en el sudoeste de Iberia. La Moho actual es plana y, en consecuencia, no se observa la raíz del orógeno

Diet quality index as a predictor of treatment efficacy in overweight and obese adolescents: The EVASYON study

Background & aim: A diet quality index (DQI) is a tool that provides an overall score of an individual''s dietary intake when assessing compliance with food-based dietary guidelines. A number of DQIs have emerged, albeit their associations with health-related outcomes are debated. The aim of the present study was to assess whether adherence to dietary intervention, and the overall quality of the diet, can predict body composition changes. Methods: To this purpose, overweight/obese adolescents (n = 117, aged: 13–16 years; 51 males, 66 females) were recruited into a multi-component (diet, physical activity and psychological support) family-based group treatment programme. We measured the adolescents’ compliance and body composition at baseline and after 2 months (intensive phase) and 13 months (extensive phase) of follow-up. Also, at baseline, after 6 months, and at the end of follow-up we calculated the DQI. Results: Global compliance with the dietary intervention was 37.4% during the intensive phase, and 14.3% during the extensive phase. Physical activity compliance was 94.1% at 2-months and 34.7% at 13months and psychological support compliance were growing over the intervention period (10.3% intensive phase and 45.3% during extensive phase). Adolescents complying with the meal frequency criteria at the end of the extensive phase had greater reductions in FMI z-scores than those did not complying (Cohen''s d = 0.53). A statistically significant association was observed with the diet quality index. DQI-A variation explained 98.1% of BMI z-score changes and 95.1% of FMI changes. Conclusions: We conclude that assessment of changes in diet quality could be a useful tool in predicting body composition changes in obese adolescents involved in a diet and physical activity intervention programme backed-up by psychological and family support

RICORS2040 : The need for collaborative research in chronic kidney disease

Chronic kidney disease (CKD) is a silent and poorly known killer. The current concept of CKD is relatively young and uptake by the public, physicians and health authorities is not widespread. Physicians still confuse CKD with chronic kidney insufficiency or failure. For the wider public and health authorities, CKD evokes kidney replacement therapy (KRT). In Spain, the prevalence of KRT is 0.13%. Thus health authorities may consider CKD a non-issue: very few persons eventually need KRT and, for those in whom kidneys fail, the problem is 'solved' by dialysis or kidney transplantation. However, KRT is the tip of the iceberg in the burden of CKD. The main burden of CKD is accelerated ageing and premature death. The cut-off points for kidney function and kidney damage indexes that define CKD also mark an increased risk for all-cause premature death. CKD is the most prevalent risk factor for lethal coronavirus disease 2019 (COVID-19) and the factor that most increases the risk of death in COVID-19, after old age. Men and women undergoing KRT still have an annual mortality that is 10- to 100-fold higher than similar-age peers, and life expectancy is shortened by ~40 years for young persons on dialysis and by 15 years for young persons with a functioning kidney graft. CKD is expected to become the fifth greatest global cause of death by 2040 and the second greatest cause of death in Spain before the end of the century, a time when one in four Spaniards will have CKD. However, by 2022, CKD will become the only top-15 global predicted cause of death that is not supported by a dedicated well-funded Centres for Biomedical Research (CIBER) network structure in Spain. Realizing the underestimation of the CKD burden of disease by health authorities, the Decade of the Kidney initiative for 2020-2030 was launched by the American Association of Kidney Patients and the European Kidney Health Alliance. Leading Spanish kidney researchers grouped in the kidney collaborative research network Red de Investigación Renal have now applied for the Redes de Investigación Cooperativa Orientadas a Resultados en Salud (RICORS) call for collaborative research in Spain with the support of the Spanish Society of Nephrology, Federación Nacional de Asociaciones para la Lucha Contra las Enfermedades del Riñón and ONT: RICORS2040 aims to prevent the dire predictions for the global 2040 burden of CKD from becoming true

Spectral discrimination of wild oat and canary grass in wheat fields for less herbicide application

Wheat, Triticum durum L, is a major cereal crop in Spain with over five million ha grown annually. Wild oat, Avena sterilis L., and canary grass, Phalaris spp., are distributed only in patches in wheat fields but herbicides are applied over entire fields, thus leading to over-application and unnecessary pollution. To reduce herbicide application, site-specific management techniques based on weed maps are being developed to treat only weed patches. Intensive weed scouting from the ground is time-consuming and expensive, and it relies on estimates of weeds at unsampled points. Remote sensing of weed canopies has been shown to be a more efficient alternative. The principle of weed remote sensing is that there are differences in the spectral reflectance between weeds and crops. To test this principle, we studied spectral signatures taken on the ground in the visible and near-infrared windows for discriminating wheat, wild oat and canary grass at their last phenological stages. Late-season phenological stages included initial seed maturation through advanced maturation for weeds, and initial senescence to senescent for wheat. Spectral signatures were collected on eight sampling dates from April 28 through May 26 using a handheld field spectroradiometer. A stepwise discriminant analysis was used to detect differences in reflectance and to determine the accuracy performance for a species classification as affected by their phenological stage. Four scenarios or classification sets were considered: wheat-wild oat-canary grass, with each species represented by a different group of spectra; wheat and grass weeds, combining the two weed species into one spectral group; wheat and wild oat with each represented as a single group, and finally, wheat and canary grass. Our analysis achieved 100% classification accuracy at the phenological stages of initial seed maturation, and green and advanced seed maturation and partly green for weeds and wheat, respectively, between the dates of April 28 and May 6. Furthermore, we reduced the number of hyperspectral wavelengths to thirteen out of 50. Multispectral analysis also showed that broad wavebands corresponding to those of QuickBird satellite imagery discriminated wild oat, canary grass and wheat at the same phenological stages and dates. Our findings are very useful for determining the timeframe during which future multispectral QuickBird satellite images will be obtained and the concrete wavelengths that should be used in case of using airborne hyperspectral imaging. Accurate and timely mapping of the spatial distribution of weeds is a key element in achieving site-specific herbicide applications for reducing spraying volume of herbicides and costs

One million years of cultural evolution in a stable environment at Atapuerca (Burgos, Spain)

Received 16 June 2009 / Received in revised form 16 February 2010 / Accepted 16 February 2010 / Available online 23 March 2010 © 2010 Elsevier Ltd. All rights reserved. Corresponding author. Tel.: +34 947 255006. E-mail address: [email protected] (J. Rodríguez). Supplementary material associated with this article can be found in the online version at doi:10.1016/j.quascirev.2010.02.021.The present paper analyses the evidence provided by three sites (Sima del Elefante, Gran Dolina, and Galería) located in the Trinchera del Ferrocarril of the Sierra de Atapuerca. These three sites are cave infillings that contain sediments deposited from approximately 1.2 Ma to 200 kyr. Pollen, herpetofauna, and small and large mammal remains are used as proxies to obtain a general picture of the environmental changes that occurred at the Sierra de Atapuerca throughout the one million-year period represented at these sites. Similarly, cultural changes are tracked analyzing the evidence of human behavior obtained from the study of several bone and lithic assemblages from these three sites. At least three periods with different cultural features, involving technology, subsistence and behavior, are determined from the available evidence. The first two periods correspond to the Mode 1 technology and Homo antecessor: the first is dated around 1.2 to 1.0 Ma and reflects opportunistic behavior both in technology and subsistence. The second period is around 800 kyr BP. Mode 1 technology is still maintained, but subsistence strategies include systematic hunting and the use of base camps. The third period is dated between 500 ka and 200 ka and corresponds to the Mode 2 technology and the acquisition of directional hunting and other organizational strategies by Homo heidelbergensis. A transition from Mode 2 to Mode 3 seems to appear at the end of this time-range, and may reflect the early phases of a fourth cultural change. With regard to the environment, our main conclusion is that there was an absence of extremely harsh conditions at Atapuerca throughout this time period. The presence of Mediterranean taxa was constant and the dominant landscape was a savannah-like open environment, probably with small forest patches. An alternation of Mediterranean and mesic species as the dominant component of the tree storey was induced by the climatic cycles, and steppes spread across the landscape during the drier periods. In any case, it is not possible to establish clear cut-off points separating entirely different environmental episodes. Our results show no evidence of any relationship between environmental change and cultural change at the Sierra de Atapuerca.Ministerio de Ciencia e Innovación (España)Ministerio de Ciencia e Innovación (España)Ministerio de Ciencia e Innovación (España)Ministerio de Educación y Ciencia (España)Junta de Castilla y LeónMinisterio de Ciencia e Innovación (España)Depto. de Geodinámica, Estratigrafía y PaleontologíaFac. de Ciencias GeológicasTRUEpu