Linfangioma gigante abdominal como causa de dolor abdominal inespecífico: presentación de un caso clínico

El linfangioma es una lesión benigna y poco frecuente que resulta de la malformación congénita del sistema linfático. Suele localizarse con mayor frecuencia en cabeza, cuello, axilas e ingles, aunque puede afectar cualquier localización corporal. El diagnóstico supone un reto para el pediatra, ya que, en la mayoría de las ocasiones, cursa de forma asintomática o con clínica inespecífica. Raramente cursa con síntomas derivados de alguna de sus complicaciones (rotura, hemorragia, infección). El tratamiento es quirúrgico en la mayoría de los casos. Presentamos el caso de un paciente de 9 años que acude al Servicio de Urgencias por dolor abdominal y estreñimiento de corta evolución, objetivándose en ecografía abdominal una gran masa quística cuya biopsia y PAAF revela el diagnóstico de linfangioma gigante. La resección parcial del tumor mejora el cuadro, permaneciendo a partir de entonces el paciente asintomático. Como conclusión, aunque el dolor abdominal y el estreñimiento son síntomas de etiología habitualmente banal, es importante plantearnos dentro del diagnóstico diferencial la posibilidad de masa abdominal.Lymphangioma is a benign and rare injury resulting from the congenital malformation of the lymphatic system. It is usually located in head, neck, armpits and groins, although it can affect any body location. The diagnosis is a challenge for the pediatrician, because, in most cases, is asymptomatic or nonspecific clinical. Rarely presents with symptoms resulting from some of its complications (rupture, hemorrhage, infection). The treatment is surgical in most cases. We report the case of a 9 years old boy who comes to the emergency department for abdominal pain and short evolution constipation. A large abdominal cystic mass was found with ultrasound, which biopsy revealed the diagnosis of giant lymphangioma. Partial resection of the tumor improves the symptoms, remaining thereafter asymptomatic. Although abdominal pain and constipation are usually banal symptoms, we must consider in the differential diagnosis the possibility of abdominal mass

Pedagogía para la práctica educativa del siglo XXI

La obra es coordinada por el doctor René Pedroza Flores, investigador del Instituto de Estudios Sobre la Universidad (iesu), de la uaem; miembro del Sistema Nacional de Investigadores (sni), nivel 2, e integrante regular en la Academia Mexicana de las Ciencias. En este libro participan profesoresinvestigadores miembros expertos en la temática y pertenecientes a nuestra universidad, así como investigadores de importante prestigio internacional en diversas disciplinas. En este sentido, destacan las investigaciones de los españoles Clara Ventura Obrador, Gloria Alguacil Buchna y el colombiano Carlos Alberto Jiménez Vélez; además de la colaboración de la antropóloga francesa Noemí Paymal. Asimismo, son relevantes las contribuciones de los investigadores mexicanos Salvador Soriano y Mónica E. Soriano. Las propuestas incluidas en Pedagogía para la práctica educativa del siglo xxi están encaminadas a conformar mejores sociedades en nuestra era, considerando que la comprensión de estas posturas y su aplicación en diversos contextos específicos representará una posibilidad para edificar sociedades mucho más justas, equitativas y humanas; sobre todo en ámbitos profesionales y universitarios urgentes de subsanar problemáticas en los procesos mundiales educativos de hoy.Pedagogía para la práctica educativa del siglo xxi es una obra que muestra cómo la dinámica de la sociedad actual lleva a concebir la educación de una forma diferente de la visión prevaleciente en la actualidad, la cual reconoce en las competencias y las habilidades el único medio para lograr en los individuos su desarrollo e inserción social. El presente libro otorga al lector un panorama epistemológico, metodológico y teórico del nacimiento de un nuevo paradigma pedagógico, al considerar que una pedagogía humana implica la enseñanza integral y holística posible, mediante el uso de diversos recursos de enseñanza-aprendizaje acordes con la formación de las sociedades de nuestro siglo.UAE

Toenail zinc as a biomarker: Relationship with sources of environmental exposure and with genetic variability in MCC-Spain study

Background: Toenails are commonly used as biomarkers of exposure to zinc (Zn), but there is scarce information about their relationship with sources of exposure to Zn. Objectives: To investigate the main determinants of toenail Zn, including selected sources of environmental exposure to Zn and individual genetic variability in Zn metabolism. Methods: We determined toenail Zn by inductively coupled plasma mass spectrometry in 3,448 general popu-lation controls from the MultiCase-Control study MCC-Spain. We assessed dietary and supplement Zn intake using food frequency questionnaires, residential proximity to Zn-emitting industries and residential topsoil Zn levels through interpolation methods. We constructed a polygenic score of genetic variability based on 81 single nucleotide polymorphisms in genes involved in Zn metabolism. Geometric mean ratios of toenail Zn across categories of each determinant were estimated from multivariate linear regression models on log-transformed toenail Zn. Results: Geometric mean toenail Zn was 104.1 mu g/g in men and 100.3 mu g/g in women. Geometric mean toenail Zn levels were 7 % lower (95 % confidence interval 1-13 %) in men older than 69 years and those in the upper tertile of fibre intake, and 9 % higher (3-16 %) in smoking men. Women residing within 3 km from Zn-emitting industries had 4 % higher geometric mean toenail Zn levels (0-9 %). Dietary Zn intake and polygenic score were unrelated to toenail Zn. Overall, the available determinants only explained 9.3 % of toenail Zn variability in men and 4.8 % in women. Discussion: Sociodemographic factors, lifestyle, diet, and environmental exposure explained little of the indi-vidual variability of toenail Zn in the study population. The available genetic variants related to Zn metabolism were not associated with toenail Zn

Jardins per a la salut

Facultat de Farmàcia, Universitat de Barcelona. Ensenyament: Grau de Farmàcia. Assignatura: Botànica farmacèutica. Curs: 2014-2015. Coordinadors: Joan Simon, Cèsar Blanché i Maria Bosch.Els materials que aquí es presenten són el recull de les fitxes botàniques de 128 espècies presents en el Jardí Ferran Soldevila de l’Edifici Històric de la UB. Els treballs han estat realitzats manera individual per part dels estudiants dels grups M-3 i T-1 de l’assignatura Botànica Farmacèutica durant els mesos de febrer a maig del curs 2014-15 com a resultat final del Projecte d’Innovació Docent «Jardins per a la salut: aprenentatge servei a Botànica farmacèutica» (codi 2014PID-UB/054). Tots els treballs s’han dut a terme a través de la plataforma de GoogleDocs i han estat tutoritzats pels professors de l’assignatura. L’objectiu principal de l’activitat ha estat fomentar l’aprenentatge autònom i col·laboratiu en Botànica farmacèutica. També s’ha pretès motivar els estudiants a través del retorn de part del seu esforç a la societat a través d’una experiència d’Aprenentatge-Servei, deixant disponible finalment el treball dels estudiants per a poder ser consultable a través d’una Web pública amb la possibilitat de poder-ho fer in-situ en el propi jardí mitjançant codis QR amb un smartphone

Population-based multicase-control study in common tumors in Spain (MCC-Spain): rationale and study design

Introduction: We present the protocol of a large population-based case-control study of 5 common tumors in Spain (MCC-Spain) that evaluates environmental exposures and genetic factors. Methods: Between 2008-2013, 10,183 persons aged 20-85 years were enrolled in 23 hospitals and primary care centres in 12 Spanish provinces including 1,115 cases of a new diagnosis of prostate cancer, 1,750 of breast cancer, 2,171 of colorectal cancer, 492 of gastro-oesophageal cancer, 554 cases of chronic lymphocytic leukaemia (CLL) and 4,101 population-based controls matched by frequency to cases by age, sex and region of residence. Participation rates ranged from 57% (stomach cancer) to 87% (CLL cases) and from 30% to 77% in controls. Participants completed a face-to-face computerized interview on sociodemographic factors, environmental exposures, occupation, medication, lifestyle, and personal and family medical history. In addition, participants completed a self-administered food-frequency questionnaire and telephone interviews. Blood samples were collected from 76% of participants while saliva samples were collected in CLL cases and participants refusing blood extractions. Clinical information was recorded for cases and paraffin blocks and/or fresh tumor samples are available in most collaborating hospitals. Genotyping was done through an exome array enriched with genetic markers in specific pathways. Multiple analyses are planned to assess the association of environmental, personal and genetic risk factors for each tumor and to identify pleiotropic effects. Discussion: This study, conducted within the Spanish Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), is a unique initiative to evaluate etiological factors for common cancers and will promote cancer research and prevention in Spain.The study was partially funded by the “Accion Transversal del Cancer”, approved on the Spanish Ministry Council on the 11th October 2007, by the Instituto de Salud Carlos III-FEDER (PI08/1770, PI08/0533, PI08/1359, PS09/00773, PS09/01286, PS09/01903, PS09/02078, PS09/01662, PI11/01403, PI11/01889, PI11/00226, PI11/01810, PI11/02213, PI12/00488, PI12/00265, PI12/01270, PI12/00715, PI12/00150), by the Fundación Marqués de Valdecilla (API 10/09), by the ICGC International Cancer Genome Consortium CLL, by the Junta de Castilla y León (LE22A10-2), by the Consejería de Salud of the Junta de Andalucía (PI-0571), by the Conselleria de Sanitat of the Generalitat Valenciana (AP 061/10), by the Recercaixa (2010ACUP 00310), by the Regional Government of the Basque Country by European Commission grants FOOD-CT- 2006-036224-HIWATE, by the Spanish Association Against Cancer (AECC) Scientific Foundation, by the The Catalan Government DURSI grant 2009SGR1489

Modelos anatómicos plastinados, reconstrucción 3D y herramienta diagnóstica para el estudio de los defectos de la pared corporal en el recién nacido.

Universidad Complutense de MadridSección Deptal. de Anatomía y Embriología (Veterinaria)Fac. de VeterinariaFALSEsubmitte

Toenail zinc as a biomarker: Relationship with sources of environmental exposure and with genetic variability in MCC-Spain study

Background Toenails are commonly used as biomarkers of exposure to zinc (Zn), but there is scarce information about their relationship with sources of exposure to Zn. Objectives To investigate the main determinants of toenail Zn, including selected sources of environmental exposure to Zn and individual genetic variability in Zn metabolism. Methods We determined toenail Zn by inductively coupled plasma mass spectrometry in 3,448 general population controls from the MultiCase-Control study MCC-Spain. We assessed dietary and supplement Zn intake using food frequency questionnaires, residential proximity to Zn-emitting industries and residential topsoil Zn levels through interpolation methods. We constructed a polygenic score of genetic variability based on 81 single nucleotide polymorphisms in genes involved in Zn metabolism. Geometric mean ratios of toenail Zn across categories of each determinant were estimated from multivariate linear regression models on log-transformed toenail Zn. Results Geometric mean toenail Zn was 104.1 µg/g in men and 100.3 µg/g in women. Geometric mean toenail Zn levels were 7 % lower (95 % confidence interval 1?13 %) in men older than 69 years and those in the upper tertile of fibre intake, and 9 % higher (3?16 %) in smoking men. Women residing within 3 km from Zn-emitting industries had 4 % higher geometric mean toenail Zn levels (0?9 %). Dietary Zn intake and polygenic score were unrelated to toenail Zn. Overall, the available determinants only explained 9.3 % of toenail Zn variability in men and 4.8 % in women. Discussion Sociodemographic factors, lifestyle, diet, and environmental exposure explained little of the individual variability of toenail Zn in the study population. The available genetic variants related to Zn metabolism were not associated with toenail Zn.Funding: The study was supported by the “Acción Transversal del Cáncer”, approved on the Spanish Ministry Council on the 11 October 2007, by the Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), by the Instituto de Salud Carlos III grants, co-funded by FEDER funds -a way to build Europe- PI08/1770, PI09/0773, PI12/00715, PI09/1903,PI09/2078; PI09/1662; PI11/01403; PI12/00150; PI12/00488; PI15/00914; PI17CIII_00034;by the Fundación Marqués de Valdecilla grant API 10/09, by the Consejería de Salud of the Junta de Andalucía grant 2009-S0143, by the Conselleria de Sanitat of the Generalitat Valenciana grant AP061/10, by the Regional Government of the Basque Country, by the Fundación Caja de Ahorros de Asturias, by the University of Oviedo and by the Spanish Ministry of Economy and Competitiveness Juan de la Cierva de Incorporación grant IJCI-2014-20900.ToenailEnvironmental exposureBiomarkerZincSingle nucleotide polymorphismPolygenic scor

Developmental outcome of electroencephalographic findings in SYNGAP1 encephalopathy

SYNGAP1 haploinsufficiency results in a developmental and epileptic encephalopathy (DEE) causing generalized epilepsies accompanied by a spectrum of neurodevelopmental symptoms. Concerning interictal epileptiform discharges (IEDs) in electroencephalograms (EEG), potential biomarkers have been postulated, including changes in background activity, fixation-off sensitivity (FOS) or eye closure sensitivity (ECS). In this study we clinically evaluate a new cohort of 36 SYNGAP1-DEE individuals. Standardized questionnaires were employed to collect clinical, electroencephalographic and genetic data. We investigated electroencephalographic findings, focusing on the cortical distribution of interictal abnormalities and their changes with age. Among the 36 SYNGAP1-DEE cases 18 presented variants in the SYNGAP1 gene that had never been previously reported. The mean age of diagnosis was 8 years and 8 months, ranging from 2 to 17 years, with 55.9% being male. All subjects had global neurodevelopmental/language delay and behavioral abnormalities; 83.3% had moderate to profound intellectual disability (ID), 91.7% displayed autistic traits, 73% experienced sleep disorders and 86.1% suffered from epileptic seizures, mainly eyelid myoclonia with absences (55.3%). A total of 63 VEEGs were revised, observing a worsening of certain EEG findings with increasing age. A disorganized background was observed in all age ranges, yet this was more common among older cases. The main IEDs were bilateral synchronous and asynchronous posterior discharges, accounting for ≥50% in all age ranges. Generalized alterations with maximum amplitude in the anterior region showed as the second most frequent IED (≥15% in all age ranges) and were also more common with increasing age. Finally, diffuse fast activity was much more prevalent in cases with 6 years or older. To the best of our knowledge, this is the first study to analyze EEG features across different age groups, revealing an increase in interictal abnormalities over infancy and adolescence. Our findings suggest that SYNGAP1 haploinsufficiency has complex effects in human brain development, some of which might unravel at different developmental stages. Furthermore, they highlight the potential of baseline EEG to identify candidate biomarkers and the importance of natural history studies to develop specialized therapies and clinical trials

El castillo de Consuegra y su alfoz

Resumen basado en el del proyecto. Premiado en la convocatoria: Premios para proyectos de innovación concluidos durante el curso 2007-2008, en los centros educativos no universitarios sostenidos con fondos públicos de la Comunidad Autónoma de Castilla-La Mancha (Orden 12-12-2008, de la Consejería de Educación y Ciencia de la Junta de Comunidades de Castilla-La Mancha. Resolución de 5-5-2009, de la Viceconsejería de Educación)El proyecto pretende favorecer líneas de innovación educativa que logren implicar al alumnado y profesorado en el conocimiento de su entorno, el desarrollo de valores, la mejora de los procedimientos, el desarrollo de la competencia lingüística y el uso de las tecnologías de la información y la comunicación. Se da a conocer toda una comarca, el antiguo 'Campo de San Juan', que incluía un vasto territorio controlado por la Orden de San Juan de Jerusalén desde el s. XII, con sede en el castillo de Consuegra, y revalorizar los aspectos básicos del Patrimonio Natural y Cultural de la comarca. Otros objetivos que se persiguen son: comprender y expresar con corrección las conclusiones de la investigación, animando a la lectura como fuente de conocimiento y divertimento; utilizar el conocimiento matemático para identificar los problemas en diversos campos de conocimiento y de la experiencia, para su resolución y para la toma de decisiones; adquirir destrezas y habilidades a partir de conocimientos teóricos; recopilar una memoria fotográfica relacionada con el estudio; respetar la creación musical, identificando y analizando los mensajes que contiene el lenguaje de las distintas manifestaciones musicales (cantigas y folklore popular); utilizar la práctica del deporte para favorecer el desarrollo en lo personal y social, junto a la adquisición de hábitos saludables; utilizar la competencia comunicativa para comprender y expresarse en otros idiomas; confeccionar un proyecto empresarial para la explotación económica del castillo; utilizar los recursos naturales de forma eficaz, respetando el desarrollo sostenible; afianzar el sentido del trabajo en equipo y valorar las perspectivas, experiencias y formas de pensar de los demás, potenciando las relaciones dentro y fuera del contexto educativo como mecanismo de enriquecimiento personal.Castilla La ManchaConsejería de Educación, Ciencia y Cultura. Viceconsejería de Educación y Cultura. Servicio de Documentación; Bulevar del Río Alberche, s. n. - 1 Planta; 45071 Toledo; Tel. +34925286045; Fax +34925247410; [email protected]