3 research outputs found
Semi-Huber potential function for image segmentation
In this work, a novel model of Markov random field is presented, named Semi-Huber potential function, applied
to image segmentation in presence of noise. The main difference with respect to other models that have been
taken as a reference, is that the number of parameters in the proposed model is significatively smaller. The idea is to choose adequate parameter values heuristically for a good segmentation of the image. In that sense, experiment results show that the proposed model allows a faster and easier parameter adjustment with razonable computation times
Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)
Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters.
Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs).
Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001).
Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio
ENGIU: Encuentro Nacional de Grupos de Investigación de UNIMINUTO.
El desarrollo del prototipo para el sistema de detección de Mina Antipersona
(MAP), inicia desde el semillero ADSSOF perteneciente al programa de Administración en Seguridad y Salud en el trabajo de la UNIMINUTO, se realiza a partir de un
detector de metales que emite una señal audible, que el usuario puede interpretar
como aviso de presencia de un objeto metálico, en este caso una MAP. La señal
audible se interpreta como un dato, como ese dato no es perceptible a 5 metros de
distancia, se implementa el transmisor de Frecuencia Modulada FM por la facilidad
de modulación y la escogencia de frecuencia de transmisión de acuerdo con las
normas y resolución del Ministerio de Comunicaciones; de manera que esta sea la
plataforma base para enviar los datos obtenidos a una frecuencia establecida. La
idea es que el ser humano no explore zonas peligrosas y buscar la forma de crear
un sistema que permita eliminar ese riesgo, por otro lado, buscar la facilidad de uso
de elementos ya disponibles en el mercado